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Protein Page:
AMPKG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AMPKG1 a non-catalytic subunit of AMPK, a highly conserved kinase of the CAMKL family. The holoenzyme consists of a catalytic subunit (alpha) and two regulatory subunits (beta, gamma). Each subunit exists as multiple genetic isoforms giving rise to 12 different possible combinations of holoenzyme. Plays a key role in regulation of energy homeostasis. Activated by an elevated AMP-ATP ratio due to environmental stress, such as heat shock, hypoxia and ischemia. AMPK phosphorylates and regulates many metabolic enzymes. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Cellular Component: nucleus; cytosol; AMP-activated protein kinase complex
Molecular Function: AMP-activated protein kinase activity; protein binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase regulator activity; ADP binding; protein kinase binding; ATP binding; AMP binding; protein kinase activity
Biological Process: protein heterooligomerization; regulation of glycolysis; positive regulation of protein kinase activity; insulin receptor signaling pathway; spermatogenesis; signal transduction; cell cycle arrest; protein amino acid phosphorylation; fatty acid biosynthetic process
Reference #:  P54619 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase, gamma-1 subunit; AAKG1; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; MGC8666; PRKAG1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Gene Symbols: PRKAG1
Molecular weight: 37,579 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AMPKG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y107-p KSALVQIyELEEHKI
0 2 K170-ub TLYILTHkRILKFLK
0 2 K234-ub ALPVVDEkGRVVDIY
0 1 K253-ub VINLAAEkTYNNLDV
0 1 Y255 NLAAEkTYNNLDVSV
1 1 S261 TYNNLDVSVTkALQH
1 0 T263 NNLDVSVTkALQHRS
0 2 K264-ac NLDVSVTkALQHRSH
0 3 K264-ub NLDVSVTkALQHRSH
1 0 S270 TkALQHRSHyFEGVL
0 62 Y272-p ALQHRSHyFEGVLKC
0 1 S314 DVVKGIVSLSDILQA
0 6 K329-ub LVLTGGEkkP_____
0 4 K330-ub VLTGGEkkP______
  mouse

 
Y106 KSALVQIYELEEHKI
K169 TLYILTHKRILKFLK
K233 ALPVVDEKGRVVDIY
K252 VINLAAEKTyNNLDV
Y254-p NLAAEKTyNNLDVsV
S260-p TyNNLDVsVTkALQH
T262 NNLDVsVTkALQHRS
K263 NLDVsVTKALQHRSH
K263-ub NLDVsVTkALQHRSH
S269 TkALQHRSHYFEGVL
Y271 ALQHRSHYFEGVLKC
S313-p DVVKGIVsLSDILQA
K328-ub LVLTGGEkKP_____
K329 VLTGGEkKP______
  rat

 
Y106 KSALVQIYELEEHKI
K169 TLYILTHKRILKFLK
K233 ALPVVDEKGRVVDIY
K252 VINLAAEKTYNNLDV
Y254 NLAAEKTYNNLDVsV
S260-p TYNNLDVsVtKALQH
T262-p NNLDVsVtKALQHRs
K263 NLDVsVtKALQHRsH
K263 NLDVsVtKALQHRsH
S269-p tKALQHRsHYFEGVL
Y271 ALQHRsHYFEGVLKC
S313 DVVKGIVSLSDILQA
K328 LVLTGGEKKP_____
K329 VLTGGEKKP______
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