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Protein Page:
SARM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SARM1 Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: microtubule; mitochondrion; axon; dendrite; cytoplasm; synapse; cytosol; cell junction
Biological Process: MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; toll-like receptor signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q6SZW1 (UniProtKB)
Alt. Names/Synonyms: FLJ36296; KIAA0524; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; Sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog
Gene Symbols: SARM1
Molecular weight: 79,388 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SARM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 G40 PDGGGGTGPWWAAGG
0 3 S54-p GRGPREVsPGAGTEV
0 1 K173-ub GVILNLAkEREPVEL
0 1 S183 EPVELARSVAGILEH
0 3 S336-p RLVPLLDsNRLEAQC
0 1 K361-ac AIKSLQGkTkVFSDI
0 2 K363-ub KSLQGkTkVFSDIGA
0 1 K375-ub IGAIQSLkRLVSYST
0 1 - gap
0 4 S548-p AAREMLHsPLPCTGG
0 1 S558 PCTGGKPSGDTPDVF
0 1 S572-p FISYRRNsGSQLASL
  mouse

► Hide Isoforms
 
S40-p PDRSGGAsPWWAAGG
S54-p GRGSREVsPGVGTEV
K173 GVILNLAKEREPVEL
S183-p EPVELARsVAGILEH
S336 SLVLLLDSSRLEAQC
K361 AIKSLQGKTkVFSDI
K363-ub KSLQGKTkVFSDIGA
K375 IGAIQSLKRLVSYST
- gap
S548-p AAREMLHsPLPCTGG
S558-p PCTGGKLsGDTPDVF
S572-p FISYRRNsGSQLASL
  SARM1 iso3  
S40 PDRSGGASPWWAAGG
S54 GRGSREVSPGVGTEV
K173 GVILNLAKEREPVEL
S183 EPVELARSVAGILEH
S336 SLVLLLDSSRLEAQC
K361 AIKSLQGKTKVFSDI
K363 KSLQGKTKVFSDIGA
K375 IGAIQSLKRLVSYST
T549-p ARGHFAQtGLRSLRR
S588 LAPEMLHSPLPCTGG
S598 PCTGGKLSGDTPDVF
S612 FISYRRNSGSQLASL
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