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Protein Page:
ATG18 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG18 May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Cellular Component: Golgi membrane; cytoskeleton; clathrin-coated vesicle; cytoplasm; pre-autophagosomal structure membrane; endosome membrane; trans-Golgi network
Molecular Function: androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding
Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; autophagy; vesicle targeting, trans-Golgi to endosome
Reference #:  Q5MNZ9 (UniProtKB)
Alt. Names/Synonyms: ATG18; Atg18 protein homolog; FLJ10055; WD repeat domain phosphoinositide-interacting protein 1; WD repeat domain, phosphoinositide interacting 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha; WIPI1; WIPI49
Gene Symbols: WIPI1
Molecular weight: 48,673 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG18

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K89-m1 QMNVYHFkkGTEICN
0 1 K90-m1 MNVYHFkkGTEICNY
0 1 T143-p LDIPANPtGLCALSI
0 1 T306 HQDRAFATARLNFSG
0 1 K325 CTLSTIQKLPRLLVA
  mouse

 
K89 QMNVYHFKKGTEICN
K90 MNVYHFKKGTEICNY
T143 LDIPSNPTGLCALSI
T306-p NQDRAFAtGRLNFSG
K325-ub CTLSTIQkLPRLLVA
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