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ATG18 (human)

Overview ATG18 May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy Cellular Component: Golgi membrane; clathrin-coated vesicle; cytoplasm; pre-autophagosomal structure membrane; endosome membrane; trans-Golgi network; cytosol Molecular Function: androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding Biological Process: unfolded protein response, activation of signaling protein activity; unfolded protein response; autophagy; autophagic vacuole formation; vesicle targeting, trans-Golgi to endosome Reference #:  Q5MNZ9 (UniProtKB) Alt. Names/Synonyms: ATG18; Atg18 protein homolog; FLJ10055; WD repeat domain phosphoinositide-interacting protein 1; WD repeat domain, phosphoinositide interacting 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha; WIPI1; WIPI49 Gene Symbols: WIPI1 Molecular weight: 48,673 Da Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG18

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K89-m1	QMNVYHFkkGTEICN
0	1		K90-m1	MNVYHFkkGTEICNY
0	1		T143-p	LDIPANPtGLCALSI
0	1		T306	HQDRAFATARLNFSG
0	1		K325	CTLSTIQKLPRLLVA

	mouse
K89	QMNVYHFKKGTEICN
K90	MNVYHFKKGTEICNY
T143	LDIPSNPTGLCALSI
T306-p	NQDRAFAtGRLNFSG
K325-u	CTLSTIQkLPRLLVA

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