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Protein Page:
S100A4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
S100A4 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Protein type: Motility/polarity/chemotaxis
Cellular Component: extracellular space; neuron projection; perinuclear region of cytoplasm; nucleus
Molecular Function: identical protein binding; protein binding; RAGE receptor binding; calcium ion binding; actin binding; calcium-dependent protein binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; epithelial to mesenchymal transition
Reference #:  P26447 (UniProtKB)
Alt. Names/Synonyms: 18A2; 42A; Calvasculin; CAPL; fibroblast-specific protein-1; FSP1; leukemia multidrug resistance associated protein; malignant transformation suppression 1; Metastasin; MTS1; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100-A4; S100 calcium binding protein A4; S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); S100 calcium-binding protein A4; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); S100A4; S10A4
Gene Symbols: S100A4
Molecular weight: 11,729 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

S100A4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K7-ac _MACPLEkALDVMVS
0 1 K18-ac VMVSTFHkYSGkEGD
0 4 K22-ub TFHkYSGkEGDKFKL
1 0 K22-sm TFHkYSGkEGDKFKL
0 4 K31-ub GDKFKLNksELkELL
0 1 K31-sc GDKFKLNksELkELL
0 2 S32-p DKFKLNksELkELLT
0 2 K35-ac KLNksELkELLTREL
0 15 K35-ub KLNksELkELLTREL
0 1 K35-sc KLNksELkELLTREL
0 1 S44-p LLTRELPsFLGkRTD
0 20 K48-ac ELPsFLGkRTDEAAF
0 31 K48-ub ELPsFLGkRTDEAAF
0 1 K48-sc ELPsFLGkRTDEAAF
0 1 K57-ac TDEAAFQkLMSNLDs
0 26 K57-ub TDEAAFQkLMSNLDs
0 1 S64-p kLMSNLDsNRDNEVD
0 2 K96-ub FFEGFPDkQPRKK__
1 0 K96-sm FFEGFPDkQPRKK__
  mouse

 
E7 _MARPLEEALDVIVS
K18 VIVSTFHKYSGKEGD
K22 TFHKYSGKEGDKFKL
K22 TFHKYSGKEGDKFKL
K31 GDKFKLNKTELkELL
K31 GDKFKLNKTELkELL
T32 DKFKLNKTELkELLT
K35 KLNKTELKELLTREL
K35-ub KLNKTELkELLTREL
K35 KLNKTELKELLTREL
S44 LLTRELPSFLGkRTD
K48-ac ELPSFLGkRTDEAAF
K48 ELPSFLGKRTDEAAF
K48 ELPSFLGKRTDEAAF
K57 TDEAAFQKVMSNLDS
K57-ub TDEAAFQkVMSNLDS
S64 kVMSNLDSNRDNEVD
K96 FFEGCPDKEPRKK__
K96 FFEGCPDKEPRKK__
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