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Protein Page:
NR0B1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NR0B1 orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. Homodimerizes with STF-1, NR5A2, NR0B2 and with COPS2. Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus. Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with STF-1 and NROB2 through its N-terminal LXXLL motifs. Defects in NR0B1 are the cause of congenital X-linked adrenal hypoplasia. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor
Cellular Component: nucleoplasm; polysomal ribosome; membrane; cytoplasm; nucleus
Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; RNA binding; transcription factor binding; steroid hormone receptor binding; DNA hairpin binding; protein binding; DNA binding; AF-2 domain binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity
Biological Process: transcription initiation from RNA polymerase II promoter; negative regulation of steroid hormone receptor signaling pathway; hypothalamus development; gonad development; intracellular receptor-mediated signaling pathway; adrenal gland development; negative regulation of transcription factor activity; male gonad development; Sertoli cell differentiation; negative regulation of transcription from RNA polymerase II promoter; protein localization; negative regulation of cell differentiation; Leydig cell differentiation; pituitary gland development; male sex determination; spermatogenesis; gene expression; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent; steroid biosynthetic process
Reference #:  P51843 (UniProtKB)
Alt. Names/Synonyms: AHC; AHCH; AHX; DAX-1; DAX1; DSS; DSS-AHC critical region on the X chromosome protein 1; GTD; HHG; NR0B1; NROB1; nuclear hormone receptor; Nuclear receptor DAX-1; Nuclear receptor subfamily 0 group B member 1; nuclear receptor subfamily 0, group B, member 1
Gene Symbols: NR0B1
Molecular weight: 51,718 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NR0B1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T100-p APKAPEAtLGPCWGC
0 1 S108-p LGPCWGCsCGsDPGV
0 1 S111-p CWGCsCGsDPGVGRA
0 8 K249 ALRPVALKSPQVVCE
0 3 K270 LKTLRFVKYLPCFQV
0 1 T328-p LTTRRREtGGNEPLP
0 1 T338-p NEPLPVPtLQHHLAP
0 1 S354-p AEARKVPsAsQVQAI
0 1 S356-p ARKVPsAsQVQAIKC
0 1 S366-p QAIKCFLsKCWSLNI
0 3 K398 VPGLQCVKYIQGLQW
  mouse

 
R100 ATQAPRARFGAPCWG
A109 GAPCWGCACGSAEPL
S112 CWGCACGSAEPLVGR
K251-ub VQRLITLkDPQVVCE
K272-ub LKTLRFVkYLPCFQI
T330 LTTRRQETEGPEPAE
T341 EPAEPQATEQPQMVS
P356 AEAGHLLPAAAVQAI
A358 AGHLLPAAAVQAIKS
F368 QAIKSFFFKCWSLNI
K400-ub LPGLQCVkYIEGLQW
  rat

 
R100 ATEAPRARFRTPCWG
A109 RTPCWGCACSNAKPL
N112 CWGCACSNAKPLVGR
K251 VQRPIALKDPQVVCE
K272 LKTLRFVKYLPCFQI
T330 LTTRRQETEGPEPAD
T341 EPADPQATEQPQTVS
S356 AEAGHVLSVAAVQAI
A358 AGHVLSVAAVQAIKS
F368 QAIKSFFFKCWSLNI
K400 LPGLQCVKYIESLQW
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