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TRAIL (human)

Overview TRAIL Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cytokine Cellular Component: extracellular space; integral to plasma membrane; extracellular region Molecular Function: protein binding; metal ion binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; cell-cell signaling; positive regulation of apoptosis; apoptosis; induction of apoptosis; positive regulation of caspase activity; immune response; signal transduction Reference #:  P50591 (UniProtKB) Alt. Names/Synonyms: Apo-2 ligand; Apo-2L; APO2L; CD253; Protein TRAIL; TL2; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNF10; TNFSF10; TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; Tumor necrosis factor ligand superfamily member 10 Gene Symbols: TNFSF10 Molecular weight: 32,509 Da Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states CST Pathways:  Death Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TRAIL 1D0G - A/D/B=114-281 (human) 1D2Q - A/B=114-281 (human) 1D4V - B=119-281 (human) 1DG6 - A=91-281 (human) 1DU3 - F/J/D/K/L/E=114-281 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1D0G 1D2Q 1D4V 1DG6 1DU3  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S133-p	ITGTRGRsNtLSSPN
0	1		T135-p	GTRGRsNtLSSPNSK
0	1		Y209	NDKQMVQYIYKytSY
0	1		Y211	KQMVQYIYKytSYPD
0	1		Y213-p	MVQYIYKytSYPDPI
0	1		T214-p	VQYIYKytSYPDPIL
0	3		S225-p	DPILLMKsARNSCWS

	mouse
S137	ITGITRRSNSALIPI
S139	GITRRSNSALIPISK
Y219	RTKQLVQYIYKYTSY
Y221	KQLVQYIYKYTSYPD
Y223	LVQYIYKYTSYPDPI
T224	VQYIYKYTSYPDPIV
S235	DPIVLMKSARNSCWS

	rat
S137	ITGITRRSNLALIPI
L139	GITRRSNLALIPISK
Y219-p	RIKQMVQyIyKYTSY
Y221-p	KQMVQyIyKYTSYPD
Y223	MVQyIyKYTSYPDPI
T224	VQyIyKYTSYPDPIL
S235	DPILLMKSARNSCWS

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