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SOCS2
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF. High expression in heart, placenta, lung, kidney and prostate. Note: This description may include information from UniProtKB.
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Cellular Component: cytoplasm; cytosol
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Molecular Function: insulin-like growth factor receptor binding; protein binding; growth hormone receptor binding; SH3/SH2 adaptor activity; prolactin receptor binding; JAK pathway signal transduction adaptor activity
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Biological Process: regulation of JAK-STAT cascade; protein ubiquitination; regulation of signal transduction; regulation of cell growth; JAK-STAT cascade; response to estradiol stimulus; cellular response to hormone stimulus; negative regulation of signal transduction; aging; negative regulation of apoptosis
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Reference #:
O14508 (UniProtKB)
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| Alt. Names/Synonyms: CIS-2; CIS2; Cish2; Cytokine-inducible SH2 protein 2; SOCS-2; SOCS2; SSI-2; SSI2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STATI2; Suppressor of cytokine signaling 2; suppressor of cytokine signaling-2 |
| Gene Symbols: SOCS2 |
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Molecular weight: 22,172 Da
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Basal Isoelectric point: 8.9
Predict pI for various phosphorylation states
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CST Pathways:
Jak/Stat/IL-6 Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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