SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF. High expression in heart, placenta, lung, kidney and prostate. Note: This description may include information from UniProtKB.
Molecular Function: insulin-like growth factor receptor binding; protein binding; growth hormone receptor binding; SH3/SH2 adaptor activity; protein kinase inhibitor activity; JAK pathway signal transduction adaptor activity
Biological Process: positive regulation of signal transduction; cytokine and chemokine mediated signaling pathway; negative regulation of protein kinase activity; regulation of signal transduction; protein ubiquitination; negative regulation of insulin receptor signaling pathway; regulation of cell growth; JAK-STAT cascade; negative regulation of JAK-STAT cascade; response to estradiol stimulus; aging; negative regulation of apoptosis; cellular response to hormone stimulus
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.