SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF. High expression in heart, placenta, lung, kidney and prostate. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 12q
Cellular Component: cytoplasm; cytosol
Molecular Function: insulin-like growth factor receptor binding; protein binding; growth hormone receptor binding; protein kinase inhibitor activity; SH3/SH2 adaptor activity; JAK pathway signal transduction adaptor activity
Biological Process: positive regulation of signal transduction; cytokine and chemokine mediated signaling pathway; negative regulation of insulin receptor signaling pathway; protein ubiquitination; regulation of signal transduction; JAK-STAT cascade; response to estradiol stimulus; cellular response to hormone stimulus; negative regulation of protein kinase activity; regulation of cell growth; negative regulation of JAK-STAT cascade; aging; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.