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Protein Page:
ERCC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ERCC1 a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA excision repair. Belongs to the ERCC1/RAD10/SWI10 family. Heterodimer composed of ERCC1 and XPF/ERRC4. Defects in ERCC1 are the cause of cerebro-oculo-facio-skeletal syndrome type 4, a degenerative autosomal recessive disorder of prenatal onset affecting the brain, eye and spinal cord. After birth, it leads to brain atrophy, hypoplasia of the corpus callosum, hypotonia, cataracts, microcornea, optic atrophy, progressive joint contractures and growth failure. Facial dysmorphism is a constant feature. Abnormalities of the skull, eyes, limbs, heart and kidney also occur. Low levels of this protein are associated with increased sensitivity to cisplatin. The overall survival of non-small cell lung cancer patients with single-nucleotide polymorphisms at codon 118 receiving platinum-based chemotherapy was significantly improved. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; transcription factor TFIID complex; nucleotide-excision repair complex; nuclear chromosome, telomeric region; cytoplasm; nucleolus; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; structure-specific DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; TATA-binding protein binding; damaged DNA binding; single-stranded DNA binding
Biological Process: oogenesis; chromosome organization and biogenesis; DNA recombination; negative regulation of telomere maintenance; UV protection; post-embryonic hemopoiesis; transcription-coupled nucleotide-excision repair; double-strand break repair; nucleotide-excision repair, DNA damage removal; nucleotide-excision repair, DNA incision, 5'-to lesion; response to nutrient; response to X-ray; mitotic recombination; multicellular organism growth; male gonad development; pyrimidine dimer repair via nucleotide-excision repair; isotype switching; multicellular organismal aging; replicative cell aging; DNA repair; syncytium formation; DNA catabolic process, endonucleolytic; response to sucrose stimulus; nucleotide-excision repair, DNA incision, 3'-to lesion; cell proliferation; nucleotide-excision repair; embryonic organ development; spermatogenesis; response to oxidative stress
Reference #:  P07992 (UniProtKB)
Alt. Names/Synonyms: COFS4; DNA excision repair protein ERCC-1; ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); UV20
Gene Symbols: ERCC1
Molecular weight: 32,562 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ERCC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K37-ac EVPPGVAkPLFRSTQ
0 1 K37 EVPPGVAKPLFRSTQ
0 1 S104-p KSNSIIVsPRQRGNP
0 1 K162-ub GRLQSLGkNFALRVL
0 1 K247 TTVKSVNKTDSQTLL
0 1 K295-ac VLHEPFLkVP_____
0 1 K295-ub VLHEPFLkVP_____
  mouse

 
K37 EVPCAGVKPLFRSSR
K37-ub EVPCAGVkPLFRSSR
S104 KSNSIIVSPRQRGNP
K162 ERLQSLGKNFALRVL
K247-ub TTVKSVNkTDSQTLL
K295 VLHEPFLKVPR____
K295 VLHEPFLKVPR____
  rat

 
- under review  
K37 EAPSSGAKPLFKSSR
S104 KSSSIIVSPRQRGNP
K162 ERLQSLGKNFALRVL
K247 TTVKSVNKTDSQTLL
K295 VLHEPFLKVPR____
K295 VLHEPFLKVPR____
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