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14-3-3 eta (human)

Overview 14-3-3 eta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor co-regulator; Adaptor/scaffold Cellular Component: cytoplasm Molecular Function: protein domain specific binding; insulin-like growth factor receptor binding; protein binding; enzyme binding; sodium channel regulator activity; actin binding; glucocorticoid receptor binding Biological Process: intracellular protein transport; regulation of neuron differentiation; glucocorticoid receptor signaling pathway; positive regulation of transcription, DNA-dependent; glucocorticoid catabolic process; regulation of synaptic plasticity; negative regulation of dendrite morphogenesis; regulation of sodium ion transport Reference #:  Q04917 (UniProtKB) Alt. Names/Synonyms: 14-3-3 eta; 14-3-3 protein eta; 1433F; Protein AS1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1; YWHAH Gene Symbols: YWHAH Molecular weight: 28,219 Da Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below 14-3-3 eta 2C63 - A/B/C/D=1-246 (human) 2C74 - A/B=1-246 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2C63 2C74  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S25-p	ERYDDMAsAMKAVTE
0	2		S38-p	TELNEPLsNEDRNLL
0	9		S46-p	NEDRNLLsVAykNVV
0	7		Y49-p	RNLLsVAykNVVGAR
0	4		K50-a	NLLsVAykNVVGARR
0	150		K50-u	NLLsVAykNVVGARR
2	9		S59-p	VVGARRSsWRVISSI
0	2		K69-u	VISSIEQkTMADGNE
0	1		K77	TMADGNEKKLEKVKA
0	11		K77-u	TMADGNEkKLEKVKA
0	1		K91-u	AYREKIEkELETVCN
0	2		K110-u	LLDKFLIkNCNDFQY
0	10		Y117	kNCNDFQYEskVFyL
0	1		S119-p	CNDFQYEskVFyLkM
0	7		K120-a	NDFQYEskVFyLkMk
0	1		K120	NDFQYEsKVFyLkMk
0	1		Y123-p	QYEskVFyLkMkGDy
0	4		K125-a	EskVFyLkMkGDyyR
0	72		K125-u	EskVFyLkMkGDyyR
0	9		K127-u	kVFyLkMkGDyyRyL
0	5		Y130-p	yLkMkGDyyRyLAEV
0	31		Y131-p	LkMkGDyyRyLAEVA
0	1		Y133-p	MkGDyyRyLAEVASG
0	2		K142-a	AEVASGEkkNSVVEA
0	11		K142-u	AEVASGEkkNSVVEA
0	2		K143-u	EVASGEkkNSVVEAS
0	3		T168-p	SKEQMQPtHPIRLGL
0	1		Y216-p	DTLNEDSyKDSTLIM

	mouse
S25	ERYDDMASAMKAVTE
S38-p	TELNEPLsNEDRNLL
S46-p	NEDRNLLsVAykNVV
Y49-p	RNLLsVAykNVVGAR
K50-a	NLLsVAykNVVGARR
K50-u	NLLsVAykNVVGARR
S59-p	VVGARRSsWRVISSI
K69-u	VISSIEQkTMADGNE
K77-a	TMADGNEkKLEKVKA
K77-u	TMADGNEkKLEKVKA
K91	AYREKIEKELETVCN
K110-u	LLDKFLIkNCNDFQy
Y117-p	kNCNDFQyESkVFYL
S119	CNDFQyESkVFYLkM
K120	NDFQyESKVFYLkMk
K120-u	NDFQyESkVFYLkMk
Y123	QyESkVFYLkMkGDY
K125-a	ESkVFYLkMkGDYyR
K125-u	ESkVFYLkMkGDYyR
K127-u	kVFYLkMkGDYyRYL
Y130	YLkMkGDYyRYLAEV
Y131-p	LkMkGDYyRYLAEVA
Y133	MkGDYyRYLAEVASG
K142	AEVASGEKkNSVVEA
K142-u	AEVASGEkkNSVVEA
K143-u	EVASGEkkNSVVEAS
T168	SKEHMQPTHPIRLGL
Y216	DTLNEDSYKDSTLIM

	rat
S25	ERYDDMASAMKAVTE
S38	TELNEPLSNEDRNLL
S46	NEDRNLLSVAYkNVV
Y49	RNLLSVAYkNVVGAR
K50	NLLSVAYKNVVGARR
K50-u	NLLSVAYkNVVGARR
S59-p	VVGARRSsWRVISSI
K69	VISSIEQKTMADGNE
K77	TMADGNEKKLEKVKA
K77-u	TMADGNEkKLEKVKA
K91	AYREKIEKELETVCN
K110	LLDKFLIKNCNDFQy
Y117-p	KNCNDFQyESKVFYL
S119	CNDFQyESKVFYLkM
K120	NDFQyESKVFYLkMk
K120	NDFQyESKVFYLkMk
Y123	QyESKVFYLkMkGDY
K125	ESKVFYLKMkGDYYR
K125-u	ESKVFYLkMkGDYYR
K127-u	KVFYLkMkGDYYRYL
Y130	YLkMkGDYYRYLAEV
Y131	LkMkGDYYRYLAEVA
Y133	MkGDYYRYLAEVASG
K142	AEVASGEKKNSVVEA
K142-u	AEVASGEkKNSVVEA
K143	EVASGEkKNSVVEAS
T168	SKEHMQPTHPIRLGL
Y216	DTLNEDSYKDSTLIM

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