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Protein Page:
14-3-3 eta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
14-3-3 eta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator
Cellular Component: cytoplasmic vesicle membrane; cytoplasm; plasma membrane; cytosol
Molecular Function: insulin-like growth factor receptor binding; protein domain specific binding; protein binding; enzyme binding; sodium channel regulator activity; protein heterodimerization activity; actin binding; glucocorticoid receptor binding
Biological Process: intracellular protein transport; substantia nigra development; regulation of neuron differentiation; apoptosis; positive regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; regulation of synaptic plasticity; glucocorticoid catabolic process; negative regulation of dendrite morphogenesis; regulation of sodium ion transport
Reference #:  Q04917 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 eta; 14-3-3 protein eta; 1433F; Protein AS1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1; YWHAH
Gene Symbols: YWHAH
Molecular weight: 28,219 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Crosstalk between PTMs  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

14-3-3 eta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S25-p ERYDDMAsAMKAVTE
0 2 S38-p TELNEPLsNEDRNLL
0 13 S46-p NEDRNLLsVAykNVV
0 8 Y49-p RNLLsVAykNVVGAR
0 5 K50-ac NLLsVAykNVVGARR
0 150 K50-ub NLLsVAykNVVGARR
2 9 S59-p VVGARRSsWRVISSI
0 1 K69-ac VISSIEQkTMADGNE
0 2 K69-ub VISSIEQkTMADGNE
0 1 K69-sc VISSIEQkTMADGNE
0 1 K77 TMADGNEKKLEKVKA
0 11 K77-ub TMADGNEkKLEKVKA
0 1 K91-ub AYREKIEkELETVCN
0 2 K110-ub LLDKFLIkNCNDFQY
0 10 Y117 kNCNDFQYEskVFyL
0 1 S119-p CNDFQYEskVFyLkM
0 7 K120-ac NDFQYEskVFyLkMk
0 1 K120 NDFQYEsKVFyLkMk
0 1 Y123-p QYEskVFyLkMkGDY
0 4 K125-ac EskVFyLkMkGDYyR
0 72 K125-ub EskVFyLkMkGDYyR
0 9 K127-ub kVFyLkMkGDYyRYL
0 35 Y131-p LkMkGDYyRYLAEVA
0 2 K142-ac AEVASGEkKNSVVEA
0 11 K142-ub AEVASGEkKNSVVEA
0 2 K143 EVASGEkKNSVVEAS
0 3 T168-p SKEQMQPtHPIRLGL
  mouse

 
S25 ERYDDMASAMKAVTE
S38-p TELNEPLsNEDRNLL
S46-p NEDRNLLsVAykNVV
Y49-p RNLLsVAykNVVGAR
K50-ac NLLsVAykNVVGARR
K50-ub NLLsVAykNVVGARR
S59-p VVGARRSsWRVISSI
K69 VISSIEQKTMADGNE
K69-ub VISSIEQkTMADGNE
K69 VISSIEQKTMADGNE
K77-ac TMADGNEkKLEKVKA
K77-ub TMADGNEkKLEKVKA
K91 AYREKIEKELETVCN
K110-ub LLDKFLIkNCNDFQy
Y117-p kNCNDFQyESkVFYL
S119 CNDFQyESkVFYLkM
K120 NDFQyESKVFYLkMk
K120-ub NDFQyESkVFYLkMk
Y123 QyESkVFYLkMkGDY
K125-ac ESkVFYLkMkGDYyR
K125-ub ESkVFYLkMkGDYyR
K127-ub kVFYLkMkGDYyRYL
Y131-p LkMkGDYyRYLAEVA
K142 AEVASGEKkNSVVEA
K142-ub AEVASGEkkNSVVEA
K143-ub EVASGEkkNSVVEAS
T168 SKEHMQPTHPIRLGL
  rat

 
S25 ERYDDMASAMKAVTE
S38 TELNEPLSNEDRNLL
S46 NEDRNLLSVAYkNVV
Y49 RNLLSVAYkNVVGAR
K50 NLLSVAYKNVVGARR
K50-ub NLLSVAYkNVVGARR
S59-p VVGARRSsWRVISSI
K69 VISSIEQKTMADGNE
K69 VISSIEQKTMADGNE
K69 VISSIEQKTMADGNE
K77 TMADGNEKKLEKVKA
K77-ub TMADGNEkKLEKVKA
K91 AYREKIEKELETVCN
K110 LLDKFLIKNCNDFQy
Y117-p KNCNDFQyESKVFYL
S119 CNDFQyESKVFYLkM
K120 NDFQyESKVFYLkMk
K120 NDFQyESKVFYLkMk
Y123 QyESKVFYLkMkGDY
K125 ESKVFYLKMkGDYYR
K125-ub ESKVFYLkMkGDYYR
K127-ub KVFYLkMkGDYYRYL
Y131 LkMkGDYYRYLAEVA
K142 AEVASGEKKNSVVEA
K142-ub AEVASGEkKNSVVEA
K143 EVASGEkKNSVVEAS
T168 SKEHMQPTHPIRLGL
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