a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; extracellular space; protein complex; cytoplasmic vesicle membrane; mast cell granule; mitochondrion; perinuclear region of cytoplasm; postsynaptic density; leading edge; cytoplasm; melanosome; cytosol
Molecular Function: protein domain specific binding; identical protein binding; protein binding; protein complex binding; transcription factor binding; protein kinase binding
Biological Process: platelet activation; histamine secretion by mast cell; RNA metabolic process; apoptosis; gene expression; signal transduction; blood coagulation; protein targeting to mitochondrion; mRNA metabolic process; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.