a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Phosphorylation apparently disrupts homodimerization. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: extracellular space; mast cell granule; protein complex; cytoplasmic vesicle membrane; mitochondrion; leading edge; postsynaptic density; cytosol; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus
Molecular Function: protein domain specific binding; identical protein binding; protein binding; protein complex binding; protein kinase binding; transcription factor binding
Biological Process: response to drug; platelet activation; histamine secretion by mast cell; apoptosis; RNA metabolic process; gene expression; blood coagulation; signal transduction; protein targeting to mitochondrion; negative regulation of apoptosis; mRNA metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.