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Oct9 (human)

Overview Oct9 Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. Defects in POU3F4 are a cause of deafness X-linked type 2 (DFNX2). A mixed type of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation and progressive sensorineural deafness. Belongs to the POU transcription factor family. Class- 3 subfamily. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleus Molecular Function: AT DNA binding; double-stranded DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; sensory perception of sound; forebrain neuron differentiation Reference #:  P49335 (UniProtKB) Alt. Names/Synonyms: Brain-4; Brain-specific homeobox/POU domain protein 4; Brn-4; BRN4; DFN3; DFNX2; Oct-9; Octamer-binding protein 9; Octamer-binding transcription factor 9; OTF-9; OTF9; PO3F4; POU class 3 homeobox 4; POU domain, class 3, transcription factor 4; POU3F4 Gene Symbols: POU3F4 Molecular weight: 39,427 Da Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states

Select Structure to View Below Oct9

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 300039 304400  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S265-p	EADSSTGsPtsIDKI
0	1		T267-p	DSSTGsPtsIDKIAA
0	1		S268-p	SSTGsPtsIDKIAAQ

	mouse
S265-p	EADSSTGsPTSIDKI
T267	DSSTGsPTSIDKIAA
S268	SSTGsPTSIDKIAAQ

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