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TLR9
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. Belongs to the Toll-like receptor family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
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Cellular Component: Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum; lysosome; basolateral plasma membrane; cytoplasm; apical plasma membrane; extracellular region; integral to membrane; plasma membrane; endosome membrane; endosome
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Molecular Function: interleukin-1 receptor binding; siRNA binding
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Biological Process: positive regulation of JNK activity; positive regulation of interleukin-12 production; maintenance of gastrointestinal epithelium; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; positive regulation of interleukin-18 production; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to molecule of bacterial origin; positive regulation of interferon-beta production; negative regulation of interleukin-8 production; negative regulation of interleukin-6 production; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; inhibition of NF-kappaB transcription factor; positive regulation of interferon-beta biosynthetic process; defense response to bacterium; negative regulation of toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process
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Reference #:
Q9NR96 (UniProtKB)
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| Alt. Names/Synonyms: CD289; TLR9; Toll-like receptor 9 |
| Gene Symbols: TLR9 |
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Molecular weight: 115,860 Da
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Basal Isoelectric point: 8.55
Predict pI for various phosphorylation states
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CST Pathways:
NF-kB Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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