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Protein Page:
14-3-3 theta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
14-3-3 theta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: cytoplasmic vesicle membrane; membrane; cytoplasm; cytosol
Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding
Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting
Reference #:  P27348 (UniProtKB)
Alt. Names/Synonyms: 14-3-3; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 1433T; 1C5; HS1; Protein HS1; protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; YWHAQ
Gene Symbols: YWHAQ
Molecular weight: 27,764 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Crosstalk between PTMs  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

14-3-3 theta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 11 K3-ac _____MEkTELIQkA
0 1 K9-ac EkTELIQkAkLAEQA
0 29 K9-ub EkTELIQkAkLAEQA
0 37 K11-ub TELIQkAkLAEQAER
0 2 Y19-p LAEQAERyDDMATCM
0 1 K27-ac DDMATCMkAVTEQGA
0 15 K27-ub DDMATCMkAVTEQGA
0 1 S37-p TEQGAELsNEERNLL
0 16 S45-p NEERNLLsVAykNVV
0 6 Y48-p RNLLsVAykNVVGGR
0 2 K49-ac NLLsVAykNVVGGRR
0 58 K49-ub NLLsVAykNVVGGRR
0 1 K49-sc NLLsVAykNVVGGRR
0 2 K68-ac VISSIEQkTDTSDkk
0 11 K68-ub VISSIEQkTDTSDkk
0 1 K68-sc VISSIEQkTDTSDkk
0 3 K74-ub QkTDTSDkkLQLIkD
0 3 K75-ub kTDTSDkkLQLIkDy
0 11 K80-ub DkkLQLIkDyREkVE
0 1 K80-sc DkkLQLIkDyREkVE
0 1 Y82-p kLQLIkDyREkVESE
0 1 K85 LIkDyREKVESELRs
0 1 K85-sc LIkDyREkVESELRs
0 2 S92-p kVESELRsICTTVLE
0 1 T110 KYLIANATNPEskVF
0 1 S114-p ANATNPEskVFYLkM
0 16 K115-ac NATNPEskVFYLkMk
0 4 K115-ub NATNPEskVFYLkMk
0 1 K115-sc NATNPEskVFYLkMk
0 4 K120-ac EskVFYLkMkGDYFR
0 72 K120-ub EskVFYLkMkGDYFR
0 10 K122-ub kVFYLkMkGDYFRYL
0 2 K139-ac VACGDDRkQtIDNsQ
0 8 K139-ub VACGDDRkQtIDNsQ
0 1 T141-p CGDDRkQtIDNsQGA
0 1 S145-p RkQtIDNsQGAyQEA
0 8 Y149-p IDNsQGAyQEAFDIs
0 1 S156-p yQEAFDIskkEMQPT
0 8 K157-ac QEAFDIskkEMQPTH
0 7 K157-ub QEAFDIskkEMQPTH
0 1 K158-ac EAFDIskkEMQPTHP
0 55 K158-ub EAFDIskkEMQPTHP
0 2 K193-ub ELACTLAkTAFDEAI
0 1 S210-p LDTLNEDsYkDSTLI
0 1 K212-m1 TLNEDsYkDSTLIMQ
0 1 T229-p RDNLTLWtsDsAGEE
0 3 S230-p DNLTLWtsDsAGEEC
2 11 S232-p LTLWtsDsAGEECDA
  mouse

 
K3-ac _____MEkTELIQkA
K9 EkTELIQKAkLAEQA
K9-ub EkTELIQkAkLAEQA
K11-ub TELIQkAkLAEQAER
Y19 LAEQAERYDDMATCM
K27 DDMATCMKAVTEQGA
K27 DDMATCMKAVTEQGA
S37 TEQGAELSNEERNLL
S45-p NEERNLLsVAykNVV
Y48-p RNLLsVAykNVVGGR
K49 NLLsVAyKNVVGGRR
K49-ub NLLsVAykNVVGGRR
K49 NLLsVAyKNVVGGRR
K68 VISSIEQKTDTSDkK
K68-ub VISSIEQkTDTSDkK
K68 VISSIEQKTDTSDkK
K74-ub QkTDTSDkKLQLIkD
K75 kTDTSDkKLQLIkDY
K80-ub DkKLQLIkDYREkVE
K80 DkKLQLIKDYREkVE
Y82 KLQLIkDYREkVESE
K85-ub LIkDYREkVESELRs
K85 LIkDYREKVESELRs
S92-p kVESELRsICTTVLE
T110-p KYLIANAtNPESkVF
S114 ANAtNPESkVFYLkM
K115-ac NAtNPESkVFYLkMk
K115-ub NAtNPESkVFYLkMk
K115 NAtNPESKVFYLkMk
K120-ac ESkVFYLkMkGDYFR
K120-ub ESkVFYLkMkGDYFR
K122-ub kVFYLkMkGDYFRYL
K139 VACGDDRKQTIENSQ
K139-ub VACGDDRkQTIENSQ
T141 CGDDRkQTIENSQGA
S145 RkQTIENSQGAYQEA
Y149 IENSQGAYQEAFDIS
S156 YQEAFDISkkEMQPT
K157 QEAFDISKkEMQPTH
K157-ub QEAFDISkkEMQPTH
K158 EAFDISkKEMQPTHP
K158-ub EAFDISkkEMQPTHP
K193-ub ELACTLAkTAFDEAI
S210 LDTLNEDSYKDSTLI
K212 TLNEDSYKDSTLIMQ
T229-p RDNLTLWtsDsAGEE
S230-p DNLTLWtsDsAGEEC
S232-p LTLWtsDsAGEECDA
  rat

 
K3-ac _____MEkTELIQkA
K9 EkTELIQKAkLAEQA
K9-ub EkTELIQkAkLAEQA
K11-ub TELIQkAkLAEQAER
Y19 LAEQAERYDDMATCM
K27 DDMATCMKAVTEQGA
K27 DDMATCMKAVTEQGA
S37 TEQGAELSNEERNLL
S45-p NEERNLLsVAYkNVV
Y48 RNLLsVAYkNVVGGR
K49-ac NLLsVAYkNVVGGRR
K49-ub NLLsVAYkNVVGGRR
K49 NLLsVAYKNVVGGRR
K68-ac VISSIEQkTDTSDKK
K68 VISSIEQKTDTSDKK
K68 VISSIEQKTDTSDKK
K74 QkTDTSDKKLQLIKD
K75 kTDTSDKKLQLIKDY
K80 DKKLQLIKDYREKVE
K80 DKKLQLIKDYREKVE
Y82 KLQLIKDYREKVESE
K85 LIKDYREKVESELRS
K85 LIKDYREKVESELRS
S92 KVESELRSICTTVLE
T110 KYLIANATNPESkVF
S114 ANATNPESkVFYLkM
K115-ac NATNPESkVFYLkMK
K115 NATNPESKVFYLkMK
K115 NATNPESKVFYLkMK
K120-ac ESkVFYLkMKGDYFR
K120-ub ESkVFYLkMKGDYFR
K122 kVFYLkMKGDYFRYL
K139 VACGDDRKQTIENSQ
K139 VACGDDRKQTIENSQ
T141 CGDDRKQTIENSQGA
S145 RKQTIENSQGAYQEA
Y149 IENSQGAYQEAFDIS
S156 YQEAFDISkKEMQPT
K157-ac QEAFDISkKEMQPTH
K157 QEAFDISKKEMQPTH
K158 EAFDISkKEMQPTHP
K158 EAFDISkKEMQPTHP
K193 ELACTLAKTAFDEAI
S210 LDTLNEDSYKDSTLI
K212 TLNEDSYKDSTLIMQ
T229 RDNLTLWTSDSAGEE
S230 DNLTLWTSDSAGEEC
S232 LTLWTSDSAGEECDA
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