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14-3-3 theta (human)

Overview 14-3-3 theta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: cytoplasm Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding Biological Process: small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting Reference #:  P27348 (UniProtKB) Alt. Names/Synonyms: 14-3-3; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 1433T; 1C5; HS1; Protein HS1; protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; YWHAQ Gene Symbols: YWHAQ Molecular weight: 27,764 Da Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  Hippo Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below 14-3-3 theta 2BTP - A/B=1-234 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	11		K3-a	_____MEkTELIQkA
0	29		K9-u	EkTELIQkAkLAEQA
0	1		K9-a	EkTELIQkAkLAEQA
0	37		K11-u	TELIQkAkLAEQAER
0	2		Y19-p	LAEQAERyDDMATCM
0	1		K27-a	DDMATCMkAVTEQGA
0	15		K27-u	DDMATCMkAVTEQGA
0	9		S45-p	NEERNLLsVAykNVV
0	5		Y48-p	RNLLsVAykNVVGGR
0	58		K49-u	NLLsVAykNVVGGRR
0	2		K49-a	NLLsVAykNVVGGRR
0	1		K68-a	VISSIEQkTDTSDkk
0	11		K68-u	VISSIEQkTDTSDkk
0	3		K74-u	QkTDTSDkkLQLIkD
0	3		K75-u	kTDTSDkkLQLIkDy
0	11		K80-u	DkkLQLIkDyREKVE
0	1		Y82-p	kLQLIkDyREKVESE
0	1		K85	LIkDyREKVESELRS
0	1		S92	KVESELRSICTTVLE
0	1		T110	KYLIANATNPESkVF
0	15		K115-a	NATNPESkVFYLkMk
0	4		K115-u	NATNPESkVFYLkMk
0	4		K120-a	ESkVFYLkMkGDyFR
0	72		K120-u	ESkVFYLkMkGDyFR
0	10		K122-u	kVFYLkMkGDyFRYL
0	4		Y125-p	YLkMkGDyFRYLAEV
0	2		K139-a	VACGDDRkQtIDNSQ
0	8		K139-u	VACGDDRkQtIDNSQ
0	1		T141-p	CGDDRkQtIDNSQGA
0	8		Y149-p	IDNSQGAyQEAFDIs
0	1		S156-p	yQEAFDIskkEMQPT
0	8		K157-a	QEAFDIskkEMQPTH
0	7		K157-u	QEAFDIskkEMQPTH
0	1		K158-a	EAFDIskkEMQPTHP
0	55		K158-u	EAFDIskkEMQPTHP
0	2		K193-u	ELACTLAkTAFDEAI
0	1		S210-p	LDTLNEDsYkDSTLI
0	1		K212-m1	TLNEDsYkDSTLIMQ
0	1		T229-p	RDNLTLWtsDsAGEE
0	2		S230-p	DNLTLWtsDsAGEEC
2	8		S232-p	LTLWtsDsAGEECDA

	mouse
K3-a	_____MEkTELIQkA
K9-u	EkTELIQkAkLAEQA
K9	EkTELIQKAkLAEQA
K11-u	TELIQkAkLAEQAER
Y19	LAEQAERYDDMATCM
K27	DDMATCMKAVTEQGA
K27	DDMATCMKAVTEQGA
S45-p	NEERNLLsVAykNVV
Y48-p	RNLLsVAykNVVGGR
K49-u	NLLsVAykNVVGGRR
K49	NLLsVAyKNVVGGRR
K68	VISSIEQKTDTSDkK
K68-u	VISSIEQkTDTSDkK
K74-u	QkTDTSDkKLQLIkD
K75	kTDTSDkKLQLIkDY
K80-u	DkKLQLIkDYREkVE
Y82	KLQLIkDYREkVESE
K85-u	LIkDYREkVESELRs
S92-p	kVESELRsICTTVLE
T110-p	KYLIANAtNPESkVF
K115	NAtNPESKVFYLkMk
K115-u	NAtNPESkVFYLkMk
K120-a	ESkVFYLkMkGDYFR
K120-u	ESkVFYLkMkGDYFR
K122-u	kVFYLkMkGDYFRYL
Y125	YLkMkGDYFRYLAEV
K139	VACGDDRKQTIENSQ
K139-u	VACGDDRkQTIENSQ
T141	CGDDRkQTIENSQGA
Y149	IENSQGAYQEAFDIS
S156	YQEAFDISkkEMQPT
K157	QEAFDISKkEMQPTH
K157-u	QEAFDISkkEMQPTH
K158	EAFDISkKEMQPTHP
K158-u	EAFDISkkEMQPTHP
K193-u	ELACTLAkTAFDEAI
S210	LDTLNEDSYKDSTLI
K212	TLNEDSYKDSTLIMQ
T229-p	RDNLTLWtsDsAGEE
S230-p	DNLTLWtsDsAGEEC
S232-p	LTLWtsDsAGEECDA

	rat
K3	_____MEKTELIQkA
K9-u	EKTELIQkAkLAEQA
K9	EKTELIQKAkLAEQA
K11-u	TELIQkAkLAEQAER
Y19	LAEQAERYDDMATCM
K27	DDMATCMKAVTEQGA
K27	DDMATCMKAVTEQGA
S45	NEERNLLSVAYkNVV
Y48	RNLLSVAYkNVVGGR
K49-u	NLLSVAYkNVVGGRR
K49	NLLSVAYKNVVGGRR
K68	VISSIEQKTDTSDKK
K68	VISSIEQKTDTSDKK
K74	QKTDTSDKKLQLIKD
K75	KTDTSDKKLQLIKDY
K80	DKKLQLIKDYREKVE
Y82	KLQLIKDYREKVESE
K85	LIKDYREKVESELRS
S92	KVESELRSICTTVLE
T110	KYLIANATNPESKVF
K115	NATNPESKVFYLkMK
K115	NATNPESKVFYLkMK
K120	ESKVFYLKMKGDYFR
K120-u	ESKVFYLkMKGDYFR
K122	KVFYLkMKGDYFRYL
Y125	YLkMKGDYFRYLAEV
K139	VACGDDRKQTIENSQ
K139	VACGDDRKQTIENSQ
T141	CGDDRKQTIENSQGA
Y149	IENSQGAYQEAFDIS
S156	YQEAFDISKKEMQPT
K157	QEAFDISKKEMQPTH
K157	QEAFDISKKEMQPTH
K158	EAFDISKKEMQPTHP
K158	EAFDISKKEMQPTHP
K193	ELACTLAKTAFDEAI
S210	LDTLNEDSYKDSTLI
K212	TLNEDSYKDSTLIMQ
T229	RDNLTLWTSDSAGEE
S230	DNLTLWTSDSAGEEC
S232	LTLWTSDSAGEECDA

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