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Protein Page:
betaIG-H3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
betaIG-H3 Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Cell adhesion
Cellular Component: extracellular matrix; extracellular space; plasma membrane; extracellular region; basement membrane; trans-Golgi network
Molecular Function: collagen binding; integrin binding; protein binding; extracellular matrix binding
Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; angiogenesis; negative regulation of cell adhesion; cell adhesion
Reference #:  Q15582 (UniProtKB)
Alt. Names/Synonyms: Beta ig-h3; beta-IG-H3; beta-IGH3; betaIG-H3; BGH3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato-epithelin; LCD1; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; transforming growth factor, beta-induced, 68kDa; Transforming growth factor-beta-induced protein ig-h3
Gene Symbols: TGFBI
Molecular weight: 74,681 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

betaIG-H3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S28-p TLAGPAKsPyQLVLQ
0 1 S28-ga TLAGPAKsPyQLVLQ
0 1 Y30-p AGPAKsPyQLVLQHs
0 1 S37-p yQLVLQHsRLRGRQH
0 1 T457-p YHGQTLEtLGGKKLR
0 1 Y537-p TLNREGVyTVFAPTN
0 1 S591-p GALVRLKsLQGDKLE
0 1 S649-p RGDELADsALEIFKQ
  mouse

 
S28 TLAGPAKSPyQLVLQ
S28 TLAGPAKSPyQLVLQ
Y30-p AGPAKSPyQLVLQHS
S37 yQLVLQHSRLRGRQH
T457 YSGQTLDTLGGKKLR
Y537 ILNREGVYTVFAPTN
S591 GALVRLKSLQGDKLE
S649 RGDELADSALEIFKQ
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