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betaIG-H3 (human)

Overview betaIG-H3 Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Note: This description may include information from UniProtKB. Protein type: Secreted; Cell adhesion; Extracellular matrix; Secreted, signal peptide Cellular Component: extracellular matrix; extracellular space; extracellular region; plasma membrane; basement membrane Molecular Function: integrin binding; extracellular matrix binding Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion Reference #:  Q15582 (UniProtKB) Alt. Names/Synonyms: Beta ig-h3; beta-IG-H3; beta-IGH3; betaIG-H3; BGH3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato-epithelin; LCD1; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; transforming growth factor, beta-induced, 68kDa; Transforming growth factor-beta-induced protein ig-h3 Gene Symbols: TGFBI Molecular weight: 74,681 Da Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below betaIG-H3 1X3B - A=502-634 (human) 2VXP - A/B=502-633 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1X3B 2VXP  |  Phospho3D  |  DISEASE 121820 121900 122200 601692 602082 607541 608470 608471  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S28-p	TLAGPAKsPyQLVLQ
0	1		Y30-p	AGPAKsPyQLVLQHS
0	1		T457-p	YHGQTLEtLGGKKLR
0	1		Y537-p	TLNREGVyTVFAPTN

	mouse
S28	TLAGPAKSPYQLVLQ
Y30	AGPAKSPYQLVLQHS
T457	YSGQTLDTLGGKKLR
Y537	ILNREGVYTVFAPTN

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