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TIMP1
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
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Cellular Component: extracellular region; basement membrane
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Molecular Function: metalloendopeptidase inhibitor activity; protein binding; metal ion binding
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Biological Process: platelet activation; response to peptide hormone stimulus; extracellular matrix disassembly; extracellular matrix organization and biogenesis; erythrocyte maturation; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; blood coagulation; negative regulation of membrane protein ectodomain proteolysis; aging; negative regulation of apoptosis
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Reference #:
P01033 (UniProtKB)
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| Alt. Names/Synonyms: CLGI; Collagenase inhibitor; EPA; EPO; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; Metalloproteinase inhibitor 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP-1; TIMP1; tissue inhibitor of metalloproteinases; Tissue inhibitor of metalloproteinases 1 |
| Gene Symbols: TIMP1 |
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Molecular weight: 23,171 Da
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Basal Isoelectric point: 8.46
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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