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Protein Page:
TIMP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TIMP1 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Cellular Component: extracellular space; extracellular region; basement membrane
Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; growth factor activity; metal ion binding; cytokine activity
Biological Process: response to peptide hormone stimulus; extracellular matrix disassembly; platelet activation; extracellular matrix organization and biogenesis; negative regulation of metalloenzyme activity; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; negative regulation of membrane protein ectodomain proteolysis; blood coagulation; negative regulation of apoptosis; aging
Reference #:  P01033 (UniProtKB)
Alt. Names/Synonyms: CLGI; Collagenase inhibitor; EPA; EPO; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; Metalloproteinase inhibitor 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP-1; TIMP1; tissue inhibitor of metalloproteinases; Tissue inhibitor of metalloproteinases 1
Gene Symbols: TIMP1
Molecular weight: 23,171 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIMP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K45-ub SDLVIRAkFVGTPEV
0 1 K70-ub IKMTKMYkGFQALGD
0 2 K180-ub QLLQGSEkGFQSRHL
  mouse

 
K46 SDLVIRAKFMGSPEI
K71 IKMTKMLKGFKAVGN
D181 QVLVGSEDYQSRHFA
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