Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CATSPER1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CATSPER1 Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7). An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: plasma membrane; cilium
Molecular Function: voltage-gated calcium channel activity; protein binding; calcium activated cation channel activity
Biological Process: sperm-egg recognition; sperm motility; fusion of sperm to egg plasma membrane; multicellular organismal development; ciliary or flagellar motility; single fertilization; spermatogenesis; regulation of calcium ion transport; cell differentiation; multicellular organism reproduction
Reference #:  Q8NEC5 (UniProtKB)
Alt. Names/Synonyms: Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CATSPER; CATSPER1; CTSR1; hCatSper; MGC33335; MGC33368; sperm ion channel; sperm-associated cation channel 1
Gene Symbols: CATSPER1
Molecular weight: 90,091 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Select Structure to View Below

CATSPER1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K396-ac KHSEDWGkEEGQFQk
0 1 K403-ac kEEGQFQkRKTGRLQ
0 1 S758 QEQQKFRSQAAVIDE
0 1 A761 QKFRSQAAVIDEIVD
  mouse

 
- gap
K309 EGEDHVQKRKKAQRA
S664-p QHQQKFRsQAyVIDE
Y667-p QKFRsQAyVIDELVD
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.