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BAG1 (human)

Overview BAG1 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2. Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium. Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator Cellular Component: mitochondrion; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol Molecular Function: protein binding; chaperone binding; receptor signaling protein activity; phosphoprotein binding Biological Process: response to drug; response to nicotine; neuron differentiation; cell surface receptor linked signal transduction; apoptosis; positive regulation of neuron apoptosis; response to lithium ion; response to stress; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis Reference #:  Q99933 (UniProtKB) Alt. Names/Synonyms: BAG family molecular chaperone regulator 1; BAG-1; BAG1; Bcl-2 associating athanogene-1 protein; Bcl-2-associated athanogene 1; Bcl-2-binding protein; BCL2-associated athanogene; glucocortoid receptor-associated protein RAP46; HAP; RAP46; receptor-associated protein, 46-KD Gene Symbols: BAG1 Molecular weight: 38,779 Da Basal Isoelectric point: 7.68  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BAG1 1HX1 - B=151-263 (human) 1WXV - A=73-151 (human) 3FZF - B=222-334 (human) 3FZH - B=222-334 (human) 3FZK - B=222-334 (human) 3FZL - B=222-334 (human) 3FZM - B=222-334 (human) 3LDQ - B=222-334 (human) 3M3Z - B=222-334 (human) 1I6Z - A=226-355 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S89	RSEELTRSEELTLSE
0	1		T93	LTRSEELTLSEEATW
0	1		S95	RSEELTLSEEATWSE
0	1		T145	EMAAAGLTVTVTHSN
0	3		S196-p	KLIFKGKsLKEMETP
0	1		S223-p	MLIGKKNsPQEEVEL
0	1		K252-u	DQLEELNkELTGIQQ
0	38		K273-u	LQAEALCkLDRRVKA

	mouse
S96-p	SSRELTRsKKVtRsK
T100-p	LTRsKKVtRsKNVTG
S102-p	RsKKVtRsKNVTGTQ
S155-p	EMETPRLsVIVTHSN
S206	KLIFKGKSLKEMETP
N233	MLIGEKSNPEEEVEL
K262	NHLQELNKELSGIQQ
K283-u	LQAEALCkLDRKVKA

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