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Protein Page:
DRD1 (human)

Overview
DRD1 a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nucleus
Molecular Function: protein binding; dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity
Biological Process: synaptic transmission, dopaminergic; peristalsis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); behavioral fear response; prepulse inhibition; positive regulation of potassium ion transport; generation of action potential; thermoregulation; adult walking behavior; positive regulation of synaptic transmission, glutamatergic; dopamine metabolic process; G-protein signaling, adenylate cyclase activating pathway; vasodilation; synaptogenesis; protein import into nucleus; behavioral response to cocaine; conditioned taste aversion; positive regulation of cAMP biosynthetic process; visual learning; dopamine receptor, adenylate cyclase activating pathway; grooming behavior; response to drug; dopamine transport; dentate gyrus development; striatum development; cerebral cortex GABAergic interneuron migration; maternal behavior; adenylate cyclase activation; response to amphetamine; regulation of dopamine metabolic process; mating behavior; regulation of dopamine uptake; transmission of nerve impulse; astrocyte development; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; habituation; glucose import; operant conditioning; sensitization; dopamine receptor, phospholipase C activating pathway; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cell migration
Reference #:  P21728 (UniProtKB)
Alt. Names/Synonyms: D(1A) dopamine receptor; DADR; Dopamine D1 receptor; dopamine receptor D1; DRD1; DRD1A
Gene Symbols: DRD1
Molecular weight: 49,293 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below

DRD1

Protein Structure Not Found.


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Sites Implicated In
receptor desensitization, altered: T360‑p
receptor internalization, altered: T360‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S56-p IRFRHLRsKVTNFFV
0 1 T136-p FRYERKMtPKAAFIL
1 0 P256 KPVECSQPESSFKMS
1 0 S258 VECSQPESSFKMSFK
1 0 S259 ECSQPESSFKMSFKR
1 0 T268 KMSFKRETKVLKTLS
1 0 T360-p ATNNAIEtVSINNNG
1 0 S421 EKLSPALSVILDYDT
1 0 T428 SVILDYDTDVSLEKI
1 0 S431 LDYDTDVSLEKIQPI
0 1 N441 KIQPITQNGQHPT__
0 1 T446 TQNGQHPT_______
  mouse

 
S55 IRFRHLRSKVTNFFV
T135 FQYERKMTPKAAFIL
S256 NPVECSQSESSFKMS
S258 VECSQSESSFKMSFK
S259 ECSQSESSFKMSFKR
T268 KMSFKRETKVLKTLS
T360 TTNNAIETVSINNNG
S421 EKLSPALSVILDYDT
T428 SVILDYDTDVSLEKI
S431 LDYDTDVSLEKIQPV
S441-p KIQPVTHsGQHSt__
T446-p THsGQHSt_______
  rat

 
S55 IRFRHLRSKVTNFFV
T135 FQYERKMTPKAAFIL
S256-p NPVECAQsEssFKMS
S258-p VECAQsEssFKMSFK
S259-p ECAQsEssFKMSFKR
T268-p KMSFKREtKVLKTLS
T360 TTNNAIETVSINNNG
S421-p EKLSPALsVILDYDt
T428-p sVILDYDtDVsLEKI
S431-p LDYDtDVsLEKIQPV
S441 KIQPVTHSGQHST__
T446 THSGQHST_______
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