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Protein Page:
Plectin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Plectin-1 a major cytoskeleton crosslinking protein that binds to actin, intermediate filaments and microtubules. A scaffold for proteins involved in cellular signaling. Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. Regulates the organization of keratin intermediate filaments (IF) and MAPK signaling during cell migration. Downregulates PKC signaling by sequestering RACK1. Redistributes to the uropod associated with vimentin and fodrin during polarization of peripheral blood T lymphocytes. This vimentin-plectin-fodrin complex provides a continuous linkage from the nucleus (lamin B) to the cortical cytoskeleton. Defects in PLEC1 are the cause of epidermolysis bullosa simplex 1 (EBS1). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: intermediate filament cytoskeleton; focal adhesion; costamere; hemidesmosome; cytoplasm; plasma membrane; sarcoplasm; cytosol; sarcolemma
Molecular Function: protein binding; structural constituent of muscle; ankyrin binding; actin binding
Biological Process: extracellular matrix organization and biogenesis; hemidesmosome assembly; apoptosis; cell structure disassembly during apoptosis
Reference #:  Q15149 (UniProtKB)
Alt. Names/Synonyms: EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; PLEC; PLEC1; PLEC1b; plectin; plectin 1, intermediate filament binding protein 500kDa; Plectin-1; PLTN
Gene Symbols: PLEC
Molecular weight: 531,791 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Plectin-1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S54 QVMRAMASLRARGLV
0 5 T113-p MVMPARRtPHVQAVQ
0 10 S125-p AVQGPLGsPPkRGPL
0 3 K128-ub GPLGsPPkRGPLPTE
0 1 K143-ub EQRVYRRkELEEVsP
0 6 S149-p RkELEEVsPEtPVVP
0 2 T152-p LEEVsPEtPVVPATt
0 1 T159-p tPVVPATtQRTLARP
0 1 - gap
0 2 - gap
0 17 - gap
0 8 - gap
0 1 - gap
0 67 - gap
0 75 - gap
0 187 - gap
0 52 - gap
0 1 - gap
0 1 - gap
0 9 - gap
0 1 - gap
0 1 K187-ac VQKKTFTkWVNKHLI
0 2 S201-p IKAQRHIsDLYEDLR
0 1 S284-p IILHFQIsDIQVSGQ
0 1 S305-p KEKLLLWsQRMVEGY
0 1 T351-p MNKVYRQtNLENLDQ
0 2 S361-p ENLDQAFsVAERDLG
0 1 T370-p AERDLGVtRLLDPED
0 1 S394 SIITYVSSLyDAMPR
0 31 Y396-p ITYVSSLyDAMPRVP
0 1 K462-ac WSQFLKFkEMELPAk
0 1 K469-ub kEMELPAkEADKNRS
0 1 K477-ub EADKNRSkGIyQsLE
0 7 Y480-p KNRSkGIyQsLEGAV
0 1 S482-p RSkGIyQsLEGAVQA
0 1 K493-ub AVQAGQLkVPPGYHP
0 1 K581-ub EVERDLDkADSMIRL
0 1 K597-ub FNDVQTLkDGRHPQG
0 1 K597-sc FNDVQTLkDGRHPQG
0 2 Y608-p HPQGEQMyRRVyRLH
0 1 Y612-p EQMyRRVyRLHERLV
0 1 K630-ub TEYNLRLkAGVAAPA
0 1 T638-p AGVAAPAtQVAQVTL
0 1 T638 AGVAAPATQVAQVTL
0 1 S647-p VAQVTLQsVQRRPEL
0 1 S687-p EWGVDLPsVEAQLGS
0 33 S720-p RSDEGQLsPATRGAY
0 2 T723 EGQLsPATRGAYRDC
0 1 K740-ub RLDLQYAkLLNSSKA
0 1 K740-sc RLDLQYAkLLNSSKA
0 1 S782-p EEVGFDWsDRNTNMT
0 1 S796-p TAKKESYsALMRELE
0 1 A815 KIKELQNAGDRLLRE
0 1 Y861-p HLKENAAyFQFFSDV
0 15 S887-p EALRRKYsCDRsATV
0 2 S891-p RKYsCDRsATVTRLE
0 3 K908-ac LQDAQDEkEQLNEyK
0 1 K908-ub LQDAQDEkEQLNEyK
0 1 Y914-p EkEQLNEyKGHLsGL
0 1 K915 kEQLNEyKGHLsGLA
0 1 S919-p NEyKGHLsGLAKRAK
0 3 K953-ac LLAVCDYkQVEVTVH
0 1 S1029-p QLHVDMKsLLAWQSL
0 10 S1047-p VQLIRSWsLATFRTL
0 1 S1077-p YQAFLRDsQDAGGFG
0 2 Y1095 RLMAEREYGSCSHHY
0 4 K1165-ub QRIAEQQkAQAEVEG
0 2 K1175-ub AEVEGLGkGVARLSA
0 1 K1186-ac RLSAEAEkVLALPEP
0 2 K1186-ub RLSAEAEkVLALPEP
0 1 S1202-p PAAPTLRsELELTLG
0 50 K1210-ub ELELTLGkLEQVRSL
0 1 S1218-p LEQVRSLsAIYLEKL
0 1 T1227-p IYLEKLKtISLVIRG
0 1 G1234 tISLVIRGTQGAEEV
0 1 T1235 ISLVIRGTQGAEEVL
0 1 K1250-ub RAHEEQLkEAQAVPA
0 1 S1352-p QLRYYREsADPLGAW
0 1 Q1389 REQLRQEQALLEEIE
0 1 K1410-ub EECQRFAkQYINAIk
0 1 K1417-ub kQYINAIkDYELQLV
0 1 K1417-sc kQYINAIkDYELQLV
0 1 Y1426-p YELQLVTykAQLEPV
0 1 K1427-ub ELQLVTykAQLEPVA
0 1 K1427-sc ELQLVTykAQLEPVA
0 37 S1435-p AQLEPVAsPAKKPKV
0 1 T1465 THYSELTTLTSQYIK
0 1 Y1470 LTTLTSQYIKFIsEt
0 1 S1475-p SQYIKFIsEtLRRME
0 1 T1477-p YIKFIsEtLRRMEEE
0 2 K1508-ub EVEAALEkQRQLAEA
0 1 S1554-p DAQQQKRsIQEELQQ
0 1 S1565-p ELQQLRQsSEAEIQA
0 1 K1573 SEAEIQAKARQAEAA
0 1 K1626-sc AEEAEAQkrQAQEEA
0 1 R1627-m1 EEAEAQkrQAQEEAE
0 1 R1637-m1 QEEAERLrRQVQDEs
0 1 S1644-p rRQVQDEsQRKRQAE
0 2 K1718-ub AEAELQSkRAsFAEk
0 16 S1721-p ELQSkRAsFAEkTAQ
0 1 K1725-ac kRAsFAEkTAQLERs
0 13 S1732-p kTAQLERsLQEEHVA
0 1 R1812-m1 EAEREARrRGKAEEQ
0 2 S1907-p EMEVLLAskARAEEE
0 1 K1908-ac MEVLLAskARAEEES
0 1 K1975-ac AERVLAEkLAAIGEA
0 1 T1983-p LAAIGEAtRLKTEAE
0 1 T2053-p QKGLVEDtLRQRRQV
0 1 K2182-ac LAQEAAQkRLQAEEk
0 2 K2189-ac kRLQAEEkAHAFAVQ
0 1 K2255-ac VEEAERLkQSAEEQA
0 1 K2274-ac QAQAAAEkLRKEAEQ
0 1 K2350-ub DEELQRLkAEAtEAA
0 1 T2354-p QRLkAEAtEAARQRs
0 3 S2361-p tEAARQRsQVEEELF
0 1 S2369-p QVEEELFsVRVQMEE
0 1 S2378-p RVQMEELsKLKARIE
0 1 S2516-p RQRQLEMsAEAERLK
0 3 S2578-p LEIQRQQsDHDAERL
0 1 K2604-ub EKLQQEAkLLQLKSE
0 1 T2615-p LKSEEMQtVQQEQLL
0 2 S2631-p ETQALQQsFLSEKDS
0 1 K2636 QQsFLSEKDSLLQRE
0 1 K2650-ub ERFIEQEkAKLEQLF
0 1 K2663-ub LFQDEVAkAQQLREE
0 2 S2688-p ERQRLVAsMEEARRR
0 3 S2755-p HSEEVTAsQVAATKT
0 2 A2774 RDALDGPAAEAEPEH
0 3 S2782-p AEAEPEHsFDGLRRK
0 5 S2791-p DGLRRKVsAQRLQEA
0 3 S2802-p LQEAGILsAEELQRL
0 10 R2826 LARREDVRHYLQGRS
0 1 K2841-ac SIAGLLLkATNEKLS
0 1 K2841-ub SIAGLLLkATNEKLS
0 42 T2886-p PVRNRRLtVNEAVKE
0 3 K2915-ub ERAVTGYkDPYTGQQ
0 1 K2915-sc ERAVTGYkDPYTGQQ
0 1 T2949-p LLEAQIAtGGVIDPV
0 2 K2988-ub ADPSDDTkGFFDPNT
0 1 K3027-ub PLTDKAAkGGELVyT
0 12 Y3033-p AkGGELVyTDsEARD
0 2 S3036-p GELVyTDsEARDVFE
0 1 K3053 TVSAPFGKFQGKTVT
0 1 K3091-ac TGRITVEkIIKIIIT
0 1 S3116-p LCFEGLRsLVPAAEL
0 1 S3126-p PAAELLEsRVIDREL
0 38 Y3134-p RVIDRELyQQLQRGE
0 5 T3152-p RDVAEVDtVRRALRG
0 1 Y3178 AGQKLSIYNALkKDL
0 1 K3182-sc LSIYNALkKDLLPsD
0 1 S3188-p LkKDLLPsDMAVALL
0 1 S3210-p HIIDPATsARLTVDE
0 1 K3237 EKLLSAEKAVTGYRD
0 1 Y3246 VTGYRDPYTGQSVsL
0 1 S3252-p PYTGQSVsLFQALKK
0 2 S3276-p RLLDAQLstGGIVDP
0 1 T3277-p LLDAQLstGGIVDPs
0 1 S3284-p tGGIVDPsKSHRVPL
0 1 E3302 CARGCLDEETSRALS
0 1 K3316-ub SAPRADAkAYSDPST
0 13 Y3329-p STGEPATyGELQQRC
0 1 K3352 SLLPLSEKAARARQE
0 134 Y3362-p RARQEELySELQARE
0 1 P3375 RETFEKTPVEVPVGG
0 3 K3384-ub EVPVGGFkGRTVTVW
0 1 K3384-sc EVPVGGFkGRTVTVW
0 1 Y3398-p WELISSEyFtAEQRQ
0 1 T3400-p LISSEyFtAEQRQEL
0 1 K3420-ac TGKVTVEkVIKILIT
0 1 T3427 kVIKILITIVEEVET
0 1 S3443-p RQERLSFsGLRAPVP
0 1 S3457-p PASELLAsGVLsRAQ
0 1 G3458 ASELLAsGVLsRAQF
0 2 S3461-p LLAsGVLsRAQFEQL
0 1 K3476-sc KDGKTTVkDLsELGs
0 1 S3479-p KTTVkDLsELGsVRt
0 2 S3483-p kDLsELGsVRtLLQG
0 1 T3486-p sELGsVRtLLQGsGC
0 1 S3491-p VRtLLQGsGCLAGIy
0 3 Y3498-p sGCLAGIyLEDTkEK
0 4 K3503-ac GIyLEDTkEKVSIyE
0 1 Y3509-p TkEKVSIyEAMRrGL
0 1 R3514-m1 SIyEAMRrGLLRATT
0 1 S3565-p ELHEQLLsAEKAVTG
0 1 K3590-ub SLFQAMQkGLVLRQH
0 1 K3647-ub ADPSDDTkGFFDPNT
0 1 T3766-p IIEIIEKtEIIRQQG
0 2 S3776-p IRQQGLAsyDyVRRR
0 41 Y3777-p RQQGLAsyDyVRRRL
0 2 Y3779-p QGLAsyDyVRRRLtA
0 8 T3785-p DyVRRRLtAEDLFEA
0 8 F3790 RLtAEDLFEARIISL
0 1 T3799-p ARIISLEtYNLLREG
0 1 T3807-p YNLLREGtRSLREAL
0 16 Y3833 TGSVAGVYLPGSRQT
0 1 Y3844-p SRQTLSIyQALkKGL
0 1 K3848-sc LSIyQALkKGLLsAE
0 1 S3853-p ALkKGLLsAEVARLL
0 1 T3930-p MKKELIPtEEALRLL
0 1 K3968-ac YQRGYLNkDTHDQLS
0 1 K3968-ub YQRGYLNkDTHDQLS
0 1 K3968-sc YQRGYLNkDTHDQLS
0 1 T4007-p RCRRDDGtGQLLLPL
0 4 T4021-p LSDARKLtFRGLRkQ
0 1 K4027-ub LtFRGLRkQItMEEL
0 62 T4030-p RGLRkQItMEELVRs
0 2 S4037-p tMEELVRsQVMDEAT
0 4 S4054-p QLREGLTsIEEVTkN
0 1 K4060-ub TsIEEVTkNLQKFLE
0 1 K4081-ub GVFVDATkERLSVYQ
0 1 K4121-ub IDPIKGLkLTVEEAV
0 1 K4138-ub GIVGPEFkDKLLSAE
0 1 K4152-ub ERAVTGYkDPySGkL
0 1 K4152-sc ERAVTGYkDPySGkL
0 48 Y4155-p VTGYkDPySGkLISL
0 1 K4158-ub YkDPySGkLISLFQA
0 1 K4167-ac ISLFQAMkKGLILkD
0 1 K4167-sc ISLFQAMkKGLILkD
0 1 K4173-sc MkKGLILkDHGIRLL
0 7 K4205-ac LPVEVAYkRGLFDEE
0 1 K4205-ub LPVEVAYkRGLFDEE
0 23 T4267-p EKKRERKtssKssVR
0 127 S4268-p KKRERKtssKssVRK
0 5 S4269-p KRERKtssKssVRKR
0 1 S4271-p ERKtssKssVRKRRV
0 8 S4272-p RKtssKssVRKRRVV
0 1 T4285-p VVIVDPEtGkEMSVY
0 1 K4287-ub IVDPEtGkEMSVYEA
0 1 R4296 MSVYEAYRKGLIDHQ
0 1 S4329-p SSDGVVKsMIIDRRs
0 1 S4336-p sMIIDRRsGRQyDID
0 1 Y4340-p DRRsGRQyDIDDAIA
0 1 K4348-ub DIDDAIAkNLIDRsA
0 4 S4354-p AkNLIDRsALDQYRA
0 3 T4367-p RAGTLSItEFADMLs
0 3 S4374-p tEFADMLsGNAGGFR
0 61 S4382-p GNAGGFRsRsssVGs
0 81 S4384-p AGGFRsRsssVGsss
0 80 S4385-p GGFRsRsssVGssss
0 289 S4386-p GFRsRsssVGssssy
0 136 S4389-p sRsssVGssssyPIs
0 47 S4390-p RsssVGssssyPIsP
0 14 S4391-p sssVGssssyPIsPA
0 13 S4392-p ssVGssssyPIsPAV
0 30 Y4393-p sVGssssyPIsPAVs
0 183 S4396-p ssssyPIsPAVsRtQ
0 1 P4397 sssyPIsPAVsRtQL
0 11 S4400-p yPIsPAVsRtQLAsW
0 5 T4402-p IsPAVsRtQLAsWsD
0 12 S4406-p VsRtQLAsWsDPTEE
0 4 S4408-p RtQLAsWsDPTEEtG
0 1 T4414-p WsDPTEEtGPVAGIL
0 1 K4480 VNKGLVDKIMVDRIN
0 1 K4491-ac DRINLAQkAFCGFED
0 1 T4501-p CGFEDPRtKTKMSAA
0 1 K4512-sc MSAAQALkkGWLyyE
0 1 K4513-ub SAAQALkkGWLyyEA
0 2 Y4517-p ALkkGWLyyEAGQRF
0 2 Y4518-p LkkGWLyyEAGQRFL
1 2 T4539-p GGLIEPDtPGRVPLD
0 3 G4566 AQKLRDVGAYSKYLT
0 1 Y4568 KLRDVGAYSKYLTCP
0 1 K4576-sc SKYLTCPkTKLKISY
0 1 K4584-sc TKLKISYkDALDRSM
0 1 S4607-p LLEAAAQsTkGyysP
0 2 K4609-ub EAAAQsTkGyysPys
0 140 Y4611-p AAQsTkGyysPysVs
0 16 Y4612-p AQsTkGyysPysVsG
0 145 S4613-p QsTkGyysPysVsGs
0 278 Y4615-p TkGyysPysVsGsGs
0 35 S4616-p kGyysPysVsGsGst
0 36 S4618-p yysPysVsGsGstAG
0 29 S4620-p sPysVsGsGstAGsR
0 81 S4622-p ysVsGsGstAGsRtG
0 31 T4623-p sVsGsGstAGsRtGs
0 77 S4626-p GsGstAGsRtGsrtG
0 1 R4627 sGstAGsRtGsrtGs
0 20 T4628-p GstAGsRtGsrtGsR
0 15 S4630-p tAGsRtGsrtGsRAG
0 1 R4631-m2 AGsRtGsrtGsRAGs
0 3 T4632-p GsRtGsrtGsRAGsR
0 8 S4634-p RtGsrtGsRAGsRrG
0 2 S4638-p rtGsRAGsRrGsFDA
0 1 R4640-m1 GsRAGsRrGsFDAtG
1 113 S4642-p RAGsRrGsFDAtGsG
0 6 T4646-p RrGsFDAtGsGFSMT
0 7 S4648-p GsFDAtGsGFSMTFS
0 1 T4653 tGsGFSMTFSsSSys
0 1 S4656-p GFSMTFSsSSysSSG
0 3 Y4659-p MTFSsSSysSSGyGR
0 1 S4660-p TFSsSSysSSGyGRR
0 1 Y4664-p SSysSSGyGRRyAsG
0 1 Y4668-p SSGyGRRyAsGssAs
0 4 S4670-p GyGRRyAsGssAsLG
0 7 S4672-p GRRyAsGssAsLGGP
0 3 S4673-p RRyAsGssAsLGGPE
0 6 S4675-p yAsGssAsLGGPESA
  Plectin-1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S16-p RAVSEDVsNGSSGsP
S22-p VsNGSSGsPSPGDtL
T28-p GsPSPGDtLPWNLGK
S42-p KTQRSRRsGGGAGSN
A46 SRRsGGGAGSNGSVL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K77 VQKKTFTKWVNKHLI
S91 IKAQRHISDLYEDLR
S174 IILHFQISDIQVSGQ
S195 KEKLLLWSQRMVEGY
T241 MNKVYRQTNLENLDQ
S251 ENLDQAFSVAERDLG
T260 AERDLGVTRLLDPED
S284 SIITYVSSLYDAMPR
Y286 ITYVSSLYDAMPRVP
K352 WSQFLKFKEMELPAK
K359 KEMELPAKEADKNRS
K367 EADKNRSKGIYQSLE
Y370 KNRSKGIYQSLEGAV
S372 RSKGIYQSLEGAVQA
K383 AVQAGQLKVPPGYHP
K471 EVERDLDKADSMIRL
K487 FNDVQTLKDGRHPQG
K487 FNDVQTLKDGRHPQG
Y498 HPQGEQMYRRVYRLH
Y502 EQMYRRVYRLHERLV
K520 TEYNLRLKAGVAAPA
T528 AGVAAPATQVAQVTL
T528 AGVAAPATQVAQVTL
S537 VAQVTLQSVQRRPEL
S577 EWGVDLPSVEAQLGS
S610 RSDEGQLSPATRGAY
T613 EGQLSPATRGAYRDC
K630 RLDLQYAKLLNSSKA
K630 RLDLQYAKLLNSSKA
S672 EEVGFDWSDRNTNMT
S686 TAKKESYSALMRELE
A705 KIKELQNAGDRLLRE
Y751 HLKENAAYFQFFSDV
S777 EALRRKYSCDRSATV
S781 RKYSCDRSATVTRLE
K798 LQDAQDEKEQLNEYK
K798 LQDAQDEKEQLNEYK
Y804 EKEQLNEYKGHLSGL
K805 KEQLNEYKGHLSGLA
S809 NEYKGHLSGLAKRAK
K843 LLAVCDYKQVEVTVH
S919 QLHVDMKSLLAWQSL
S937 VQLIRSWSLATFRTL
S967 YQAFLRDSQDAGGFG
Y985 RLMAEREYGSCSHHY
K1055 QRIAEQQKAQAEVEG
K1065 AEVEGLGKGVARLSA
K1076 RLSAEAEKVLALPEP
K1076 RLSAEAEKVLALPEP
S1092 PAAPTLRSELELTLG
K1100 ELELTLGKLEQVRSL
S1108 LEQVRSLSAIYLEKL
T1117 IYLEKLKTISLVIRG
G1124 TISLVIRGTQGAEEV
T1125 ISLVIRGTQGAEEVL
K1140 RAHEEQLKEAQAVPA
S1242 QLRYYRESADPLGAW
Q1279 REQLRQEQALLEEIE
K1300 EECQRFAKQYINAIK
K1307 KQYINAIKDYELQLV
K1307 KQYINAIKDYELQLV
Y1316 YELQLVTYKAQLEPV
K1317 ELQLVTYKAQLEPVA
K1317 ELQLVTYKAQLEPVA
S1325 AQLEPVASPAKKPKV
T1355 THYSELTTLTSQYIK
Y1360 LTTLTSQYIKFISET
S1365 SQYIKFISETLRRME
T1367 YIKFISETLRRMEEE
K1398 EVEAALEKQRQLAEA
S1444 DAQQQKRSIQEELQQ
S1455 ELQQLRQSSEAEIQA
K1463 SEAEIQAKARQAEAA
K1516 AEEAEAQKRQAQEEA
R1517 EEAEAQKRQAQEEAE
R1527 QEEAERLRRQVQDES
S1534 RRQVQDESQRKRQAE
K1608 AEAELQSKRASFAEK
S1611 ELQSKRASFAEKTAQ
K1615 KRASFAEKTAQLERS
S1622 KTAQLERSLQEEHVA
R1702 EAEREARRRGKAEEQ
S1797 EMEVLLASKARAEEE
K1798 MEVLLASKARAEEES
K1865 AERVLAEKLAAIGEA
T1873 LAAIGEATRLKTEAE
T1943 QKGLVEDTLRQRRQV
K2072 LAQEAAQKRLQAEEK
K2079 KRLQAEEKAHAFAVQ
K2145-ac VEEAERLkQSAEEQA
K2164-ac QAQAAAEkLRKEAEQ
K2240 DEELQRLKAEATEAA
T2244 QRLKAEATEAARQRS
S2251 TEAARQRSQVEEELF
S2259 QVEEELFSVRVQMEE
S2268 RVQMEELSKLKARIE
S2406 RQRQLEMSAEAERLK
S2468 LEIQRQQSDHDAERL
K2494 EKLQQEAKLLQLKSE
T2505 LKSEEMQTVQQEQLL
S2521 ETQALQQSFLSEKDS
K2526 QQSFLSEKDSLLQRE
K2540 ERFIEQEKAKLEQLF
K2553 LFQDEVAKAQQLREE
S2578 ERQRLVASMEEARRR
S2645 HSEEVTASQVAATKT
A2664 RDALDGPAAEAEPEH
S2672 AEAEPEHSFDGLRRK
S2681 DGLRRKVSAQRLQEA
S2692 LQEAGILSAEELQRL
R2716 LARREDVRHYLQGRS
K2731 SIAGLLLKATNEKLS
K2731 SIAGLLLKATNEKLS
T2776-p PVRNRRLtVNEAVKE
K2805 ERAVTGYKDPYTGQQ
K2805 ERAVTGYKDPYTGQQ
T2839 LLEAQIATGGVIDPV
K2878 ADPSDDTKGFFDPNT
K2917 PLTDKAAKGGELVYT
Y2923 AKGGELVYTDSEARD
S2926 GELVYTDSEARDVFE
K2943 TVSAPFGKFQGKTVT
K2981 TGRITVEKIIKIIIT
S3006 LCFEGLRSLVPAAEL
S3016 PAAELLESRVIDREL
Y3024 RVIDRELYQQLQRGE
T3042 RDVAEVDTVRRALRG
Y3068 AGQKLSIYNALKKDL
K3072 LSIYNALKKDLLPSD
S3078 LKKDLLPSDMAVALL
S3100 HIIDPATSARLTVDE
K3127 EKLLSAEKAVTGYRD
Y3136 VTGYRDPYTGQSVSL
S3142 PYTGQSVSLFQALKK
S3166 RLLDAQLSTGGIVDP
T3167 LLDAQLSTGGIVDPS
S3174 TGGIVDPSKSHRVPL
E3192 CARGCLDEETSRALS
K3206 SAPRADAKAYSDPST
Y3219 STGEPATYGELQQRC
K3242 SLLPLSEKAARARQE
Y3252 RARQEELYSELQARE
P3265 RETFEKTPVEVPVGG
K3274 EVPVGGFKGRTVTVW
K3274 EVPVGGFKGRTVTVW
Y3288 WELISSEYFTAEQRQ
T3290 LISSEYFTAEQRQEL
K3310 TGKVTVEKVIKILIT
T3317 KVIKILITIVEEVET
S3333 RQERLSFSGLRAPVP
S3347 PASELLASGVLSRAQ
G3348 ASELLASGVLSRAQF
S3351 LLASGVLSRAQFEQL
K3366 KDGKTTVKDLSELGS
S3369 KTTVKDLSELGSVRT
S3373 KDLSELGSVRTLLQG
T3376 SELGSVRTLLQGSGC
S3381 VRTLLQGSGCLAGIY
Y3388 SGCLAGIYLEDTKEK
K3393 GIYLEDTKEKVSIYE
Y3399 TKEKVSIYEAMRRGL
R3404 SIYEAMRRGLLRATT
S3455 ELHEQLLSAEKAVTG
K3480 SLFQAMQKGLVLRQH
K3537 ADPSDDTKGFFDPNT
T3656 IIEIIEKTEIIRQQG
S3666 IRQQGLASYDYVRRR
Y3667 RQQGLASYDYVRRRL
Y3669 QGLASYDYVRRRLTA
T3675 DYVRRRLTAEDLFEA
F3680 RLTAEDLFEARIISL
T3689 ARIISLETYNLLREG
T3697 YNLLREGTRSLREAL
Y3723 TGSVAGVYLPGSRQT
Y3734 SRQTLSIYQALKKGL
K3738 LSIYQALKKGLLSAE
S3743 ALKKGLLSAEVARLL
T3820 MKKELIPTEEALRLL
K3858 YQRGYLNKDTHDQLS
K3858 YQRGYLNKDTHDQLS
K3858 YQRGYLNKDTHDQLS
T3897 RCRRDDGTGQLLLPL
T3911 LSDARKLTFRGLRKQ
K3917 LTFRGLRKQITMEEL
T3920 RGLRKQITMEELVRS
S3927 TMEELVRSQVMDEAT
S3944 QLREGLTSIEEVTKN
K3950 TSIEEVTKNLQKFLE
K3971 GVFVDATKERLSVYQ
K4011 IDPIKGLKLTVEEAV
K4028 GIVGPEFKDKLLSAE
K4042 ERAVTGYKDPySGKL
K4042 ERAVTGYKDPySGKL
Y4045-p VTGYKDPySGKLISL
K4048 YKDPySGKLISLFQA
K4057 ISLFQAMKKGLILKD
K4057 ISLFQAMKKGLILKD
K4063 MKKGLILKDHGIRLL
K4095 LPVEVAYKRGLFDEE
K4095 LPVEVAYKRGLFDEE
T4157-p EKKRERKtssKSsVR
S4158-p KKRERKtssKSsVRK
S4159-p KRERKtssKSsVRKR
S4161 ERKtssKSsVRKRRV
S4162-p RKtssKSsVRKRRVV
T4175 VVIVDPETGKEMSVY
K4177 IVDPETGKEMSVYEA
R4186 MSVYEAYRKGLIDHQ
S4219 SSDGVVKSMIIDRRS
S4226 SMIIDRRSGRQYDID
Y4230 DRRSGRQYDIDDAIA
K4238 DIDDAIAKNLIDRSA
S4244 AKNLIDRSALDQYRA
T4257 RAGTLSITEFADMLS
S4264 TEFADMLSGNAGGFR
S4272-p GNAGGFRsRsssVGs
S4274-p AGGFRsRsssVGsss
S4275-p GGFRsRsssVGssss
S4276-p GFRsRsssVGssssY
S4279-p sRsssVGssssYPIs
S4280-p RsssVGssssYPIsP
S4281-p sssVGssssYPIsPA
S4282-p ssVGssssYPIsPAV
Y4283 sVGssssYPIsPAVs
S4286-p ssssYPIsPAVsRTQ
P4287 sssYPIsPAVsRTQL
S4290-p YPIsPAVsRTQLASW
T4292 IsPAVsRTQLASWSD
S4296 VsRTQLASWSDPTEE
S4298 RTQLASWSDPTEETG
T4304 WSDPTEETGPVAGIL
K4370 VNKGLVDKIMVDRIN
K4381 DRINLAQKAFCGFED
T4391 CGFEDPRTKTKMSAA
K4402 MSAAQALKKGWLYYE
K4403 SAAQALKKGWLYYEA
Y4407 ALKKGWLYYEAGQRF
Y4408 LKKGWLYYEAGQRFL
T4429 GGLIEPDTPGRVPLD
G4456 AQKLRDVGAYSKYLT
Y4458 KLRDVGAYSKYLTCP
K4466 SKYLTCPKTKLKISY
K4474 TKLKISYKDALDRSM
S4497 LLEAAAQSTKGyySP
K4499 EAAAQSTKGyySPyS
Y4501-p AAQSTKGyySPySVS
Y4502-p AQSTKGyySPySVSG
S4503 QSTKGyySPySVSGS
Y4505-p TKGyySPySVSGSGS
S4506 KGyySPySVSGSGST
S4508 yySPySVSGSGSTAG
S4510 SPySVSGSGSTAGSR
S4512 ySVSGSGSTAGSRTG
T4513 SVSGSGSTAGSRTGS
S4516 GSGSTAGSRTGSRTG
R4517 SGSTAGSRTGSRTGS
T4518 GSTAGSRTGSRTGSR
S4520 TAGSRTGSRTGSRAG
R4521 AGSRTGSRTGSRAGS
T4522 GSRTGSRTGSRAGSR
S4524 RTGSRTGSRAGSRRG
S4528 RTGSRAGSRRGsFDA
R4530 GSRAGSRRGsFDATG
S4532-p RAGSRRGsFDATGSG
T4536 RRGsFDATGSGFSMT
S4538 GsFDATGSGFSMTFS
T4543 TGSGFSMTFSSSSYS
S4546 GFSMTFSSSSYSSSG
Y4549 MTFSSSSYSSSGYGR
S4550 TFSSSSYSSSGYGRR
Y4554 SSYSSSGYGRRYASG
Y4558 SSGYGRRYASGSSAS
S4560 GYGRRYASGSSASLG
S4562 GRRYASGSSASLGGP
S4563 RRYASGSSASLGGPE
S4565 YASGSSASLGGPESA
  Plectin-1 iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T19-p EGLGRKRtssEDNLy
S20-p GLGRKRtssEDNLyL
S21-p LGRKRtssEDNLyLA
Y26-p tssEDNLyLAVLRAs
S33-p yLAVLRAsEGKKDER
- gap
- gap
- gap
K50 VQKKTFTKWVNKHLI
S64 IKAQRHISDLYEDLR
S147 IILHFQISDIQVSGQ
S168 KEKLLLWSQRMVEGY
T214 MNKVYRQTNLENLDQ
S224 ENLDQAFSVAERDLG
T233 AERDLGVTRLLDPED
S257 SIITYVSSLYDAMPR
Y259 ITYVSSLYDAMPRVP
K325 WSQFLKFKEMELPAK
K332 KEMELPAKEADKNRS
K340 EADKNRSKGIYQSLE
Y343 KNRSKGIYQSLEGAV
S345 RSKGIYQSLEGAVQA
K356 AVQAGQLKVPPGYHP
K444 EVERDLDKADSMIRL
K460 FNDVQTLKDGRHPQG
K460 FNDVQTLKDGRHPQG
Y471 HPQGEQMYRRVYRLH
Y475 EQMYRRVYRLHERLV
K493 TEYNLRLKAGVAAPA
T501 AGVAAPATQVAQVTL
T501 AGVAAPATQVAQVTL
S510 VAQVTLQSVQRRPEL
S550 EWGVDLPSVEAQLGS
S583 RSDEGQLSPATRGAY
T586 EGQLSPATRGAYRDC
K603 RLDLQYAKLLNSSKA
K603 RLDLQYAKLLNSSKA
S645 EEVGFDWSDRNTNMT
S659 TAKKESYSALMRELE
A678 KIKELQNAGDRLLRE
Y724 HLKENAAYFQFFSDV
S750 EALRRKYSCDRSATV
S754 RKYSCDRSATVTRLE
K771 LQDAQDEKEQLNEYK
K771 LQDAQDEKEQLNEYK
Y777 EKEQLNEYKGHLSGL
K778 KEQLNEYKGHLSGLA
S782 NEYKGHLSGLAKRAK
K816 LLAVCDYKQVEVTVH
S892 QLHVDMKSLLAWQSL
S910 VQLIRSWSLATFRTL
S940 YQAFLRDSQDAGGFG
Y958 RLMAEREYGSCSHHY
K1028 QRIAEQQKAQAEVEG
K1038 AEVEGLGKGVARLSA
K1049 RLSAEAEKVLALPEP
K1049 RLSAEAEKVLALPEP
S1065 PAAPTLRSELELTLG
K1073 ELELTLGKLEQVRSL
S1081 LEQVRSLSAIYLEKL
T1090 IYLEKLKTISLVIRG
G1097 TISLVIRGTQGAEEV
T1098 ISLVIRGTQGAEEVL
K1113 RAHEEQLKEAQAVPA
S1215 QLRYYRESADPLGAW
Q1252 REQLRQEQALLEEIE
K1273 EECQRFAKQYINAIK
K1280 KQYINAIKDYELQLV
K1280 KQYINAIKDYELQLV
Y1289 YELQLVTYKAQLEPV
K1290 ELQLVTYKAQLEPVA
K1290 ELQLVTYKAQLEPVA
S1298 AQLEPVASPAKKPKV
T1328 THYSELTTLTSQYIK
Y1333 LTTLTSQYIKFISET
S1338 SQYIKFISETLRRME
T1340 YIKFISETLRRMEEE
K1371 EVEAALEKQRQLAEA
S1417 DAQQQKRSIQEELQQ
S1428 ELQQLRQSSEAEIQA
K1436 SEAEIQAKARQAEAA
K1489 AEEAEAQKRQAQEEA
R1490 EEAEAQKRQAQEEAE
R1500 QEEAERLRRQVQDEs
S1507-p RRQVQDEsQRKRQAE
K1581 AEAELQSKRASFAEK
S1584 ELQSKRASFAEKTAQ
K1588 KRASFAEKTAQLERS
S1595 KTAQLERSLQEEHVA
R1675 EAEREARRRGKAEEQ
S1770 EMEVLLASKARAEEE
K1771 MEVLLASKARAEEES
K1838 AERVLAEKLAAIGEA
T1846 LAAIGEATRLKTEAE
T1916 QKGLVEDTLRQRRQV
K2045 LAQEAAQKRLQAEEK
K2052 KRLQAEEKAHAFAVQ
K2118-ac VEEAERLkQSAEEQA
K2137-ac QAQAAAEkLRKEAEQ
K2213 DEELQRLKAEATEAA
T2217 QRLKAEATEAARQRS
S2224 TEAARQRSQVEEELF
S2232 QVEEELFSVRVQMEE
S2241 RVQMEELSKLKARIE
S2379 RQRQLEMSAEAERLK
S2441 LEIQRQQSDHDAERL
K2467 EKLQQEAKLLQLKSE
T2478 LKSEEMQTVQQEQLL
S2494 ETQALQQSFLSEKDS
K2499 QQSFLSEKDSLLQRE
K2513 ERFIEQEKAKLEQLF
K2526 LFQDEVAKAQQLREE
S2551 ERQRLVASMEEARRR
S2618 HSEEVTASQVAATKT
A2637 RDALDGPAAEAEPEH
S2645 AEAEPEHSFDGLRRK
S2654 DGLRRKVSAQRLQEA
S2665 LQEAGILSAEELQRL
R2689 LARREDVRHYLQGRS
K2704 SIAGLLLKATNEKLS
K2704 SIAGLLLKATNEKLS
T2749-p PVRNRRLtVNEAVKE
K2778 ERAVTGYKDPYTGQQ
K2778 ERAVTGYKDPYTGQQ
T2812 LLEAQIATGGVIDPV
K2851 ADPSDDTKGFFDPNT
K2890 PLTDKAAKGGELVYT
Y2896 AKGGELVYTDSEARD
S2899 GELVYTDSEARDVFE
K2916 TVSAPFGKFQGKTVT
K2954 TGRITVEKIIKIIIT
S2979 LCFEGLRSLVPAAEL
S2989 PAAELLESRVIDREL
Y2997 RVIDRELYQQLQRGE
T3015 RDVAEVDTVRRALRG
Y3041 AGQKLSIYNALKKDL
K3045 LSIYNALKKDLLPSD
S3051 LKKDLLPSDMAVALL
S3073 HIIDPATSARLTVDE
K3100 EKLLSAEKAVTGYRD
Y3109 VTGYRDPYTGQSVSL
S3115 PYTGQSVSLFQALKK
S3139 RLLDAQLSTGGIVDP
T3140 LLDAQLSTGGIVDPS
S3147 TGGIVDPSKSHRVPL
E3165 CARGCLDEETSRALS
K3179 SAPRADAKAYSDPST
Y3192 STGEPATYGELQQRC
K3215 SLLPLSEKAARARQE
Y3225 RARQEELYSELQARE
P3238 RETFEKTPVEVPVGG
K3247 EVPVGGFKGRTVTVW
K3247 EVPVGGFKGRTVTVW
Y3261 WELISSEYFTAEQRQ
T3263 LISSEYFTAEQRQEL
K3283 TGKVTVEKVIKILIT
T3290 KVIKILITIVEEVET
S3306 RQERLSFSGLRAPVP
S3320 PASELLASGVLSRAQ
G3321 ASELLASGVLSRAQF
S3324 LLASGVLSRAQFEQL
K3339 KDGKTTVKDLSELGS
S3342 KTTVKDLSELGSVRT
S3346 KDLSELGSVRTLLQG
T3349 SELGSVRTLLQGSGC
S3354 VRTLLQGSGCLAGIY
Y3361 SGCLAGIYLEDTKEK
K3366 GIYLEDTKEKVSIYE
Y3372 TKEKVSIYEAMRRGL
R3377 SIYEAMRRGLLRATT
S3428 ELHEQLLSAEKAVTG
K3453 SLFQAMQKGLVLRQH
K3510 ADPSDDTKGFFDPNT
T3629 IIEIIEKTEIIRQQG
S3639 IRQQGLASYDYVRRR
Y3640 RQQGLASYDYVRRRL
Y3642 QGLASYDYVRRRLTA
T3648 DYVRRRLTAEDLFEA
F3653 RLTAEDLFEARIISL
T3662 ARIISLETYNLLREG
T3670 YNLLREGTRSLREAL
Y3696 TGSVAGVYLPGSRQT
Y3707 SRQTLSIYQALKKGL
K3711 LSIYQALKKGLLSAE
S3716 ALKKGLLSAEVARLL
T3793 MKKELIPTEEALRLL
K3831 YQRGYLNKDTHDQLS
K3831 YQRGYLNKDTHDQLS
K3831 YQRGYLNKDTHDQLS
T3870 RCRRDDGTGQLLLPL
T3884 LSDARKLTFRGLRKQ
K3890 LTFRGLRKQITMEEL
T3893 RGLRKQITMEELVRS
S3900 TMEELVRSQVMDEAT
S3917 QLREGLTSIEEVTKN
K3923 TSIEEVTKNLQKFLE
K3944 GVFVDATKERLSVYQ
K3984 IDPIKGLKLTVEEAV
K4001 GIVGPEFKDKLLSAE
K4015 ERAVTGYKDPySGKL
K4015 ERAVTGYKDPySGKL
Y4018-p VTGYKDPySGKLISL
K4021 YKDPySGKLISLFQA
K4030 ISLFQAMKKGLILKD
K4030 ISLFQAMKKGLILKD
K4036 MKKGLILKDHGIRLL
K4068 LPVEVAYKRGLFDEE
K4068 LPVEVAYKRGLFDEE
T4130-p EKKRERKtssKSsVR
S4131-p KKRERKtssKSsVRK
S4132-p KRERKtssKSsVRKR
S4134 ERKtssKSsVRKRRV
S4135-p RKtssKSsVRKRRVV
T4148 VVIVDPETGKEMSVY
K4150 IVDPETGKEMSVYEA
R4159 MSVYEAYRKGLIDHQ
S4192 SSDGVVKSMIIDRRS
S4199 SMIIDRRSGRQYDID
Y4203 DRRSGRQYDIDDAIA
K4211 DIDDAIAKNLIDRSA
S4217 AKNLIDRSALDQYRA
T4230 RAGTLSITEFADMLS
S4237 TEFADMLSGNAGGFR
S4245-p GNAGGFRsRsssVGs
S4247-p AGGFRsRsssVGsss
S4248-p GGFRsRsssVGssss
S4249-p GFRsRsssVGssssY
S4252-p sRsssVGssssYPIs
S4253-p RsssVGssssYPIsP
S4254-p sssVGssssYPIsPA
S4255-p ssVGssssYPIsPAV
Y4256 sVGssssYPIsPAVs
S4259-p ssssYPIsPAVsRTQ
P4260 sssYPIsPAVsRTQL
S4263-p YPIsPAVsRTQLASW
T4265 IsPAVsRTQLASWSD
S4269 VsRTQLASWSDPTEE
S4271 RTQLASWSDPTEETG
T4277 WSDPTEETGPVAGIL
K4343 VNKGLVDKIMVDRIN
K4354 DRINLAQKAFCGFED
T4364 CGFEDPRTKTKMSAA
K4375 MSAAQALKKGWLYYE
K4376 SAAQALKKGWLYYEA
Y4380 ALKKGWLYYEAGQRF
Y4381 LKKGWLYYEAGQRFL
T4402 GGLIEPDTPGRVPLD
G4429 AQKLRDVGAYSKYLT
Y4431 KLRDVGAYSKYLTCP
K4439 SKYLTCPKTKLKISY
K4447 TKLKISYKDALDRSM
S4470 LLEAAAQSTKGyySP
K4472 EAAAQSTKGyySPyS
Y4474-p AAQSTKGyySPySVS
Y4475-p AQSTKGyySPySVSG
S4476 QSTKGyySPySVSGS
Y4478-p TKGyySPySVSGSGS
S4479 KGyySPySVSGSGST
S4481 yySPySVSGSGSTAG
S4483 SPySVSGSGSTAGSR
S4485 ySVSGSGSTAGSRTG
T4486 SVSGSGSTAGSRTGS
S4489 GSGSTAGSRTGSRTG
R4490 SGSTAGSRTGSRTGS
T4491 GSTAGSRTGSRTGSR
S4493 TAGSRTGSRTGSRAG
R4494 AGSRTGSRTGSRAGS
T4495 GSRTGSRTGSRAGSR
S4497 RTGSRTGSRAGSRRG
S4501 RTGSRAGSRRGsFDA
R4503 GSRAGSRRGsFDATG
S4505-p RAGSRRGsFDATGSG
T4509 RRGsFDATGSGFSMT
S4511 GsFDATGSGFSMTFS
T4516 TGSGFSMTFSSSSYS
S4519 GFSMTFSSSSYSSSG
Y4522 MTFSSSSYSSSGYGR
S4523 TFSSSSYSSSGYGRR
Y4527 SSYSSSGYGRRYASG
Y4531 SSGYGRRYASGSSAS
S4533 GYGRRYASGSSASLG
S4535 GRRYASGSSASLGGP
S4536 RRYASGSSASLGGPE
S4538 YASGSSASLGGPESA
  Plectin-1 iso6  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S2-p ______MsGAGGAFA
Y35-p PARRGYLyQQLCCVD
- gap
K54 VQKKTFTKWVNKHLI
S68 IKAQRHISDLYEDLR
S151 IILHFQISDIQVSGQ
S172 KEKLLLWSQRMVEGY
T218 MNKVYRQTNLENLDQ
S228 ENLDQAFSVAERDLG
T237 AERDLGVTRLLDPED
S261 SIITYVSSLYDAMPR
Y263 ITYVSSLYDAMPRVP
K329 WSQFLKFKEMELPAK
K336 KEMELPAKEADKNRS
K344 EADKNRSKGIYQSLE
Y347 KNRSKGIYQSLEGAV
S349 RSKGIYQSLEGAVQA
K360 AVQAGQLKVPPGYHP
K448 EVERDLDKADSMIRL
K464 FNDVQTLKDGRHPQG
K464 FNDVQTLKDGRHPQG
Y475 HPQGEQMYRRVYRLH
Y479 EQMYRRVYRLHERLV
K497 TEYNLRLKAGVAAPA
T505 AGVAAPATQVAQVTL
T505 AGVAAPATQVAQVTL
S514 VAQVTLQSVQRRPEL
S554 EWGVDLPSVEAQLGS
S587 RSDEGQLSPATRGAY
T590 EGQLSPATRGAYRDC
K607 RLDLQYAKLLNSSKA
K607 RLDLQYAKLLNSSKA
S649 EEVGFDWSDRNTNMT