a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding
Biological Process: release of virus from host; protein targeting to lysosome; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; protein to membrane docking; protein transport; early endosome to late endosome transport; positive regulation of viral reproduction; positive regulation of protein catabolic process; endosome to lysosome transport; Rab protein signal transduction; retrograde transport, endosome to Golgi; epidermal growth factor ligand processing; bone resorption
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.