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Protein Page:
Rab7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rab7 a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein
Cellular Component: Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; lysosome; lysosomal membrane; late endosome; melanosome; phagocytic vesicle
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding
Biological Process: cell death; protein transport; protein targeting to lysosome; early endosome to late endosome transport; GTP catabolic process; small GTPase mediated signal transduction; antigen processing and presentation of exogenous peptide antigen via MHC class II; endosome to lysosome transport; endocytosis; epidermal growth factor ligand processing; bone resorption
Reference #:  P51149 (UniProtKB)
Alt. Names/Synonyms: FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a
Gene Symbols: RAB7A
Molecular weight: 23,490 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S17-p KVIILGDsGVGKTSL
0 1 K32-ub MNQYVNKkFSNQykA
0 11 Y37-p NKkFSNQykAtIGAD
0 8 K38-ub KkFSNQykAtIGADF
0 1 T40-p FSNQykAtIGADFLT
0 43 S72-p AGQERFQsLGVAFYR
0 2 K97-ub VTAPNTFkTLDsWRD
0 1 S101-p NTFkTLDsWRDEFLI
0 3 K126-ub PFVVLGNkIDLENRQ
0 1 K137-ub ENRQVATkRAQAWCY
0 1 K157-ub PYFETSAkEAINVEQ
0 5 T168-p NVEQAFQtIARNALk
0 1 K175-ub tIARNALkQEtEVEL
0 2 T178-p RNALkQEtEVELyNE
0 241 Y183-p QEtEVELyNEFPEPI
0 46 K191-ub NEFPEPIkLDkNDRA
0 13 K194-ub PEPIkLDkNDRAKAs
0 1 S201-p kNDRAKAsAEsCsC_
0 1 S204-p RAKAsAEsCsC____
0 1 S206-p KAsAEsCsC______
  mouse

 
S17-p KVIILGDsGVGKTSL
K32 MNQYVNKKFSNQYkA
Y37 NKKFSNQYkATIGAD
K38-ub KKFSNQYkATIGADF
T40 FSNQYkATIGADFLT
S72-p AGQERFQsLGVAFYR
K97 VTAPNTFKTLDSWRD
S101 NTFKTLDSWRDEFLI
K126-ub PFVVLGNkIDLENRQ
K137 ENRQVATKRAQAWCY
K157 PYFETSAKEAINVEQ
T168 NVEQAFQTIARNALK
K175 TIARNALKQETEVEL
T178 RNALKQETEVELyNE
Y183-p QETEVELyNEFPEPI
K191-ub NEFPEPIkLDkNDRA
K194-ub PEPIkLDkNDRAKAS
S201 kNDRAKASAESCSC_
S204 RAKASAESCSC____
S206 KASAESCSC______
  rat

 
S17 KVIILGDSGVGKTSL
K32 MNQYVNKKFSNQYKA
Y37 NKKFSNQYKATIGAD
K38 KKFSNQYKATIGADF
T40 FSNQYKATIGADFLT
S72 AGQERFQSLGVAFYR
K97 VTAPNTFKTLDSWRD
S101 NTFKTLDSWRDEFLI
K126 PFVVLGNKIDLENRQ
K137 ENRQVATKRAQAWCY
K157 PYFETSAKEAINVEQ
T168 NVEQAFQTIARNALK
K175 TIARNALKQETEVEL
T178 RNALKQETEVELyNE
Y183-p QETEVELyNEFPEPI
K191 NEFPEPIKLDKNERA
K194 PEPIKLDKNERAKAS
S201 KNERAKASAESCSC_
S204 RAKASAESCSC____
S206 KASAESCSC______
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