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Rab7
a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric (Rab) |
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Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; lysosome; lysosomal membrane; late endosome; melanosome; phagocytic vesicle
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Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
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Biological Process: protein targeting to lysosome; protein transport; early endosome to late endosome transport; GTP catabolic process; small GTPase mediated signal transduction; endosome to lysosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; epidermal growth factor ligand processing
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Reference #:
P51149 (UniProtKB)
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| Alt. Names/Synonyms: FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a |
| Gene Symbols: RAB7A |
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Molecular weight: 23,490 Da
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Basal Isoelectric point: 6.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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