linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: mast cell granule; plasma membrane; integral to membrane; lipid raft
Molecular Function: protein binding; SH2 domain binding
Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation
Alt. Names/Synonyms: HSPC046; LAB; LAT2; linker for activation of B cells; Linker for activation of B-cells; linker for activation of T cells family, member 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; NTAL; WBS15; WBSCR15; WBSCR5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 15; Williams-Beuren syndrome chromosome region 5; WSCR5
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.