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LAB (human)

Overview LAB linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Adaptor/scaffold Cellular Component: integral to membrane; plasma membrane; intracellular; lipid raft Molecular Function: protein binding; SH2 domain binding Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; mast cell degranulation Reference #:  Q9GZY6 (UniProtKB) Alt. Names/Synonyms: HSPC046; LAB; LAT2; linker for activation of B cells; Linker for activation of B-cells; linker for activation of T cells family, member 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; NTAL; WBS15; WBSCR15; WBSCR5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 15; Williams-Beuren syndrome chromosome region 5; WSCR5 Gene Symbols: LAT2 Molecular weight: 26,550 Da Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LAB 3MAZ - B=133-143 (human)

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	Sites Implicated In
cell differentiation, altered: Y136‑p, Y193‑p, Y233‑p molecular association, regulation: Y136‑p, Y193‑p, Y233‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	7		Y40-p	AKRSEKIyQQRsLRE
0	26		S44-p	EKIyQQRsLREDQQs
0	29		S51-p	sLREDQQsFTGsRty
0	1		S55-p	DQQsFTGsRtysLVG
0	1		T57-p	QsFTGsRtysLVGQA
1	22		Y58-p	sFTGsRtysLVGQAW
0	12		S59-p	FTGsRtysLVGQAWP
0	1		-	gap
0	2		K77-u	ADMAPTRkDkLLQFy
0	6		K79-u	MAPTRkDkLLQFyPS
1	4		Y84-p	kDkLLQFyPSLEDPA
0	2		S92	PSLEDPASSRyQNFS
2	5		Y95-p	EDPASSRyQNFSkGS
0	2		K100-u	SRyQNFSkGSRHGSE
1	11		Y110-p	RHGSEEAyIDPIAME
2	19		Y118-p	IDPIAMEyyNWGRFS
1	14		Y119-p	DPIAMEyyNWGRFSk
0	1		K126-u	yNWGRFSkPPEDDDA
0	28		S135-p	PEDDDANsyENVLIC
3	174		Y136-p	EDDDANsyENVLICK
0	1		S183-p	SGLCPSAsPEEDEEs
0	2		S190-p	sPEEDEEsEDyQNsA
3	156		Y193-p	EDEEsEDyQNsAsIH
0	2		S196-p	EsEDyQNsAsIHQWR
0	1		S198-p	EDyQNsAsIHQWREs
0	1		S205-p	sIHQWREsRKVMGQL
3	7		Y233-p	EEDGEPDyVNGEVAA

	mouse
Y41-p	VKRNEKIyEQRNRQE
N45	EKIyEQRNRQENAQS
S52	NRQENAQSSAAAQTy
A56	NAQSSAAAQTysLAR
T58	QSSAAAQTysLARQV
Y59-p	SSAAAQTysLARQVW
S60-p	SAAAQTysLARQVWP
S78-p	MDTAPNKsFERKNKM
K82	PNKsFERKNKMLFSH
K84	KsFERKNKMLFSHLE
F87	ERKNKMLFSHLEGPE
S95-p	SHLEGPEsPRyQNFY
Y98-p	EGPEsPRyQNFYKGS
K103	PRyQNFYKGSNQEPD
Y113	NQEPDAAYVDPIPTN
Y121-p	VDPIPTNyYNWGCFQ
Y122	DPIPTNyYNWGCFQK
K129	YNWGCFQKPSEDDDS
S138	SEDDDSNSyENVLVC
Y139-p	EDDDSNSyENVLVCK
-	gap
F157	PESGVEDFEDyQNSV
Y160-p	GVEDFEDyQNSVSIH
S163	DFEDyQNSVSIHQWR
S165	EDyQNSVSIHQWRES
S172	SIHQWRESKRTMGAP
Y192-p	SPDEEPDyVNGDVAA

	rat
Y42	VKRNEKIYEQRNQQE
N46	EKIYEQRNQQENEQS
S53	NQQENEQSVASSQTY
S57	NEQSVASSQTYSLAR
T59	QSVASSQTYSLARPV
Y60	SVASSQTYSLARPVR
S61	VASSQTYSLARPVRT
S79	MDAASNKSFERKNKL
K83	SNKSFERKNKLLFSH
K85	KSFERKNKLLFSHLE
F88	ERKNKLLFSHLEGPE
S96	SHLEGPESPRYQNFY
Y99	EGPESPRYQNFYKGS
K104	PRYQNFYKGSRRESD
Y114	RRESDAAYVDPIPTD
Y122	VDPIPTDYYNWGCFQ
Y123	DPIPTDYYNWGCFQK
K130	YNWGCFQKPPEDNDS
S139	PEDNDSNSYENVLIC
Y140	EDNDSNSYENVLICK
-	gap
S158	PESGTEESEDYQNSV
Y161	GTEESEDYQNSVSIL
S164	ESEDYQNSVSILQWR
S166	EDYQNSVSILQWRES
S173	SILQWRESKRTMGAR
Y193	SPDEEPDYVNGDVAT

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