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FOXD3 (human)

Overview FOXD3 Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: transcription factor complex; nuclear chromatin Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; double-stranded DNA binding; transcription factor binding; DNA bending activity; transcription factor activity Biological Process: embryonic placenta development; in utero embryonic development; lateral line nerve glial cell development; negative regulation of transcription from RNA polymerase II promoter; enteric nervous system development; pattern specification process; trophectodermal cell differentiation; peripheral nervous system development; axon extension involved in axon guidance; sympathetic nervous system development; regulation of transcription factor activity; ureteric bud branching; cartilage development; melanocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; kidney development; neural crest cell migration; iridophore differentiation Reference #:  Q9UJU5 (UniProtKB) Alt. Names/Synonyms: AIS1; forkhead box D3; Forkhead box protein D3; FOXD3; Genesis; HFH2; HNF3/FH transcription factor genesis Gene Symbols: FOXD3 Molecular weight: 47,630 Da Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXD3 2HDC - A=2-98 (rat) 2HFH - A=2-101 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 607836 611539  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S46-p	DSDAGCDsPAGPPEL
0	1		Y214-p	GNPGKGNyWTLDPQS
0	1		S229-p	EDMFDNGsFLRRRKR
0	1		S260	MQSFGAYSLAAAAGA

	mouse
S46	DSDAGCDSPAGPPDL
Y204	GNPGKGNYWTLDPQS
S219	EDMFDNGSFLRRRKR
S250	MQSFGAYSLAAAAGA

	rat
S46	DSDAGCDSPAGPPDL
Y204	GNPGKGNYWTLDPQS
S219	EDMFDNGSFLRRRKR
S250-p	MQSFGAYsLAAAASA

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