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Protein Page:
FOXD3 (human)

Overview
FOXD3 Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: nuclear chromatin
Molecular Function: protein binding; double-stranded DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; embryonic placenta development; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation
Reference #:  Q9UJU5 (UniProtKB)
Alt. Names/Synonyms: AIS1; forkhead box D3; Forkhead box protein D3; FOXD3; Genesis; HFH2; HNF3/FH transcription factor genesis
Gene Symbols: FOXD3
Molecular weight: 47,630 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXD3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S46-p DSDAGCDsPAGPPEL
0 1 Y214-p GNPGKGNyWTLDPQS
0 1 S229-p EDMFDNGsFLRRRKR
0 1 S260 MQSFGAYSLAAAAGA
  mouse

 
S46 DSDAGCDSPAGPPDL
Y204 GNPGKGNYWTLDPQS
S219 EDMFDNGSFLRRRKR
S250 MQSFGAYSLAAAAGA
  rat

 
S46 DSDAGCDSPAGPPDL
Y204 GNPGKGNYWTLDPQS
S219 EDMFDNGSFLRRRKR
S250-p MQSFGAYsLAAAASA
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