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Protein Page:
BIRC6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BIRC6 Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase
Cellular Component: spindle pole; membrane; microtubule organizing center; trans-Golgi network; midbody; endosome
Molecular Function: protein binding; acid-amino acid ligase activity; ubiquitin-protein ligase activity; cysteine protease inhibitor activity
Biological Process: mitosis; apoptosis; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; regulation of cell proliferation; negative regulation of apoptosis
Reference #:  Q9NR09 (UniProtKB)
Alt. Names/Synonyms: APOLLON; baculoviral IAP repeat-containing 6; Baculoviral IAP repeat-containing protein 6; BIRC6; BRUCE; FLJ13726; FLJ13786; KIAA1289; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
Gene Symbols: BIRC6
Molecular weight: 530,255 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BIRC6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K92 VTSRGTIKVIDGTSG
0 1 K110-ub QASALSAkPGGQVKC
0 2 Y132-p KVIFVDDyAVGCRKD
0 1 K201-ub TQLKDGLkNTSHETA
0 1 K212-ub HETAANHkVAKWATV
0 1 Y301-p TSWPHVGyRWAQPDP
0 1 K416-ub ICIWDVSkLMKVHLK
0 5 S449-p DPSSGVDsRRPtLAW
0 10 T453-p GVDsRRPtLAWLEDS
0 3 S462-p AWLEDSSsCSDIPKL
0 6 S473-p IPKLEGDsDDLLEDs
0 27 S480-p sDDLLEDsDsEEHSR
0 5 S482-p DLLEDsDsEEHSRsD
0 3 S486 DsDsEEHSRsDSVTG
0 4 S488-p DsEEHSRsDSVTGHT
0 1 S490 EEHSRsDSVTGHTSQ
0 2 T492 HSRsDSVTGHTSQKE
0 1 S496 DSVTGHTSQKEAMEV
0 1 S504 QKEAMEVSLDITALS
0 1 S511 SLDITALSILQQPEK
0 3 C543 EELGANPCLTNSKSE
0 1 K548 NPCLTNSKSEKTKEK
0 1 T574-p LLAGGLLtyKsPAts
0 3 Y575-p LAGGLLtyKsPAtsP
0 14 S577-p GGLLtyKsPAtsPIs
0 13 T580-p LtyKsPAtsPIssNs
0 11 S581-p tyKsPAtsPIssNsH
0 2 S584-p sPAtsPIssNsHRsL
0 1 S585-p PAtsPIssNsHRsLD
0 4 S587-p tsPIssNsHRsLDGL
0 5 S590-p IssNsHRsLDGLSRT
0 1 T597 sLDGLSRTQGESISE
0 1 S601 LSRTQGESISEQGST
0 1 S603 RTQGESISEQGSTDN
0 1 S616 DNESCTNSELNsPLV
0 2 S620-p CTNSELNsPLVRRtL
0 1 T626-p NsPLVRRtLPVLLLy
0 1 Y633-p tLPVLLLySIKEsDE
0 2 S638-p LLySIKEsDEKAGKI
0 1 S647-p EKAGKIFsQMNNIMS
0 1 S999-p SEGSKPLsNPSSPGI
0 1 T1123-p NIPQIQVtLLKNKAP
0 1 T1204-p HAGMLTLtSPKLVKG
0 9 S1248-p RPVVRLPsLkHQSNK
0 1 K1250-m1 VVRLPsLkHQSNKGY
0 2 K1265-ub SLASLLAkVAAGKEK
0 1 K1277-ub KEKSSNVkNENtsGt
0 1 T1281-p SNVkNENtsGtRKSE
0 1 S1282-p NVkNENtsGtRKSEN
0 1 T1284-p kNENtsGtRKSENLR
0 1 T1302-p LLQEVSVtIRRFKKT
0 2 K1643-ub EKQQQLLkLQQQKAK
0 2 T1710-p LFMTPPLtPPNEAVS
0 1 Y1864-p KITVIGRyGstNARA
0 1 S1866-p TVIGRyGstNARAKI
0 1 T1867-p VIGRyGstNARAKIP
0 1 S2018-p PEDLIQTssTEQLRT
0 1 S2019-p EDLIQTssTEQLRTI
0 1 S2122-p DRVFMLLsCIGQRSL
0 1 K2193 EDEAAAAKKPLNGNQ
0 1 - gap
0 1 S2216 HTQSLNRSSKGSSsL
0 1 S2217 TQSLNRSSKGSSsLD
0 1 S2221 NRSSKGSSsLDRLYS
0 2 S2222-p RSSKGSSsLDRLYSR
0 5 K2258-ub ALVEQMEkEKIQSNk
0 5 K2265-ub kEKIQSNkGSSYkLL
0 139 K2270-ub SNkGSSYkLLVEQAk
0 7 K2277-ub kLLVEQAkLKQATSK
0 1 K2284 kLKQATSKHFkDLIR
0 1 K2287 QATSKHFKDLIRLRR
0 1 K2287-ub QATSKHFkDLIRLRR
0 1 T2295-p DLIRLRRtAEWSRSN
0 1 T2305-p WSRSNLDtEVTtAKE
0 1 T2309-p NLDtEVTtAKESPEI
0 1 K2511-ub EKDPLAAkVFKPISS
0 1 T2530-p YWGADYGtYNYNPYI
0 1 S2879 TCSDKVMSRSGSDSS
0 1 S2881 SDKVMSRSGSDSSVG
0 1 K2907-ub LIRPGDAkAVCGEMT
0 2 S2955-p TNTTDSVsDEEKVSG
0 1 K3139 FLDSGPNKAVDsTLk
0 8 S3143-p GPNKAVDsTLkTRIL
0 3 K3146-ub KAVDsTLkTRILASE
0 2 K3395-ub QSTRIGLkLIDILLR
0 3 S3578-p VQCHHRLsMTDDSKK
0 1 S3629-p AIKQLLDsGLPsLLV
0 1 S3633-p LLDsGLPsLLVRSLA
0 1 S3649-p FCFSHISsSESIAQS
0 1 S3660-p IAQSIDIsQDKLRRH
0 1 K3675-m3 HVPQQCNkMPItADL
0 1 T3679-p QCNkMPItADLVAPI
0 1 S3745 ARSASLSSAATTGLT
0 1 T3748 ASLSSAATTGLTTQQ
0 1 T3749 SLSSAATTGLTTQQR
0 1 K3834-ub QSPCPLYkGRINATS
0 1 K3854-ub PMYGAGHkFRTLHLP
0 34 Y3912-p ENGFQDNysVVVASG
0 1 S3913-p NGFQDNysVVVASGL
0 1 K3921 VVVASGLKSQSKRAV
0 1 T3931-p SKRAVSAtPPRPPsR
0 2 S3937-p AtPPRPPsRRGRTIP
0 1 K3958 SGAEAANKIITVPVF
0 1 S4010-p DLTVKLGsRVITDPS
0 1 S4019-p VITDPSLsktDsYKR
0 2 K4020-ub ITDPSLsktDsYKRL
0 1 T4021-p TDPSLsktDsYKRLH
0 6 S4023-p PSLsktDsYKRLHPE
0 1 S4039 DHGDLLASCPEDEAL
0 5 K4110-ub VTSTTQEkPKDSDQF
0 1 Y4130-p EQSGELVyEAPETVA
0 1 T4227-p LFSTTPLtTDDGVLL
0 19 Y4288-p STEEQQLyWAKGTGF
0 5 S4299-p GTGFGTGsTASGWDV
0 2 K4312-ub DVEQALTkQRLEEEH
0 1 S4365 SVLLELLSQSCLIPA
0 1 K4459 RSKRENVKTGVKPDA
0 27 Y4489-p QKTAEIVyAATTSLR
0 1 S4523-p KPLSVLKsLEEkyVA
0 1 K4527-m1 VLKsLEEkyVAVMKk
0 1 Y4528-p LKsLEEkyVAVMKkL
0 1 K4534-m1 kyVAVMKkLQFDTFE
0 1 S4561-p KVNYHYMsQVKNAND
0 1 S4571-p KNANDANsAARARRL
0 1 S4593 STSLPLSSSSSVFVR
0 1 S4714-p NEPGYERsRGtPSGT
0 1 T4717-p GYERsRGtPSGTQSs
0 1 S4724-p tPSGTQSsREYDGNI
0 1 S4791 KRVGRTMSHHAAALK
  mouse

 
K95-ub VTSRGTIkVIDGTSG
K113 QASALSAKPGGQVKC
Y135-p KVIFVDDyAVGCRKD
K204 TQLKDGLKNTSHETA
K215 HETAANHKVAKWATV
Y304 TSWPHVGYRWAQPDP
K419 ICIWDVSKLMKVHLK
S452-p DPSSGVDsRRPtLAW
T456-p GVDsRRPtLAWLEDS
S465-p AWLEDSSsCSDIPKL
S476-p IPKLEGDsDDLLEDs
S483-p sDDLLEDsDsEEHsR
S485-p DLLEDsDsEEHsRsD
S489-p DsDsEEHsRsDsVtG
S491-p DsEEHsRsDsVtGHT
S493-p EEHsRsDsVtGHTSQ
T495-p HsRsDsVtGHTSQKE
S499 DsVtGHTSQKEAMEV
S507 QKEAMEVSLDITALS
S514 SLDITALSILQQPEK
S546-p EELGANPsLTNSkSE
K551-ub NPsLTNSkSEKTKEK
T577 LLAGGLLTyKsPAts
Y578-p LAGGLLTyKsPAtsP
S580-p GGLLTyKsPAtsPIs
T583-p LTyKsPAtsPIsSNs
S584-p TyKsPAtsPIsSNsH
S587-p sPAtsPIsSNsHRsL
S588 PAtsPIsSNsHRsLD
S590-p tsPIsSNsHRsLDGL
S593-p IsSNsHRsLDGLSRt
T600-p sLDGLSRtQGEsIsE
S604-p LSRtQGEsIsEQGST
S606-p RtQGEsIsEQGSTDN
S619-p DNESCTNsELNsPLV
S623-p CTNsELNsPLVRRTL
T629 NsPLVRRTLPVLLLY
Y636 TLPVLLLYSIKESDE
S641 LLYSIKESDEKAGKI
S650 EKAGKIFSQMNNIMS
S1003 LEGSRPLSNPSSPGI
T1127 SVPQIQVTLLKNKAP
T1208 HAGMLTLTSPKLVKG
S1253-p RPVVRLPsLKQQGHK
K1255 VVRLPsLKQQGHKGY
K1270 SLASLLAKVAAGKEK
K1282 KEKSSNVKNENAGGT
A1286 SNVKNENAGGTRKSE
G1287 NVKNENAGGTRKSEN
T1289 KNENAGGTRKSENLR
T1307 LLQEVSVTIRRFKKT
K1652-ub EKQQQLLkLQQQKAK
T1724 LFMTPPLTPPNEAVS
Y1878 KITVIGRYGSTNARA
S1880 TVIGRYGSTNARAKI
T1881 VIGRYGSTNARAKIP
S2032 PEDLIQTSSTEQLRT
S2033 EDLIQTSSTEQLRTI
S2136 DRVFMLLSCIGQRSL
K2207-ub EDEAAAAkKPLNGKD
T2220-p KDRERFLtGNQWSFI
S2239-p HTQNLNRssKGGssL
S2240-p TQNLNRssKGGssLD
S2244-p NRssKGGssLDRLYS
S2245-p RssKGGssLDRLYSR
K2281-ub ALVEQMEkEKIQSNk
K2288-ub kEKIQSNkGSSYkLL
K2293-ub SNkGSSYkLLVEQAk
K2300-ub kLLVEQAkLKQATSk
K2307-ac kLKQATSkHFkDLIR
K2310-ac QATSkHFkDLIRLRR
K2310 QATSkHFKDLIRLRR
T2318 DLIRLRRTAEWSRSN
T2328 WSRSNLDTEVTTTKE
T2332 NLDTEVTTTKESPEI
K2534 EKDPLAAKVFKPISS
T2553 YWGADYGTYNYNPYI
S2902-p TCSDKVMsRsGSDSS
S2904-p SDKVMsRsGSDSSAG
K2930 LIRPGDAKAVCGEMT
S2978-p TNTTDSVsDEEKVSG
K3162-ub FLDSGPNkAVDSTLK
S3166 GPNkAVDSTLKTRIL
K3169 kAVDSTLKTRILASE
K3418 QSTRIGLKLIDILLR
S3601-p VQCHHRLsMTDDSKK
S3652 AIKQLLDSGLPSLLV
S3656 LLDSGLPSLLVRSLA
Y3672 FCFSHISYSESIAQS
S3683 IAQSVDNSQDKLRRH
K3698 HVPQHCNKMPITADL
T3702 HCNKMPITADLVAPI
S3768-p TRSASHSsATttVLT
T3771-p ASHSsATttVLTTQQ
T3772-p SHSsATttVLTTQQR
K3857 QSPCPLYKGRINATS
K3877 PMFGAGHKFRTLHLP
Y3935 ENGFQDNYSVVVASG
S3936 NGFQDNYSVVVASGL
K3944-ub VVVASGLkSQSKRAM
T3954 SKRAMASTPPRPPsR
S3960-p STPPRPPsRRGRTIP
K3982-ub SSADAASkIITVPVF
S4034 DLTVKLGSKVITDPS
S4043 VITDPSLSkTDsFKR
K4044-ub ITDPSLSkTDsFKRL
T4045 TDPSLSkTDsFKRLH
S4047-p PSLSkTDsFKRLHPE
S4063-p DHGDLVGsCPEDEAL
K4134-ub IASTTQEkPKDSDQF
Y4154 EQSGELVYEAPETIA
T4251 LFSATPLTTDDGVLL
Y4312-p SAEEQQLyWAKGTGF
S4323 GTGFGTGSTASGWDV
K4336 DVEQALTKQRLEEEH
S4389-p SVLLELLsQSCLIPA
K4484-ac RSKRENVkAGVKPDA
H4514 QRTAEIVHAATANLR
S4548 KPLSVLKSLEEKYVA
K4552 VLKSLEEKYVAVMKK
Y4553 LKSLEEKYVAVMKKL
K4559 KYVAVMKKLQFDTFE
S4586 KVNYHYMSQVKNAND
S4596 KNANDANSAARARRL
S4618-p STSLPLSsSSSVFVR
S4739 NEPGYERSRGTPSGT
T4742 GYERSRGTPSGTQSS
S4749 TPSGTQSSREYDGNI
S4816-p KRVGRTMsHHAAALK
  rat

 
K95 VTSRGTIKVIDGTSG
K113 QASALSAKPGGQVKC
Y135 KVIFVDDYAVGCRKD
K204 TQLKDGLKNTSHETA
K215 HETAANHKVAKWATV
Y304 TSWPHVGYRWAQPDP
K419 ICIWDVSKLMKVHLK
S452-p DPSSGVDsRRPtLAW
T456-p GVDsRRPtLAWLEDS
S465 AWLEDSSSCSDIPKL
S476 IPKLEGDSDDLLEDs
S483-p SDDLLEDsDSEEHSR
S485 DLLEDsDSEEHSRsD
S489 DsDSEEHSRsDSVtG
S491-p DSEEHSRsDSVtGHT
S493 EEHSRsDSVtGHTsQ
T495-p HSRsDSVtGHTsQKE
S499-p DSVtGHTsQKEAMEV
S507-p QKEAMEVsLDITALs
S514-p sLDITALsILQQPEK
C546 EELGANPCLTNSKSE
K551 NPCLTNSKSEKTKEK
T577 LLAGGLLTYKSPATS
Y578 LAGGLLTYKSPATSP
S580 GGLLTYKSPATSPIS
T583 LTYKSPATSPISSNS
S584 TYKSPATSPISSNSH
S587 SPATSPISSNSHRSL
S588 PATSPISSNSHRSLD
S590 TSPISSNSHRSLDGL
S593 ISSNSHRSLDGLSRT
- under review  
- under review  
- under review  
- under review  
- under review  
T629 NSPLVRRTLPVLLLY
Y636 TLPVLLLYSIKESDE
S641 LLYSIKESDEKAGKI
S650 EKAGKIFSQMNNIMS
S1002 LEGSRPLSNPSSPGI
S1126 SVPQIQVSLLRNRAP
T1207 HAGMLTLTSPKLVKG
S1251 RPVVRLPSLKQQGHK
K1253 VVRLPSLKQQGHKGY
K1268 SLASLLAKVAAGKEK
K1280 KEKSSNVKNESAGGT
A1284 SNVKNESAGGTRKSE
G1285 NVKNESAGGTRKSEN
T1287 KNESAGGTRKSENLR
T1305 LLQEVSVTIRRFKKT
K1646 EKQQQLLKLQQQKAK
T1716 LFMTPPLTPPNEAVS
Y1870 KITVIGRYGSTNARA
S1872 TVIGRYGSTNARAKI
T1873 VIGRYGSTNARAKIP
S2024 PEDLIPTSSTEQLRT
S2025 EDLIPTSSTEQLRTI
S2128 DRVFMLLSCIGQRSL
K2199 EDEAAAAKKPLNGNQ
- gap
S2222 HTQSLNRSSKGGSSL
S2223 TQSLNRSSKGGSSLD
S2227 NRSSKGGSSLDRLYS
S2228 RSSKGGSSLDRLYSR
K2264 ALVEQMEKEKIQSNK
K2271 KEKIQSNKGSSYkLL
K2276-ub SNKGSSYkLLVEQAK
K2283 kLLVEQAKLKQATSK
K2290 KLKQATSKHFKDLIR
K2293 QATSKHFKDLIRLRR
K2293 QATSKHFKDLIRLRR
T2301 DLIRLRRTAEWSRSN
T2311 WSRSNLDTEVTTTKE
T2315 NLDTEVTTTKESPEI
K2517 EKDPLAAKVFKPISS
T2536 YWGADYGTYNYNPYI
S2885 TCSDKVMSRSGSDSS
S2887 SDKVMSRSGSDSSVG
K2913 LIRPGDAKAVCGEMT
S2961 TNTTDSVSDEEKVSG
K3145 FLDSGPNKAVDSTLK
S3149 GPNKAVDSTLKTRIL
K3152 KAVDSTLKTRILASE
K3401 QSTRIGLKLIDILLR
S3584 VQCHHRLSMTDDSKK
S3635 AIKQLLDSGLPSLLV
S3639 LLDSGLPSLLVRSLA
Y3655 FCFSHISYSESIAQS
S3666 IAQSIDNSQDKLRRH
- under review  
T3685 HCNKMPITADLVAPI
S3751 TRSASHSSAATTVLT
T3754 ASHSSAATTVLTTQQ
T3755 SHSSAATTVLTTQQR
K3840 QSPCPLYKGRINATS
K3860 PMFGAGHKFRTLHLP
Y3918 DNGFQDNYSVVVASG
S3919 NGFQDNYSVVVASGL
K3927 VVVASGLKSQSKRAV
- under review  
S3943 STPPRPPSRRGRAIP
K3965 SSADTANKIITVPVF
S4017 DLTVKLGSKVITDPS
S4026 VITDPSLSKTDSFKR
K4027 ITDPSLSKTDSFKRL
T4028 TDPSLSKTDSFKRLH
S4030 PSLSKTDSFKRLHPE
S4046 DHGELIGSCPEDEAL
K4117 VASTTQEKPKDSDQF
Y4137 EQSGELVYEAPETIA
T4234 LFSATPLTTDDGVLL
Y4295 STEEQQLYWAKGTGF
S4306 GTGFGTGSTASGWDV
K4319 DVEQALTKQRLEEEH
- under review  
K4467 RSKRENIKTGVKPDA
H4497 QRTAEIVHAATTNLR
S4531 KPLSVLKSLEEKYVA
K4535 VLKSLEEKYVAVMKT
Y4536 LKSLEEKYVAVMKTL
T4542 KYVAVMKTLQFDTFE
S4569 KVNYHYMSQVKNAND
S4579 KNANDANSAARARRL
S4601 STSLPLSSSSSVFVR
S4722 NEPGYERSRGTPSGT
T4725 GYERSRGTPSGTQSS
S4732 TPSGTQSSREYDGNI
S4799 KRVGRTMSHHAAALK
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