Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
BIRC6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BIRC6 Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19
Cellular Component: Golgi apparatus; spindle pole; membrane; microtubule organizing center; trans-Golgi network; midbody; endosome
Molecular Function: protein binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity
Biological Process: mitosis; apoptosis; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; regulation of cell proliferation; negative regulation of apoptosis
Reference #:  Q9NR09 (UniProtKB)
Alt. Names/Synonyms: APOLLON; baculoviral IAP repeat-containing 6; Baculoviral IAP repeat-containing protein 6; BIRC6; BRUCE; FLJ13726; FLJ13786; KIAA1289; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
Gene Symbols: BIRC6
Molecular weight: 530,255 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BIRC6

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K92 VTSRGTIKVIDGTSG
0 1 K110-u QASALSAkPGGQVKC
0 2 Y132-p KVIFVDDyAVGCRKD
0 1 K201-u TQLKDGLkNTSHETA
0 1 K212-u HETAANHkVAKWATV
0 1 Y301-p TSWPHVGyRWAQPDP
0 1 K416-u ICIWDVSkLMKVHLK
0 5 S449-p DPSSGVDsRRPtLAW
0 10 T453-p GVDsRRPtLAWLEDS
0 2 S462-p AWLEDSSsCSDIPKL
0 5 S473-p IPKLEGDsDDLLEDs
0 24 S480-p sDDLLEDsDsEEHSR
0 5 S482-p DLLEDsDsEEHSRSD
0 3 S486 DsDsEEHSRSDSVTG
0 3 S488 DsEEHSRSDSVTGHT
0 1 S490 EEHSRSDSVTGHTSQ
0 2 T492 HSRSDSVTGHTSQKE
0 1 S496 DSVTGHTSQKEAMEV
0 1 S504 QKEAMEVSLDITALS
0 1 S511 SLDITALSILQQPEK
0 3 C543 EELGANPCLTNSKSE
0 1 K548 NPCLTNSKSEKTKEK
0 3 Y575-p LAGGLLTyKsPAtsP
0 14 S577-p GGLLTyKsPAtsPIs
0 12 T580-p LTyKsPAtsPIsSNs
0 9 S581-p TyKsPAtsPIsSNsH
0 2 S584-p sPAtsPIsSNsHRsL
0 4 S587-p tsPIsSNsHRsLDGL
0 4 S590-p IsSNsHRsLDGLSRT
0 1 T597 sLDGLSRTQGESISE
0 1 S601 LSRTQGESISEQGST
0 1 S603 RTQGESISEQGSTDN
0 1 S616 DNESCTNSELNSPLV
0 1 S620 CTNSELNSPLVRRTL
0 2 S638-p LLYSIKEsDEKAGKI
0 1 S999-p SEGSKPLsNPSSPGI
0 8 S1248-p RPVVRLPsLkHQSNK
0 1 K1250-m1 VVRLPsLkHQSNKGY
0 2 K1265-u SLASLLAkVAAGKEK
0 1 K1277-u KEKSSNVkNENTSGT
0 2 K1643-u EKQQQLLkLQQQKAK
0 1 K2193 EDEAAAAKKPLNGNQ
0 2 S2222-p RSSKGSSsLDRLYSR
0 5 K2258-u ALVEQMEkEKIQSNk
0 5 K2265-u kEKIQSNkGSSYkLL
0 139 K2270-u SNkGSSYkLLVEQAk
0 7 K2277-u kLLVEQAkLKQATSK
0 1 K2287-u QATSKHFkDLIRLRR
0 1 K2511-u EKDPLAAkVFKPISS
0 2 S2955-p TNTTDSVsDEEKVSG
0 1 K3139 FLDSGPNKAVDsTLk
0 8 S3143-p GPNKAVDsTLkTRIL
0 3 K3146-u KAVDsTLkTRILASE
0 2 K3395-u QSTRIGLkLIDILLR
0 2 S3578-p VQCHHRLsMTDDSKK
0 1 S3649-p FCFSHISsSESIAQS
0 1 S3660-p IAQSIDIsQDKLRRH
0 1 K3675-m3 HVPQQCNkMPITADL
0 1 K3834-u QSPCPLYkGRINATS
0 1 K3854-u PMYGAGHkFRTLHLP
0 34 Y3912-p ENGFQDNySVVVASG
0 1 K3921 VVVASGLKSQSKRAV
0 1 T3931-p SKRAVSAtPPRPPsR
0 2 S3937-p AtPPRPPsRRGRTIP
0 2 K4020-u ITDPSLSkTDsYKRL
0 6 S4023-p PSLSkTDsYKRLHPE
0 5 K4110-u VTSTTQEkPKDSDQF
0 20 Y4288-p STEEQQLyWAKGTGF
0 5 S4299-p GTGFGTGsTASGWDV
0 2 K4312-u DVEQALTkQRLEEEH
0 1 S4365 SVLLELLSQSCLIPA
0 25 Y4489-p QKTAEIVyAATTSLR
0 1 S4523-p KPLSVLKsLEEKYVA
0 1 S4561-p KVNYHYMsQVKNAND
0 1 S4571-p KNANDANsAARARRL
  mouse

 
K95-u VTSRGTIkVIDGTSG
K113 QASALSAKPGGQVKC
Y135-p KVIFVDDyAVGCRKD
K204 TQLKDGLKNTSHETA
K215 HETAANHKVAKWATV
Y304 TSWPHVGYRWAQPDP
K419 ICIWDVSKLMKVHLK
S452-p DPSSGVDsRRPtLAW
T456-p GVDsRRPtLAWLEDS
S465-p AWLEDSSsCSDIPKL
S476-p IPKLEGDsDDLLEDs
S483-p sDDLLEDsDsEEHsR
S485-p DLLEDsDsEEHsRsD
S489-p DsDsEEHsRsDsVtG
S491-p DsEEHsRsDsVtGHT
S493-p EEHsRsDsVtGHTSQ
T495-p HsRsDsVtGHTSQKE
S499 DsVtGHTSQKEAMEV
S507 QKEAMEVSLDITALS
S514 SLDITALSILQQPEK
S546-p EELGANPsLTNSkSE
K551-u NPsLTNSkSEKTKEK
Y578-p LAGGLLTyKsPAtsP
S580-p GGLLTyKsPAtsPIs
T583-p LTyKsPAtsPIsSNs
S584-p TyKsPAtsPIsSNsH
S587-p sPAtsPIsSNsHRsL
S590-p tsPIsSNsHRsLDGL
S593-p IsSNsHRsLDGLSRt
T600-p sLDGLSRtQGEsIsE
S604-p LSRtQGEsIsEQGST
S606-p RtQGEsIsEQGSTDN
S619-p DNESCTNsELNsPLV
S623-p CTNsELNsPLVRRTL
S641 LLYSIKESDEKAGKI
S1003 LEGSRPLSNPSSPGI
S1253-p RPVVRLPsLKQQGHK
K1255 VVRLPsLKQQGHKGY
K1270 SLASLLAKVAAGKEK
K1282 KEKSSNVKNENAGGT
K1652-u EKQQQLLkLQQQKAK
K2207-u EDEAAAAkKPLNGKD
S2245-p RSSKGGSsLDRLYSR
K2281-u ALVEQMEkEKIQSNk
K2288-u kEKIQSNkGSSYkLL
K2293-u SNkGSSYkLLVEQAk
K2300-u kLLVEQAkLKQATSK
K2310 QATSKHFKDLIRLRR
K2534 EKDPLAAKVFKPISS
S2978-p TNTTDSVsDEEKVSG
K3162-u FLDSGPNkAVDSTLK
S3166 GPNkAVDSTLKTRIL
K3169 kAVDSTLKTRILASE
K3418 QSTRIGLKLIDILLR
S3601-p VQCHHRLsMTDDSKK
Y3672 FCFSHISYSESIAQS
S3683 IAQSVDNSQDKLRRH
K3698 HVPQHCNKMPITADL
K3857 QSPCPLYKGRINATS
K3877 PMFGAGHKFRTLHLP
Y3935 ENGFQDNYSVVVASG
K3944-u VVVASGLkSQSKRAM
T3954 SKRAMASTPPRPPsR
S3960-p STPPRPPsRRGRTIP
K4044-u ITDPSLSkTDsFKRL
S4047-p PSLSkTDsFKRLHPE
K4134-u IASTTQEkPKDSDQF
Y4312-p SAEEQQLyWAKGTGF
S4323 GTGFGTGSTASGWDV
K4336 DVEQALTKQRLEEEH
S4389-p SVLLELLsQSCLIPA
H4514 QRTAEIVHAATANLR
S4548 KPLSVLKSLEEKYVA
S4586 KVNYHYMSQVKNAND
S4596 KNANDANSAARARRL
  rat

 
K95 VTSRGTIKVIDGTSG
K113 QASALSAKPGGQVKC
Y135 KVIFVDDYAVGCRKD
K204 TQLKDGLKNTSHETA
K215 HETAANHKVAKWATV
Y304 TSWPHVGYRWAQPDP
K419 ICIWDVSKLMKVHLK
S452-p DPSSGVDsRRPtLAW
T456-p GVDsRRPtLAWLEDS
S465 AWLEDSSSCSDIPKL
S476 IPKLEGDSDDLLEDs
S483-p SDDLLEDsDSEEHSR
S485 DLLEDsDSEEHSRsD
S489 DsDSEEHSRsDSVtG
S491-p DSEEHSRsDSVtGHT
S493 EEHSRsDSVtGHTsQ
T495-p HSRsDSVtGHTsQKE
S499-p DSVtGHTsQKEAMEV
S507-p QKEAMEVsLDITALs
S514-p sLDITALsILQQPEK
C546 EELGANPCLTNSKSE
K551 NPCLTNSKSEKTKEK
Y578 LAGGLLTYKSPATSP
S580 GGLLTYKSPATSPIS
T583 LTYKSPATSPISSNS
S584 TYKSPATSPISSNSH
S587 SPATSPISSNSHRSL
S590 TSPISSNSHRSLDGL
S593 ISSNSHRSLDGLSRT
- under review  
- under review  
- under review  
- under review  
- under review  
S641 LLYSIKESDEKAGKI
S1002 LEGSRPLSNPSSPGI
S1251 RPVVRLPSLKQQGHK
K1253 VVRLPSLKQQGHKGY
K1268 SLASLLAKVAAGKEK
K1280 KEKSSNVKNESAGGT
K1646 EKQQQLLKLQQQKAK
K2199 EDEAAAAKKPLNGNQ
S2228 RSSKGGSSLDRLYSR
K2264 ALVEQMEKEKIQSNK
K2271 KEKIQSNKGSSYkLL
K2276-u SNKGSSYkLLVEQAK
K2283 kLLVEQAKLKQATSK
K2293 QATSKHFKDLIRLRR
K2517 EKDPLAAKVFKPISS
S2961 TNTTDSVSDEEKVSG
K3145 FLDSGPNKAVDSTLK
S3149 GPNKAVDSTLKTRIL
K3152 KAVDSTLKTRILASE
K3401 QSTRIGLKLIDILLR
S3584 VQCHHRLSMTDDSKK
Y3655 FCFSHISYSESIAQS
S3666 IAQSIDNSQDKLRRH
- under review  
K3840 QSPCPLYKGRINATS
K3860 PMFGAGHKFRTLHLP
Y3918 DNGFQDNYSVVVASG
K3927 VVVASGLKSQSKRAV
- under review  
S3943 STPPRPPSRRGRAIP
K4027 ITDPSLSKTDSFKRL
S4030 PSLSKTDSFKRLHPE
K4117 VASTTQEKPKDSDQF
Y4295 STEEQQLYWAKGTGF
S4306 GTGFGTGSTASGWDV
K4319 DVEQALTKQRLEEEH
- under review  
H4497 QRTAEIVHAATTNLR
S4531 KPLSVLKSLEEKYVA
S4569 KVNYHYMSQVKNAND
S4579 KNANDANSAARARRL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.