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Protein Page:
EPB41L3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EPB41L3 a possible tumor suppressor protein that plays a role in cell adhesion and apoptosis. Critical growth regulator in the pathogenesis of meningiomas. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: cytoskeleton; extrinsic to membrane; paranode region of axon; cytoplasm; plasma membrane; intercellular junction; axolemma
Molecular Function: protein binding; structural constituent of cytoskeleton; actin binding
Biological Process: regulation of cell shape; cytoskeletal anchoring; apoptosis; myelin maintenance; cortical cytoskeleton organization and biogenesis; cortical actin cytoskeleton organization and biogenesis; neurite morphogenesis; paranodal junction assembly
Reference #:  Q9Y2J2 (UniProtKB)
Alt. Names/Synonyms: 4.1B; Band 4.1-like protein 3; DAL-1; DAL1; Differentially expressed in adenocarcinoma of the lung protein 1; E41L3; EPB41L3; erythrocyte membrane protein band 4.1-like 3; FLJ37633; KIAA0987
Gene Symbols: EPB41L3
Molecular weight: 120,678 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Select Structure to View Below

EPB41L3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T2-p ______MttEsGsDs
0 1 T3-p _____MttEsGsDsE
0 2 S5-p ___MttEsGsDsEsK
0 3 S7-p _MttEsGsDsEsKPD
0 1 S9-p ttEsGsDsEsKPDQE
0 2 S11-p EsGsDsEsKPDQEAE
0 2 S55-p FAAAAAHstPVRREV
0 7 T56-p AAAAAHstPVRREVT
0 1 K75-ub EFAARAAkQLEyQQL
0 2 Y79-p RAAkQLEyQQLEDDK
0 1 K86 yQQLEDDKLsQKsss
0 42 S88-p QLEDDKLsQKssssK
0 6 S91-p DDKLsQKssssKLsR
0 3 S92-p DKLsQKssssKLsRs
0 1 S93-p KLsQKssssKLsRsP
0 3 S94-p LsQKssssKLsRsPL
0 2 S97-p KssssKLsRsPLKIV
0 3 S99-p sssKLsRsPLKIVKK
0 1 Y122-p ILLDGSEytCDVEKR
0 1 T123-p LLDGSEytCDVEKRs
0 1 K128 EytCDVEKRsRGQVL
0 1 S130-p tCDVEKRsRGQVLFD
0 2 K138-ub RGQVLFDkVCEHLNL
0 1 K148 EHLNLLEKDYFGLTY
0 2 K162-ub YRDAENQkNWLDPAK
0 1 Y189-p FSFNVKFyPPDPAQL
0 1 K261 RFAPNHTKELEDkVI
0 2 K266-ub HTKELEDkVIELHKs
0 1 S273-p kVIELHKsHRGMtPA
0 1 T278-p HKsHRGMtPAEAEMH
0 1 S294 LENAKKLSMYGVDLH
0 1 K336-ub INRFAWPkVLKISYK
0 1 S361-p GEFEQFEsTIGFKLP
0 1 K397 LLPEAPPKKFLtLGs
0 4 T401-p APPKKFLtLGskFRy
0 2 S404-p KKFLtLGskFRysGR
0 5 K405-ac KFLtLGskFRysGRT
0 4 K405-ub KFLtLGskFRysGRT
0 5 Y408-p tLGskFRysGRTQAQ
0 3 S409-p LGskFRysGRTQAQT
0 1 T416 sGRTQAQTRRAsALI
0 24 S420-p QAQTRRAsALIDRPA
0 16 S443-p KRYTMSRsLDGEVGT
0 7 - gap
0 2 - gap
0 3 - gap
0 2 - gap
0 1 T450 sLDGEVGTGQyATTK
0 17 Y453-p GEVGTGQyATTKGIs
0 42 S460-p yATTKGIsQtNLItt
0 7 T462-p TTKGIsQtNLIttVt
1 2 T466-p IsQtNLIttVtPEKK
1 3 T467-p sQtNLIttVtPEKKA
0 39 T469-p tNLIttVtPEKKAEE
0 1 K472 IttVtPEKKAEEERD
0 13 T492-p RRKGEEVtPIsAIRH
0 1 S495-p GEEVtPIsAIRHEGK
0 1 T703 DTAADGETtAtEsDQ
0 9 T704-p TAADGETtAtEsDQE
0 8 T706-p ADGETtAtEsDQEED
0 10 S708-p GETtAtEsDQEEDAE
0 4 T724 KAQELEKTQDDLMKH
0 1 S736-p MKHQTNIsELKRTFL
0 1 K739 QTNIsELKRTFLETs
0 1 T745 LKRTFLETsTDTAVT
0 2 S746-p KRTFLETsTDTAVTN
0 7 S760-p NEWEKRLstsPVRLA
0 7 T761-p EWEKRLstsPVRLAA
0 14 S762-p WEKRLstsPVRLAAR
0 1 T784 EPLVPEETKQSSGEK
0 1 S787 VPEETKQSSGEKLMD
0 1 S788 PEETKQSSGEKLMDG
0 1 K791 TKQSSGEKLMDGSEI
0 1 S800 MDGSEIFSLLESARK
0 1 K807 SLLESARKPTEFIGG
0 1 T840 SGIETEPTVHHLPLS
0 1 Y872-p HASGDASySAGDSGD
0 3 P884 SGDAAAQPAFTGIKG
0 1 F886 DAAAQPAFTGIKGKE
0 1 - gap
0 1 A896 IKGKEGSALTEGAKE
0 1 K902 SALTEGAKEEGGEEV
0 1 I956 STVKTETISFGsVsP
0 2 S957 TVKTETISFGsVsPG
1 3 S960-p TETISFGsVsPGGVK
1 25 S962-p TISFGsVsPGGVKLE
0 1 T980 KEVPVVHTETKTITy
0 6 Y987-p TETKTITyESSQVDP
0 3 S1031-p KTVKGGIsETRIEKR
0 1 S1068-p KEQHPDMsVTKVVVH
0 10 T1081 VHKETEITPEDGED_
  EPB41L3 iso2  
T2 ______MTTESGSDS
T3 _____MTTESGSDSE
S5 ___MTTESGSDSESK
S7 _MTTESGSDSESKPD
S9 TTESGSDSESKPDQE
S11 ESGSDSESKPDQEAE
S55 FAAAAAHSTPVRREV
T56 AAAAAHSTPVRREVT
K75 EFAARAAKQLEYQQL
Y79 RAAKQLEYQQLEDDK
K86 YQQLEDDKLSQKSSS
S88 QLEDDKLSQKSSSSK
S91 DDKLSQKSSSSKLSR
S92 DKLSQKSSSSKLSRS
S93 KLSQKSSSSKLSRSP
S94 LSQKSSSSKLSRSPL
S97 KSSSSKLSRSPLKIV
S99 SSSKLSRSPLKIVKK
Y122 ILLDGSEYTCDVEKR
T123 LLDGSEYTCDVEKRS
K128 EYTCDVEKRSRGQVL
S130 TCDVEKRSRGQVLFD
K138 RGQVLFDKVCEHLNL
K148 EHLNLLEKDYFGLTY
K162 YRDAENQKNWLDPAK
Y189 FSFNVKFYPPDPAQL
K261 RFAPNHTKELEDKVI
K266 HTKELEDKVIELHKS
S273 KVIELHKSHRGMTPA
T278 HKSHRGMTPAEAEMH
S294 LENAKKLSMYGVDLH
K336 INRFAWPKVLKISYK
S361 GEFEQFESTIGFKLP
K397 LLPEAPPKKFLTLGS
T401 APPKKFLTLGSKFRY
S404 KKFLTLGSKFRYSGR
K405 KFLTLGSKFRYSGRT
K405 KFLTLGSKFRYSGRT
Y408 TLGSKFRYSGRTQAQ
S409 LGSKFRYSGRTQAQT
T416 SGRTQAQTRRAsALI
S420-p QAQTRRAsALIDRPA
S443-p KRYTMSRsLDGAsVN
S448-p SRsLDGAsVNENHEI
N450 sLDGAsVNENHEIyM
Y456-p VNENHEIyMKDSMSA
S462 IyMKDSMSAAEVGTG
T468 MSAAEVGTGQyATTK
Y471-p AEVGTGQyATTKGIS
S478 yATTKGISQTNLITT
T480 TTKGISQTNLITTVT
T484 ISQTNLITTVTPEKK
T485 SQTNLITTVTPEKKA
T487 TNLITTVTPEKKAEE
K490 ITTVTPEKKAEEERD
T510 RRKGEEVTPISAIRH
S513 GEEVTPISAIRHEGK
T534 DTAADGETtAtEELE
T535-p TAADGETtAtEELEK
T537-p ADGETtAtEELEKtQ
- gap
T543-p AtEELEKtQDDLMKH
S555 MKHQTNISELKRTFL
K558 QTNISELKRTFLETS
T564 LKRTFLETSTDTAVT
S565 KRTFLETSTDTAVTN
S579 NEWEKRLSTSPVRLA
T580 EWEKRLSTSPVRLAA
S581 WEKRLSTSPVRLAAR
- gap
- gap
- gap
- gap
- gap
- gap
T618 SGIETEPTVHHLPLS
Y650 HASGDASYSAGDSGD
P662 SGDAAAQPAFTGIKG
F664 DAAAQPAFTGIKGKE
- gap
A674 IKGKEGSALTEGAKE
K680 SALTEGAKEEGGEEV
I734 STVKTETISFGSVSP
S735 TVKTETISFGSVSPG
S738 TETISFGSVSPGGVK
S740 TISFGSVSPGGVKLE
T758 KEVPVVHTETKTITY
Y765 TETKTITYESSQVDP
S809 KTVKGGISETRIEKR
S846 KEQHPDMSVTKVVVH
T859 VHKETEITPEDGED_
  mouse

► Hide Isoforms
 
T2 ______MTTESGSDS
T3 _____MTTESGSDSE
S5 ___MTTESGSDSESK
S7 _MTTESGSDSESKPD
S9 TTESGSDSESKPDQE
S11 ESGSDSESKPDQEAE
S63-p FPEAAAHstPVKREI
T64-p PEAAAHstPVKREIG
K83 DFAAAAAKQLEyQQF
Y87-p AAAKQLEyQQFEDDk
K94-ub yQQFEDDkLsQRssS
S96-p QFEDDkLsQRssSSK
S99-p DDkLsQRssSSKLSR
S100-p DkLsQRssSSKLSRs
S101 kLsQRssSSKLSRsP
S102 LsQRssSSKLSRsPL
S105 RssSSKLSRsPLKIV
S107-p sSSKLSRsPLKIVKR
Y130 TLLDGSEYGCDVDkR
G131 LLDGSEYGCDVDkRS
K136-ub EYGCDVDkRSRGQVL
S138 GCDVDkRSRGQVLFD
K146-ub RGQVLFDkVCEHLNL
K156-ub EHLNLLEkDYFGLTY
K170-ub YRDAENQkNWLDPAK
Y197 FSFNVKFYPPDPAQL
K269-ub RFAPNHTkELEDkVI
K274-ub HTkELEDkVIELHKS
S281 kVIELHKSHRGMTPA
T286 HKSHRGMTPAEAEMH
S302-p LENAKKLsMYGVDLH
K344 INRFAWPKVLKISYK
S369 GEFEQFESTIGFKLP
K405-ub LLPEAPPkKFLtLGs
T409-p APPkKFLtLGskFRY
S412-p kKFLtLGskFRYsGR
K413 KFLtLGsKFRYsGRT
K413-ub KFLtLGskFRYsGRT
Y416 tLGskFRYsGRTQAQ
S417-p LGskFRYsGRTQAQt
T424-p sGRTQAQtRRAsALI
S428-p QAQtRRAsALIDRPA
S451-p KRYTMSRsLDGAsVs
S456-p SRsLDGAsVsENHEI
S458-p sLDGAsVsENHEIyM
Y464-p VsENHEIyMKDSVsA
S470-p IyMKDSVsAAEVGtG
T476-p VsAAEVGtGQyATTK
Y479-p AEVGtGQyATTKGIs
S486-p yATTKGIsQtNLItt
T488-p TTKGIsQtNLIttVt
T492-p IsQtNLIttVtPEkK
T493-p sQtNLIttVtPEkKA
T495-p tNLIttVtPEkKAEE
K498-ub IttVtPEkKAEEERV
T518-p RKKAEEAtPVTALRH
T521 AEEAtPVTALRHEGK
T542-p DTAADGEtsAtEsDQ
S543-p TAADGEtsAtEsDQE
T545-p ADGEtsAtEsDQEED
S547-p GEtsAtEsDQEEDAE
T563-p KAQDLDKtQDELMKH
S575 MKHQTNISELkRTFL
K578-ub QTNISELkRTFLEts
T584-p LkRTFLEtsTETALT
S585-p kRTFLEtsTETALTN
S599-p NEWEKRLstsPVRLA
T600-p EWEKRLstsPVRLAA
S601-p WEKRLstsPVRLAAR
T623-p EPLVPEEtKQssGEk
S626-p VPEEtKQssGEkLMD
S627-p PEEtKQssGEkLMDG
K630-ub tKQssGEkLMDGSEI
S639-p MDGSEILsLLESARk
K646-ub sLLESARkPTEFIGG
T679-p VEAEVEStPHPQPLS
H713 HASGDASHTARDEVD
T725-p EVDAAEStPtDRRHT
T727-p DAAEStPtDRRHTGK
T732 tPtDRRHTGKGKEGS
S740-p GKGKEGSsVTEAAkE
K746-ub SsVTEAAkEQRGEEV
T798-p STVRVEStsVGsIsP
S799-p TVRVEStsVGsIsPG
S802-p VEStsVGsIsPGGAK
S804-p StsVGsIsPGGAKLE
T822-gl KEVPVVHtETKTITY
Y829 tETKTITYESSQVDP
S873 KTVKGGISETRIEKR
S910 KEQHPDMSVTKVVVH
T923-p VHKETEItPEDGED_
  EPB41L3 iso7  
T2 ______MTTESGSDS
T3 _____MTTESGSDSE
S5 ___MTTESGSDSESK
S7 _MTTESGSDSESKPD
S9 TTESGSDSESKPDQE
S11 ESGSDSESKPDQEAE
S63 FPEAAAHSTPVKREI
T64 PEAAAHSTPVKREIG
K83 DFAAAAAKQLEYQQF
Y87 AAAKQLEYQQFEDDK
K94 YQQFEDDKLsQRssS
S96-p QFEDDKLsQRssSSK
S99-p DDKLsQRssSSKLSR
S100-p DKLsQRssSSKLSRS
S101 KLsQRssSSKLSRSP
S102 LsQRssSSKLSRSPL
S105 RssSSKLSRSPLKIV
S107 sSSKLSRSPLKIVKR
Y130 TLLDGSEYGCDVDKR
G131 LLDGSEYGCDVDKRS
K136 EYGCDVDKRSRGQVL
S138 GCDVDKRSRGQVLFD
K146 RGQVLFDKVCEHLNL
K156 EHLNLLEKDYFGLTY
K170 YRDAENQKNWLDPAK
Y197 FSFNVKFYPPDPAQL
K269 RFAPNHTKELEDKVI
K274 HTKELEDKVIELHKS
S281 KVIELHKSHRGMTPA
T286 HKSHRGMTPAEAEMH
S302-p LENAKKLsMYGVDLH
K344 INRFAWPKVLKISYK
S369 GEFEQFESTIGFKLP
K405 LLPEAPPKKFLTLGs
T409 APPKKFLTLGsKFRY
S412-p KKFLTLGsKFRYSGR
K413 KFLTLGsKFRYSGRT
K413 KFLTLGsKFRYSGRT
Y416 TLGsKFRYSGRTQAQ
S417 LGsKFRYSGRTQAQT
T424 SGRTQAQTRRAsALI
S428-p QAQTRRAsALIDRPA
S451-p KRYTMSRsLDGEVGT
- gap
- gap
- gap
- gap
T458 sLDGEVGTGQYATTK
Y461 GEVGTGQYATTKGIs
S468-p YATTKGIsQtNLItt
T470-p TTKGIsQtNLIttVt
T474-p IsQtNLIttVtPEKK
T475-p sQtNLIttVtPEKKA
T477-p tNLIttVtPEKKAEE
K480 IttVtPEKKAEEERV
T500-p RKKAEEAtPVTALRH
T503 AEEAtPVTALRHEGK
T524 DTAADGETsATEDLD
S525-p TAADGETsATEDLDK
T527 ADGETsATEDLDKTQ
- gap
T533 ATEDLDKTQDELMKH
S545 MKHQTNISELKRTFL
K548 QTNISELKRTFLETS
T554 LKRTFLETSTETALT
S555 KRTFLETSTETALTN
S569-p NEWEKRLstsPVRLA
T570-p EWEKRLstsPVRLAA
S571-p WEKRLstsPVRLAAR
- gap
- gap
- gap
- gap
- gap
- gap
T608 VEAEVESTPHPQPLS
H642 HASGDASHTARDEVD
T654-p EVDAAEStPTDRRHT
T656 DAAEStPTDRRHTGK
T661 tPTDRRHTGKGKEGS
S669 GKGKEGSSVTEAAKE
K675 SSVTEAAKEQRGEEV
T727 STVRVESTSVGsIsP
S728 TVRVESTSVGsIsPG
S731-p VESTSVGsIsPGGAK
S733-p STSVGsIsPGGAKLE
T751 KEVPVVHTETKTITY
Y758 TETKTITYESSQVDP
S802 KTVKGGISETRIEKR
- gap
- gap
  rat

 
T2 ______MTTESGSDS
T3 _____MTTESGSDSE
S5 ___MTTESGSDSESK
S7 _MTTESGSDSESKPD
S9 TTESGSDSESKPDQE
S11 ESGSDSESKPDQEAE
S58 FPEAAAHSTPVKREV
T59 PEAAAHSTPVKREVS
K78 DFAAAAAKQLEYQQF
Y82 AAAKQLEYQQFEDDK
K89 YQQFEDDKLsQKsSS
S91-p QFEDDKLsQKsSSSK
S94-p DDKLsQKsSSSKLSR
S95 DKLsQKsSSSKLSRS
S96 KLsQKsSSSKLSRSP
S97 LsQKsSSSKLSRSPL
S100 KsSSSKLSRSPLKIV
S102 SSSKLSRSPLKIVKR
Y125 TLLDGSEYGCDVDKR
G126 LLDGSEYGCDVDKRS
K131 EYGCDVDKRSRGQVL
S133 GCDVDKRSRGQVLFD
K141 RGQVLFDKVCEHLNL
K151 EHLNLLEKDYFGLTY
K165 YRDAENQKNWLDPAK
Y192 FSFNVKFYPPDPAQL
K264 RFAPNHTKELEDKVI
K269 HTKELEDKVIELHKS
S276 KVIELHKSHRGMTPA
T281 HKSHRGMTPAEAEMH
S297 LENAKKLSMYGVDLH
K339 INRFAWPKVLKISYK
S364 GEFEQFESTIGFKLP
K400 LLPEAPPKKFLTLGs
T404 APPKKFLTLGskFRy
S407-p KKFLTLGskFRysGR
K408-ac KFLTLGskFRysGRT
K408 KFLTLGsKFRysGRT
Y411-p TLGskFRysGRTQAQ
S412-p LGskFRysGRTQAQT
T419 sGRTQAQTRRAsALI
S423-p QAQTRRAsALIDRPA
S446-p KRYTMSRsLDGASVN
S451 SRsLDGASVNENHEI
N453 sLDGASVNENHEIYM
Y459 VNENHEIYMKDSMSA
S465 IYMKDSMSAAEVGTG
T471 MSAAEVGTGQyATTK
Y474-p AEVGTGQyATTKVIs
S481-p yATTKVIsQTNLITT
T483 TTKVIsQTNLITTVt
T487 IsQTNLITTVtPEKK
T488 sQTNLITTVtPEKKA
T490-p TNLITTVtPEKKAEE
K493 ITTVtPEKKAEEEHV
T513 RKKAEEATPVAALRH
A516 AEEATPVAALRHEGK
T719 DTAADGETSATESDQ
S720 TAADGETSATESDQE
T722 ADGETSATESDQEED
S724 GETSATESDQEEDAE
T740-p KAQELDKtQDELVKH
S752 VKHQTNISELKRTFL
K755 QTNISELKRTFLETS
T761 LKRTFLETSTETALT
S762 KRTFLETSTETALTN
S776 NEWEKRLSTSPVRLA
T777 EWEKRLSTSPVRLAA
S778 WEKRLSTSPVRLAAR
T800 EPLVPEETKQSSGEK
S803 VPEETKQSSGEKLMD
S804 PEETKQSSGEKLMDG
K807 TKQSSGEKLMDGSEI
S816 MDGSEILSLLESARK
K823 SLLESARKPTEFIGG
T856 IETEVEPTPHPQPLS
H890 HASGDASHTARDDVD
A902 DVDATESAPADRHsG
A904 DATESAPADRHsGNG
S908-p SAPADRHsGNGKEGS
S916 GNGKEGSSVTEAAKE
K922 SSVTEAAKEQRGEEA
I974 STVKVESISVGSVSP
S975 TVKVESISVGSVSPG
S978 VESISVGSVSPGGVK
S980 SISVGSVSPGGVKLE
T998 KEVPVVHTETKTITY
Y1005 TETKTITYESSQVDP
S1049 KTVKGGISETRIEKR
S1086 KEQHPDMSVTKVVVH
T1099 VHKETEITPEDGED_
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