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talin 1 (human)

Overview talin 1 a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: ruffle; centrosome; focal adhesion; intracellular membrane-bound organelle; extracellular region; plasma membrane; intercellular junction; cytosol; actin cytoskeleton Molecular Function: LIM domain binding; protein binding; structural constituent of cytoskeleton; actin binding; insulin receptor binding; vinculin binding Biological Process: axon guidance; intercellular junction assembly; platelet activation; unfolded protein response; cytoskeletal anchoring; platelet degranulation; unfolded protein response, activation of signaling protein activity; muscle contraction; cell-substrate junction assembly; cortical actin cytoskeleton organization and biogenesis; cell motility; blood coagulation; cell adhesion Reference #:  Q9Y490 (UniProtKB) Alt. Names/Synonyms: ILWEQ; KIAA1027; talin 1; Talin-1; TLN; TLN1 Gene Symbols: TLN1 Molecular weight: 269,767 Da Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below talin 1 1SYQ - B=607-631 (human) 4DJ9 - B=2075-2103 (human) 1SJ7 - A/B/C=482-655 (mouse) 1SJ8 - A=482-789 (mouse) 1T01 - B=605-628 (mouse) 1U89 - A=755-889 (mouse) 1XWX - A=486-889 (mouse) 1Y19 - B/D/F/H/J/L=209-410 (mouse) 1ZW3 - B=1628-1652 (mouse) 2B0H - A=1843-1973 (mouse) 2G35 - A=305-404 (mouse) 2JSW - A=2300-2482 (mouse) 2KBB - A=1655-1822 (mouse) 2KC2 - A=86-202 (mouse) 2KGX - A=1655-1822 (mouse) 2KVP - A=1815-1973 (mouse) 2L10 - A=1206-1357 (mouse) 2L7A - A=787-911 (mouse) 2L7N - A=1046-1207 (mouse) 2LQG - A=913-1044 (mouse) 2QDQ - A/B=2494-2541 (mouse) 2X0C - A=1359-1659 (mouse) 3DYJ - A/B=1974-2293 (mouse) 3IVF - A=1-400 (mouse) 3S90 - D/C=1512-1546 (mouse) 4F7G - A=206-405 B=1654-1847 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1SYQ 4DJ9  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: S425‑p cell motility, altered: S425‑p molecular association, regulation: S425‑p protein stabilization: S425‑p ubiquitination: S425‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K15	ISIGNVVKtMQFEPs
0	1		T16-p	SIGNVVKtMQFEPst
0	1		S22-p	KtMQFEPstMVyDAC
0	2		T23-p	tMQFEPstMVyDACR
0	928		Y26-p	FEPstMVyDACRIIR
0	11		K57-a	FLSDDDPkKGIWLEA
0	1388		Y70-p	EAGKALDyyMLRNGD
0	22		Y71-p	AGKALDyyMLRNGDt
0	4		T78-p	yMLRNGDtMEyRKKQ
0	1		Y81-p	RNGDtMEyRKKQRPL
0	1		T122-p	ICARIGItNHDEysL
0	183		Y127-p	GItNHDEysLVRELM
0	10		S128-p	ItNHDEysLVRELME
0	3		T142-p	EEKKEEItGtLRKDK
0	13		T144-p	KKEEItGtLRKDKtL
0	2		T150-p	GtLRKDKtLLRDEKK
0	6		T167-p	KLKQKLHtDDELNWL
0	4		Y199-p	LLRRKFFySDQNVDS
0	6		K256-u	PHNEQKHkAGFLDLK
0	1		Y270-p	KDFLPKEyVKQKGER
0	4		K334-u	PRLLGITkECVMRVD
0	1		K357-u	EWNLTNIkRWAASPK
0	1		S405-p	IILKKKKsKDHFGLE
0	1		K406	ILKKKKsKDHFGLEG
0	1		S417	GLEGDEESTMLEDSV
1	13		S425-p	TMLEDSVsPKKSTVL
0	1		K428	EDSVsPKKSTVLQQQ
0	1		S429	DSVsPKKSTVLQQQy
0	1		T430	SVsPKKSTVLQQQyN
0	897		Y436-p	STVLQQQyNRVGKVE
0	1		S446-p	VGKVEHGsVALPAIM
0	1		T568-p	TAGDPAEtDytAVGC
0	10		Y570-p	GDPAEtDytAVGCAV
0	2		T571-p	DPAEtDytAVGCAVT
0	2		S620	KGLAGAVSELLRSAQ
0	2		S729	VVAPTISSPVCQEQL
0	1		K841	SDLVNAIKADAEGES
0	1		K861	RKLLSAAKILADATA
0	1		K869-a	ILADATAkMVEAAkG
0	2		K869-u	ILADATAkMVEAAkG
0	1		K875-u	AkMVEAAkGAAAHPD
0	2		K910	AAAQNAIKKKLVQRL
0	1		K910	AAAQNAIKKKLVQRL
0	4		T941-p	AAQHAAStPKASAGP
0	1		S955-p	PQPLLVQsCKAVAEQ
0	1		S979	GSQAQPDSPSAQLAL
0	1		S981	QAQPDSPSAQLALIA
0	1		K999	SFLQPGGKMVAAAKA
0	1		K1068	EKDLQEVKAAARDGK
0	1		K1096	QDLGNSTKAVSSAIA
0	423		Y1116-p	VAQGNENyAGIAARD
0	1		S1130-p	DVAGGLRsLAQAARG
0	1		S1143	RGVAALTSDPAVQAI
0	2		S1164-p	DVLDKASsLIEEAKK
0	1		K1190	QRLAQVAKAVTQALN
0	14		S1201-p	QALNRCVsCLPGQRD
0	2		S1225	DASKRLLSDSLPPST
0	3		T1263	LVQASRGTPQDLARA
0	1		K1306	AQVVSNLKGISMSSS
0	2		S1323-p	LLAAKALstDPAAPN
0	1		T1324-p	LAAKALstDPAAPNL
0	4		A1328	ALstDPAAPNLKSQL
0	1		K1332	DPAAPNLKSQLAAAA
0	2		Y1445-p	EAAAQAAyLVGVSDP
0	4		K1541-u	NSTANLVkTIkALDG
0	3		K1544-u	ANLVkTIkALDGAFT
0	1		S1589	SSIPAQISPEGRAAM
0	2		T1616-p	SAGGLIQtARALAVN
0	1		S1631	PRDPPSWSVLAGHSR
0	1		S1732-p	SQLGHKVsQMAQyFE
0	4		Y1737-p	KVsQMAQyFEPLTLA
0	1		T1767	ALLDQTKTLAESALQ
0	1		S1771	QTKTLAESALQLLyT
0	7		Y1777-p	ESALQLLyTAKEAGG
0	1		S1875	VQEMVTKSNTSPEEL
0	1		S1878	MVTKSNTSPEELGPL
0	2		Y1893-p	ANQLTSDyGRLASEA
0	1		S1940	KAGALQCSPSDAytk
0	12		Y1945-p	QCSPSDAytkKELIE
0	5		T1946-p	CSPSDAytkKELIEC
0	6		K1947-a	SPSDAytkKELIECA
0	1		K1960	CARRVSEKVSHVLAA
0	2		K2021-u	DHREGILkTAKVLVE
0	1		T2030-p	AKVLVEDtkVLVQNA
0	1		K2031-a	KVLVEDtkVLVQNAA
0	7		S2040-p	LVQNAAGsQEKLAQA
0	1		K2043	NAAGsQEKLAQAAQS
0	1		K2089-a	NAVKDVAkALGDLIs
0	1		K2089	NAVKDVAKALGDLIs
0	1		S2096-p	kALGDLIsAtKAAAG
0	1		T2098-p	LGDLIsAtKAAAGKV
0	1		K2099	GDLIsAtKAAAGKVG
0	1		K2115-a	DPAVWQLkNSAKVMV
0	2		S2162-p	QELAVFCsPEPPAKT
0	2		T2171-p	EPPAKTStPEDFIRM
0	10		Y2224-p	RACKEAAyHPEVAPD
0	3		Y2239-p	VRLRALHyGRECANG
0	2		S2273	KQQLTGHSKRVAGSV
0	1		T2281-p	KRVAGSVtELIQAAE
0	1		K2333	LKPRAKPKEADEsLN
0	2		S2338-p	KPKEADEsLNFEEQI
0	1		S2467	GNAVKRASDNLVKAA
0	1		K2476	NLVKAAQKAAAFEEQ
0	1		K2491	ENETVVVKEKMVGGI
0	8		Y2530-p	AQIRQQQykFLPsEL
0	1		K2531-u	QIRQQQykFLPsELR
0	1		S2535-p	QQykFLPsELRDEH_

	mouse
K15-u	ISIGNVVkTMQFEPS
T16	SIGNVVkTMQFEPSt
S22	kTMQFEPStMVyDAC
T23-p	TMQFEPStMVyDACR
Y26-p	FEPStMVyDACRMIR
K57-a	FLSDDDPkKGIWLEA
Y70-p	EAGKALDyyMLRNGD
Y71-p	AGKALDyyMLRNGDt
T78-p	yMLRNGDtMEYRKKQ
Y81	RNGDtMEYRKKQRPL
T122	ICARIGITNHDEysL
Y127-p	GITNHDEysLVRELM
S128-p	ITNHDEysLVRELME
T142	EEKKDEGTGtLRKDK
T144-p	KKDEGTGtLRKDKtL
T150-p	GtLRKDKtLLRDEKK
T167	KLKQKLHTDDELNWL
Y199	LLRRKFFYSDQNVDS
K256	PHNEQKHKAGFLDLK
Y270	KDFLPKEYVKQKGER
K334	PRLLGITKECVMRVD
K357	EWSLTNIKRWAASPK
S405-p	IILKKKKskDHFGLE
K406-u	ILKKKKskDHFGLEG
S417-p	GLEGDEEsTMLEDSV
S425-p	TMLEDSVsPKkstVL
K428-u	EDSVsPKkstVLQQQ
S429-p	DSVsPKkstVLQQQy
T430-p	SVsPKkstVLQQQyN
Y436-p	stVLQQQyNRVGKVE
S446-p	VGKVEHGsVALPAIM
T568	TAGDPAETDYTAVGC
Y570	GDPAETDYTAVGCAV
T571	DPAETDYTAVGCAVT
S620-p	KGLAGAVsELLRSAQ
S729-p	VVAPTISsPVCQEQL
K841-u	SDLVNAIkADAEGES
K861-u	RKLLSAAkILADATA
K869	ILADATAKMVEAAKG
K869-u	ILADATAkMVEAAKG
K875	AkMVEAAKGAAAHPD
K910-a	AAAQNAIkKKLVQRL
K910-u	AAAQNAIkKKLVQRL
A941	AAQHAASAPKASAGP
S955	PQPLLVQSCKAVAEQ
S979-p	GSQAQPDsPsAQLAL
S981-p	QAQPDsPsAQLALIA
K999-u	SFLQPGGkMVAAAKA
K1068-u	EKDLQEIkAAARDGK
K1096-u	QDLGNSTkAVSSAIA
Y1116-p	IAQGNENyAGIAARD
S1130	DVAGGLRSLAQAARG
S1143-p	RGVAALTsDPAVQAI
S1164-p	DVLDKASsLIEEAKK
K1190-u	QRLAQVAkAVTQALN
S1201-p	QALNRCVsCLPGQRD
S1225-p	DASKRLLsDSLPPST
T1263-p	LVQASRGtPQDLARA
K1306-u	AQVVSNLkGISMSSS
S1323	LLAAKALSTDPAsPN
T1324	LAAKALSTDPAsPNL
S1328-p	ALSTDPAsPNLkSQL
K1332-u	DPAsPNLkSQLAAAA
Y1445-p	EAAAQAAyLVGVSDP
K1541-u	NSTANLVkTIkALDG
K1544-u	ANLVkTIkALDGDFT
S1589-p	SSVPAQIsPEGRAAM
T1616	SAGGLIQTARALAVN
S1631-p	PRDPPRWsVLAGHSR
S1732	SQLGHKVSQMAQYFE
Y1737	KVSQMAQYFEPLTLA
T1767-p	ALLDQTKtLAEsALQ
S1771-p	QTKtLAEsALQLLyT
Y1777-p	EsALQLLyTAKEAGG
S1875-p	VQEMVTKsNTsPEEL
S1878-p	MVTKsNTsPEELGPL
Y1893	ANQLTSDYGRLASQA
S1940	KAGALQCSPSDVytK
Y1945-p	QCSPSDVytKKELIE
T1946-p	CSPSDVytKKELIEC
K1947	SPSDVytKKELIECA
K1960-u	CARRVSEkVSHVLAA
K2021-u	DHREGILkTAKVLVE
T2030	AKVLVEDTKVLVQNA
K2031	KVLVEDTKVLVQNAA
S2040-p	LVQNAAGsQEkLAQA
K2043-u	NAAGsQEkLAQAAQS
K2089	NAVKDVAKALGDLIS
K2089-u	NAVKDVAkALGDLIS
S2096	kALGDLISATkAAAG
T2098	LGDLISATkAAAGKV
K2099-u	GDLISATkAAAGKVG
K2115	DPAVWQLKNSAKVMV
S2162	QELAVFCSPEPPAKT
T2171-p	EPPAKTStPEDFIRM
F2224	RACKEAAFHPEVAPD
Y2239	VRLRALHYGRECANG
S2273-p	KQQLTGHsKRVAGSV
T2281	KRVAGSVTELIQAAE
K2333-u	LKPRAKPkEADESLN
S2338	KPkEADESLNFEEQI
S2467-p	GNAVKRAsDNLVKAA
K2476-u	NLVKAAQkAAAFEDQ
K2491-u	ENETVVVkEKMVGGI
Y2530	AQIRQQQYKFLPSEL
K2531	QIRQQQYKFLPSELR
S2535	QQYKFLPSELRDEH_

	rat
K15	ISIGNVVKTMQFEPS
T16	SIGNVVKTMQFEPST
S22	KTMQFEPSTMVyDAC
T23	TMQFEPSTMVyDACR
Y26-p	FEPSTMVyDACRMIR
K57	FLSDDDPKKGIWLEA
Y70-p	EAGKALDyyMLRNGD
Y71-p	AGKALDyyMLRNGDT
T78	yMLRNGDTMEYRKKQ
Y81	RNGDTMEYRKKQRPL
T122	ICARIGITNHDEYSL
Y127	GITNHDEYSLVRELM
S128	ITNHDEYSLVRELME
T142	EEKKDEGTGTLRKDK
T144	KKDEGTGTLRKDKTL
T150	GTLRKDKTLLRDEKK
T167	KLKQKLHTDDELNWL
Y199	LLRRKFFYSDQNVDS
K256	PHNEQKHKAGFLDLK
Y270	KDFLPKEYVKQKGER
K334	PRLLGITKECVMRVD
K357	EWSLTNIKRWAASPK
S405	IILKKKKSKDHFGLE
K406	ILKKKKSKDHFGLEG
S417	GLEGDEESTMLEDSV
S425	TMLEDSVSPKKSTVL
K428	EDSVSPKKSTVLQQQ
S429	DSVSPKKSTVLQQQy
T430	SVSPKKSTVLQQQyN
Y436-p	STVLQQQyNRVGKAE
S446	VGKAEHGSVALPAIM
T568	TAGDPAETDYTAVGC
Y570	GDPAETDYTAVGCAV
T571	DPAETDYTAVGCAVT
S620	KGLAGAVSELLRSAQ
S729	VVAPTISSPVCQEQL
K841	SDLVNAIKADAEGES
K861	RKLLSAAKILADATA
K869	ILADATAKMVEAAKG
K869	ILADATAKMVEAAKG
K875	AKMVEAAKGAAAHPD
K910	AAAQNAIKKKLVQRL
K910	AAAQNAIKKKLVQRL
A941	AAQHAASAPKASAGP
S955	PQPLLVQSCKAVAEQ
S979	GSQAQPDSPSAQLAL
S981	QAQPDSPSAQLALIA
K999	SFLQPGGKMVAAAKA
K1068	EKDLQEIKAAAREGK
K1096	QDLGNSTKAVSSAIA
Y1116-p	IAQGNENyAGIAARD
S1130	DVAGGLRSLAQAARG
T1143	RGVAALTTDPAVQAI
S1164	DALDKASSLIEEAKK
K1190	QRLAQVAKAVTQALN
S1201	QALNRCVSCLPGQRD
S1225	DASKRLLSDSLPPST
T1263	LVQASRGTPQDLARA
K1306	AQVVSNLKGISMSSS
S1323	LLAAKALSTDPAAPN
T1324	LAAKALSTDPAAPNL
A1328	ALSTDPAAPNLKSQL
K1332	DPAAPNLKSQLAAAA
Y1445	EAAAQAAYLVGVSDP
K1541	NSTANLVKTIKALDG
K1544	ANLVKTIKALDGAFT
S1589	SSVPAQISPEGRAAM
T1616	SAGGLIQTARALAVN
S1631	PRDPPRWSVLAGHSR
S1732	SQLGHKVSQMAQYFE
Y1737	KVSQMAQYFEPLTLA
T1767	ALLDQTKTLAESALQ
S1771	QTKTLAESALQLLYT
Y1777	ESALQLLYTAKEAGG
S1875	VQEMVTKSNTSPEEL
S1878	MVTKSNTSPEELGPL
Y1893-p	ANQLTSDyGRLASQA
S1940-p	KAGALQCsPSDVytK
Y1945-p	QCsPSDVytKKELIE
T1946-p	CsPSDVytKKELIEC
K1947	sPSDVytKKELIECA
K1960	CARRVSEKVSHVLAA
K2021	DHREGILKTAKVLVE
T2030	AKVLVEDTKVLVQNA
K2031	KVLVEDTKVLVQNAA
S2040-p	LVQNAAGsQEKLAQA
K2043	NAAGsQEKLAQAAQS
K2089	NAVKDVAKALGDLIS
K2089	NAVKDVAKALGDLIS
S2096	KALGDLISATKAAAG
T2098	LGDLISATKAAAGKV
K2099	GDLISATKAAAGKVG
K2115	DPAVWQLKNSAKVMV
S2162	QELAVFCSPEPPAKT
T2171	EPPAKTSTPEDFIRM
F2224	RACKEAAFHPEVAPD
F2239	VRLRALHFGRECANG
S2273	KQQLTGHSKRVAGSV
T2281	KRVAGSVTELIQAAE
K2333	LKPRAKPKEADESLN
S2338	KPKEADESLNFEEQI
S2467	GNAVKRASDNLVKAA
K2476	NLVKAAQKAAAFEDQ
K2491	ENETVVVKEKMVGGI
Y2530	AQIRQQQYKFLPSEL
K2531	QIRQQQYKFLPSELR
S2535	QQYKFLPSELRDEH_

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