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Protein Page:
Talin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Talin-1 a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: ruffle; cell surface; focal adhesion; cytoplasm; extracellular region; plasma membrane; microtubule organizing center; intercellular junction; cytosol; actin cytoskeleton
Molecular Function: integrin binding; LIM domain binding; protein binding; structural constituent of cytoskeleton; actin binding; insulin receptor binding; vinculin binding
Biological Process: axon guidance; platelet activation; intercellular junction assembly; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; platelet degranulation; muscle contraction; unfolded protein response; cytoskeletal anchoring; cell-substrate junction assembly; cortical actin cytoskeleton organization and biogenesis; cell motility; blood coagulation; cell adhesion
Reference #:  Q9Y490 (UniProtKB)
Alt. Names/Synonyms: KIAA1027; talin 1; Talin-1; TLN; TLN1
Gene Symbols: TLN1
Molecular weight: 269,767 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Talin-1

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S425‑p
cell motility, altered: S425‑p
molecular association, regulation: S425‑p
protein stabilization: S425‑p
ubiquitination: S425‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K15 ISIGNVVKtMQFEPs
0 1 T16-p SIGNVVKtMQFEPst
0 3 S22-p KtMQFEPstMVyDAC
0 2 T23-p tMQFEPstMVyDACR
0 914 Y26-p FEPstMVyDACRIIR
0 11 K57-ac FLSDDDPkKGIWLEA
1 1382 Y70-p EAGKALDyyMLRNGD
0 28 Y71-p AGKALDyyMLRNGDt
0 4 T78-p yMLRNGDtMEyRKKQ
0 1 Y81-p RNGDtMEyRKKQRPL
0 2 T99-p MLDGTVKtIMVDDsK
0 2 S105-p KtIMVDDsKTVTDML
0 1 T107 IMVDDsKTVTDMLMt
0 1 T109 VDDsKTVTDMLMtIC
0 2 T114-p TVTDMLMtICARIGI
0 1 T122-p ICARIGItNHDEysL
0 179 Y127-p GItNHDEysLVRELM
0 9 S128-p ItNHDEysLVRELME
0 4 T142-p EEKKEEItGtLRKDK
0 17 T144-p KKEEItGtLRKDKtL
0 3 T150-p GtLRKDKtLLRDEKK
0 10 T167-p KLKQKLHtDDELNWL
0 6 K256-ub PHNEQKHkAGFLDLK
0 1 K256 PHNEQKHKAGFLDLK
0 1 Y270-p KDFLPKEyVKQKGER
0 4 K334-ub PRLLGITkECVMRVD
0 1 T354-p VIQEWNLtNIkRWAA
0 1 K357-ub EWNLtNIkRWAASPK
0 3 S405-p IILKKKKsKDHFGLE
0 1 K406 ILKKKKsKDHFGLEG
0 1 S417 GLEGDEESTMLEDsV
0 2 S423-p ESTMLEDsVsPKKST
2 22 S425-p TMLEDsVsPKKSTVL
0 1 K428 EDsVsPKKSTVLQQQ
0 1 S429 DsVsPKKSTVLQQQy
0 1 T430 sVsPKKSTVLQQQyN
0 883 Y436-p STVLQQQyNRVGKVE
0 2 S446-p VGKVEHGsVALPAIM
0 1 T568-p TAGDPAEtDytAVGC
0 10 Y570-p GDPAEtDytAVGCAV
0 2 T571-p DPAEtDytAVGCAVT
0 4 S620-p KGLAGAVsELLRSAQ
0 1 T726 CTKVVAPTISSPVCQ
0 1 S728 KVVAPTISSPVCQEQ
0 3 S729 VVAPTISSPVCQEQL
0 2 S834-p RILAQATsDLVNAIK
0 1 K841 sDLVNAIKADAEGES
0 1 K861 RKLLSAAKILADATA
0 1 K869-ac ILADATAkMVEAAkG
0 2 K869-ub ILADATAkMVEAAkG
0 1 K875-ub AkMVEAAkGAAAHPD
0 2 K910 AAAQNAIKKKLVQRL
0 1 K910 AAAQNAIKKKLVQRL
0 1 T931-p AAASATQtIAAAQHA
0 3 T941-p AAQHAAStPKAsAGP
0 1 S945-p AAStPKAsAGPQPLL
0 1 S955-p PQPLLVQsCKAVAEQ
0 1 S973-p LVQGVRGsQAQPDsP
0 2 S979-p GsQAQPDsPSAQLAL
0 2 S981 QAQPDsPSAQLALIA
0 1 S992-p ALIAASQsFLQPGGK
0 1 K999 sFLQPGGKMVAAAKA
0 1 T1010-p AAKASVPtIQDQASA
0 2 S1021-p QASAMQLsQCAKNLG
0 1 T1029-p QCAKNLGtALAELRT
0 1 S1055-p LEMDSALsVVQNLEK
0 1 K1068 EKDLQEVKAAARDGK
0 1 K1096 QDLGNSTKAVSSAIA
0 416 Y1116-p VAQGNENyAGIAARD
0 1 S1130-p DVAGGLRsLAQAARG
0 1 T1142-p ARGVAALtSDPAVQA
0 1 S1143 RGVAALtSDPAVQAI
0 2 S1164-p DVLDKASsLIEEAKK
0 1 K1190 QRLAQVAKAVTQALN
0 21 S1201-p QALNRCVsCLPGQRD
0 4 S1225-p DASKRLLsDsLPPST
0 3 S1227-p SKRLLsDsLPPSTGT
0 1 T1234 sLPPSTGTFQEAQSR
0 1 S1260-p ATELVQAsRGtPQDL
0 7 T1263-p LVQAsRGtPQDLARA
0 1 K1306 AQVVSNLKGISMSSS
0 4 S1323-p LLAAKALstDPAAPN
0 1 T1324-p LAAKALstDPAAPNL
0 6 A1328 ALstDPAAPNLKSQL
0 1 K1332 DPAAPNLKSQLAAAA
0 1 S1411-p GEAMTGIsQNAKNGN
0 2 Y1445-p EAAAQAAyLVGVSDP
0 1 S1528-p AKRQFVQsAKEVANs
0 1 S1535-p sAKEVANsTANLVkT
0 4 K1541-ub NsTANLVkTIkALDG
0 1 K1544-ac ANLVkTIkALDGAFT
0 3 K1544-ub ANLVkTIkALDGAFT
0 2 S1589-p SSIPAQIsPEGRAAM
0 2 T1616-p SAGGLIQtARALAVN
0 2 S1631 PRDPPSWSVLAGHSR
0 3 S1641-p AGHSRTVsDSIKKLI
0 2 S1732-p SQLGHKVsQMAQyFE
0 4 Y1737-p KVsQMAQyFEPLTLA
0 1 T1742 AQyFEPLTLAAVGAA
0 2 S1750-p LAAVGAAsKTLSHPQ
0 2 T1767-p ALLDQTKtLAESALQ
0 1 S1771 QTKtLAESALQLLyT
0 7 Y1777-p ESALQLLyTAKEAGG
0 1 S1849-p PMGEPEGsFVDYQtT
0 1 T1855-p GsFVDYQtTMVRTAK
0 1 S1875 VQEMVTKSNTSPEEL
0 1 S1878 MVTKSNTSPEELGPL
0 2 Y1893-p ANQLTSDyGRLASEA
0 1 S1940 KAGALQCSPSDAytk
0 12 Y1945-p QCSPSDAytkKELIE
0 5 T1946-p CSPSDAytkKELIEC
0 6 K1947-ac SPSDAytkKELIECA
0 1 K1960 CARRVSEKVSHVLAA
0 2 K2021-ub DHREGILkTAKVLVE
0 1 T2030-p AKVLVEDtkVLVQNA
0 2 K2031-ac KVLVEDtkVLVQNAA
0 15 S2040-p LVQNAAGsQEKLAQA
0 1 K2043 NAAGsQEKLAQAAQS
0 1 S2068-p VVKLGAAsLGAEDPE
0 1 K2089-ac NAVKDVAkALGDLIs
0 1 K2089 NAVKDVAKALGDLIs
0 1 S2096-p kALGDLIsAtKAAAG
0 1 T2098-p LGDLIsAtKAAAGKV
0 1 K2099 GDLIsAtKAAAGKVG
0 1 K2115-ac DPAVWQLkNSAKVMV
0 3 S2162-p QELAVFCsPEPPAKT
0 2 T2171-p EPPAKTStPEDFIRM
0 10 Y2224-p RACKEAAyHPEVAPD
0 3 Y2239-p VRLRALHyGRECANG
0 2 S2273 KQQLTGHSKRVAGSV
0 1 T2281-p KRVAGSVtELIQAAE
0 1 K2333 LKPRAKPKEADEsLN
0 3 S2338-p KPKEADEsLNFEEQI
0 1 S2390-p ALDDGQWsQGLISAA
0 2 S2426-p ASQEKLIsSAKQVAA
0 1 S2467 GNAVKRASDNLVKAA
0 1 K2476 NLVKAAQKAAAFEEQ
0 1 K2491 ENETVVVKEKMVGGI
0 8 Y2530-p AQIRQQQykFLPsEL
0 1 K2531-ub QIRQQQykFLPsELR
0 1 S2535-p QQykFLPsELRDEH_
5426 : Phospho-Talin (Ser425) Antibody
13589 : Phospho-Talin (Ser425) (D2P2M) Rabbit mAb
  mouse

 
K15-ub ISIGNVVkTMQFEPS
T16 SIGNVVkTMQFEPSt
S22 kTMQFEPStMVyDAC
T23-p TMQFEPStMVyDACR
Y26-p FEPStMVyDACRMIR
K57-ac FLSDDDPkKGIWLEA
Y70-p EAGKALDyyMLRNGD
Y71-p AGKALDyyMLRNGDt
T78-p yMLRNGDtMEYRKKQ
Y81 RNGDtMEYRKKQRPL
T99-p MLDGTVKtIMVDDsK
S105-p KtIMVDDsKtVtDML
T107-p IMVDDsKtVtDMLMt
T109-p VDDsKtVtDMLMtIC
T114-p tVtDMLMtICARIGI
T122 ICARIGITNHDEysL
Y127-p GITNHDEysLVRELM
S128-p ITNHDEysLVRELME
T142 EEKKDEGTGtLRKDK
T144-p KKDEGTGtLRKDKtL
T150-p GtLRKDKtLLRDEKK
T167 KLKQKLHTDDELNWL
K256 PHNEQKHKAGFLDLK
K256-sc PHNEQKHkAGFLDLK
Y270 KDFLPKEYVKQKGER
K334 PRLLGITKECVMRVD
T354 VIQEWSLTNIKRWAA
K357 EWSLTNIKRWAASPK
S405-p IILKKKKskDHFGLE
K406-ub ILKKKKskDHFGLEG
S417-p GLEGDEEsTMLEDSV
S423 EsTMLEDSVsPKkst
S425-p TMLEDSVsPKkstVL
K428-ub EDSVsPKkstVLQQQ
S429-p DSVsPKkstVLQQQy
T430-p SVsPKkstVLQQQyN
Y436-p stVLQQQyNRVGKVE
S446-p VGKVEHGsVALPAIM
T568 TAGDPAETDYTAVGC
Y570 GDPAETDYTAVGCAV
T571 DPAETDYTAVGCAVT
S620-p KGLAGAVsELLRSAQ
T726-p CTKVVAPtIssPVCQ
S728-p KVVAPtIssPVCQEQ
S729-p VVAPtIssPVCQEQL
S834 RILAQATSDLVNAIk
K841-ub SDLVNAIkADAEGES
K861-ub RKLLSAAkILADATA
K869 ILADATAKMVEAAKG
K869-ub ILADATAkMVEAAKG
K875 AkMVEAAKGAAAHPD
K910-ac AAAQNAIkKKLVQRL
K910-ub AAAQNAIkKKLVQRL
T931 AAASATQTIAAAQHA
A941 AAQHAASAPKASAGP
S945 AASAPKASAGPQPLL
S955 PQPLLVQSCKAVAEQ
S973 LVQGVRGSQAQPDsP
S979-p GSQAQPDsPsAQLAL
S981-p QAQPDsPsAQLALIA
S992 ALIAASQSFLQPGGk
K999-ub SFLQPGGkMVAAAKA
T1010 AAKASVPTIQDQASA
S1021 QASAMQLSQCAKNLG
T1029 QCAKNLGTALAELRT
S1055 LEMDSALSVVQNLEK
K1068-ub EKDLQEIkAAARDGK
K1096-ub QDLGNSTkAVSSAIA
Y1116-p IAQGNENyAGIAARD
S1130 DVAGGLRSLAQAARG
T1142 ARGVAALTsDPAVQA
S1143-p RGVAALTsDPAVQAI
S1164-p DVLDKASsLIEEAKK
K1190-ub QRLAQVAkAVTQALN
S1201-p QALNRCVsCLPGQRD
S1225-p DASKRLLsDsLPPST
S1227-p SKRLLsDsLPPSTGt
T1234-p sLPPSTGtFQEAQSR
S1260 ATELVQASRGtPQDL
T1263-p LVQASRGtPQDLARA
K1306-ub AQVVSNLkGISMSSS
S1323-p LLAAKALsTDPAsPN
T1324 LAAKALsTDPAsPNL
S1328-p ALsTDPAsPNLkSQL
K1332-ub DPAsPNLkSQLAAAA
S1411 GEAMTGISQNAKNGN
Y1445-p EAAAQAAyLVGVSDP
S1528 AKRQFVQSAKEVANS
S1535 SAKEVANSTANLVkT
K1541-ub NSTANLVkTIkALDG
K1544-ac ANLVkTIkALDGDFT
K1544-ub ANLVkTIkALDGDFT
S1589-p SSVPAQIsPEGRAAM
T1616 SAGGLIQTARALAVN
S1631-p PRDPPRWsVLAGHSR
S1641-p AGHSRTVsDSIKKLI
S1732 SQLGHKVSQMAQYFE
Y1737 KVSQMAQYFEPLtLA
T1742-p AQYFEPLtLAAVGAA
S1750-p LAAVGAAsKTLSHPQ
T1767-p ALLDQTKtLAEsALQ
S1771-p QTKtLAEsALQLLyT
Y1777-p EsALQLLyTAKEAGG
S1849 PMGDPEGSFVDYQTT
T1855 GSFVDYQTTMVRTAK
S1875-p VQEMVTKsNTsPEEL
S1878-p MVTKsNTsPEELGPL
Y1893 ANQLTSDYGRLASQA
S1940 KAGALQCSPSDVytK
Y1945-p QCSPSDVytKKELIE
T1946-p CSPSDVytKKELIEC
K1947 SPSDVytKKELIECA
K1960-ub CARRVSEkVSHVLAA
K2021-ub DHREGILkTAKVLVE
T2030 AKVLVEDTKVLVQNA
K2031 KVLVEDTKVLVQNAA
S2040-p LVQNAAGsQEkLAQA
K2043-ub NAAGsQEkLAQAAQS
S2068 VVKLGAASLGAEDPE
K2089 NAVKDVAKALGDLIS
K2089-ub NAVKDVAkALGDLIS
S2096 kALGDLISATkAAAG
T2098 LGDLISATkAAAGKV
K2099-ub GDLISATkAAAGKVG
K2115 DPAVWQLKNSAKVMV
S2162-p QELAVFCsPEPPAKT
T2171-p EPPAKTStPEDFIRM
F2224 RACKEAAFHPEVAPD
Y2239 VRLRALHYGRECANG
S2273-p KQQLTGHsKRVAGSV
T2281 KRVAGSVTELIQAAE
K2333-ub LKPRAKPkEADESLN
S2338 KPkEADESLNFEEQI
S2390 ALDDGQWSQGLISAA
S2426-p ASQEKLIsSAKQVAA
S2467-p GNAVKRAsDNLVKAA
K2476-ub NLVKAAQkAAAFEDQ
K2491-ub ENETVVVkEKMVGGI
Y2530 AQIRQQQYKFLPSEL
K2531 QIRQQQYKFLPSELR
S2535 QQYKFLPSELRDEH_
5426 : Phospho-Talin (Ser425) Antibody
13589 : Phospho-Talin (Ser425) (D2P2M) Rabbit mAb
  rat

 
K15 ISIGNVVKTMQFEPS
T16 SIGNVVKTMQFEPST
S22 KTMQFEPSTMVyDAC
T23 TMQFEPSTMVyDACR
Y26-p FEPSTMVyDACRMIR
K57 FLSDDDPKKGIWLEA
Y70-p EAGKALDyYMLRNGD
Y71 AGKALDyYMLRNGDT
T78 YMLRNGDTMEYRKKQ
Y81 RNGDTMEYRKKQRPL
T99 MLDGTVKTIMVDDSK
S105 KTIMVDDSKTVTDML
T107 IMVDDSKTVTDMLMT
T109 VDDSKTVTDMLMTIC
T114 TVTDMLMTICARIGI
T122 ICARIGITNHDEYSL
Y127 GITNHDEYSLVRELM
S128 ITNHDEYSLVRELME
T142 EEKKDEGTGTLRKDK
T144 KKDEGTGTLRKDKTL
T150 GTLRKDKTLLRDEKK
T167 KLKQKLHTDDELNWL
K256 PHNEQKHKAGFLDLK
K256 PHNEQKHKAGFLDLK
Y270 KDFLPKEYVKQKGER
K334 PRLLGITKECVMRVD
T354 VIQEWSLTNIKRWAA
K357 EWSLTNIKRWAASPK
S405 IILKKKKSKDHFGLE
K406 ILKKKKSKDHFGLEG
S417 GLEGDEESTMLEDSV
S423 ESTMLEDSVsPKKST
S425-p TMLEDSVsPKKSTVL
K428 EDSVsPKKSTVLQQQ
S429 DSVsPKKSTVLQQQy
T430 SVsPKKSTVLQQQyN
Y436-p STVLQQQyNRVGKAE
S446 VGKAEHGSVALPAIM
T568 TAGDPAETDYTAVGC
Y570 GDPAETDYTAVGCAV
T571 DPAETDYTAVGCAVT
S620-p KGLAGAVsELLRSAQ
T726 CTKVVAPTISSPVCQ
S728 KVVAPTISSPVCQEQ
S729 VVAPTISSPVCQEQL
S834 RILAQATSDLVNAIK
K841 SDLVNAIKADAEGES
K861 RKLLSAAKILADATA
K869-ac ILADATAkMVEAAKG
K869 ILADATAKMVEAAKG
K875 AkMVEAAKGAAAHPD
K910 AAAQNAIKKKLVQRL
K910 AAAQNAIKKKLVQRL
T931 AAASATQTIAAAQHA
A941 AAQHAASAPKASAGP
S945 AASAPKASAGPQPLL
S955 PQPLLVQSCKAVAEQ
S973 LVQGVRGSQAQPDsP
S979-p GSQAQPDsPSAQLAL
S981 QAQPDsPSAQLALIA
S992 ALIAASQSFLQPGGK
K999 SFLQPGGKMVAAAKA
T1010 AAKASVPTIQDQASA
S1021 QASAMQLSQCAKNLG
T1029 QCAKNLGTALAELRT
S1055 LEMDSALSVVQNLEK
K1068 EKDLQEIKAAAREGK
K1096 QDLGNSTKAVSSAIA
Y1116-p IAQGNENyAGIAARD
S1130 DVAGGLRSLAQAARG
T1142 ARGVAALTTDPAVQA
T1143 RGVAALTTDPAVQAI
S1164-p DALDKASsLIEEAKK
K1190 QRLAQVAKAVTQALN
S1201 QALNRCVSCLPGQRD
S1225 DASKRLLSDSLPPST
S1227 SKRLLSDSLPPSTGT
T1234 SLPPSTGTFQEAQSR
S1260 ATELVQASRGtPQDL
T1263-p LVQASRGtPQDLARA
K1306 AQVVSNLKGISMSSS
S1323 LLAAKALSTDPAAPN
T1324 LAAKALSTDPAAPNL
A1328 ALSTDPAAPNLKSQL
K1332 DPAAPNLKSQLAAAA
S1411 GEAMTGISQNAKNGN
Y1445 EAAAQAAYLVGVSDP
S1528 AKRQFVQSAKEVANS
S1535 SAKEVANSTANLVKT
K1541 NSTANLVKTIkALDG
K1544-ac ANLVKTIkALDGAFT
K1544 ANLVKTIKALDGAFT
S1589-p SSVPAQIsPEGRAAM
T1616 SAGGLIQTARALAVN
S1631-p PRDPPRWsVLAGHSR
S1641-p AGHSRTVsDSIKKLI
S1732 SQLGHKVSQMAQYFE
Y1737 KVSQMAQYFEPLTLA
T1742 AQYFEPLTLAAVGAA
S1750 LAAVGAASKTLSHPQ
T1767 ALLDQTKTLAESALQ
S1771 QTKTLAESALQLLYT
Y1777 ESALQLLYTAKEAGG
S1849 PMGEPEGSFVDYQTT
T1855 GSFVDYQTTMVRTAK
S1875 VQEMVTKSNTsPEEL
S1878-p MVTKSNTsPEELGPL
Y1893-p ANQLTSDyGRLASQA
S1940-p KAGALQCsPSDVytK
Y1945-p QCsPSDVytKKELIE
T1946-p CsPSDVytKKELIEC
K1947 sPSDVytKKELIECA
K1960 CARRVSEKVSHVLAA
K2021 DHREGILKTAKVLVE
T2030 AKVLVEDTkVLVQNA
K2031-ac KVLVEDTkVLVQNAA
S2040-p LVQNAAGsQEKLAQA
K2043 NAAGsQEKLAQAAQS
S2068 VVKLGAASLGAEDPE
K2089 NAVKDVAKALGDLIS
K2089 NAVKDVAKALGDLIS
S2096 KALGDLISATKAAAG
T2098 LGDLISATKAAAGKV
K2099 GDLISATKAAAGKVG
K2115 DPAVWQLKNSAKVMV
S2162 QELAVFCSPEPPAKT
T2171-p EPPAKTStPEDFIRM
F2224 RACKEAAFHPEVAPD
F2239 VRLRALHFGRECANG
S2273 KQQLTGHSKRVAGSV
T2281 KRVAGSVTELIQAAE
K2333 LKPRAKPKEADESLN
S2338 KPKEADESLNFEEQI
S2390 ALDDGQWSQGLISAA
S2426 ASQEKLISSAKQVAA
S2467 GNAVKRASDNLVKAA
K2476 NLVKAAQKAAAFEDQ
K2491 ENETVVVKEKMVGGI
Y2530 AQIRQQQYKFLPSEL
K2531 QIRQQQYKFLPSELR
S2535 QQYKFLPSELRDEH_
5426 : Phospho-Talin (Ser425) Antibody
13589 : Phospho-Talin (Ser425) (D2P2M) Rabbit mAb
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