a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric
Cellular Component: extrinsic to internal side of plasma membrane; nuclear membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; signal transducer activity; protein binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activator activity
Biological Process: platelet activation; regulation of action potential; protein stabilization; glutamate signaling pathway; maternal behavior; heart development; pigmentation during development; G-protein signaling, adenylate cyclase activating pathway; post-embryonic development; regulation of melanocyte differentiation; forebrain neuron development; phospholipase C activation; GTP catabolic process; negative regulation of protein kinase activity; dopamine receptor, phospholipase C activating pathway; embryonic digit morphogenesis; blood coagulation; skeletal development; positive regulation of GTPase activity; neuron remodeling
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.