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Protein Page:
SAA1 (human)

Overview
SAA1 Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: extracellular region
Molecular Function: heparin binding; G-protein-coupled receptor binding
Biological Process: positive regulation of interleukin-1 secretion; platelet activation; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; positive regulation of cell adhesion; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cytokine secretion
Reference #:  P0DJI8 (UniProtKB)
Alt. Names/Synonyms: Amyloid fibril protein AA; Amyloid protein A; MGC111216; PIG4; SAA; SAA1; Serum amyloid A protein; serum amyloid A1; Serum amyloid protein A(2-102); Serum amyloid protein A(2-103); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(4-101); TP53I4; tumor protein p53 inducible protein 4
Gene Symbols: SAA1
Molecular weight: 13,532 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Select Structure to View Below

SAA1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y60 YFHARGNYDAAKRGP
0 2 S77-p VWAAEAIsDARENIQ
0 2 Y122-p PAGLPEKy_______
  mouse

 
Y112-p RSGKDPNyYRPPGLP
Y113 SGKDPNyYRPPGLPD
Y122 PPGLPDKY_______
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