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Protein Page:
RNF126 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RNF126 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; epidermal growth factor receptor binding; ligase activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; protein ubiquitination during ubiquitin-dependent protein catabolic process; retrograde transport, endosome to Golgi; regulation of cell proliferation
Reference #:  Q9BV68 (UniProtKB)
Alt. Names/Synonyms: FLJ20552; MGC1022; MGC14317; RING finger protein 126; RN126; RNF126
Gene Symbols: RNF126
Molecular weight: 35,585 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Select Structure to View Below

RNF126

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 S5-p ___MAEAsPHPGRYF
0 1 S17-p RYFCHCCsVEIVPRL
0 1 R128-m2 RYGARQPrArLTTRR
0 1 R130-m1 GARQPrArLTTRRAT
0 1 R130-m2 GARQPrArLTTRRAT
0 2 K209-ub PPPADKEkIQALPTV
0 2 K233-ub GLECPVCkDDYALGE
0 1 T278 KSLTGQNTATNPPGL
0 1 T286 ATNPPGLTGVSFSSS
0 2 S295-p VSFSSSSssSSSSSP
0 2 S296-p SFSSSSssSSSSSPS
0 1 T308 SPSNENATWSPLGRP
  RNF126 iso2  
S5 ___MAEASPHPGRYF
S17 RYFCHCCSVEIVPRL
R128 RYGARQPRARLTTRR
R130 GARQPRARLTTRRAT
R130 GARQPRARLTTRRAT
K209 PPPADKEKIQALPTV
K233 GLECPVCKDDYALGE
T278-p KSLTGQNtATNPPGL
T286-p ATNPPGLtGVSFSSS
S295-p VSFSSSSssSSSSSP
S296-p SFSSSSssSSSSSPS
T308-p SPSNENAtSNS____
  mouse

 
S5-p ___MAEAsPQPGRYF
S17-p RYFCHCCsVEIVPRL
R128 RYGARQPRARLTARR
R130 GARQPRARLTARRAT
R130 GARQPRARLTARRAT
K211 PPPADKEKIQALPTV
K235 GLECPVCKEDYALGE
T280 KSLTGQNTATNPPGL
T288 ATNPPGLTGVGFSSS
S297 VGFSSSSSSSSSSSP
S298 GFSSSSSSSSSSSPS
T310 SPSNENATSNS____
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