2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase; EC 220.127.116.11
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; epidermal growth factor receptor binding; ligase activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; protein ubiquitination during ubiquitin-dependent protein catabolic process; retrograde transport, endosome to Golgi; regulation of cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.