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Barkor (human)

Overview Barkor Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with PIK3CB. Belongs to the Barkor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy Cellular Component: endoplasmic reticulum; pre-autophagosomal structure membrane; autophagic vacuole Molecular Function: protein binding Biological Process: positive regulation of autophagy; autophagic vacuole formation Reference #:  Q6ZNE5 (UniProtKB) Alt. Names/Synonyms: ATG14; ATG14 autophagy related 14 homolog; Atg14L; Barkor; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; KIAA0831; MGC126291; MGC126292 Gene Symbols: ATG14 Molecular weight: 55,309 Da Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Barkor

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S29-p	LARDLVDsVDDAEGL
0	1		Y37-p	VDDAEGLyVAVERCP
0	1		T180-p	GDLVEKKtIDLRSHY
0	2		K236-u	MTSSTVSkLAEARRT
0	1		S404-p	VRADLEEsMEFVDPG
0	2		S416-p	DPGVAGEsDEsGDER
0	1		S419-p	VAGEsDEsGDERVsD
0	1		S425-p	EsGDERVsDEEtDLG
0	1		T429-p	ERVsDEEtDLGTDWE

	mouse
S29-p	LARDLVDsVDDAEGL
Y37	VDDAEGLYVAVERCP
T180	GDLVEKKTIDLKSHY
K236-u	MTSSMVSkLAEARRT
S404	VRADLEESMEFVDPG
S416	DPGVAGESDASGDER
S419	VAGESDASGDERVSD
S425	ASGDERVSDEETDLG
T429	ERVSDEETDLGTDWE

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