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Protein Page:
Barkor (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Barkor Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with PIK3CB. Belongs to the Barkor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Cellular Component: endoplasmic reticulum membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme; nucleus
Molecular Function: protein binding
Biological Process: positive regulation of autophagy; autophagic vacuole formation
Reference #:  Q6ZNE5 (UniProtKB)
Alt. Names/Synonyms: ATG14; ATG14 autophagy related 14 homolog; Atg14L; Barkor; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; KIAA0831; MGC126291; MGC126292
Gene Symbols: ATG14
Molecular weight: 55,309 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Barkor

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S29-p LARDLVDsVDDAEGL
0 1 Y37-p VDDAEGLyVAVERCP
0 2 K236-u MTSSTVSkLAEARRT
0 1 S404-p VRADLEEsMEFVDPG
0 2 S416-p DPGVAGEsDEsGDER
0 1 S419-p VAGEsDEsGDERVsD
0 1 S425-p EsGDERVsDEEtDLG
0 1 T429-p ERVsDEEtDLGTDWE
  mouse

 
S29-p LARDLVDsVDDAEGL
Y37 VDDAEGLYVAVERCP
K236-u MTSSMVSkLAEARRT
S404 VRADLEESMEFVDPG
S416 DPGVAGESDASGDER
S419 VAGESDASGDERVSD
S425 ASGDERVSDEETDLG
T429 ERVSDEETDLGTDWE
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