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Protein Page:
desmin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
desmin a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: intermediate filament; fascia adherens; neuromuscular junction; Z disc; cytosol; sarcolemma
Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding
Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding
Reference #:  P17661 (UniProtKB)
Alt. Names/Synonyms: CMD1I; CSM1; CSM2; DES; DESM; Desmin; FLJ12025; FLJ39719; FLJ41013; FLJ41793
Gene Symbols: DES
Molecular weight: 53,536 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

desmin

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S12‑p, T17‑p, S60‑p, T76‑p, T77‑p
intracellular localization: S12‑p, S60‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y5-p ___MSQAysSSQRVs
1 1 S6-p __MSQAysSSQRVss
2 0 S7 _MSQAysSSQRVssY
1 0 S8 MSQAysSSQRVssYR
1 0 S12-p ysSSQRVssYRRtFG
2 0 S13-p sSSQRVssYRRtFGG
0 1 R16 QRVssYRRtFGGAPG
1 2 T17-p RVssYRRtFGGAPGF
0 11 P25 FGGAPGFPLGsPLss
1 69 S28-p APGFPLGsPLssPVF
0 17 S31-p FPLGsPLssPVFPRA
2 38 S32-p PLGsPLssPVFPRAG
0 6 R37 LssPVFPRAGFGSkG
0 1 R37 LssPVFPRAGFGSkG
2 0 G39 sPVFPRAGFGSkGSS
0 4 K43-m1 PRAGFGSkGSSSSVT
0 2 K43 PRAGFGSKGSSSSVT
1 1 S45 AGFGSkGSSSSVTSR
0 1 S46 GFGSkGSSSSVTSRV
0 1 S47 FGSkGSSSSVTSRVy
1 1 S48 GSkGSSSSVTSRVyQ
0 21 Y54-p SSVTSRVyQVsRtsG
0 1 S57-p TSRVyQVsRtsGGAG
0 3 T59-p RVyQVsRtsGGAGGL
2 2 S60-p VyQVsRtsGGAGGLG
1 11 S68-p GGAGGLGsLRASRLG
0 1 R70 AGGLGsLRASRLGtt
1 0 T76-p LRASRLGttRtPssy
1 0 T77-p RASRLGttRtPssyG
1 2 T79-p SRLGttRtPssyGAG
0 4 S81-p LGttRtPssyGAGEL
1 9 S82-p GttRtPssyGAGELL
0 7 Y83-p ttRtPssyGAGELLD
0 1 S92 AGELLDFSLADAVNQ
0 3 K109-ac LTTRTNEkVELQELN
0 61 K109-ub LTTRTNEkVELQELN
0 7 Y122-p LNDRFANyIEKVRFL
0 3 K125 RFANyIEKVRFLEQQ
0 18 Y155-p PTRVAELyEEELREL
0 2 K193 DLQRLKAKLQEEIQL
0 1 S231-p DLERRIEsLNEEIAF
0 36 K240-ac NEEIAFLkkVHEEEI
0 8 K241-ac EEIAFLkkVHEEEIR
0 2 K241 EEIAFLkKVHEEEIR
0 40 Y281-p LRDIRAQyETIAAKN
0 1 K287 QyETIAAKNISEAEE
0 4 Y296-p ISEAEEWyKSKVSDL
0 2 K297 SEAEEWyKSKVSDLT
0 3 K309 DLTQAANKNNDALRQ
0 2 K318 NDALRQAKQEMMEyR
0 6 Y324-p AKQEMMEyRHQIQsy
0 1 S330-p EyRHQIQsytCEIDA
0 14 Y331-p yRHQIQsytCEIDAL
0 12 T332-p RHQIQsytCEIDALk
0 1 K339-ac tCEIDALkGTNDSLM
0 2 K339 tCEIDALKGTNDSLM
0 6 S358-p ELEDRFAsEASGyQD
0 136 Y363-p FAsEASGyQDNIARL
0 1 K407-ac VEIATYRkLLEGEES
0 59 K407-ub VEIATYRkLLEGEES
0 101 Y423-p INLPIQTysALNFRE
0 5 S424-p NLPIQTysALNFRET
0 2 S432-p ALNFRETsPEQRGSE
0 1 S438 TsPEQRGSEVHTKKT
0 1 T442 QRGSEVHTKKTVMIK
0 1 T445 SEVHTKKTVMIKTIE
0 1 K449 TKKTVMIKTIETRDG
  mouse

 
Y5 ___MSQAYsssQRVS
S6-p __MSQAYsssQRVSS
S7-p _MSQAYsssQRVSSY
S8-p MSQAYsssQRVSSYR
S12 YsssQRVSSYRrtFG
S13 sssQRVSSYRrtFGG
R16-m1 QRVSSYRrtFGGAPG
T17-p RVSSYRrtFGGAPGF
S25-p FGGAPGFsLGsPLss
S28-p APGFsLGsPLssPVF
S31-p FsLGsPLssPVFPrA
S32-p sLGsPLssPVFPrAG
R37-m1 LssPVFPrAGFGTkG
R37-m2 LssPVFPrAGFGTkG
G39 sPVFPrAGFGTkGss
K43-m1 PrAGFGTkGssssMT
K43-ub PrAGFGTkGssssMT
S45-p AGFGTkGssssMTSR
S46-p GFGTkGssssMTSRV
S47-p FGTkGssssMTSRVY
S48-p GTkGssssMTSRVYQ
Y54 ssMTSRVYQVSRtsG
S57 TSRVYQVSRtsGGAG
T59-p RVYQVSRtsGGAGGL
S60-p VYQVSRtsGGAGGLG
S68-p GGAGGLGsLrSSRLG
R70-m1 AGGLGsLrSSRLGTT
T76 LrSSRLGTTRAPsyG
T77 rSSRLGTTRAPsyGA
- gap
- gap
S81-p LGTTRAPsyGAGELL
Y82-p GTTRAPsyGAGELLD
S91-p AGELLDFsLADAVNQ
K108 LATRTNEKVELQELN
K108-ub LATRTNEkVELQELN
Y121 LNDRFANYIEkVRFL
K124-ub RFANYIEkVRFLEQQ
Y154 PTRVAELYEEEMREL
K192-ub DLQRLKAkLQEEIQL
S230 DLERRIESLNEEIAF
K239 NEEIAFLKkVHEEEI
K240 EEIAFLKKVHEEEIR
K240-ub EEIAFLKkVHEEEIR
Y280 LRDIRAQYETIAAkN
K286-ub QYETIAAkNISEAEE
Y295 ISEAEEWYkSKVSDL
K296-ub SEAEEWYkSKVSDLT
K308-ub DLTQAANkNNDALRQ
K317-ub NDALRQAkQEMMEYR
Y323 AkQEMMEYRHQIQSy
S329 EYRHQIQSyTCEIDA
Y330-p YRHQIQSyTCEIDAL
T331 RHQIQSyTCEIDALk
K338 TCEIDALKGTNDSLM
K338-ub TCEIDALkGTNDSLM
S357-p ELEDRFAsEANGyQD
Y362-p FAsEANGyQDNIARL
K406 VEIATYRKLLEGEES
K406-ub VEIATYRkLLEGEES
F422 INLPIQTFsALNFRE
S423-p NLPIQTFsALNFRET
S431-p ALNFRETsPEQRGsE
S437-p TsPEQRGsEVHtKKt
T441-p QRGsEVHtKKtVMIk
T444-p sEVHtKKtVMIkTIE
K448-ub tKKtVMIkTIETRDG
  rat

 
Y5 ___MSQAYSSSQRVS
S6 __MSQAYSSSQRVSS
S7 _MSQAYSSSQRVSSY
S8 MSQAYSSSQRVSSYR
S12 YSSSQRVSSYRRTFG
S13 SSSQRVSSYRRTFGG
R16 QRVSSYRRTFGGAPG
T17 RVSSYRRTFGGAPGF
S25-p FGGAPGFsLGsPLSs
S28-p APGFsLGsPLSsPVF
S31 FsLGsPLSsPVFPRA
S32-p sLGsPLSsPVFPRAG
R37 LSsPVFPRAGFGTKG
R37 LSsPVFPRAGFGTKG
G39 sPVFPRAGFGTKGsS
K43 PRAGFGTKGsSSsVT
K43 PRAGFGTKGsSSsVT
S45-p AGFGTKGsSSsVTSR
S46 GFGTKGsSSsVTSRV
S47 FGTKGsSSsVTSRVY
S48-p GTKGsSSsVTSRVYQ
Y54 SsVTSRVYQVSRTsG
S57 TSRVYQVSRTsGGAG
T59 RVYQVSRTsGGAGGL
S60-p VYQVSRTsGGAGGLG
S68-p GGAGGLGsLRASRLG
R70 AGGLGsLRASRLGTT
T76 LRASRLGTTRAPsYG
T77 RASRLGTTRAPsYGA
- gap
- gap
S81-p LGTTRAPsYGAGELL
Y82 GTTRAPsYGAGELLD
S91 AGELLDFSLADAVNQ
K108-ac LATRTNEkVELQELN
K108 LATRTNEKVELQELN
Y121 LNDRFANYFEKVRFL
K124 RFANYFEKVRFLEQQ
Y154 PTRVAELYEEEMREL
K192 DLQRLKAKLQEEIQL
S230 DLERRIESLNEEIAF
K239-ac NEEIAFLkKVHEEEI
K240 EEIAFLkKVHEEEIR
K240 EEIAFLkKVHEEEIR
Y280 LRDIRAQYETIAAKN
K286 QYETIAAKNISEAEE
Y295 ISEAEEWYKSKVSDL
K296 SEAEEWYKSKVSDLT
K308 DLTQAANKNNDALRQ
K317 NDALRQAKQEMMEYR
Y323 AKQEMMEYRHQIQSy
S329 EYRHQIQSyTCEIDA
Y330-p YRHQIQSyTCEIDAL
T331 RHQIQSyTCEIDALK
K338 TCEIDALKGTNDSLM
K338 TCEIDALKGTNDSLM
S357-p ELEDRFAsEASGYQD
Y362 FAsEASGYQDNIARL
K406-ac VEIATYRkLLEGEES
K406 VEIATYRKLLEGEES
F422 INLPIQTFsALNFRE
S423-p NLPIQTFsALNFRET
S431-p ALNFRETsPEQRGsE
S437-p TsPEQRGsEVHTKKT
T441 QRGsEVHTKKTVMIK
T444 sEVHTKKTVMIKTIE
K448 TKKTVMIKTIETRDG
  chicken

 
Y4 ____SQSYSsSQRVS
S5 ___SQSYSsSQRVSs
S6-p __SQSYSsSQRVSsY
S7 _SQSYSsSQRVSsYR
S11 YSsSQRVSsYRRTFG
S12-p SsSQRVSsYRRTFGG
R15 QRVSsYRRTFGGGTs
T16 RVSsYRRTFGGGTsP
- gap
- gap
T21 RRTFGGGTsPVFPRA
S22-p RTFGGGTsPVFPRAs
R27 GTsPVFPRAsFGSRG
R27 GTsPVFPRAsFGSRG
S29-p sPVFPRAsFGSRGsG
R33 PRAsFGSRGsGSsVT
R33 PRAsFGSRGsGSsVT
S35-p AsFGSRGsGSsVTSR
G36 sFGSRGsGSsVTSRV
S37 FGSRGsGSsVTSRVY
S38-p GSRGsGSsVTSRVYQ
Y44 SsVTSRVYQVSRTsA
S47 TSRVYQVSRTsAVPT
T49 RVYQVSRTsAVPTLs
S50-p VYQVSRTsAVPTLsT
S56-p TsAVPTLsTFRTTRV
R59 VPTLsTFRTTRVtPL
T60 PTLsTFRTTRVtPLR
T61 TLsTFRTTRVtPLRT
T64-p TFRTTRVtPLRTYGS
S71 tPLRTYGSAYQGAGE
- gap
Y73 LRTYGSAYQGAGELL
S83 AGELLDFSLADAMNQ
K100 LQTRTNEKVELQELN
K100 LQTRTNEKVELQELN
Y113 LNDRFANYIEKVRFL
K116 RFANYIEKVRFLEQQ
Y146 PTRVAEMYEEELREL
K184 NLQKLKQKLQEEIQL
S222 DLERRIESLQEEIAF
K231 QEEIAFLKKVHEEEI
K232 EEIAFLKKVHEEEIR
K232 EEIAFLKKVHEEEIR
Y272 LRDIRAQYESIAAKN
K278 QYESIAAKNIAEAEE
Y287 IAEAEEWYKSKVSDL
K288 AEAEEWYKSKVSDLT
K300 DLTQAANKNNDALRQ
K309 NDALRQAKQEMLEYR
Y315 AKQEMLEYRHQIQSY
S321 EYRHQIQSYTCEIDA
Y322 YRHQIQSYTCEIDAL
T323 RHQIQSYTCEIDALK
K330 TCEIDALKGTNDSLM
K330 TCEIDALKGTNDSLM
G349 EMEERFAGEAGGYQD
Y354 FAGEAGGYQDTIARL
K398 VEIATYRKLLEGEEN
K398 VEIATYRKLLEGEEN
F415 SIPMHQTFASALNFR
S417 PMHQTFASALNFRET
S425 ALNFRETSPDQRGSE
S431 TSPDQRGSEVHTKKT
T435 QRGSEVHTKKTVMIK
T438 SEVHTKKTVMIKTIE
K442 TKKTVMIKTIETRDG
  dog

 
Y5 ___MSQAYSSSQRVS
S6 __MSQAYSSSQRVSS
S7 _MSQAYSSSQRVSSY
S8 MSQAYSSSQRVSSYR
S12 YSSSQRVSSYRRTFG
S13 SSSQRVSSYRRTFGG
R16 QRVSSYRRTFGGAGG
T17 RVSSYRRTFGGAGGF
P25 FGGAGGFPLGsPLGs
S28-p AGGFPLGsPLGsPVF
G31 FPLGsPLGsPVFPRA
S32-p PLGsPLGsPVFPRAG
R37 LGsPVFPRAGFGTKG
R37 LGsPVFPRAGFGTKG
G39 sPVFPRAGFGTKGSS
K43 PRAGFGTKGSSSSVT
K43 PRAGFGTKGSSSSVT
S45 AGFGTKGSSSSVTSR
S46 GFGTKGSSSSVTSRV
S47 FGTKGSSSSVTSRVY
S48 GTKGSSSSVTSRVYQ
Y54 SSVTSRVYQVSRTSG
S57 TSRVYQVSRTSGGAG
T59 RVYQVSRTSGGAGGL
S60 VYQVSRTSGGAGGLG
- gap
R70 AGGLGALRAGRLGTG
T76 LRAGRLGTGRAPSYS
- gap
- gap
- gap
S81 LGTGRAPSYSAGELL
Y82 GTGRAPSYSAGELLD
S91 AGELLDFSLADAVNQ
K108 LTTRTNEKVELQELN
K108 LTTRTNEKVELQELN
Y121 LNDRFANYIEKVRFL
K124 RFANYIEKVRFLEQQ
Y154 PTRVAEIYEEELREL
K192 DLQRLKAKLQEEIQL
S230 DLERRIESLNEEIAF
K239 NEEIAFLKKVHEEEI
K240 EEIAFLKKVHEEEIR
K240 EEIAFLKKVHEEEIR
Y280 LRDIRAQYETIAAKN
K286 QYETIAAKNISEAEE
Y295 ISEAEEWYKSKVSDL
K296 SEAEEWYKSKVSDLT
K308 DLTQAANKNNDALRQ
K317 NDALRQAKQEMMEYR
Y323 AKQEMMEYRHQIQSY
S329 EYRHQIQSYTCEIDA
Y330 YRHQIQSYTCEIDAL
T331 RHQIQSYTCEIDALK
K338 TCEIDALKGTNDSLM
K338 TCEIDALKGTNDSLM
S357 EMEDRFASEASGYQD
Y362 FASEASGYQDNIARL
K406 VEIATYRKLLEGEES
K406 VEIATYRKLLEGEES
Y422 INLPIQTYSALNFRE
S423 NLPIQTYSALNFRET
S431 ALNFRETSPEQRGSE
S437 TSPEQRGSEVHTKKT
T441 QRGSEVHTKKTVMIK
T444 SEVHTKKTVMIKTIE
K448 TKKTVMIKTIETRDG
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