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Protein Page:
CPEB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CPEB cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Translation
Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; dendrite; cell junction; nucleus
Molecular Function: metal ion binding; translation repressor activity, nucleic acid binding; nucleotide binding
Biological Process: cellular response to insulin stimulus; mRNA processing
Reference #:  Q9BZB8 (UniProtKB)
Alt. Names/Synonyms: CEBP; CPE-binding protein 1; CPE-BP1; CPEB; CPEB1; cytoplasmic polyadenylation element binding protein 1; Cytoplasmic polyadenylation element-binding protein 1; FLJ13203; h-CEBP; hCPEB-1; MGC34136; MGC60106
Gene Symbols: CPEB1
Molecular weight: 62,595 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPEB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S43-p INAILDNsLDFSRVC
0 1 T52-p DFSRVCTtPINRGIH
8 0 T172 VRGSRLDTRPILDSR
3 0 S178 DTRPILDSRSSSPSD
0 1 S208 LISSLRISPPLPFLS
0 1 K347-ac EWPGKDGkHPRCPPK
  mouse

 
S43 INAILDDSLDFSKVC
T52 DFSKVCTTPINRGIH
T171-p VRGSRLDtRPILDsR
S177-p DtRPILDsRSSSPSD
S207-p LISSLRIsPPLPFLS
K346 EWPGKDGKHPRCPPK
  rat

 
S43 INAILDDSLDFSKVC
T52 DFSKVCTTPINRGIH
T171-p VRGSRLDtRPILDSR
S177 DtRPILDSRSSSPSD
S207 LISSLRISPPLPFLS
K346 EWPGKDGKHPRCPPK
  pig

 
S43 INTILDNSLDFSRVC
T52 DFSRVCTTPINRGIH
T172-p VRRSRLDtRPILDsR
S178-p DtRPILDsRSSSPSD
S208 LISSLRISPPLPFLS
K347 EWPGKDGKHPRCPPK
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