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Protein Page:
CPEB (human)

Overview
CPEB cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Note: This description may include information from UniProtKB.
Protein type: Translation; RNA binding protein
Cellular Component: postsynaptic membrane; postsynaptic density; cytoplasm; dendrite; cell junction; nucleus
Molecular Function: metal ion binding; translation repressor activity, nucleic acid binding; nucleotide binding
Biological Process: cellular response to insulin stimulus; mRNA processing
Reference #:  Q9BZB8 (UniProtKB)
Alt. Names/Synonyms: CEBP; CPE-binding protein 1; CPE-BP1; CPEB; CPEB1; cytoplasmic polyadenylation element binding protein 1; Cytoplasmic polyadenylation element-binding protein 1; FLJ13203; h-CEBP; hCPEB-1; MGC34136; MGC60106
Gene Symbols: CPEB1
Molecular weight: 62,595 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPEB

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S43-p INAILDNsLDFSRVC
7 0 T172 VRGSRLDTRPILDSR
2 0 S178 DTRPILDSRSSSPSD
0 1 S208 LISSLRISPPLPFLS
  mouse

 
S43 INAILDDSLDFSKVC
T171-p VRGSRLDtRPILDsR
S177-p DtRPILDsRSSSPSD
S207-p LISSLRIsPPLPFLS
  rat

 
S43 INAILDDSLDFSKVC
T171-p VRGSRLDtRPILDSR
S177 DtRPILDSRSSSPSD
S207 LISSLRISPPLPFLS
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