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Protein Page:
Casp9 (rat)

Overview
Casp9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.62; Apoptosis; Protease
Cellular Component: mitochondrion; cytoplasm; nucleus; cytosol; apoptosome
Molecular Function: peptidase activity; protein binding; cysteine-type endopeptidase activity; SH3 domain binding; protein kinase binding; cysteine-type peptidase activity
Biological Process: caspase activation; positive regulation of apoptosis; apoptosis; DNA damage response, signal transduction; response to lipopolysaccharide; proteolysis; response to organic cyclic substance; response to estradiol stimulus; response to antibiotic; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of neuron apoptosis; response to cobalt ion; response to DNA damage stimulus; aging; response to UV
Reference #:  Q9JHK1 (UniProtKB)
Alt. Names/Synonyms: 25 kDa caspase-9 dominant negative protein; Apaf3; apoptotic protease activating factor 3; apoptotic protease Mch-6; Casp-9-CTD; Casp9; Casp9_v1; caspase 9, apoptosis-related cysteine peptidase; Caspase 9, isoform CRA_a; Caspase-9; caspase-9 dominant negative form; Caspase-9 long isoform; caspase-9-carboxyl-terminal divergent; Ice-Lap6; Ice-like apoptotic protease 6; Mch6; RNCASP9
Gene Symbols: Casp9
Molecular weight: 50,400 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Casp9

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
1 0 S132 KVVKLDPSQPALGNL
6 5 T163 PEVLTPETPRPVDIG
1 0 K182 HDVCTPGKIERHADM
1 0 Y191 ERHADMAYTLDSDPC
1 0 S221 GLSTRIGSHVDCEKL
1 0 C233 EKLQHRFCWLRFMVE
2 1 W234 KLQHRFCWLRFMVEV
0 1 T339 HGFEVAFTSSQDKAF
0 1 S340 GFEVAFTSSQDKAFD
0 3 A345 FTSSQDKAFDsDSEP
1 2 S348-p SQDKAFDsDSEPDAV
  human

 
S99-p NRQAAKLsKPTLENL
T125-p PEVLRPEtPRPVDIG
S144-p GDVGALEsLRGNADL
Y153-p RGNADLAyILSMEPC
S183-p GLRTRTGsNIDCEKL
S195-p EKLRRRFssLHFMVE
S196-p KLRRRFssLHFMVEV
T301-p HGFEVAStsPEDEsP
S302-p GFEVAStsPEDEsPG
S307-p StsPEDEsPGsNPEP
S310-p PEDEsPGsNPEPDAT
  mouse

 
S132 RVVKLEPSQPAVGNL
T163-p PEVLRPEtPRPVDIG
K182 HDVCVPGKIRGHADM
Y191 RGHADMAYTLDSDPC
S221 GLGTRTGSNLDRDKL
R233 DKLEHRFRWLRFMVE
W234 KLEHRFRWLRFMVEV
T339 HGFEVACTSSQGRTL
S340 GFEVACTSSQGRTLD
T345 CTSSQGRTLDsDSEP
S348-p SQGRTLDsDSEPDAV
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