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Protein Page:
GluR3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GluR3 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated
Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction
Molecular Function: extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; transport; glutamate signaling pathway
Reference #:  P42263 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 3; dJ1171F9.1; GluR-3; GluR-C; GluR-K3; GLUR3; GLURC; Glutamate receptor 3; glutamate receptor C; Glutamate receptor ionotropic, AMPA 3; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; GRIA3; MRX94
Gene Symbols: GRIA3
Molecular weight: 101,157 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GluR3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 R378 QFDTYGRRTNYTIDV
0 1 Y451-p QLEGNERyEGYCVDL
0 1 Y460-p GYCVDLAyEIAKHVR
0 1 Y705 VYEKMWSYMKSAEPS
0 1 T715 SAEPSVFTKTTADGV
1 0 S728 GVARVRKSKGKFAFL
0 10 K867 TKNTQNFKPAPATNT
0 137 Y877-p PATNTQNyATYREGY
0 18 Y880 NTQNyATYREGYNVY
0 2 Y884 yATYREGYNVYGTES
0 96 Y887 YREGYNVYGTESVKI
3 0 S891 YNVYGTESVKI____
  mouse

 
R372-m2 QFDTYGRrTNYTIDV
Y445 QLEGNERYEGYCVDL
Y454 GYCVDLAYEIAKHVR
Y699-p VYEKMWSyMKSAEPS
T709-p SAEPSVFtKTTADGV
S722 GVARVRKSKGKFAFL
K861-u TKNTQNFkPAPATNT
Y871-p PATNTQNyATYREGY
Y874 NTQNyATYREGYNVy
Y878 yATYREGYNVyGTES
Y881-p YREGYNVyGTESVKI
S885 YNVyGTESVKI____
  rat

 
R372 QFDTYGRRTNYTIDV
Y445 QLEGNERYEGYCVDL
Y454 GYCVDLAYEIAKHVR
Y699 VYEKMWSYMKSAEPS
T709 SAEPSVFTKTTADGV
S722-p GVARVRKsKGKFAFL
K861-u TKNTQNFkPAPATNT
Y871-p PATNTQNyATyREGy
Y874-p NTQNyATyREGyNVy
Y878-p yATyREGyNVyGTEs
Y881-p yREGyNVyGTEsVKI
S885-p yNVyGTEsVKI____
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