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GluR3
an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Channel, ligand-gated |
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Cellular Component: asymmetric synapse; postsynaptic membrane; postsynaptic density; plasma membrane; terminal button; perikaryon; dendritic shaft; cell junction
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Molecular Function: extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; PDZ domain binding
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Biological Process: synaptic transmission; transport; glutamate signaling pathway; response to lithium ion; regulation of receptor recycling
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Reference #:
P42263 (UniProtKB)
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| Alt. Names/Synonyms: AMPA-selective glutamate receptor 3; dJ1171F9.1; GluR-3; GluR-C; GluR-K3; GLUR3; GLURC; Glutamate receptor 3; glutamate receptor C; Glutamate receptor ionotropic, AMPA 3; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; GRIA3; MRX94 |
| Gene Symbols: GRIA3 |
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Molecular weight: 101,157 Da
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Basal Isoelectric point: 8.72
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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Parkinson's Disease
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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