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Protein Page:
PIK3R2 (human)

Overview
PIK3R2 regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis
Cellular Component: cytosol; phosphoinositide 3-kinase complex
Molecular Function: protein binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity; receptor tyrosine kinase binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; innate immune response; blood coagulation; leukocyte migration
Reference #:  O00459 (UniProtKB)
Alt. Names/Synonyms: p85; p85-BETA; P85B; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PIK3R2; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta
Gene Symbols: PIK3R2
Molecular weight: 81,545 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Select Structure to View Below

PIK3R2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 Y74-p RGDFPGTyVEFLGPV
0 4 R195 PEASAEARRALREAA
0 2 S263-p RAPPPPSsPPPGGAP
0 2 Y365-p SSKIQGEyTLTLRKG
0 7 Y423-p KLDTRLLyPVSKYQQ
0 11 Y449-p VGAQLKVyHQQyQDK
0 31 Y453-p LKVyHQQyQDKsREy
0 3 S457-p HQQyQDKsREyDQLy
0 13 Y460-p yQDKsREyDQLyEEy
1 1713 Y464-p sREyDQLyEEytRTS
0 175 Y467-p yDQLyEEytRTSQEL
0 13 T468-p DQLyEEytRTSQELQ
0 12 Y577-p LRKIRDQyLVWLTQK
0 1 T601-p WLGIKNEtEDQyALM
0 230 Y605-p KNEtEDQyALMEDED
0 1 A606 NEtEDQyALMEDEDD
1 1 Y655-p ESSQRGCyACSVVVD
0 64 Y671-p DTKHCVIyRTATGFG
4228 : Phospho-PI3K p85 (Tyr458)/p55 (Tyr199) Antibody
  mouse

 
Y74 RGDFPGTYVEFLGPV
Y195-p PEAAAEAyRALREVA
- gap
Y359 SSKIQGEYTLTLRKG
Y417-p KLDTRLLyPVSKYQQ
Y443 VGAQLKVYHQQyQDK
Y447-p LKVYHQQyQDKSREY
S451 HQQyQDKSREYDQLy
Y454 yQDKSREYDQLyEEy
Y458-p SREYDQLyEEyTRTS
Y461-p YDQLyEEyTRTSQEL
T462 DQLyEEyTRTSQELQ
Y571 LRKIRDQYLVWLTQK
T595 WLGIKNETEDQysLM
Y599-p KNETEDQysLMEDED
S600-p NETEDQysLMEDEDA
Y649-p ESSQRGCyACSVVVD
Y665-p DTKHCVIyRTATGFG
4228 : Phospho-PI3K p85 (Tyr458)/p55 (Tyr199) Antibody
  rat

 
Y74-p RGDFPGTyVEFLGPV
Y195 PEAASEAYRAMREVT
- gap
Y359 SSKIQGEYTLTLRKG
Y417 KLDTRLLYPVSKYQQ
Y443 VGAQLKVYHQQYQDK
Y447 LKVYHQQYQDKSREY
S451 HQQYQDKSREYDQLy
Y454 YQDKSREYDQLyEEY
Y458-p SREYDQLyEEYTRTS
Y461 YDQLyEEYTRTSQEL
T462 DQLyEEYTRTSQELQ
Y571 LRKIRDQYLVWLTQK
T595 WLGIKNETEDQySLM
Y599-p KNETEDQySLMEDED
S600 NETEDQySLMEDEDA
Y649 ESSQRGCYACSVVVD
Y665 DTKHCVIYRTATGFG
4228 : Phospho-PI3K p85 (Tyr458)/p55 (Tyr199) Antibody
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