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tau iso8 (human)

Overview tau iso8 a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: cilium axoneme; microtubule; microtubule associated complex; growth cone; axon; tubulin complex; plasma membrane; cytosol Molecular Function: protein binding; enzyme binding; structural constituent of cytoskeleton; microtubule binding; apolipoprotein binding; protein kinase binding; SH3 domain binding Biological Process: apoptosis; positive regulation of axon extension; positive regulation of microtubule polymerization; axon cargo transport; neuron migration; microtubule cytoskeleton organization and biogenesis; regulation of microtubule polymerization; adult walking behavior; mitochondrion transport along microtubule; negative regulation of intracellular transport; generation of neurons; axon extension involved in development; regulation of autophagy; cell structure disassembly during apoptosis Reference #:  P10636-8 (UniProtKB) Alt. Names/Synonyms: DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MAPTL; MGC138549; Microtubule-associated protein tau; MSTD; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; PPND; TAU Gene Symbols: MAPT Molecular weight: 45,850 Da Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Regulation of Microtubule Dynamics  |  Signaling Pathways Activating p38 MAPK

Select Structure to View Below tau iso8 1I8H - A=542-554 (human) 3FQP - A=623-628 (human) 3OVL - A=623-628 (human)

Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T212‑p, T231‑p, S262‑p apoptosis, induced: T175‑p, S262‑p cytoskeletal reorganization: T175‑p, T181‑p, S199‑p, S202‑p, T205‑p, T212‑p, S214‑p, T217‑p, T231‑p, S235‑p, S262‑p, S320‑p, S324‑p, S356‑p, S396‑p, S404‑p, S422‑p signaling pathway regulation: T231‑p intracellular localization: T181‑p, S199‑p, S202‑p, T205‑p, T212‑p, S214‑p, T217‑p, T231‑p, S235‑p, S396‑p, S404‑p molecular association, regulation: S198‑p, S199‑p, S202‑p, T205‑p, T212‑p, S214‑p, T231‑p, S235‑p, T245‑p, S258‑p, S262‑p, S289‑p, S293‑p, S305‑p, S324‑p, S352‑p, S356‑p, S356‑g, S396‑p, S404‑p, S422‑p O-GlcNAc glycosylation: S199‑p, S202‑p, T205‑p, T212‑p, T217‑p, S262‑p, S396‑p, S404‑p, S422‑p phosphorylation: T231‑p, S235‑p, S262‑p, S396‑p, S404‑p protein conformation: S199‑p, S202‑p, T205‑p, T212‑p, S214‑p, T231‑p, S262‑p, S356‑g, S356‑p, S396‑p, S404‑p protein processing: T212‑p, T231‑p, S396‑p, S404‑p, S422‑p protein stabilization: S262‑p, S320‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T17	VMEDHAGTyGLGDRK
5	1		Y18-p	MEDHAGTyGLGDRKD
1	0		Y29	DRKDQGGYTMHQDQE
1	1		T39	HQDQEGDTDAGLKEs
1	0		K44	GDTDAGLKEsPLQtP
2	4		S46-p	TDAGLKEsPLQtPTE
2	2		T50-p	LKEsPLQtPTEDGSE
0	1		T52	EsPLQtPTEDGSEEP
0	1		S56	QtPTEDGSEEPGsEt
0	1		S61-p	DGSEEPGsEtsDAKS
0	1		T63-p	SEEPGsEtsDAKSTP
0	1		S64-p	EEPGsEtsDAKSTPT
0	2		S68	sEtsDAKSTPTAEDV
0	3		T69	EtsDAKSTPTAEDVT
0	1		T71	sDAKSTPTAEDVTAP
0	1		T95	QAAAQPHTEIPEGTT
0	1		T101	HTEIPEGTTAEEAGI
0	1		T102	TEIPEGTTAEEAGIG
1	5		T111	EEAGIGDTPSLEDEA
0	1		S113	AGIGDTPSLEDEAAG
1	0		T123	DEAAGHVTQEPESGK
0	1		T123	DEAAGHVTQEPESGK
0	7		S171-p	REATRQPsGtGPEDT
0	1		T173-p	ATRQPsGtGPEDTEG
0	3		S214-p	GGKERPGsKEEVDED
0	1		S235	SPQDSPPSKASPAQD
0	2		S382	KARMVSKSKDGtGsD
0	3		T386-p	VSKSKDGtGsDDKKA
0	2		S388-p	KSKDGtGsDDKKAKT
0	1		S411-p	LKNRPCLsPKHPTPG
0	1		T449-p	VSSVTSRtGsSGAKE
0	1		S451-p	SVTSRtGsSGAKEMK
0	1		T466	LKGADGKTKIATPRG
2	1		T470	DGKTKIATPRGAAPP
0	2		P476	ATPRGAAPPGQKGQA
1	0		K480	GAAPPGQKGQANATR
0	1		Q482	APPGQKGQANATRIP
0	1		T486	QKGQANATRIPAKtP
1	0		K491	NATRIPAKtPPAPKt
5	3		T492-p	ATRIPAKtPPAPKtP
1	4		P493	TRIPAKtPPAPKtPP
1	6		A495	IPAKtPPAPKtPPsS
1	0		K497	AKtPPAPKtPPsSGE
35	36		T498-p	KtPPAPKtPPsSGEP
2	4		S501-p	PAPKtPPsSGEPPKs
2	4		S502	APKtPPsSGEPPKsG
0	10		S508-p	sSGEPPKsGDRsGys
3	16		S512-p	PPKsGDRsGyssPGs
4	47		Y514-p	KsGDRsGyssPGsPG
13	18		S515-p	sGDRsGyssPGsPGt
52	47		S516-p	GDRsGyssPGsPGtP
79	128		S519-p	sGyssPGsPGtPGsR
49	37		T522-p	ssPGsPGtPGsRSRt
2	0		S525	GsPGtPGSRSRtPsL
0	8		S525-p	GsPGtPGsRSRtPsL
2	4		S527	PGtPGsRSRtPsLPt
30	14		T529-p	tPGsRSRtPsLPtPP
40	41		S531-p	GsRSRtPsLPtPPtR
18	22		T534-p	SRtPsLPtPPtREPK
1	5		T537-p	PsLPtPPtREPKKVA
68	27		T548-p	KKVAVVRtPPKsPss
28	38		S552-p	VVRtPPKsPssAKsR
1	7		S554-p	RtPPKsPssAKsRLQ
1	0		S555	tPPKsPsSAKsRLQT
1	3		S555-p	tPPKsPssAKsRLQT
1	1		A556	PPKsPssAKsRLQTA
1	2		S558-p	KsPssAKsRLQTAPV
2	1		T562	sAKsRLQTAPVPMPD
1	0		K571	PVPMPDLKNVKSKIG
2	1		K571	PVPMPDLKNVKSKIG
2	1		S575	PDLKNVKSKIGsTEN
0	1		K576	DLKNVKSKIGsTENL
64	8		S579-p	NVKSKIGsTENLKHQ
0	2		T580	VKSKIGsTENLKHQP
1	0		K584	IGsTENLKHQPGGGK
1	0		-	under review
1	0		K597	GKVQIINKKLDLSNV
0	1		K598	KVQIINKKLDLSNVQ
0	1		S602	INKKLDLSNVQSKCG
1	2		S606	LDLSNVQSKCGSKDN
1	0		K607	DLSNVQSKCGSKDNI
0	1		K607	DLSNVQSKCGSKDNI
5	0		S610	NVQSKCGSKDNIKHV
2	1		S622	KHVPGGGSVQIVykP
2	13		Y627-p	GGSVQIVykPVDLsK
0	3		K628-a	GSVQIVykPVDLsKV
2	1		K628	GSVQIVyKPVDLsKV
1	1		S633-p	VykPVDLsKVtSKCG
0	1		T636-p	PVDLsKVtSKCGsLG
3	0		S637	VDLsKVtSKCGsLGN
6	4		S641-p	KVtSKCGsLGNIHHK
1	0		K657	GGGQVEVKSEKLDFK
0	1		S658	GGQVEVKSEKLDFKD
2	1		S669	DFKDRVQSKIGsLDN
2	0		K670	FKDRVQSKIGsLDNI
20	10		S673-p	RVQSKIGsLDNITHV
1	0		S673	RVQSKIGSLDNITHV
0	1		T678	IGsLDNITHVPGGGN
0	27		K686-a	HVPGGGNkkIETHKL
0	17		K687-a	VPGGGNkkIETHKLT
0	1		T690	GGNkkIETHKLTFRE
0	1		T694	kIETHKLTFRENAKA
1	1		T703	RENAKAKTDHGAEIV
2	38		Y711-p	DHGAEIVyKsPVVsG
87	110		S713-p	GAEIVyKsPVVsGDt
2	0		S717	VyKsPVVSGDtsPRH
11	87		S717-p	VyKsPVVsGDtsPRH
3	45		T720-p	sPVVsGDtsPRHLsN
80	97		S721-p	PVVsGDtsPRHLsNV
10	12		S726-p	DtsPRHLsNVsstGS
1	9		S729-p	PRHLsNVsstGSIDM
3	6		S730-p	RHLsNVsstGSIDMV
1	7		T731-p	HLsNVsstGSIDMVD
4	5		S733	sNVsstGSIDMVDsP
26	3		S739-p	GSIDMVDsPQLAtLA
2	2		T744-p	VDsPQLAtLADEVSA
0	1		S750	AtLADEVSASLAKQG
0	1		S752	LADEVSASLAKQGL_

	tau iso2
T17	VMEDHAGTYGLGDRK
Y18	MEDHAGTYGLGDRKD
Y29	DRKDQGGYTMHQDQE
T39	HQDQEGDTDAGLKAE
K44	GDTDAGLKAEEAGIG
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T53	EEAGIGDTPSLEDEA
S55	AGIGDTPSLEDEAAG
T65	DEAAGHVTQARMVSK
T65	DEAAGHVTQARMVSK
-	gap
-	gap
-	gap
-	gap
S73-p	QARMVSKsKDGtGsD
T77-p	VSKsKDGtGsDDKKA
S79-p	KsKDGtGsDDKKAKG
-	gap
-	gap
-	gap
T91	AKGADGKTKIATPRG
T95	DGKTKIATPRGAAPP
P101	ATPRGAAPPGQKGQA
K105	GAAPPGQKGQANATR
Q107	APPGQKGQANATRIP
T111	QKGQANATRIPAKTP
K116	NATRIPAKTPPAPKT
T117	ATRIPAKTPPAPKTP
P118	TRIPAKTPPAPKTPP
A120	IPAKTPPAPKTPPSS
K122	AKTPPAPKTPPSSGE
T123	KTPPAPKTPPSSGEP
S126	PAPKTPPSSGEPPKS
S127	APKTPPSSGEPPKSG
S133	SSGEPPKSGDRSGYS
S137	PPKSGDRSGYSSPGS
Y139	KSGDRSGYSSPGSPG
S140	SGDRSGYSSPGSPGT
S141	GDRSGYSSPGSPGTP
S144	SGYSSPGSPGTPGSR
T147	SSPGSPGTPGSRSRt
S150	GSPGTPGSRSRtPsL
S150	GSPGTPGSRSRtPsL
S152	PGTPGSRSRtPsLPT
T154-p	TPGSRSRtPsLPTPP
S156-p	GSRSRtPsLPTPPTR
T159	SRtPsLPTPPTREPK
T162	PsLPTPPTREPKKVA
T173-p	KKVAVVRtPPKsPSS
S177-p	VVRtPPKsPSSAKSR
S179	RtPPKsPSSAKSRLQ
S180	tPPKsPSSAKSRLQT
S180	tPPKsPSSAKSRLQT
A181	PPKsPSSAKSRLQTA
S183	KsPSSAKSRLQTAPV
T187	SAKSRLQTAPVPMPD
K196	PVPMPDLKNVKSKIG
K196	PVPMPDLKNVKSKIG
S200	PDLKNVKSKIGSTEN
K201	DLKNVKSKIGSTENL
S204	NVKSKIGSTENLKHQ
T205	VKSKIGSTENLKHQP
K209	IGSTENLKHQPGGGK
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y221	GGKVQIVYKPVDLsK
K222	GKVQIVYKPVDLsKV
K222	GKVQIVYKPVDLsKV
S227-p	VYKPVDLsKVtSKCG
T230-p	PVDLsKVtSKCGsLG
S231	VDLsKVtSKCGsLGN
S235-p	KVtSKCGsLGNIHHK
K251	GGGQVEVKSEKLDFK
S252	GGQVEVKSEKLDFKD
S263	DFKDRVQSKIGsLDN
K264	FKDRVQSKIGsLDNI
S267-p	RVQSKIGsLDNITHV
S267	RVQSKIGSLDNITHV
T272	IGsLDNITHVPGGGN
K280-a	HVPGGGNkkIETHKL
K281-a	VPGGGNkkIETHKLT
T284	GGNkkIETHKLTFRE
T288	kIETHKLTFRENAKA
T297	RENAKAKTDHGAEIV
Y305	DHGAEIVYKsPVVSG
S307-p	GAEIVYKsPVVSGDT
S311	VYKsPVVSGDTsPRH
S311	VYKsPVVSGDTsPRH
T314	sPVVSGDTsPRHLsN
S315-p	PVVSGDTsPRHLsNV
S320-p	DTsPRHLsNVSSTGS
S323	PRHLsNVSSTGSIDM
S324	RHLsNVSSTGSIDMV
T325	HLsNVSSTGSIDMVD
S327	sNVSSTGSIDMVDSP
S333	GSIDMVDSPQLATLA
T338	VDSPQLATLADEVSA
S344	ATLADEVSASLAKQG
S346	LADEVSASLAKQGL_

	tau iso3
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T17	REAGIGDTPSLEDEA
S19	AGIGDTPSLEDEAAG
T29	DEAAGHVTQARMVSK
T29	DEAAGHVTQARMVSK
-	gap
-	gap
-	gap
-	gap
S37	QARMVSKSKDGtGsD
T41-p	VSKSKDGtGsDDKKA
S43-p	KSKDGtGsDDKKAKG
-	gap
-	gap
-	gap
T55	AKGADGKTKIATPRG
T59	DGKTKIATPRGAAPP
P65	ATPRGAAPPGQKGQA
K69	GAAPPGQKGQANATR
Q71	APPGQKGQANATRIP
T75	QKGQANATRIPAKTP
K80	NATRIPAKTPPAPKT
T81	ATRIPAKTPPAPKTP
P82	TRIPAKTPPAPKTPP
A84	IPAKTPPAPKTPPSS
K86	AKTPPAPKTPPSSGE
T87	KTPPAPKTPPSSGEP
S90	PAPKTPPSSGEPPKS
S91	APKTPPSSGEPPKSG
S97	SSGEPPKSGDRSGYs
S101	PPKSGDRSGYssPGs
Y103	KSGDRSGYssPGsPG
S104-p	SGDRSGYssPGsPGT
S105-p	GDRSGYssPGsPGTP
S108-p	SGYssPGsPGTPGSR
T111	ssPGsPGTPGSRSRt
S114	GsPGTPGSRSRtPsL
S114	GsPGTPGSRSRtPsL
S116	PGTPGSRSRtPsLPT
T118-p	TPGSRSRtPsLPTPP
S120-p	GSRSRtPsLPTPPTR
T123	SRtPsLPTPPTREPK
T126	PsLPTPPTREPKKVA
T137-p	KKVAVVRtPPKsPSS
S141-p	VVRtPPKsPSSAKSR
S143	RtPPKsPSSAKSRLQ
S144	tPPKsPSSAKSRLQT
S144	tPPKsPSSAKSRLQT
A145	PPKsPSSAKSRLQTA
S147	KsPSSAKSRLQTAPV
T151	SAKSRLQTAPVPMPD
K160	PVPMPDLKNVKSKIG
K160	PVPMPDLKNVKSKIG
S164	PDLKNVKSKIGSTEN
K165	DLKNVKSKIGSTENL
S168	NVKSKIGSTENLKHQ
T169	VKSKIGSTENLKHQP
K173	IGSTENLKHQPGGGK
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y185	GGKVQIVYKPVDLsK
K186	GKVQIVYKPVDLsKV
K186	GKVQIVYKPVDLsKV
S191-p	VYKPVDLsKVtSKCG
T194-p	PVDLsKVtSKCGsLG
S195	VDLsKVtSKCGsLGN
S199-p	KVtSKCGsLGNIHHK
K215	GGGQVEVKSEKLDFK
S216	GGQVEVKSEKLDFKD
S227	DFKDRVQSKIGSLDN
K228	FKDRVQSKIGSLDNI
S231	RVQSKIGSLDNITHV
S231	RVQSKIGSLDNITHV
T236	IGSLDNITHVPGGGN
K244-a	HVPGGGNkkIETHKL
K245-a	VPGGGNkkIETHKLt
T248	GGNkkIETHKLtFRE
T252-p	kIETHKLtFRENAKA
T261	RENAKAKTDHGAEIV
Y269	DHGAEIVYKsPVVSG
S271-p	GAEIVYKsPVVSGDT
S275	VYKsPVVSGDTsPRH
S275	VYKsPVVSGDTsPRH
T278	sPVVSGDTsPRHLsN
S279-p	PVVSGDTsPRHLsNV
S284-p	DTsPRHLsNVSsTGS
S287	PRHLsNVSsTGSIDM
S288-p	RHLsNVSsTGSIDMV
T289	HLsNVSsTGSIDMVD
S291	sNVSsTGSIDMVDsP
S297-p	GSIDMVDsPQLATLA
T302	VDsPQLATLADEVSA
S308	ATLADEVSASLAKQG
S310	LADEVSASLAKQGL_

	tau iso5
T17	VMEDHAGTYGLGDRK
Y18	MEDHAGTYGLGDRKD
Y29	DRKDQGGYTMHQDQE
T39	HQDQEGDTDAGLKES
K44	GDTDAGLKESPLQTP
S46	TDAGLKESPLQTPTE
T50	LKESPLQTPTEDGSE
T52	ESPLQTPTEDGSEEP
S56	QTPTEDGSEEPGSET
S61	DGSEEPGSETSDAKS
T63	SEEPGSETSDAKSTP
S64	EEPGSETSDAKSTPT
S68	SETSDAKSTPTAEDV
T69	ETSDAKSTPTAEDVT
T71	SDAKSTPTAEDVTAP
T95	QAAAQPHTEIPEGTT
T101	HTEIPEGTTAEEAGI
T102	TEIPEGTTAEEAGIG
T111	EEAGIGDTPSLEDEA
S113	AGIGDTPSLEDEAAG
T123	DEAAGHVTQARMVSK
T123	DEAAGHVTQARMVSK
-	gap
-	gap
-	gap
-	gap
S131	QARMVSKSKDGtGsD
T135-p	VSKSKDGtGsDDKKA
S137-p	KSKDGtGsDDKKAKG
-	gap
-	gap
-	gap
T149	AKGADGKTKIATPRG
T153	DGKTKIATPRGAAPP
P159	ATPRGAAPPGQKGQA
K163	GAAPPGQKGQANATR
Q165	APPGQKGQANATRIP
T169	QKGQANATRIPAKTP
K174	NATRIPAKTPPAPKt
T175	ATRIPAKTPPAPKtP
P176	TRIPAKTPPAPKtPP
A178	IPAKTPPAPKtPPsS
K180	AKTPPAPKtPPsSGE
T181-p	KTPPAPKtPPsSGEP
S184-p	PAPKtPPsSGEPPKS
S185	APKtPPsSGEPPKSG
S191	sSGEPPKSGDRsGYs
S195-p	PPKSGDRsGYssPGs
Y197	KSGDRsGYssPGsPG
S198-p	SGDRsGYssPGsPGt
S199-p	GDRsGYssPGsPGtP
S202-p	sGYssPGsPGtPGSR
T205-p	ssPGsPGtPGSRSRt
S208	GsPGtPGSRSRtPsL
S208	GsPGtPGSRSRtPsL
S210	PGtPGSRSRtPsLPT
T212-p	tPGSRSRtPsLPTPP
S214-p	GSRSRtPsLPTPPTR
T217	SRtPsLPTPPTREPK
T220	PsLPTPPTREPKKVA
T231-p	KKVAVVRtPPKsPSS
S235-p	VVRtPPKsPSSAKSR
S237	RtPPKsPSSAKSRLQ
S238	tPPKsPSSAKSRLQT
S238	tPPKsPSSAKSRLQT
A239	PPKsPSSAKSRLQTA
S241	KsPSSAKSRLQTAPV
T245	SAKSRLQTAPVPMPD
K254	PVPMPDLKNVKSKIG
K254	PVPMPDLKNVKSKIG
S258	PDLKNVKSKIGsTEN
K259	DLKNVKSKIGsTENL
S262-p	NVKSKIGsTENLKHQ
T263	VKSKIGsTENLKHQP
K267	IGsTENLKHQPGGGK
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y279	GGKVQIVYKPVDLsK
K280	GKVQIVYKPVDLsKV
K280	GKVQIVYKPVDLsKV
S285-p	VYKPVDLsKVtSKCG
T288-p	PVDLsKVtSKCGsLG
S289	VDLsKVtSKCGsLGN
S293-p	KVtSKCGsLGNIHHK
K309	GGGQVEVKSEKLDFK
S310	GGQVEVKSEKLDFKD
S321	DFKDRVQSKIGsLDN
K322	FKDRVQSKIGsLDNI
S325-p	RVQSKIGsLDNITHV
S325	RVQSKIGSLDNITHV
T330	IGsLDNITHVPGGGN
K338-a	HVPGGGNkkIETHKL
K339-a	VPGGGNkkIETHKLT
T342	GGNkkIETHKLTFRE
T346	kIETHKLTFRENAKA
T355	RENAKAKTDHGAEIV
Y363	DHGAEIVYKsPVVsG
S365-p	GAEIVYKsPVVsGDT
S369	VYKsPVVSGDTsPRH
S369-p	VYKsPVVsGDTsPRH
T372	sPVVsGDTsPRHLSN
S373-p	PVVsGDTsPRHLSNV
S378	DTsPRHLSNVSSTGS
S381	PRHLSNVSSTGSIDM
S382	RHLSNVSSTGSIDMV
T383	HLSNVSSTGSIDMVD
S385	SNVSSTGSIDMVDSP
S391	GSIDMVDSPQLATLA
T396	VDSPQLATLADEVSA
S402	ATLADEVSASLAKQG
S404	LADEVSASLAKQGL_

	tau iso6
T17	VMEDHAGTYGLGDRK
Y18	MEDHAGTYGLGDRKD
Y29	DRKDQGGYTMHQDQE
T39	HQDQEGDTDAGLKAE
K44	GDTDAGLKAEEAGIG
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T53	EEAGIGDTPSLEDEA
S55	AGIGDTPSLEDEAAG
T65	DEAAGHVTQARMVSK
T65	DEAAGHVTQARMVSK
-	gap
-	gap
-	gap
-	gap
S73	QARMVSKSKDGtGsD
T77-p	VSKSKDGtGsDDKKA
S79-p	KSKDGtGsDDKKAKG
-	gap
-	gap
-	gap
T91	AKGADGKTKIATPRG
T95	DGKTKIATPRGAAPP
P101	ATPRGAAPPGQKGQA
K105	GAAPPGQKGQANATR
Q107	APPGQKGQANATRIP
T111	QKGQANATRIPAKTP
K116	NATRIPAKTPPAPKt
T117	ATRIPAKTPPAPKtP
P118	TRIPAKTPPAPKtPP
A120	IPAKTPPAPKtPPSS
K122	AKTPPAPKtPPSSGE
T123-p	KTPPAPKtPPSSGEP
S126	PAPKtPPSSGEPPKS
S127	APKtPPSSGEPPKSG
S133	SSGEPPKSGDRSGYS
S137	PPKSGDRSGYSSPGs
Y139	KSGDRSGYSSPGsPG
S140	SGDRSGYSSPGsPGt
S141	GDRSGYSSPGsPGtP
S144-p	SGYSSPGsPGtPGSR
T147-p	SSPGsPGtPGSRSRt
S150	GsPGtPGSRSRtPsL
S150	GsPGtPGSRSRtPsL
S152	PGtPGSRSRtPsLPT
T154-p	tPGSRSRtPsLPTPP
S156-p	GSRSRtPsLPTPPTR
T159	SRtPsLPTPPTREPK
T162	PsLPTPPTREPKKVA
T173-p	KKVAVVRtPPKsPSS
S177-p	VVRtPPKsPSSAKSR
S179	RtPPKsPSSAKSRLQ
S180	tPPKsPSSAKSRLQT
S180	tPPKsPSSAKSRLQT
A181	PPKsPSSAKSRLQTA
S183	KsPSSAKSRLQTAPV
T187	SAKSRLQTAPVPMPD
K196	PVPMPDLKNVKSKIG
K196	PVPMPDLKNVKSKIG
S200	PDLKNVKSKIGsTEN
K201	DLKNVKSKIGsTENL
S204-p	NVKSKIGsTENLKHQ
T205	VKSKIGsTENLKHQP
K209	IGsTENLKHQPGGGK
-	under review
K222	GKVQIINKKLDLSNV
K223	KVQIINKKLDLSNVQ
S227	INKKLDLSNVQSKCG
S231	LDLSNVQSKCGSKDN
K232	DLSNVQSKCGSKDNI
K232	DLSNVQSKCGSKDNI
S235	NVQSKCGSKDNIKHV
S247	KHVPGGGSVQIVYKP
Y252	GGSVQIVYKPVDLsK
K253	GSVQIVYKPVDLsKV
K253	GSVQIVYKPVDLsKV
S258-p	VYKPVDLsKVtSKCG
T261-p	PVDLsKVtSKCGsLG
S262	VDLsKVtSKCGsLGN
S266-p	KVtSKCGsLGNIHHK
K282	GGGQVEVKSEKLDFK
S283	GGQVEVKSEKLDFKD
S294	DFKDRVQSKIGsLDN
K295	FKDRVQSKIGsLDNI
S298-p	RVQSKIGsLDNITHV
S298	RVQSKIGSLDNITHV
T303	IGsLDNITHVPGGGN
K311-a	HVPGGGNkkIETHKL
K312-a	VPGGGNkkIETHKLT
T315	GGNkkIETHKLTFRE
T319	kIETHKLTFRENAKA
T328	RENAKAKTDHGAEIV
Y336	DHGAEIVYKsPVVSG
S338-p	GAEIVYKsPVVSGDT
S342	VYKsPVVSGDTsPRH
S342	VYKsPVVSGDTsPRH
T345	sPVVSGDTsPRHLSN
S346-p	PVVSGDTsPRHLSNV
S351	DTsPRHLSNVSSTGS
S354	PRHLSNVSSTGSIDM
S355	RHLSNVSSTGSIDMV
T356	HLSNVSSTGSIDMVD
S358	SNVSSTGSIDMVDSP
S364	GSIDMVDSPQLATLA
T369	VDSPQLATLADEVSA
S375	ATLADEVSASLAKQG
S377	LADEVSASLAKQGL_

	tau iso8
T17-p	VMEDHAGtyGLGDRK
Y18-p	MEDHAGtyGLGDRKD
Y29-p	DRKDQGGyTMHQDQE
T39-p	HQDQEGDtDAGLkEs
K44-m1	GDtDAGLkEsPLQtP
S46-p	tDAGLkEsPLQtPtE
T50-p	LkEsPLQtPtEDGsE
T52-p	EsPLQtPtEDGsEEP
S56-p	QtPtEDGsEEPGSET
S61	DGsEEPGSETSDAKs
T63	sEEPGSETSDAKstP
S64	EEPGSETSDAKstPt
S68-p	SETSDAKstPtAEDV
T69-p	ETSDAKstPtAEDVT
T71-p	SDAKstPtAEDVTAP
T95-p	QAAAQPHtEIPEGtt
T101-p	HtEIPEGttAEEAGI
T102-p	tEIPEGttAEEAGIG
T111-p	EEAGIGDtPsLEDEA
S113-p	AGIGDtPsLEDEAAG
T123-g	DEAAGHVtQARMVSK
T123-p	DEAAGHVtQARMVSK
-	gap
-	gap
-	gap
-	gap
S131-p	QARMVSKsKDGtGsD
T135-p	VSKsKDGtGsDDKKA
S137-p	KsKDGtGsDDKKAKG
-	gap
-	gap
-	gap
T149-p	AKGADGKtKIAtPRG
T153-p	DGKtKIAtPRGAAPP
P159	AtPRGAAPPGQkGQA
K163-m1	GAAPPGQkGQANAtR
Q165	APPGQkGQANAtRIP
T169-p	QkGQANAtRIPAktP
K174-m1	NAtRIPAktPPAPkt
T175-p	AtRIPAktPPAPktP
P176	tRIPAktPPAPktPP
A178	IPAktPPAPktPPss
K180-m1	AktPPAPktPPssGE
T181-p	ktPPAPktPPssGEP
S184-p	PAPktPPssGEPPKs
S185-p	APktPPssGEPPKsG
S191-p	ssGEPPKsGDRsGys
S195-p	PPKsGDRsGyssPGs
Y197-p	KsGDRsGyssPGsPG
S198-p	sGDRsGyssPGsPGt
S199-p	GDRsGyssPGsPGtP
S202-p	sGyssPGsPGtPGsR
T205-p	ssPGsPGtPGsRsRt
S208-g	GsPGtPGsRsRtPsL
S208-p	GsPGtPGsRsRtPsL
S210-p	PGtPGsRsRtPsLPt
T212-p	tPGsRsRtPsLPtPP
S214-p	GsRsRtPsLPtPPtR
T217-p	sRtPsLPtPPtREPK
T220-p	PsLPtPPtREPKKVA
T231-p	KKVAVVRtPPKsPss
S235-p	VVRtPPKsPssAKsR
S237-p	RtPPKsPssAKsRLQ
S238-g	tPPKsPssAKsRLQt
S238-p	tPPKsPssAKsRLQt
A239	PPKsPssAKsRLQtA
S241-p	KsPssAKsRLQtAPV
T245-p	sAKsRLQtAPVPMPD
K254-m1	PVPMPDLkNVKsKIG
K254-u	PVPMPDLkNVKsKIG
S258-p	PDLkNVKsKIGstEN
K259	DLkNVKsKIGstENL
S262-p	NVKsKIGstENLkHQ
T263-p	VKsKIGstENLkHQP
K267-m1	IGstENLkHQPGGGk
K274-a	kHQPGGGkVQIINkK
K280-a	GkVQIINkKLDLsNV
K281	kVQIINkKLDLsNVQ
S285-p	INkKLDLsNVQskCG
S289-p	LDLsNVQskCGsKDN
K290-m1	DLsNVQskCGsKDNI
K290	DLsNVQsKCGsKDNI
S293-p	NVQskCGsKDNIKHV
S305-p	KHVPGGGsVQIVykP
Y310-p	GGsVQIVykPVDLsK
K311	GsVQIVyKPVDLsKV
K311-u	GsVQIVykPVDLsKV
S316-p	VykPVDLsKVtsKCG
T319-p	PVDLsKVtsKCGsLG
S320-p	VDLsKVtsKCGsLGN
S324-p	KVtsKCGsLGNIHHK
K340-s	GGGQVEVksEKLDFK
S341-p	GGQVEVksEKLDFKD
S352-p	DFKDRVQskIGsLDN
K353-u	FKDRVQskIGsLDNI
S356-p	RVQskIGsLDNItHV
S356-g	RVQskIGsLDNItHV
T361-p	IGsLDNItHVPGGGN
K369-a	HVPGGGNkkIEtHKL
K370-a	VPGGGNkkIEtHKLT
T373-p	GGNkkIEtHKLTFRE
T377	kIEtHKLTFRENAKA
T386-p	RENAKAKtDHGAEIV
Y394-p	DHGAEIVyKsPVVsG
S396-p	GAEIVyKsPVVsGDt
S400-g	VyKsPVVsGDtsPRH
S400-p	VyKsPVVsGDtsPRH
T403-p	sPVVsGDtsPRHLsN
S404-p	PVVsGDtsPRHLsNV
S409-p	DtsPRHLsNVsstGs
S412-p	PRHLsNVsstGsIDM
S413-p	RHLsNVsstGsIDMV
T414-p	HLsNVsstGsIDMVD
S416-p	sNVsstGsIDMVDsP
S422-p	GsIDMVDsPQLAtLA
T427-p	VDsPQLAtLADEVsA
S433-p	AtLADEVsAsLAKQG
S435-p	LADEVsAsLAKQGL_

	mouse ► Hide Isoforms
-	gap
-	gap
Y18	MEDHAGDYTLLQDQE
M28	LQDQEGDMDHGLKEs
K33	GDMDHGLKEsPPQPP
S35-p	MDHGLKEsPPQPPAD
P39	LKEsPPQPPADDGAE
A41	EsPPQPPADDGAEEP
A45	QPPADDGAEEPGsEt
S50-p	DGAEEPGsEtsDAKs
T52-p	AEEPGsEtsDAKstP
S53-p	EEPGsEtsDAKstPt
S57-p	sEtsDAKstPtAEDV
T58-p	EtsDAKstPtAEDVT
T60-p	sDAKstPtAEDVTAP
T84	QAAAQPHTEIPEGIT
I90	HTEIPEGITAEEAGI
T91	TEIPEGITAEEAGIG
T100-p	EEAGIGDtPNQEDQA
N102	AGIGDtPNQEDQAAG
T112	DQAAGHVTQGRREGQ
T112	DQAAGHVTQGRREGQ
S154	REATCQPSGTRPEDI
T156	ATCQPSGTRPEDIEK
S188-p	WGQDRLGsEEEVDED
S208-p	SSQDSPPsQASLTPG
S355	QLKARVASKDRTGND
T359	RVASKDRTGNDEKKA
N361	ASKDRTGNDEKKAKT
S384	PSHRPCLSPTRPTLG
N422	VSSVTPRNGSPGTKQ
S424	SVTPRNGSPGTKQMK
T439	LKGADGKTGAKIATP
T445	KTGAKIATPRGAAsP
S451-p	ATPRGAAsPAQKGtS
K455	GAAsPAQKGtSNATR
T457-p	AsPAQKGtSNATRIP
T461	QKGtSNATRIPAKtt
K466	NATRIPAKttPsPKt
T467-p	ATRIPAKttPsPKtP
T468-p	TRIPAKttPsPKtPP
S470-p	IPAKttPsPKtPPGs
K472	AKttPsPKtPPGsGE
T473-p	KttPsPKtPPGsGEP
G476	PsPKtPPGsGEPPKs
S477-p	sPKtPPGsGEPPKsG
S483-p	GsGEPPKsGERsGys
S487-p	PPKsGERsGyssPGs
Y489-p	KsGERsGyssPGsPG
S490-p	sGERsGyssPGsPGt
S491-p	GERsGyssPGsPGtP
S494-p	sGyssPGsPGtPGsR
T497-p	ssPGsPGtPGsRsRt
S500	GsPGtPGSRsRtPsL
S500-p	GsPGtPGsRsRtPsL
S502-p	PGtPGsRsRtPsLPt
T504-p	tPGsRsRtPsLPtPP
S506-p	GsRsRtPsLPtPPtR
T509-p	sRtPsLPtPPtREPK
T512-p	PsLPtPPtREPKKVA
T523-p	KKVAVVRtPPKsPsA
S527-p	VVRtPPKsPsAsKSR
S529-p	RtPPKsPsAsKSRLQ
A530	tPPKsPsAsKSRLQT
A530	tPPKsPsAsKSRLQT
S531-p	PPKsPsAsKSRLQTA
S533	KsPsAsKSRLQTAPV
T537	AsKSRLQTAPVPMPD
K546	PVPMPDLKNVRSkIG
K546-u	PVPMPDLkNVRSkIG
S550	PDLkNVRSkIGstEN
K551-m1	DLkNVRSkIGstENL
S554-p	NVRSkIGstENLKHQ
T555-p	VRSkIGstENLKHQP
K559	IGstENLKHQPGGGK
-	under review
K572	GKVQIINKkLDLSNV
K573-u	KVQIINKkLDLSNVQ
S577	INKkLDLSNVQskCG
S581-p	LDLSNVQskCGSKDN
K582	DLSNVQsKCGSKDNI
K582-u	DLSNVQskCGSKDNI
S585	NVQskCGSKDNIKHV
S597	KHVPGGGSVQIVykP
Y602-p	GGSVQIVykPVDLSK
K603	GSVQIVyKPVDLSKV
K603-u	GSVQIVykPVDLSKV
S608	VykPVDLSKVTSKCG
T611	PVDLSKVTSKCGSLG
S612	VDLSKVTSKCGSLGN
S616	KVTSKCGSLGNIHHK
K632	GGGQVEVKSEKLDFK
S633	GGQVEVKSEKLDFKD
S644	DFKDRVQSKIGsLDN
K645	FKDRVQSKIGsLDNI
S648-p	RVQSKIGsLDNITHV
S648	RVQSKIGSLDNITHV
T653	IGsLDNITHVPGGGN
K661-a	HVPGGGNkKIETHKL
K662	VPGGGNkKIETHKLt
T665	GGNkKIETHKLtFRE
T669-p	KIETHKLtFRENAKA
T678	RENAKAKTDHGAEIV
Y686-p	DHGAEIVyKsPVVsG
S688-p	GAEIVyKsPVVsGDt
S692	VyKsPVVSGDtsPRH
S692-p	VyKsPVVsGDtsPRH
T695-p	sPVVsGDtsPRHLsN
S696-p	PVVsGDtsPRHLsNV
S701-p	DtsPRHLsNVsstGs
S704-p	PRHLsNVsstGsIDM
S705-p	RHLsNVsstGsIDMV
T706-p	HLsNVsstGsIDMVD
S708-p	sNVsstGsIDMVDsP
S714-p	GsIDMVDsPQLAtLA
T719-p	VDsPQLAtLADEVSA
S725	AtLADEVSASLAKQG
S727	LADEVSASLAKQGL_

	tau iso3
-	gap
-	gap
Y18	MEDHAGDYTLLQDQE
M28	LQDQEGDMDHGLKES
K33	GDMDHGLKESPPQPP
S35	MDHGLKESPPQPPAD
P39	LKESPPQPPADDGAE
A41	ESPPQPPADDGAEEP
A45	QPPADDGAEEPGSET
S50	DGAEEPGSETSDAKS
T52	AEEPGSETSDAKSTP
S53	EEPGSETSDAKSTPT
S57	SETSDAKSTPTAEDV
T58	ETSDAKSTPTAEDVT
T60	SDAKSTPTAEDVTAP
T84	QAAAQPHTEIPEGIT
I90	HTEIPEGITAEEAGI
T91	TEIPEGITAEEAGIG
T100-p	EEAGIGDtPNQEDQA
N102	AGIGDtPNQEDQAAG
T112	DQAAGHVTQARVASK
T112	DQAAGHVTQARVASK
-	gap
-	gap
-	gap
-	gap
S118	VTQARVASKDRTGND
T122	RVASKDRTGNDEKKA
N124	ASKDRTGNDEKKAKG
-	gap
-	gap
-	gap
T136	AKGADGKTGAKIATP
T142	KTGAKIATPRGAASP
S148	ATPRGAASPAQKGTS
K152	GAASPAQKGTSNATR
T154	ASPAQKGTSNATRIP
T158	QKGTSNATRIPAKTT
K163	NATRIPAKTTPSPKT
T164	ATRIPAKTTPSPKTP
T165	TRIPAKTTPSPKTPP
S167	IPAKTTPSPKTPPGS
K169	AKTTPSPKTPPGSGE
T170	KTTPSPKTPPGSGEP
G173	PSPKTPPGSGEPPKS
S174	SPKTPPGSGEPPKSG
S180	GSGEPPKSGERSGYS
S184	PPKSGERSGYSSPGS
Y186	KSGERSGYSSPGSPG
S187	SGERSGYSSPGSPGT
S188	GERSGYSSPGSPGTP
S191	SGYSSPGSPGTPGSR
T194	SSPGSPGTPGSRSRT
S197	GSPGTPGSRSRTPSL
S197	GSPGTPGSRSRTPSL
S199	PGTPGSRSRTPSLPT
T201	TPGSRSRTPSLPTPP
S203	GSRSRTPSLPTPPTR
T206	SRTPSLPTPPTREPK
T209	PSLPTPPTREPKKVA
T220	KKVAVVRTPPKSPSA
S224	VVRTPPKSPSASKSR
S226	RTPPKSPSASKSRLQ
A227	TPPKSPSASKSRLQT
A227	TPPKSPSASKSRLQT
S228	PPKSPSASKSRLQTA
S230	KSPSASKSRLQTAPV
T234	ASKSRLQTAPVPMPD
K243	PVPMPDLKNVRSKIG
K243	PVPMPDLKNVRSKIG
S247	PDLKNVRSKIGSTEN
K248	DLKNVRSKIGSTENL
S251	NVRSKIGSTENLKHQ
T252	VRSKIGSTENLKHQP
K256	IGSTENLKHQPGGGK
-	under review
K269	GKVQIINKKLDLSNV
K270	KVQIINKKLDLSNVQ
S274	INKKLDLSNVQSKCG
S278	LDLSNVQSKCGSKDN
K279	DLSNVQSKCGSKDNI
K279	DLSNVQSKCGSKDNI
S282	NVQSKCGSKDNIKHV
S294	KHVPGGGSVQIVYKP
Y299	GGSVQIVYKPVDLSK
K300	GSVQIVYKPVDLSKV
K300	GSVQIVYKPVDLSKV
S305	VYKPVDLSKVTSKCG
T308	PVDLSKVTSKCGSLG
S309	VDLSKVTSKCGSLGN
S313	KVTSKCGSLGNIHHK
K329	GGGQVEVKSEKLDFK
S330	GGQVEVKSEKLDFKD
S341	DFKDRVQSKIGSLDN
K342	FKDRVQSKIGSLDNI
S345	RVQSKIGSLDNITHV
S345	RVQSKIGSLDNITHV
T350	IGSLDNITHVPGGGN
K358	HVPGGGNKKIETHKL
K359	VPGGGNKKIETHKLT
T362	GGNKKIETHKLTFRE
T366	KIETHKLTFRENAKA
T375	RENAKAKTDHGAEIV
Y383	DHGAEIVYKSPVVSG
S385	GAEIVYKSPVVSGDT
S389	VYKSPVVSGDTSPRH
S389	VYKSPVVSGDTSPRH
T392	SPVVSGDTSPRHLSN
S393	PVVSGDTSPRHLSNV
S398	DTSPRHLSNVSSTGS
S401	PRHLSNVSSTGSIDM
S402	RHLSNVSSTGSIDMV
T403	HLSNVSSTGSIDMVD
S405	SNVSSTGSIDMVDSP
S411	GSIDMVDSPQLATLA
T416	VDSPQLATLADEVSA
S422	ATLADEVSASLAKQG
S424	LADEVSASLAKQGL_