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Protein Page:
TCF3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TCF3 Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. Belongs to the TCF/LEF family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: transcription factor complex; nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; transcription factor activity
Biological Process: skin development; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; somatic stem cell maintenance; regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; axial mesoderm morphogenesis; generation of neurons; determination of anterior/posterior axis, embryo; brain development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter, mitotic
Reference #:  Q9HCS4 (UniProtKB)
Alt. Names/Synonyms: HMG box transcription factor 3; HMG-box transcription factor TCF-3; TCF-3; TCF3; TCF7L1; TF7L1; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG-box)
Gene Symbols: TCF7L1
Molecular weight: 62,631 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

TCF3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R146 PLSPGGARTYLQMKW
0 1 S325-p EPAPPSLsPAVSVKS
0 1 K348-ub EKKPHVKkPLNAFML
0 1 K358-ac NAFMLYMkEMRAkVV
0 1 K363-ac YMkEMRAkVVAECTL
0 1 S388 GRKWHNLSREEQAky
0 8 K394-ub LSREEQAkyyELARK
0 2 Y395-p SREEQAkyyELARKE
0 5 Y396-p REEQAkyyELARKER
0 4 S432 RKREKQLSQTQSQQQ
0 1 S449-p EAEGALAsKSKKPCV
0 1 S488-p TPSAALAsPAAPAAt
0 1 T495-p sPAAPAAtHSEQAQP
0 1 T511-p SLTTKPEtRAQLALH
0 1 S519-p RAQLALHsAAFLsAK
0 1 S524-p LHsAAFLsAKAAASS
0 1 S543 GSQPPLLSRPLPLGS
0 1 S550 SRPLPLGSMPTALLA
  mouse

 
R144-m2 PLSPGGArTYLQMKW
S336 EPAAPSLSPAVSAKS
K359 EKKPHVKKPLNAFML
K369 NAFMLYMKEMRAKVV
K374 YMKEMRAKVVAECTL
S399-p GRKWHNLsREEQAKy
K405 LsREEQAKyyELARK
Y406-p sREEQAKyyELARKE
Y407-p REEQAKyyELARKER
S443-p RKREKQLsQTQSQQQ
S460 EAEGALASKSKKPCI
S499 TPSAALASPAAPAAT
T506 SPAAPAATHSEQAQP
A522 SLTTKPEARAQLALH
S530 RAQLALHSAAFLSAK
S535 LHSAAFLSAKAAASN
S554-p GSQPPLLsRPLPLGs
S561-p sRPLPLGsMPAALLT
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