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TCF3 (human)

Overview TCF3 Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. Belongs to the TCF/LEF family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: transcription factor complex; nucleus Molecular Function: DNA binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; transcription factor activity Biological Process: skin development; establishment and/or maintenance of chromatin architecture; Wnt receptor signaling pathway; transcription, DNA-dependent; somatic stem cell maintenance; regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; regulation of transcription from RNA polymerase II promoter; neurogenesis; regulation of transcription, DNA-dependent; generation of neurons; axial mesoderm morphogenesis; determination of anterior/posterior axis, embryo; brain development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter, mitotic Reference #:  Q9HCS4 (UniProtKB) Alt. Names/Synonyms: HMG box transcription factor 3; HMG-box transcription factor TCF-3; TCF-3; TCF3; TCF7L1; TF7L1; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG-box) Gene Symbols: TCF7L1 Molecular weight: 62,631 Da Basal Isoelectric point: 9  Predict pI for various phosphorylation states

Select Structure to View Below TCF3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K348-u	EKKPHVKkPLNAFML
0	1		K358-a	NAFMLYMkEMRAkVV
0	1		K363-a	YMkEMRAkVVAECTL
0	1		S388	GRKWHNLSREEQAky
0	8		K394-u	LSREEQAkyyELARK
0	2		Y395-p	SREEQAkyyELARKE
0	5		Y396-p	REEQAkyyELARKER
0	4		S432	RKREKQLSQTQSQQQ
0	1		S449-p	EAEGALAsKSKKPCV
0	1		S488-p	TPSAALAsPAAPAAt
0	1		T495-p	sPAAPAAtHSEQAQP
0	1		T511-p	SLTTKPEtRAQLALH
0	1		S519-p	RAQLALHsAAFLsAK
0	1		S524-p	LHsAAFLsAKAAASS
0	1		S543	GSQPPLLSRPLPLGS
0	1		S550	SRPLPLGSMPTALLA

	mouse
K359	EKKPHVKKPLNAFML
K369	NAFMLYMKEMRAKVV
K374	YMKEMRAKVVAECTL
S399-p	GRKWHNLsREEQAKy
K405	LsREEQAKyyELARK
Y406-p	sREEQAKyyELARKE
Y407-p	REEQAKyyELARKER
S443-p	RKREKQLsQTQSQQQ
S460	EAEGALASKSKKPCI
S499	TPSAALASPAAPAAT
T506	SPAAPAATHSEQAQP
A522	SLTTKPEARAQLALH
S530	RAQLALHSAAFLSAK
S535	LHSAAFLSAKAAASN
S554-p	GSQPPLLsRPLPLGs
S561-p	sRPLPLGsMPAALLT

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