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Protein Page:
ZO1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ZO1 a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with tight junctions (TJ). May mediate dynamic changes in the composition of TJs. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting the protein kinase MRCKb to the leading edge of migrating cells. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Forms homodimers and heterodimers with ZO-2 or ZO-3. Interacts with occludin, CALM, claudins, CGN, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with MRCKb and MYZAP. Interacts (via PDZ domain) with Cx43. ZO-2 and ZO-3 shuttle between the TJ and the nucleus, where they may regulate gene expression. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins can be up- or downregulated in cancer and are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Alternative splicing produces two isoforms. The long isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: apical junction complex; intercellular canaliculus; tight junction; apicolateral plasma membrane; basolateral plasma membrane; cytosol; cell-cell adherens junction; apical part of cell; cytoplasm; apical plasma membrane; plasma membrane; gap junction; nucleus; cell junction
Molecular Function: protein C-terminus binding; calmodulin binding; protein domain specific binding; protein binding
Biological Process: response to drug; intercellular junction assembly; response to ethanol; apoptosis; negative regulation of vascular permeability; blastocyst formation; response to lipopolysaccharide; cell structure disassembly during apoptosis
Reference #:  Q07157 (UniProtKB)
Alt. Names/Synonyms: DKFZp686M05161; MGC133289; Tight junction protein 1; tight junction protein 1 (zona occludens 1); Tight junction protein ZO-1; TJP1; ZO-1; ZO1; zona occludens 1; Zona occludens protein 1; zonula occludens 1 protein; Zonula occludens protein 1
Gene Symbols: TJP1
Molecular weight: 195,459 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ZO1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
intracellular localization: S168‑p
molecular association, regulation: S168‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 56 S125-p RPDPEPVsDNEEDsy
0 32 S131-p VsDNEEDsyDEEIHD
0 26 Y132-p sDNEEDsyDEEIHDP
0 2 S141-p EEIHDPRsGRsGVVN
0 2 S144-p HDPRsGRsGVVNRRs
0 1 S151-p sGVVNRRsEKIWPRD
0 7 S160-p KIWPRDRsAsRERsL
0 2 S162-p WPRDRsAsRERsLsP
0 9 S166-p RsAsRERsLsPRSDR
2 18 S168-p AsRERsLsPRSDRRs
0 16 S175-p sPRSDRRsVAssQPA
0 14 S178-p SDRRsVAssQPAkPt
0 10 S179-p DRRsVAssQPAkPtK
0 2 K183-u VAssQPAkPtKVTLV
0 2 T185-p ssQPAkPtKVTLVKS
0 1 K194 VTLVKSRKNEEYGLR
0 7 S212-p HIFVKEIsQDSLAAR
0 1 S241 GTVTENMSLTDAKTL
0 7 S275-p LLNVPDLsDsIHsAN
0 8 S277-p NVPDLsDsIHsANAs
0 7 S280-p DLsDsIHsANAsERD
0 4 S284-p sIHsANAsERDDISE
0 1 S290 AsERDDISEIQsLAs
0 4 S294-p DDISEIQsLAsDHsG
0 10 S297-p SEIQsLAsDHsGRSH
0 8 S300-p QsLAsDHsGRSHDRP
0 1 S311 HDRPPRRSRsRsPDQ
0 2 S313-p RPPRRSRsRsPDQRS
0 4 S315-p PRRSRsRsPDQRSEP
0 1 S320 sRsPDQRSEPSDHSR
0 3 S323 PDQRSEPSDHSRHsP
0 3 S326 RSEPSDHSRHsPQQP
0 12 S329-p PSDHSRHsPQQPsNG
0 1 S334-p RHsPQQPsNGsLRsR
0 8 S337-p PQQPsNGsLRsRDEE
0 1 S340-p PsNGsLRsRDEERIs
0 2 S347-p sRDEERIsKPGAVst
0 1 K348 RDEERIsKPGAVstP
0 20 S353-p IsKPGAVstPVKHAD
0 19 T354-p sKPGAVstPVKHADD
0 7 T363-p VKHADDHtPKTVEEV
0 1 R374 VEEVTVERNEKQtPS
0 2 T379-p VERNEKQtPSLPEPK
0 15 Y389-p LPEPKPVyAQVGQPD
0 1 S402 PDVDLPVSPSDGVLP
0 1 S432-p VKFRKGDsVGLRLAG
0 1 T476-p RVNNVDFtNIIREEA
0 3 Y550-p FRVVDTLyNGkLGSW
0 2 K553-u VDTLyNGkLGSWLAI
0 1 S585-p NRAEQLAsVQytLPk
0 149 Y588-p EQLAsVQytLPkTAG
0 5 T589-p QLAsVQytLPkTAGG
0 1 K592-u sVQytLPkTAGGDRA
0 31 S617-p SKRNLRKsREDLsAQ
0 3 S622-p RKsREDLsAQPVQTK
0 1 T648-p AGFLRPVtIFGPIAD
0 3 Y669-p AREEPDIyQIAKSEP
0 1 K695-u IIRLHTIkQIIDQDk
0 1 K702-u kQIIDQDkHALLDVT
0 4 Y718-p NAVDRLNyAQWYPIV
0 1 T738-p DSKQGVKtMRMRLCP
1 0 T770-p KNNHHLFtTtINLNS
1 1 T772-p NHHLFtTtINLNSMN
0 1 T809-p EGKADGAtsDDLDLH
0 4 S810-p GKADGAtsDDLDLHD
0 12 S821-p DLHDDRLsyLsAPGs
0 3 Y822-p LHDDRLsyLsAPGsE
0 34 S824-p DDRLsyLsAPGsEys
0 7 S828-p syLsAPGsEysMyST
0 77 Y830-p LsAPGsEysMySTDs
0 6 S831-p sAPGsEysMySTDsR
0 2 Y833-p PGsEysMySTDsRHt
0 2 S837-p ysMySTDsRHtSDyE
0 1 T840-p ySTDsRHtSDyEDTD
0 1 S841 STDsRHtSDyEDTDT
0 1 Y843-p DsRHtSDyEDTDTEG
0 1 T846 HtSDyEDTDTEGGAY
0 2 T848 SDyEDTDTEGGAYtD
0 8 T854-p DTEGGAYtDQELDEt
0 1 T861-p tDQELDEtLNDEVGt
0 17 T868-p tLNDEVGtPPESAIT
0 1 T875 tPPESAITRSSEPVR
0 3 S886-p EPVREDSsGMHHENQ
0 3 Y895-p MHHENQTyPPYsPQA
0 2 S899-p NQTyPPYsPQAQPQP
0 31 S912-p QPIHRIDsPGFKPAs
0 3 S919-p sPGFKPAsQQKAEAs
0 2 S926-p sQQKAEAssPVPyLs
0 5 S927-p QQKAEAssPVPyLsP
0 9 Y931-p EAssPVPyLsPETNP
0 3 S933-p ssPVPyLsPETNPAS
0 2 S964-p EEPTPAPsTsysPQA
0 1 S966-p PTPAPsTsysPQADs
0 2 Y967-p TPAPsTsysPQADsL
0 5 S968-p PAPsTsysPQADsLR
0 2 S973-p sysPQADsLRtPstE
0 1 T976-p PQADsLRtPstEAAH
0 6 S978-p ADsLRtPstEAAHIM
0 10 T979-p DsLRtPstEAAHIML
0 8 Y1003 HVDPTKVYRKDPYPE
0 1 K1005 DPTKVYRKDPYPEEM
0 2 S1025-p VLKQPAVsHPGHRPD
0 3 Y1039-p DKEPNLTyEPQLPYV
0 4 S1051-p PYVEKQAsRDLEQPt
0 6 T1058-p sRDLEQPtyRyESSs
0 12 Y1059-p RDLEQPtyRyESSsy
0 4 Y1061-p LEQPtyRyESSsytD
0 2 S1065-p tyRyESSsytDQFSR
0 180 Y1066-p yRyESSsytDQFSRN
0 1 T1067-p RyESSsytDQFSRNy
0 1 S1071 SsytDQFSRNyEHRL
0 10 Y1074-p tDQFSRNyEHRLRYE
0 8 M1086 RYEDRVPMyEEQWSY
0 3 Y1087-p YEDRVPMyEEQWSYY
0 1 K1097 QWSYYDDKQPyPSRP
0 3 Y1100-p YYDDKQPyPSRPPFD
0 1 N1108 PSRPPFDNQHsQDLD
0 7 S1111-p PPFDNQHsQDLDSRQ
0 3 S1139-p FEEPAPLsyDSRPRy
0 6 Y1140-p EEPAPLsyDSRPRyE
0 13 Y1146-p syDSRPRyEQAPRAS
0 3 A1154 EQAPRASALRHEEQP
0 142 Y1165-p EEQPAPGyDtHGRLR
0 6 T1167-p QPAPGyDtHGRLRPE
0 41 H1178 LRPEAQPHPsAGPKP
0 1 S1180-p PEAQPHPsAGPKPAE
0 2 K1189-u GPKPAESkQyFEQys
0 50 Y1191-p KPAESkQyFEQysRs
0 99 Y1195-p SkQyFEQysRsyEQV
0 3 S1196-p kQyFEQysRsyEQVP
0 4 S1198-p yFEQysRsyEQVPPQ
0 7 Y1199-p FEQysRsyEQVPPQG
0 1 T1251 LPPPPTQTEEEEDPA
0 8 T1322-p QFSEHDKtLyRIPEP
0 111 Y1324-p SEHDKtLyRIPEPQK
0 27 Y1346-p DIVRSNHyDPEEDEE
0 17 Y1354-p DPEEDEEyyRKQLSy
0 28 Y1355-p PEEDEEyyRKQLSyF
0 1 K1357 EDEEyyRKQLSyFDR
0 3 Y1361-p yyRKQLSyFDRRsFE
0 4 S1366-p LSyFDRRsFENKPPA
0 1 P1372 RsFENKPPAHIAASH
0 1 S1389 EPAKPAHSQNQSNFS
0 2 N1391 AKPAHSQNQSNFSSy
0 1 Y1398-p NQSNFSSySSKGKPP
0 2 S1413-p EADGVDRsFGEkRyE
0 2 K1417-a VDRsFGEkRyEPIQA
0 3 Y1419-p RsFGEkRyEPIQAtP
0 10 T1425-p RyEPIQAtPPPPPLP
0 45 S1433-p PPPPPLPsQyAQPsQ
0 84 Y1435-p PPPLPsQyAQPsQPV
0 10 S1439-p PsQyAQPsQPVtsAs
0 3 T1443-p AQPsQPVtsAsLHIH
0 3 S1444-p QPsQPVtsAsLHIHs
0 19 S1446-p sQPVtsAsLHIHsKG
0 12 S1451-p sAsLHIHsKGAHGEG
0 20 Y1524-p QKTVTPAyNRFTPKP
0 3 Y1532-p NRFTPKPyTsSARPF
0 1 S1534-p FTPKPyTsSARPFER
0 3 S1545-p PFERKFEsPKFNHNL
0 2 S1570-p LSSKTPTsPKTLVKS
0 1 K1601-u SIHAEKPkyQINNIS
0 1 Y1602-p IHAEKPkyQINNIST
0 15 S1617-p VPKAIPVsPsAVEED
0 6 S1619-p KAIPVsPsAVEEDED
0 1 S1655-p SSIETGVsIIIPQGA
0 3 K1709-u PHGLKFLkPVELRLP
  ZO1 iso2  
S125 RPDPEPVSDNEEDSY
S131 VSDNEEDSYDEEIHD
Y132 SDNEEDSYDEEIHDP
S141 EEIHDPRSGRSGVVN
S144 HDPRSGRSGVVNRRS
S151 SGVVNRRSEKIWPRD
S160 KIWPRDRSASRERSL
S162 WPRDRSASRERSLSP
S166 RSASRERSLSPRSDR
S168 ASRERSLSPRSDRRS
S175 SPRSDRRSVASSQPA
S178 SDRRSVASSQPAKPT
S179 DRRSVASSQPAKPTK
K183 VASSQPAKPTKVTLV
T185 SSQPAKPTKVTLVKS
K194 VTLVKSRKNEEYGLR
S212 HIFVKEISQDSLAAR
S241 GTVTENMSLTDAKTL
S275 LLNVPDLSDSIHSAN
S277 NVPDLSDSIHSANAS
S280 DLSDSIHSANASERD
S284 SIHSANASERDDISE
S290 ASERDDISEIQSLAS
S294 DDISEIQSLASDHSG
S297 SEIQSLASDHSGRSH
S300 QSLASDHSGRSHDRP
S311 HDRPPRRSRSRSPDQ
S313 RPPRRSRSRSPDQRS
S315 PRRSRSRSPDQRSEP
S320 SRSPDQRSEPSDHSR
S323 PDQRSEPSDHSRHSP
S326 RSEPSDHSRHSPQQP
S329 PSDHSRHSPQQPSNG
S334 RHSPQQPSNGSLRSR
S337 PQQPSNGSLRSRDEE
S340 PSNGSLRSRDEERIS
S347 SRDEERISKPGAVSt
K348 RDEERISKPGAVStP
S353 ISKPGAVStPVKHAD
T354-p SKPGAVStPVKHADD
T363 VKHADDHTPKTVEEV
R374 VEEVTVERNEKQTPS
T379 VERNEKQTPSLPEPK
Y389 LPEPKPVYAQVGQPD
S402 PDVDLPVSPSDGVLP
S432 VKFRKGDSVGLRLAG
T476 RVNNVDFTNIIREEA
Y550 FRVVDTLYNGKLGSW
K553 VDTLYNGKLGSWLAI
S585 NRAEQLASVQyTLPK
Y588-p EQLASVQyTLPKTAG
T589 QLASVQyTLPKTAGG
K592 SVQyTLPKTAGGDRA
S617 SKRNLRKSREDLSAQ
S622 RKSREDLSAQPVQTK
T648 AGFLRPVTIFGPIAD
Y669 AREEPDIYQIAKSEP
K695 IIRLHTIKQIIDQDK
K702 KQIIDQDKHALLDVT
Y718 NAVDRLNYAQWYPIV
T738 DSKQGVKTMRMRLCP
T770 KNNHHLFTTTINLNS
T772 NHHLFTTTINLNSMN
T809 EGKADGATSDDLDLH
S810 GKADGATSDDLDLHD
S821 DLHDDRLSYLsAPGS
Y822 LHDDRLSYLsAPGSE
S824-p DDRLSYLsAPGSEyS
S828 SYLsAPGSEySMYST
Y830-p LsAPGSEySMYSTDS
S831 sAPGSEySMYSTDSR
Y833 PGSEySMYSTDSRHT
S837 ySMYSTDSRHTSDYE
T840 YSTDSRHTSDYEDTD
S841 STDSRHTSDYEDTDT
Y843 DSRHTSDYEDTDTEG
T846 HTSDYEDTDTEGGAY
T848 SDYEDTDTEGGAYtD
T854-p DTEGGAYtDQELDET
T861 tDQELDETLNDEVGT
T868 TLNDEVGTPPESAIT
T875 TPPESAITRSSEPVR
S886 EPVREDSSGMHHENQ
Y895 MHHENQTYPPYSPQA
S899 NQTYPPYSPQAQPQP
S912-p QPIHRIDsPGFKPAS
S919 sPGFKPASQQVyRKD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y923-p KPASQQVyRKDPYPE
K925 ASQQVyRKDPYPEEM
S945 VLKQPAVSHPGHRPD
Y959 DKEPNLTYEPQLPYV
S971 PYVEKQASRDLEQPT
T978 SRDLEQPTyRYESSS
Y979-p RDLEQPTyRYESSSy
Y981 LEQPTyRYESSSyTD
S985 TyRYESSSyTDQFSR
Y986-p yRYESSSyTDQFSRN
T987 RYESSSyTDQFSRNY
S991 SSyTDQFSRNYEHRL
Y994 TDQFSRNYEHRLRYE
M1006 RYEDRVPMYEEQWSY
Y1007 YEDRVPMYEEQWSYY
K1017 QWSYYDDKQPYPSRP
Y1020 YYDDKQPYPSRPPFD
N1028 PSRPPFDNQHSQDLD
S1031 PPFDNQHSQDLDSRQ
S1059 FEEPAPLSYDSRPRY
Y1060 EEPAPLSYDSRPRYE
Y1066 SYDSRPRYEQAPRAS
A1074 EQAPRASALRHEEQP
Y1085-p EEQPAPGyDTHGRLR
T1087 QPAPGyDTHGRLRPE
H1098 LRPEAQPHPSAGPKP
S1100 PEAQPHPSAGPKPAE
K1109 GPKPAESKQyFEQyS
Y1111-p KPAESKQyFEQySRS
Y1115-p SKQyFEQySRSYEQV
S1116 KQyFEQySRSYEQVP
S1118 yFEQySRSYEQVPPQ
Y1119 FEQySRSYEQVPPQG
T1171 LPPPPTQTEEEEDPA
T1242 QFSEHDKTLYRIPEP
Y1244 SEHDKTLYRIPEPQK
Y1266 DIVRSNHYDPEEDEE
Y1274 DPEEDEEYyRKQLSY
Y1275-p PEEDEEYyRKQLSYF
K1277 EDEEYyRKQLSYFDR
Y1281 YyRKQLSYFDRRSFE
S1286 LSYFDRRSFENKPPA
P1292 RSFENKPPAHIAASH
S1309 EPAKPAHSQNQSNFS
N1311 AKPAHSQNQSNFSSY
Y1318 NQSNFSSYSSKGKPP
S1333 EADGVDRSFGEkRYE
K1337-a VDRSFGEkRYEPIQA
Y1339 RSFGEkRYEPIQATP
T1345 RYEPIQATPPPPPLP
S1353 PPPPPLPSQyAQPSQ
Y1355-p PPPLPSQyAQPSQPV
S1359 PSQyAQPSQPVTSAS
T1363 AQPSQPVTSASLHIH
S1364 QPSQPVTSASLHIHS
S1366 SQPVTSASLHIHSKG
S1371 SASLHIHSKGAHGEG
Y1444 QKTVTPAYNRFTPKP
Y1452 NRFTPKPYTSSARPF
S1454 FTPKPYTSSARPFER
S1465 PFERKFESPKFNHNL
S1490 LSSKTPTSPKTLVKS
K1521 SIHAEKPKYQINNIS
Y1522 IHAEKPKYQINNIST
S1537 VPKAIPVSPSAVEED
S1539 KAIPVSPSAVEEDED
S1575 SSIETGVSIIIPQGA
K1629 PHGLKFLKPVELRLP
  mouse

► Hide Isoforms
 
S125-p HPDPEPVsDNEDDsy
S131-p VsDNEDDsyDEEVHD
Y132-p sDNEDDsyDEEVHDP
A141 EEVHDPRAGRGALAN
G144 HDPRAGRGALANRRS
S151 GALANRRSEKSWARD
S160-p KSWARDRsAsRERsL
S162-p WARDRsAsRERsLsP
S166-p RsAsRERsLsPRSDR
S168-p AsRERsLsPRSDRRs
S175-p sPRSDRRsVAssQPA
S178-p SDRRsVAssQPAkPT
S179-p DRRsVAssQPAkPTK
K183-u VAssQPAkPTKVTLV
T185 ssQPAkPTKVTLVKS
K194-u VTLVKSRkNEEYGLR
S212-p HIFVKEIsQDSLAAR
S241-p GTVTENMsLTDAKTL
S275-p LLNVPDLsDsIHsAN
S277-p NVPDLsDsIHsANAs
S280-p DLsDsIHsANAsERD
S284-p sIHsANAsERDDIsE
S290-p AsERDDIsEIQsLAs
S294-p DDIsEIQsLAsDHsG
S297-p sEIQsLAsDHsGRSH
S300-p QsLAsDHsGRSHDRP
S311-p HDRPPRRsQsRsPDQ
S313-p RPPRRsQsRsPDQRs
S315-p PRRsQsRsPDQRsEP
S320-p sRsPDQRsEPsDHsT
S323-p PDQRsEPsDHsTQsP
S326-p RsEPsDHsTQsPQQP
S329-p PsDHsTQsPQQPSNG
S334 TQsPQQPSNGsLRSR
S337-p PQQPSNGsLRSREEE
S340 PSNGsLRSREEERMS
S347 SREEERMSkPGAIst
K348-u REEERMSkPGAIstP
S353-p MSkPGAIstPVKHVD
T354-p SkPGAIstPVKHVDD
P363 VKHVDDHPPKAVEEV
K374-u VEEVTVEkNEKQtPT
T379-p VEkNEKQtPTLPEPK
Y389 LPEPKPVYAQVGQPD
S402 PDVDLPVSPSDGALP
S432 VKFRKGDSVGLRLAG
T476 RVNNVDFTNIIREEA
Y550 FRVVDTLYNGkLGSW
K553-u VDTLYNGkLGSWLAI
S585 NRAEQLASVQytLPK
Y588-p EQLASVQytLPKTAG
T589-p QLASVQytLPKTAGG
K592 SVQytLPKTAGGDRA
S617-p SKRNLRKsREDLsAQ
S622-p RKsREDLsAQPVQTK
T648 AGFLRPVTIFGPIAD
Y669 AREEPDIYQIAKSEP
K695 IIRLHTIKQIIDQDK
K702 KQIIDQDKHALLDVT
Y718 NAVDRLNYAQWYPIV
T738 DSKQGVKTMRMRLCP
T770 KNNHHLFTTTINLNS
T772 NHHLFTTTINLNSMN
T809-p EGKADGAtsDDLDLH
S810-p GKADGAtsDDLDLHD
S821-p DLHDDRLsyLsAPGs
Y822-p LHDDRLsyLsAPGsE
S824-p DDRLsyLsAPGsEys
S828-p syLsAPGsEysMYST
Y830-p LsAPGsEysMYSTDs
S831-p sAPGsEysMYSTDsR
Y833 PGsEysMYSTDsRHt
S837-p ysMYSTDsRHtsDyE
T840-p YSTDsRHtsDyEDtD
S841-p STDsRHtsDyEDtDt
Y843-p DsRHtsDyEDtDtEG
T846-p HtsDyEDtDtEGGAY
T848-p sDyEDtDtEGGAYtD
T854-p DtEGGAYtDQELDEt
T861-p tDQELDEtLNDEVGt
T868-p tLNDEVGtPPESAIT
T875 tPPESAITRSSEPVR
S886-p EPVREDSsGMHHENQ
Y895-p MHHENQTyPPYSPQA
S899 NQTyPPYSPQAQPQA
S912-p QAIHRIDsPGLKPAS
S919 sPGLKPASQQKAEAS
S926 SQQKAEASSPVPYLS
S927 QQKAEASSPVPYLSP
Y931 EASSPVPYLSPETTP
S933 SSPVPYLSPETTPAS
- gap
S966 PAPAPPTSHASQPGC
H967 APAPPTSHASQPGCL
- gap
- gap
- gap
S978 PGCLGAPSAEAAHVV
- gap
Y1003 HADPAKVYRkEPYSE
K1005-u DPAKVYRkEPYSEEM
G1025 ILKQPALGHPGQRPD
Y1039 DKEPNLAYEPQLPYI
S1051-p PYIEKQAsRDLEQPS
S1058 sRDLEQPSYRyEVSS
Y1059 RDLEQPSYRyEVSSy
Y1061-p LEQPSYRyEVSSyTD
S1065 SYRyEVSSyTDQFsR
Y1066-p YRyEVSSyTDQFsRN
T1067 RyEVSSyTDQFsRNY
S1071-p SSyTDQFsRNYDHRL
Y1074 TDQFsRNYDHRLRFE
T1086-p RFEDRIPtyEDQWSY
Y1087-p FEDRIPtyEDQWSYY
K1097-u QWSYYDDkQPyQPRP
Y1100-p YYDDkQPyQPRPFEN
N1107 yQPRPFENQHPRDLD
P1110 RPFENQHPRDLDSRQ
S1138-p FEEPAPLsYDSRTRy
Y1139 EEPAPLsYDSRTRyE
Y1145-p sYDSRTRyEQLPRTS
T1153-p EQLPRTStLRHEEQP
Y1164-p EEQPAPAyEVHNRYR
V1166 QPAPAyEVHNRYRPE
Y1177-p YRPEAQPySSTGPKS
S1179 PEAQPySSTGPKSSE
K1188-u GPKSSEPkQyFDQYP
Y1190-p KSSEPkQyFDQYPRS
Y1194 PkQyFDQYPRSYEQV
P1195 kQyFDQYPRSYEQVP
S1197 yFDQYPRSYEQVPPP
Y1198 FDQYPRSYEQVPPPG
T1250-p QPPPPTLtEEEEDPA
T1321 QFSEHDKTLyRLPEP
Y1323-p SEHDKTLyRLPEPQK
Y1345-p DIVRSNHyDPEEDEE
Y1353-p DPEEDEEyYRkQLSY
Y1354 PEEDEEyYRkQLSYF
K1356-u EDEEyYRkQLSYFDR
Y1360 yYRkQLSYFDRRSFE
S1365 LSYFDRRSFESKPsA
S1371-p RSFESKPsAHLPAGH
S1388-p EPAKPVHsQsQPNFS
S1390-p AKPVHsQsQPNFSSY
Y1397 sQPNFSSYSSKGKPE
S1411 ETDAVDRSFSEKRYD
K1415 VDRSFSEKRYDPAQA
Y1417 RSFSEKRYDPAQATP
T1423 RYDPAQATPPPPPLP
S1431 PPPPPLPSQYSQPAP
Y1433 PPPLPSQYSQPAPPL
A1437 PSQYSQPAPPLSSSs
S1441 SQPAPPLSSSsLHIH
S1442 QPAPPLSSSsLHIHS
S1444-p APPLSSSsLHIHSKG
S1449 SSsLHIHSKGAQGEG
Y1521-p QKTITPVyNRFTPKP
Y1529 NRFTPKPYTSSARPF
S1531 FTPKPYTSSARPFER
S1542-p PFERKFEsPKFNHNL
S1567 LSSKTPTSPKTLMKA
K1598 SVHTDKPKYQMNNIS
Y1599 VHTDKPKYQMNNIST
S1614-p MPKAVPVsPsAVEED
S1616-p KAVPVsPsAVEEDED
S1652 SSIETGVSIIIPQGA
K1706 PHGLKFLKPVELRLP
  ZO1 iso2  
S125 HPDPEPVSDNEDDSY
S131 VSDNEDDSYDEEVHD
Y132 SDNEDDSYDEEVHDP
A141 EEVHDPRAGRGALAN
G144 HDPRAGRGALANRRS
S151 GALANRRSEKSWARD
S160 KSWARDRSASRERSL
S162 WARDRSASRERSLSP
S166 RSASRERSLSPRSDR
S168 ASRERSLSPRSDRRS
S175 SPRSDRRSVASSQPA
S178 SDRRSVASSQPAKPT
S179 DRRSVASSQPAKPTK
K183 VASSQPAKPTKVTLV
T185 SSQPAKPTKVTLVKS
K194 VTLVKSRKNEEYGLR
S212 HIFVKEISQDSLAAR
S241 GTVTENMSLTDAKTL
S275 LLNVPDLSDSIHSAN
S277 NVPDLSDSIHSANAS
S280 DLSDSIHSANASERD
S284 SIHSANASERDDISE
S290 ASERDDISEIQSLAS
S294 DDISEIQSLASDHSG
S297 SEIQSLASDHSGRSH
S300 QSLASDHSGRSHDRP
S311 HDRPPRRSQSRSPDQ
S313 RPPRRSQSRSPDQRS
S315 PRRSQSRSPDQRSEP
S320 SRSPDQRSEPSDHST
S323 PDQRSEPSDHSTQSP
S326 RSEPSDHSTQSPQQP
S329 PSDHSTQSPQQPSNG
S334 TQSPQQPSNGSLRSR
S337 PQQPSNGSLRSREEE
S340 PSNGSLRSREEERMS
S347 SREEERMSKPGAIST
K348 REEERMSKPGAISTP
S353 MSKPGAISTPVKHVD
T354 SKPGAISTPVKHVDD
P363 VKHVDDHPPKAVEEV
K374 VEEVTVEKNEKQTPT
T379 VEKNEKQTPTLPEPK
Y389 LPEPKPVYAQVGQPD
S402 PDVDLPVSPSDGALP
S432 VKFRKGDSVGLRLAG
T476 RVNNVDFTNIIREEA
Y550 FRVVDTLYNGKLGSW
K553 VDTLYNGKLGSWLAI
S585 NRAEQLASVQYTLPK
Y588 EQLASVQYTLPKTAG
T589 QLASVQYTLPKTAGG
K592 SVQYTLPKTAGGDRA
S617 SKRNLRKSREDLSAQ
S622 RKSREDLSAQPVQTK
T648 AGFLRPVTIFGPIAD
Y669 AREEPDIYQIAKSEP
K695 IIRLHTIKQIIDQDK
K702 KQIIDQDKHALLDVT
Y718 NAVDRLNYAQWYPIV
T738 DSKQGVKTMRMRLCP
T770 KNNHHLFTTTINLNS
T772 NHHLFTTTINLNSMN
T809 EGKADGATSDDLDLH
S810 GKADGATSDDLDLHD
S821 DLHDDRLSYLSAPGS
Y822 LHDDRLSYLSAPGSE
S824 DDRLSYLSAPGSEYS
S828 SYLSAPGSEYSMYST
Y830 LSAPGSEYSMYSTDS
S831 SAPGSEYSMYSTDSR
Y833 PGSEYSMYSTDSRHT
S837 YSMYSTDSRHTSDYE
T840 YSTDSRHTSDYEDTD
S841 STDSRHTSDYEDTDT
Y843 DSRHTSDYEDTDTEG
T846 HTSDYEDTDTEGGAY
T848 SDYEDTDTEGGAYTD
T854 DTEGGAYTDQELDET
T861 TDQELDETLNDEVGT
T868 TLNDEVGTPPESAIT
T875 TPPESAITRSSEPVR
S886 EPVREDSSGMHHENQ
Y895 MHHENQTYPPYSPQA
S899 NQTYPPYSPQAQPQA
S912-p QAIHRIDsPGLKPAs
S919-p sPGLKPAsQQVyRKE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y923-p KPAsQQVyRKEPYSE
K925 AsQQVyRKEPYSEEM
G945 ILKQPALGHPGQRPD
Y959 DKEPNLAYEPQLPYI
S971 PYIEKQASRDLEQPS
S978 SRDLEQPSYRYEVSS
Y979 RDLEQPSYRYEVSSY
Y981 LEQPSYRYEVSSYTD
S985 SYRYEVSSYTDQFSR
Y986 YRYEVSSYTDQFSRN
T987 RYEVSSYTDQFSRNY
S991 SSYTDQFSRNYDHRL
Y994 TDQFSRNYDHRLRFE
T1006 RFEDRIPTYEDQWSY
Y1007 FEDRIPTYEDQWSYY
K1017 QWSYYDDKQPYQPRP
Y1020 YYDDKQPYQPRPFEN
N1027 YQPRPFENQHPRDLD
P1030 RPFENQHPRDLDSRQ
S1058 FEEPAPLSYDSRTRY
Y1059 EEPAPLSYDSRTRYE
Y1065 SYDSRTRYEQLPRTS
T1073 EQLPRTSTLRHEEQP
Y1084 EEQPAPAYEVHNRYR
V1086 QPAPAYEVHNRYRPE
Y1097 YRPEAQPYSSTGPKS
S1099 PEAQPYSSTGPKSSE
K1108 GPKSSEPKQYFDQYP
Y1110 KSSEPKQYFDQYPRS
Y1114 PKQYFDQYPRSYEQV
P1115 KQYFDQYPRSYEQVP
S1117 YFDQYPRSYEQVPPP
Y1118 FDQYPRSYEQVPPPG
T1170 QPPPPTLTEEEEDPA
T1241 QFSEHDKTLYRLPEP
Y1243 SEHDKTLYRLPEPQK
Y1265 DIVRSNHYDPEEDEE
Y1273 DPEEDEEYYRKQLSY
Y1274 PEEDEEYYRKQLSYF
K1276 EDEEYYRKQLSYFDR
Y1280 YYRKQLSYFDRRSFE
S1285 LSYFDRRSFESKPSA
S1291 RSFESKPSAHLPAGH
S1308 EPAKPVHSQSQPNFS
S1310 AKPVHSQSQPNFSSY
Y1317 SQPNFSSYSSKGKPE
S1331 ETDAVDRSFSEKRYD
K1335 VDRSFSEKRYDPAQA
Y1337 RSFSEKRYDPAQATP
T1343 RYDPAQATPPPPPLP
S1351 PPPPPLPSQYSQPAP
Y1353 PPPLPSQYSQPAPPL
A1357 PSQYSQPAPPLSSSS
S1361 SQPAPPLSSSSLHIH
S1362 QPAPPLSSSSLHIHS
S1364 APPLSSSSLHIHSKG
S1369 SSSLHIHSKGAQGEG
Y1441 QKTITPVYNRFTPKP
Y1449 NRFTPKPYTSSARPF
S1451 FTPKPYTSSARPFER
S1462 PFERKFESPKFNHNL
S1487 LSSKTPTSPKTLMKA
K1518 SVHTDKPKYQMNNIS
Y1519 VHTDKPKYQMNNIST
S1534 MPKAVPVSPSAVEED
S1536 KAVPVSPSAVEEDED
S1572 SSIETGVSIIIPQGA
K1626 PHGLKFLKPVELRLP
  rat

 
S113-p HPDPDPVsDNEDDsy
S119-p VsDNEDDsyDEDVHD
Y120-p sDNEDDsyDEDVHDP
S129 EDVHDPRSGRGALAN
G132 HDPRSGRGALANRRG
G139 GALANRRGEKSWARD
S148 KSWARDRSASRDRsL
S150 WARDRSASRDRsLsP
S154-p RSASRDRsLsPRSDR
S156-p ASRDRsLsPRSDRRs
S163-p sPRSDRRsVAssQPA
S166-p SDRRsVAssQPAKPt
S167-p DRRsVAssQPAKPtK
K171 VAssQPAKPtKVTLV
T173-p ssQPAKPtKVTLVKS
K182 VTLVKSRKNEEYGLR
S200-p HIFVKEIsQDSLAAR
S229 GTVTENMSLTDAKTL
S263 LLNVPDLSDSIHSAN
S265 NVPDLSDSIHSANAS
S268 DLSDSIHSANASERD
S272 SIHSANASERDDISE
S278 ASERDDISEIQSLAs
S282 DDISEIQSLAsDHSV
S285-p SEIQSLAsDHSVRSH
S288 QSLAsDHSVRSHDRP
S299 HDRPPRRSQSRsPDQ
S301 RPPRRSQSRsPDQRS
S303-p PRRSQSRsPDQRSEP
S308 SRsPDQRSEPSDHST
S311 PDQRSEPSDHSTQsP
S314 RSEPSDHSTQsPQQP
S317-p PSDHSTQsPQQPSNG
S322 TQsPQQPSNGsLRSR
S325-p PQQPSNGsLRSREEE
S328 PSNGsLRSREEERMS
S335 SREEERMSKPGAVST
K336 REEERMSKPGAVSTP
S341 MSKPGAVSTPVKHVD
T342 SKPGAVSTPVKHVDD
T351 VKHVDDHTPKAVEEV
K362 VEEVTVEKHEKQTPT
T367 VEKHEKQTPTLPEPK
Y377 LPEPKPVYAQVGQPD
S390-p PDVDLPVsPSDGVLP
S420 VKFRKGDSVGLRLAG
T464 RVNNVDFTNIIREEA
Y538 FRVVDTLYNGKLGSW
K541 VDTLYNGKLGSWLAI
S573 NRAEQLASVQYTLPK
Y576 EQLASVQYTLPKTAG
T577 QLASVQYTLPKTAGG
K580 SVQYTLPKTAGGDRA
S605-p SKRNLRKsREDLSAQ
S610 RKsREDLSAQPVQTK
T636 AGFLRPVTIFGPIAD
Y657 AREEPDIYQIAKSEP
K683 IIRLHTIKQIIDQDK
K690 KQIIDQDKHALLDVT
Y706 NAVDRLNYAQWYPIV
T726 DSKQGVKTMRMRLCP
T758 KNNHHLFTTTINLNS
T760 NHHLFTTTINLNSMN
T797 EGKADGATSDDLDLH
S798 GKADGATSDDLDLHD
S809 DLHDDRLSYLSAPGS
Y810 LHDDRLSYLSAPGSE
S812 DDRLSYLSAPGSEYS
S816 SYLSAPGSEYSMYST
Y818 LSAPGSEYSMYSTDS
S819 SAPGSEYSMYSTDSR
Y821 PGSEYSMYSTDSRHt
S825 YSMYSTDSRHtSDYE
T828-p YSTDSRHtSDYEDTD
S829 STDSRHtSDYEDTDT
Y831 DSRHtSDYEDTDTEG
T834 HtSDYEDTDTEGGAY
T836 SDYEDTDTEGGAYTD
T842 DTEGGAYTDQELDET
T849 TDQELDETLNDEVGt
T856-p TLNDEVGtPPESAIt
T863-p tPPESAItRSSEPVR
S874 EPVREDSSGMHHENQ
Y883 MHHENQTYPPYSPQA
S887 NQTYPPYSPQAQPQA
S900-p QAIHRIDsPGLKTAS
S907 sPGLKTASQQKAEAS
S914 SQQKAEASSPVPYLS
S915 QQKAEASSPVPYLSP
Y919 EASSPVPYLSPETNP
S921 SSPVPYLSPETNPAS
- gap
S954 PTPAPPTSHVSQADC
H955 TPAPPTSHVSQADCL
- gap
- gap
- gap
S966 ADCLGAPSPEAPHTM
- gap
Y991 HVDPAKVYRKEPYPE
K993 DPAKVYRKEPYPEEM
G1013 ILKQPALGHPGQRLD
Y1027 DKEPNPAYDPQLPYV
S1039-p PYVEKQAsRDLEQPP
P1046 sRDLEQPPYRYESSS
Y1047 RDLEQPPYRYESSSY
Y1049 LEQPPYRYESSSYTD
S1053 PYRYESSSYTDQFSR
Y1054 YRYESSSYTDQFSRN
T1055 RYESSSYTDQFSRNY
S1059 SSYTDQFSRNYDHRL
Y1062 TDQFSRNYDHRLRFE
T1074 RFEDRVPTYEDQWSY
Y1075 FEDRVPTYEDQWSYY
K1085 QWSYYDDKQPYPTRP
Y1088 YYDDKQPYPTRPFDt
T1095-p YPTRPFDtQHPRDLD
P1098 RPFDtQHPRDLDSRQ
P1126 FEEPAPLPYDSRPRY
Y1127 EEPAPLPYDSRPRYE
Y1133 PYDSRPRYEQLPRTS
T1141 EQLPRTSTLRHEEQP
Y1152-p EEQPTSGyEVHNRYR
V1154 QPTSGyEVHNRYRPE
Y1165-p YRPEAQPyAPAGPKS
P1167 PEAQPyAPAGPKSSE
K1176 GPKSSEPKQYFDQYP
Y1178 KSSEPKQYFDQYPRS
Y1182 PKQYFDQYPRSYEQV
P1183 KQYFDQYPRSYEQVP
S1185 YFDQYPRSYEQVPPP
Y1186 FDQYPRSYEQVPPPG
T1238 QPPPPALTEEEEDPA
T1309 QFSEHDKTLYRLPEP
Y1311 SEHDKTLYRLPEPQK
Y1333 DIVRSNHYDPEEDEE
Y1341 DPEEDEEYYRKQLSY
Y1342 PEEDEEYYRKQLSYF
K1344 EDEEYYRKQLSYFDR
Y1348 YYRKQLSYFDRRSFE
S1353 LSYFDRRSFESKPPA
P1359 RSFESKPPAHIPAGH
S1376 EPAKPVHSQSQPNFS
S1378 AKPVHSQSQPNFSSY
Y1385 SQPNFSSYSSKGKPE
S1399 ETDAMDRSFSEKRYD
K1403 MDRSFSEKRYDPTQA
Y1405 RSFSEKRYDPTQAMP
M1411 RYDPTQAMPPPPPLP
S1419 PPPPPLPSQYSQPVP
Y1421 PPPLPSQYSQPVPPL
V1425 PSQYSQPVPPLSNSS
S1429 SQPVPPLSNSSLHIH
N1430 QPVPPLSNSSLHIHS
S1432 VPPLSNSSLHIHSKA
S1437 NSSLHIHSKAAQSEG
Y1509 QKTITPAYNRFTPKP
Y1517 NRFTPKPYTSSARPF
S1519 FTPKPYTSSARPFER
S1530 PFERKFESPKFNHNL
S1555 LSSKPPPSPKTLMKA
K1586 SVHTDKPKYQINNIS
Y1587 VHTDKPKYQINNIST
S1602-p MPKAVPVsPsAVEED
S1604-p KAVPVsPsAVEEDED
S1640 SSIETGVSIIIPQGA
K1694 PHGLKFLKPVELRLP
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