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ZO1 (human)

Overview ZO1 a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with tight junctions (TJ). May mediate dynamic changes in the composition of TJs. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting the protein kinase MRCKb to the leading edge of migrating cells. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Forms homodimers and heterodimers with ZO-2 or ZO-3. Interacts with occludin, CALM, claudins, CGN, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with MRCKb and MYZAP. Interacts (via PDZ domain) with Cx43. ZO-2 and ZO-3 shuttle between the TJ and the nucleus, where they may regulate gene expression. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins can be up- or downregulated in cancer and are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Alternative splicing produces two isoforms. The long isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: apical junction complex; intercellular canaliculus; tight junction; basolateral plasma membrane; apicolateral plasma membrane; cytosol; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; gap junction; cell junction; nucleus Molecular Function: calmodulin binding; protein domain specific binding; protein binding Biological Process: intercellular junction assembly; apoptosis; blastocyst formation; cell structure disassembly during apoptosis Reference #:  Q07157 (UniProtKB) Alt. Names/Synonyms: DKFZp686M05161; MGC133289; Tight junction protein 1; tight junction protein 1 (zona occludens 1); Tight junction protein ZO-1; TJP1; ZO-1; ZO1; zona occludens 1; Zona occludens protein 1; zonula occludens 1 protein; Zonula occludens protein 1 Gene Symbols: TJP1 Molecular weight: 195,459 Da Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ZO1 2H2B - A=18-110 (human) 2H2C - A=18-110 (human) 2H3M - A=18-110 (human) 2JWE - A/B=185-264 (human) 2KXR - A=1631-1748 (human) 2KXS - A=1631-1748 (human) 2RCZ - A/B=185-264 (human) 3CYY - A/B=182-273 (human) 3LH5 - A=626-803 (human) 3SHU - A/B=421-512 (human) 3SHW - A=421-888 (human) 3TSV - A=417-516 (human) 3TSW - A/D/C/B=417-803 (human) 3TSZ - A=417-803 (human) 2RRM - A=18-110 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S168‑p molecular association, regulation: S168‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	52		S125-p	RPDPEPVsDNEEDsy
0	28		S131-p	VsDNEEDsyDEEIHD
0	24		Y132-p	sDNEEDsyDEEIHDP
0	2		S141-p	EEIHDPRsGRsGVVN
0	2		S144-p	HDPRsGRsGVVNRRs
0	1		S151-p	sGVVNRRsEKIWPRD
0	7		S160-p	KIWPRDRsAsRERsL
0	2		S162-p	WPRDRsAsRERsLsP
0	8		S166-p	RsAsRERsLsPRSDR
1	17		S168-p	AsRERsLsPRSDRRs
0	15		S175-p	sPRSDRRsVAssQPA
0	12		S178-p	SDRRsVAssQPAkPt
0	8		S179-p	DRRsVAssQPAkPtK
0	2		K183-u	VAssQPAkPtKVTLV
0	1		T185-p	ssQPAkPtKVTLVKS
0	1		K194	VTLVKSRKNEEYGLR
0	6		S212-p	HIFVKEIsQDSLAAR
0	1		S241	GTVTENMSLTDAKTL
0	6		S275-p	LLNVPDLsDsIHsAN
0	7		S277-p	NVPDLsDsIHsANAS
0	6		S280-p	DLsDsIHsANASERD
0	4		S284	sIHsANASERDDISE
0	1		S290	ASERDDISEIQsLAs
0	4		S294-p	DDISEIQsLAsDHsG
0	9		S297-p	SEIQsLAsDHsGRSH
0	8		S300-p	QsLAsDHsGRSHDRP
0	1		S311	HDRPPRRSRsRsPDQ
0	2		S313-p	RPPRRSRsRsPDQRS
0	3		S315-p	PRRSRsRsPDQRSEP
0	1		S320	sRsPDQRSEPsDHSR
0	3		S323-p	PDQRSEPsDHSRHsP
0	3		S326	RSEPsDHSRHsPQQP
0	1		R327	SEPsDHSRHsPQQPs
0	10		S329-p	PsDHSRHsPQQPsNG
0	1		S334-p	RHsPQQPsNGsLRsR
0	6		S337-p	PQQPsNGsLRsRDEE
0	1		S340-p	PsNGsLRsRDEERIs
0	2		S347-p	sRDEERIsKPGAVst
0	1		K348	RDEERIsKPGAVstP
0	20		S353-p	IsKPGAVstPVKHAD
0	18		T354-p	sKPGAVstPVKHADD
0	7		T363-p	VKHADDHtPKTVEEV
0	1		R374	VEEVTVERNEKQtPS
0	2		T379-p	VERNEKQtPSLPEPK
0	15		Y389-p	LPEPKPVyAQVGQPD
0	1		S432-p	VKFRKGDsVGLRLAG
0	1		T476-p	RVNNVDFtNIIREEA
0	2		Y520-p	SDVGDSFyIRTHFEY
0	1		T548-p	EVFRVVDtLyNGkLG
0	3		Y550-p	FRVVDtLyNGkLGSW
0	2		K553-u	VDtLyNGkLGSWLAI
0	1		S585-p	NRAEQLAsVQytLPk
0	149		Y588-p	EQLAsVQytLPkTAG
0	5		T589-p	QLAsVQytLPkTAGG
0	1		K592-u	sVQytLPkTAGGDRA
0	28		S617-p	SKRNLRKsREDLsAQ
0	3		S622-p	RKsREDLsAQPVQTK
0	1		Y633-p	VQTKFPAyERVVLRE
0	1		T648-p	AGFLRPVtIFGPIAD
0	3		Y669-p	AREEPDIyQIAKSEP
0	1		K695-u	IIRLHTIkQIIDQDk
0	1		K702-u	kQIIDQDkHALLDVT
0	4		Y718-p	NAVDRLNyAQWYPIV
0	1		K733-a	VFLNPDSkQGVktMR
0	1		K737-a	PDSkQGVktMRMRLC
0	1		T738-p	DSkQGVktMRMRLCP
0	1		T772-p	NHHLFTTtINLNSMN
0	1		T809	EGKADGATsDDLDLH
0	4		S810-p	GKADGATsDDLDLHD
0	11		S821-p	DLHDDRLsyLsAPGs
0	3		Y822-p	LHDDRLsyLsAPGsE
0	33		S824-p	DDRLsyLsAPGsEys
0	7		S828-p	syLsAPGsEysMyST
0	75		Y830-p	LsAPGsEysMySTDs
0	6		S831-p	sAPGsEysMySTDsR
0	2		Y833-p	PGsEysMySTDsRHT
0	1		S837-p	ysMySTDsRHTSDyE
0	1		S841	STDsRHTSDyEDTDt
0	1		Y843-p	DsRHTSDyEDTDtEG
0	1		T846	HTSDyEDTDtEGGAY
0	2		T848-p	SDyEDTDtEGGAYtD
0	8		T854-p	DtEGGAYtDQELDET
0	1		T861	tDQELDETLNDEVGt
0	15		T868-p	TLNDEVGtPPESAIT
0	1		S877-p	PESAITRsSEPVRED
0	1		S885	SEPVREDSsGMHHEN
0	3		S886-p	EPVREDSsGMHHENQ
0	1		T894-p	GMHHENQtyPPYsPQ
0	2		Y895-p	MHHENQtyPPYsPQA
0	1		S899-p	NQtyPPYsPQAQPQP
0	26		S912-p	QPIHRIDsPGFKPAs
0	3		S919-p	sPGFKPAsQQKAEAs
0	1		S926-p	sQQKAEAssPVPyLs
0	5		S927-p	QQKAEAssPVPyLsP
0	9		Y931-p	EAssPVPyLsPETNP
0	3		S933-p	ssPVPyLsPETNPAS
0	2		S964-p	EEPTPAPsTsysPQA
0	1		S966-p	PTPAPsTsysPQADs
0	2		Y967-p	TPAPsTsysPQADsL
0	4		S968-p	PAPsTsysPQADsLR
0	2		S973-p	sysPQADsLRtPstE
0	1		T976-p	PQADsLRtPstEAAH
0	6		S978-p	ADsLRtPstEAAHIM
0	10		T979-p	DsLRtPstEAAHIML
0	7		Y1003	HVDPTKVYRKDPYPE
0	1		K1005	DPTKVYRKDPYPEEM
0	2		S1025-p	VLKQPAVsHPGHRPD
0	3		Y1039-p	DKEPNLTyEPQLPYV
0	2		S1051-p	PYVEKQAsRDLEQPt
0	6		T1058-p	sRDLEQPtyRyESss
0	11		Y1059-p	RDLEQPtyRyESssy
0	3		Y1061-p	LEQPtyRyESssytD
0	1		S1064-p	PtyRyESssytDQFS
0	2		S1065-p	tyRyESssytDQFSR
0	177		Y1066-p	yRyESssytDQFSRN
0	1		T1067-p	RyESssytDQFSRNy
0	1		S1071	ssytDQFSRNyEHRL
0	10		Y1074-p	tDQFSRNyEHRLRYE
0	8		M1086	RYEDRVPMyEEQWSY
0	3		Y1087-p	YEDRVPMyEEQWSYY
0	1		K1097	QWSYYDDKQPYPSRP
0	3		Y1100	YYDDKQPYPSRPPFD
0	6		S1111-p	PPFDNQHsQDLDSRQ
0	1		Y1128-p	EESSERGyFPRFEEP
0	3		S1139-p	FEEPAPLsyDsRPRy
0	5		Y1140-p	EEPAPLsyDsRPRyE
0	1		S1142-p	PAPLsyDsRPRyEQA
0	12		Y1146-p	syDsRPRyEQAPRAS
0	3		A1154	EQAPRASALRHEEQP
0	141		Y1165-p	EEQPAPGyDtHGRLR
0	6		T1167-p	QPAPGyDtHGRLRPE
0	40		H1178	LRPEAQPHPSAGPKP
0	1		P1179	RPEAQPHPSAGPKPA
0	1		A1186	PSAGPKPAESkQyFE
0	2		K1189-u	GPKPAESkQyFEQys
0	49		Y1191-p	KPAESkQyFEQysRs
0	98		Y1195-p	SkQyFEQysRsyEQV
0	3		S1196-p	kQyFEQysRsyEQVP
0	4		S1198-p	yFEQysRsyEQVPPQ
0	7		Y1199-p	FEQysRsyEQVPPQG
0	1		T1251	LPPPPTQTEEEEDPA
0	1		K1274	RVKMFENKRSASLET
0	8		T1322-p	QFSEHDKtLyRIPEP
0	111		Y1324-p	SEHDKtLyRIPEPQK
0	26		Y1346-p	DIVRSNHyDPEEDEE
0	16		Y1354-p	DPEEDEEyyRKQLSy
0	27		Y1355-p	PEEDEEyyRKQLSyF
0	1		K1357	EDEEyyRKQLSyFDR
0	2		Y1361-p	yyRKQLSyFDRRsFE
0	4		S1366-p	LSyFDRRsFENKPPA
0	1		P1372	RsFENKPPAHIAASH
0	1		S1389	EPAKPAHSQNQSNFS
0	2		N1391	AKPAHSQNQSNFSSY
0	1		S1396	SQNQSNFSSYSSKGK
0	1		S1413-p	EADGVDRsFGEkRyE
0	2		K1417-a	VDRsFGEkRyEPIQA
0	3		Y1419-p	RsFGEkRyEPIQAtP
0	10		T1425-p	RyEPIQAtPPPPPLP
0	45		S1433-p	PPPPPLPsQyAQPsQ
0	84		Y1435-p	PPPLPsQyAQPsQPV
0	10		S1439-p	PsQyAQPsQPVtsAs
0	3		T1443-p	AQPsQPVtsAsLHIH
0	3		S1444-p	QPsQPVtsAsLHIHs
0	19		S1446-p	sQPVtsAsLHIHsKG
0	12		S1451-p	sAsLHIHsKGAHGEG
0	20		Y1524-p	QKTVTPAyNRFTPKP
0	2		Y1532-p	NRFTPKPyTsSARPF
0	1		S1534-p	FTPKPyTsSARPFER
0	3		S1545-p	PFERKFEsPKFNHNL
0	1		S1570-p	LSSKTPTsPKTLVKS
0	1		K1601-u	SIHAEKPkyQINNIS
0	1		Y1602-p	IHAEKPkyQINNIST
0	13		S1617-p	VPKAIPVsPsAVEED
0	5		S1619-p	KAIPVsPsAVEEDED
0	1		S1655-p	SSIETGVsIIIPQGA
0	3		K1709-u	PHGLKFLkPVELRLP

	ZO1 iso2
S125	RPDPEPVSDNEEDSY
S131	VSDNEEDSYDEEIHD
Y132	SDNEEDSYDEEIHDP
S141	EEIHDPRSGRSGVVN
S144	HDPRSGRSGVVNRRS
S151	SGVVNRRSEKIWPRD
S160	KIWPRDRSASRERSL
S162	WPRDRSASRERSLSP
S166	RSASRERSLSPRSDR
S168	ASRERSLSPRSDRRS
S175	SPRSDRRSVASSQPA
S178	SDRRSVASSQPAKPT
S179	DRRSVASSQPAKPTK
K183	VASSQPAKPTKVTLV
T185	SSQPAKPTKVTLVKS
K194	VTLVKSRKNEEYGLR
S212	HIFVKEISQDSLAAR
S241	GTVTENMSLTDAKTL
S275	LLNVPDLSDSIHSAN
S277	NVPDLSDSIHSANAS
S280	DLSDSIHSANASERD
S284	SIHSANASERDDISE
S290	ASERDDISEIQSLAS
S294	DDISEIQSLASDHSG
S297	SEIQSLASDHSGRSH
S300	QSLASDHSGRSHDRP
S311	HDRPPRRSRSRSPDQ
S313	RPPRRSRSRSPDQRS
S315	PRRSRSRSPDQRSEP
S320	SRSPDQRSEPSDHSR
S323	PDQRSEPSDHSRHSP
S326	RSEPSDHSRHSPQQP
R327	SEPSDHSRHSPQQPS
S329	PSDHSRHSPQQPSNG
S334	RHSPQQPSNGSLRSR
S337	PQQPSNGSLRSRDEE
S340	PSNGSLRSRDEERIS
S347	SRDEERISKPGAVSt
K348	RDEERISKPGAVStP
S353	ISKPGAVStPVKHAD
T354-p	SKPGAVStPVKHADD
T363	VKHADDHTPKTVEEV
R374	VEEVTVERNEKQTPS
T379	VERNEKQTPSLPEPK
Y389	LPEPKPVYAQVGQPD
S432	VKFRKGDSVGLRLAG
T476	RVNNVDFTNIIREEA
Y520	SDVGDSFYIRTHFEY
T548	EVFRVVDTLYNGKLG
Y550	FRVVDTLYNGKLGSW
K553	VDTLYNGKLGSWLAI
S585	NRAEQLASVQyTLPK
Y588-p	EQLASVQyTLPKTAG
T589	QLASVQyTLPKTAGG
K592	SVQyTLPKTAGGDRA
S617	SKRNLRKSREDLSAQ
S622	RKSREDLSAQPVQTK
Y633	VQTKFPAYERVVLRE
T648	AGFLRPVTIFGPIAD
Y669	AREEPDIYQIAKSEP
K695	IIRLHTIKQIIDQDK
K702	KQIIDQDKHALLDVT
Y718	NAVDRLNYAQWYPIV
K733	VFLNPDSKQGVKTMR
K737	PDSKQGVKTMRMRLC
T738	DSKQGVKTMRMRLCP
T772	NHHLFTTTINLNSMN
T809	EGKADGATSDDLDLH
S810	GKADGATSDDLDLHD
S821	DLHDDRLSYLsAPGS
Y822	LHDDRLSYLsAPGSE
S824-p	DDRLSYLsAPGSEyS
S828	SYLsAPGSEySMYST
Y830-p	LsAPGSEySMYSTDS
S831	sAPGSEySMYSTDSR
Y833	PGSEySMYSTDSRHT
S837	ySMYSTDSRHTSDYE
S841	STDSRHTSDYEDTDT
Y843	DSRHTSDYEDTDTEG
T846	HTSDYEDTDTEGGAY
T848	SDYEDTDTEGGAYtD
T854-p	DTEGGAYtDQELDET
T861	tDQELDETLNDEVGT
T868	TLNDEVGTPPESAIT
S877	PESAITRSSEPVRED
S885	SEPVREDSSGMHHEN
S886	EPVREDSSGMHHENQ
T894	GMHHENQTYPPYSPQ
Y895	MHHENQTYPPYSPQA
S899	NQTYPPYSPQAQPQP
S912-p	QPIHRIDsPGFKPAS
S919	sPGFKPASQQVyRKD
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y923-p	KPASQQVyRKDPYPE
K925	ASQQVyRKDPYPEEM
S945	VLKQPAVSHPGHRPD
Y959	DKEPNLTYEPQLPYV
S971	PYVEKQASRDLEQPT
T978	SRDLEQPTyRYESSS
Y979-p	RDLEQPTyRYESSSy
Y981	LEQPTyRYESSSyTD
S984	PTyRYESSSyTDQFS
S985	TyRYESSSyTDQFSR
Y986-p	yRYESSSyTDQFSRN
T987	RYESSSyTDQFSRNY
S991	SSyTDQFSRNYEHRL
Y994	TDQFSRNYEHRLRYE
M1006	RYEDRVPMYEEQWSY
Y1007	YEDRVPMYEEQWSYY
K1017	QWSYYDDKQPYPSRP
Y1020	YYDDKQPYPSRPPFD
S1031	PPFDNQHSQDLDSRQ
Y1048	EESSERGYFPRFEEP
S1059	FEEPAPLSYDSRPRY
Y1060	EEPAPLSYDSRPRYE
S1062	PAPLSYDSRPRYEQA
Y1066	SYDSRPRYEQAPRAS
A1074	EQAPRASALRHEEQP
Y1085-p	EEQPAPGyDTHGRLR
T1087	QPAPGyDTHGRLRPE
H1098	LRPEAQPHPSAGPKP
P1099	RPEAQPHPSAGPKPA
A1106	PSAGPKPAESKQyFE
K1109	GPKPAESKQyFEQyS
Y1111-p	KPAESKQyFEQySRS
Y1115-p	SKQyFEQySRSYEQV
S1116	KQyFEQySRSYEQVP
S1118	yFEQySRSYEQVPPQ
Y1119	FEQySRSYEQVPPQG
T1171	LPPPPTQTEEEEDPA
K1194	RVKMFENKRSASLET
T1242	QFSEHDKTLYRIPEP
Y1244	SEHDKTLYRIPEPQK
Y1266	DIVRSNHYDPEEDEE
Y1274	DPEEDEEYyRKQLSY
Y1275-p	PEEDEEYyRKQLSYF
K1277	EDEEYyRKQLSYFDR
Y1281	YyRKQLSYFDRRSFE
S1286	LSYFDRRSFENKPPA
P1292	RSFENKPPAHIAASH
S1309	EPAKPAHSQNQSNFS
N1311	AKPAHSQNQSNFSSY
S1316	SQNQSNFSSYSSKGK
S1333	EADGVDRSFGEkRYE
K1337-a	VDRSFGEkRYEPIQA
Y1339	RSFGEkRYEPIQATP
T1345	RYEPIQATPPPPPLP
S1353	PPPPPLPSQyAQPSQ
Y1355-p	PPPLPSQyAQPSQPV
S1359	PSQyAQPSQPVTSAS
T1363	AQPSQPVTSASLHIH
S1364	QPSQPVTSASLHIHS
S1366	SQPVTSASLHIHSKG
S1371	SASLHIHSKGAHGEG
Y1444	QKTVTPAYNRFTPKP
Y1452	NRFTPKPYTSSARPF
S1454	FTPKPYTSSARPFER
S1465	PFERKFESPKFNHNL
S1490	LSSKTPTSPKTLVKS
K1521	SIHAEKPKYQINNIS
Y1522	IHAEKPKYQINNIST
S1537	VPKAIPVSPSAVEED
S1539	KAIPVSPSAVEEDED
S1575	SSIETGVSIIIPQGA
K1629	PHGLKFLKPVELRLP

	mouse ► Hide Isoforms
S125-p	HPDPEPVsDNEDDsy
S131-p	VsDNEDDsyDEEVHD
Y132-p	sDNEDDsyDEEVHDP
A141	EEVHDPRAGRGALAN
G144	HDPRAGRGALANRRS
S151	GALANRRSEKSWARD
S160-p	KSWARDRsAsRERsL
S162-p	WARDRsAsRERsLsP
S166-p	RsAsRERsLsPRSDR
S168-p	AsRERsLsPRSDRRs
S175-p	sPRSDRRsVAssQPA
S178-p	SDRRsVAssQPAkPT
S179-p	DRRsVAssQPAkPTK
K183-u	VAssQPAkPTKVTLV
T185	ssQPAkPTKVTLVKS
K194-u	VTLVKSRkNEEYGLR
S212-p	HIFVKEIsQDSLAAR
S241-p	GTVTENMsLTDAKTL
S275-p	LLNVPDLsDsIHsAN
S277-p	NVPDLsDsIHsANAs
S280-p	DLsDsIHsANAsERD
S284-p	sIHsANAsERDDIsE
S290-p	AsERDDIsEIQsLAs
S294-p	DDIsEIQsLAsDHsG
S297-p	sEIQsLAsDHsGRSH
S300-p	QsLAsDHsGRSHDRP
S311-p	HDRPPRRsQsRsPDQ
S313-p	RPPRRsQsRsPDQRs
S315-p	PRRsQsRsPDQRsEP
S320-p	sRsPDQRsEPsDHst
S323-p	PDQRsEPsDHstQsP
S326-p	RsEPsDHstQsPQQP
T327-p	sEPsDHstQsPQQPS
S329-p	PsDHstQsPQQPSNG
S334	tQsPQQPSNGsLRSR
S337-p	PQQPSNGsLRSREEE
S340	PSNGsLRSREEERMS
S347	SREEERMSkPGAIst
K348-u	REEERMSkPGAIstP
S353-p	MSkPGAIstPVKHVD
T354-p	SkPGAIstPVKHVDD
P363	VKHVDDHPPKAVEEV
K374-u	VEEVTVEkNEKQtPT
T379-p	VEkNEKQtPTLPEPK
Y389	LPEPKPVYAQVGQPD
S432	VKFRKGDSVGLRLAG
T476	RVNNVDFTNIIREEA
Y520	SDVGDSFYIRTHFEY
T548	EVFRVVDTLYNGkLG
Y550	FRVVDTLYNGkLGSW
K553-u	VDTLYNGkLGSWLAI
S585	NRAEQLASVQytLPK
Y588-p	EQLASVQytLPKTAG
T589-p	QLASVQytLPKTAGG
K592	SVQytLPKTAGGDRA
S617-p	SKRNLRKsREDLsAQ
S622-p	RKsREDLsAQPVQTK
Y633	VQTKFPAYERVVLRE
T648	AGFLRPVTIFGPIAD
Y669	AREEPDIYQIAKSEP
K695	IIRLHTIKQIIDQDK
K702	KQIIDQDKHALLDVT
Y718	NAVDRLNYAQWYPIV
K733	VFLNPDSKQGVKTMR
K737	PDSKQGVKTMRMRLC
T738	DSKQGVKTMRMRLCP
T772	NHHLFTTTINLNSMN
T809-p	EGKADGAtsDDLDLH
S810-p	GKADGAtsDDLDLHD
S821-p	DLHDDRLsyLsAPGs
Y822-p	LHDDRLsyLsAPGsE
S824-p	DDRLsyLsAPGsEys
S828-p	syLsAPGsEysMYST
Y830-p	LsAPGsEysMYSTDs
S831-p	sAPGsEysMYSTDsR
Y833	PGsEysMYSTDsRHT
S837-p	ysMYSTDsRHTsDyE
S841-p	STDsRHTsDyEDtDt
Y843-p	DsRHTsDyEDtDtEG
T846-p	HTsDyEDtDtEGGAY
T848-p	sDyEDtDtEGGAYtD
T854-p	DtEGGAYtDQELDEt
T861-p	tDQELDEtLNDEVGt
T868-p	tLNDEVGtPPESAIT
S877	PESAITRSSEPVRED
S885-p	SEPVREDssGMHHEN
S886-p	EPVREDssGMHHENQ
T894	GMHHENQTyPPYSPQ
Y895-p	MHHENQTyPPYSPQA
S899	NQTyPPYSPQAQPQA
S912-p	QAIHRIDsPGLKPAS
S919	sPGLKPASQQKAEAS
S926	SQQKAEASSPVPYLS
S927	QQKAEASSPVPYLSP
Y931	EASSPVPYLSPETTP
S933	SSPVPYLSPETTPAS
P964	EEPAPAPPTSHASQP
S966	PAPAPPTSHASQPGC
H967	APAPPTSHASQPGCL
A968	PAPPTSHASQPGCLG
C973	SHASQPGCLGAPSAE
A976	SQPGCLGAPSAEAAH
S978	PGCLGAPSAEAAHVV
A979	GCLGAPSAEAAHVVL
Y1003	HADPAKVYRkEPYSE
K1005-u	DPAKVYRkEPYSEEM
G1025	ILKQPALGHPGQRPD
Y1039	DKEPNLAYEPQLPYI
S1051-p	PYIEKQAsRDLEQPS
S1058	sRDLEQPSYRyEVSS
Y1059	RDLEQPSYRyEVSSy
Y1061-p	LEQPSYRyEVSSyTD
S1064	PSYRyEVSSyTDQFs
S1065	SYRyEVSSyTDQFsR
Y1066-p	YRyEVSSyTDQFsRN
T1067	RyEVSSyTDQFsRNY
S1071-p	SSyTDQFsRNYDHRL
Y1074	TDQFsRNYDHRLRFE
T1086-p	RFEDRIPtyEDQWSY
Y1087-p	FEDRIPtyEDQWSYY
K1097-u	QWSYYDDkQPyQPRP
Y1100-p	YYDDkQPyQPRPFEN
P1110	RPFENQHPRDLDSRQ
Y1127	EEASERGYFQRFEEP
S1138-p	FEEPAPLsYDSRTRy
Y1139	EEPAPLsYDSRTRyE
S1141	PAPLsYDSRTRyEQL
Y1145-p	sYDSRTRyEQLPRTS
T1153-p	EQLPRTStLRHEEQP
Y1164-p	EEQPAPAyEVHNRYR
V1166	QPAPAyEVHNRYRPE
Y1177-p	YRPEAQPysSTGPKS
S1178-p	RPEAQPysSTGPKSs
S1185-p	sSTGPKSsEPkQyFD
K1188-u	GPKSsEPkQyFDQYP
Y1190-p	KSsEPkQyFDQYPRS
Y1194	PkQyFDQYPRSYEQV
P1195	kQyFDQYPRSYEQVP
S1197	yFDQYPRSYEQVPPP
Y1198	FDQYPRSYEQVPPPG
T1250-p	QPPPPTLtEEEEDPA
K1273-a	RVKMFENkRSASLEN
T1321	QFSEHDKTLyRLPEP
Y1323-p	SEHDKTLyRLPEPQK
Y1345-p	DIVRSNHyDPEEDEE
Y1353-p	DPEEDEEyYRkQLSY
Y1354	PEEDEEyYRkQLSYF
K1356-u	EDEEyYRkQLSYFDR
Y1360	yYRkQLSYFDRRSFE
S1365	LSYFDRRSFESKPsA
S1371-p	RSFESKPsAHLPAGH
S1388-p	EPAKPVHsQsQPNFs
S1390-p	AKPVHsQsQPNFsSY
S1395-p	sQsQPNFsSYSSKGK
S1411	ETDAVDRSFSEKRYD
K1415	VDRSFSEKRYDPAQA
Y1417	RSFSEKRYDPAQATP
T1423	RYDPAQATPPPPPLP
S1431	PPPPPLPSQYSQPAP
Y1433	PPPLPSQYSQPAPPL
A1437	PSQYSQPAPPLSSSs
S1441	SQPAPPLSSSsLHIH
S1442	QPAPPLSSSsLHIHS
S1444-p	APPLSSSsLHIHSKG
S1449	SSsLHIHSKGAQGEG
Y1521-p	QKTITPVyNRFTPKP
Y1529	NRFTPKPYTSSARPF
S1531	FTPKPYTSSARPFER
S1542-p	PFERKFEsPKFNHNL
S1567	LSSKTPTSPKTLMKA
K1598	SVHTDKPKYQMNNIS
Y1599	VHTDKPKYQMNNIST
S1614-p	MPKAVPVsPSAVEED
S1616	KAVPVsPSAVEEDED
S1652	SSIETGVSIIIPQGA
K1706	PHGLKFLKPVELRLP

	ZO1 iso2
S125	HPDPEPVSDNEDDSY
S131	VSDNEDDSYDEEVHD
Y132	SDNEDDSYDEEVHDP
A141	EEVHDPRAGRGALAN
G144	HDPRAGRGALANRRS
S151	GALANRRSEKSWARD
S160	KSWARDRSASRERSL
S162	WARDRSASRERSLSP
S166	RSASRERSLSPRSDR
S168	ASRERSLSPRSDRRS
S175	SPRSDRRSVASSQPA
S178	SDRRSVASSQPAKPT
S179	DRRSVASSQPAKPTK
K183	VASSQPAKPTKVTLV
T185	SSQPAKPTKVTLVKS
K194	VTLVKSRKNEEYGLR
S212	HIFVKEISQDSLAAR
S241	GTVTENMSLTDAKTL
S275	LLNVPDLSDSIHSAN
S277	NVPDLSDSIHSANAS
S280	DLSDSIHSANASERD
S284	SIHSANASERDDISE
S290	ASERDDISEIQSLAS
S294	DDISEIQSLASDHSG
S297	SEIQSLASDHSGRSH
S300	QSLASDHSGRSHDRP
S311	HDRPPRRSQSRSPDQ
S313	RPPRRSQSRSPDQRS
S315	PRRSQSRSPDQRSEP
S320	SRSPDQRSEPSDHST
S323	PDQRSEPSDHSTQSP
S326	RSEPSDHSTQSPQQP
T327	SEPSDHSTQSPQQPS
S329	PSDHSTQSPQQPSNG
S334	TQSPQQPSNGSLRSR
S337	PQQPSNGSLRSREEE
S340	PSNGSLRSREEERMS
S347	SREEERMSKPGAIST
K348	REEERMSKPGAISTP
S353	MSKPGAISTPVKHVD
T354	SKPGAISTPVKHVDD
P363	VKHVDDHPPKAVEEV
K374	VEEVTVEKNEKQTPT
T379	VEKNEKQTPTLPEPK
Y389	LPEPKPVYAQVGQPD
S432	VKFRKGDSVGLRLAG
T476	RVNNVDFTNIIREEA
Y520	SDVGDSFYIRTHFEY
T548	EVFRVVDTLYNGKLG
Y550	FRVVDTLYNGKLGSW
K553	VDTLYNGKLGSWLAI
S585	NRAEQLASVQYTLPK
Y588	EQLASVQYTLPKTAG
T589	QLASVQYTLPKTAGG
K592	SVQYTLPKTAGGDRA
S617	SKRNLRKSREDLSAQ
S622	RKSREDLSAQPVQTK
Y633	VQTKFPAYERVVLRE
T648	AGFLRPVTIFGPIAD
Y669	AREEPDIYQIAKSEP
K695	IIRLHTIKQIIDQDK
K702	KQIIDQDKHALLDVT
Y718	NAVDRLNYAQWYPIV
K733	VFLNPDSKQGVKTMR
K737	PDSKQGVKTMRMRLC
T738	DSKQGVKTMRMRLCP
T772	NHHLFTTTINLNSMN
T809	EGKADGATSDDLDLH
S810	GKADGATSDDLDLHD
S821	DLHDDRLSYLSAPGS
Y822	LHDDRLSYLSAPGSE
S824	DDRLSYLSAPGSEYS
S828	SYLSAPGSEYSMYST
Y830	LSAPGSEYSMYSTDS
S831	SAPGSEYSMYSTDSR
Y833	PGSEYSMYSTDSRHT
S837	YSMYSTDSRHTSDYE
S841	STDSRHTSDYEDTDT
Y843	DSRHTSDYEDTDTEG
T846	HTSDYEDTDTEGGAY
T848	SDYEDTDTEGGAYTD
T854	DTEGGAYTDQELDET
T861	TDQELDETLNDEVGT
T868	TLNDEVGTPPESAIT
S877	PESAITRSSEPVRED
S885	SEPVREDSSGMHHEN
S886	EPVREDSSGMHHENQ
T894	GMHHENQTYPPYSPQ
Y895	MHHENQTYPPYSPQA
S899	NQTYPPYSPQAQPQA
S912-p	QAIHRIDsPGLKPAs
S919-p	sPGLKPAsQQVyRKE
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y923-p	KPAsQQVyRKEPYSE
K925	AsQQVyRKEPYSEEM
G945	ILKQPALGHPGQRPD
Y959	DKEPNLAYEPQLPYI
S971	PYIEKQASRDLEQPS
S978	SRDLEQPSYRYEVSS
Y979	RDLEQPSYRYEVSSY
Y981	LEQPSYRYEVSSYTD
S984	PSYRYEVSSYTDQFS
S985	SYRYEVSSYTDQFSR
Y986	YRYEVSSYTDQFSRN
T987	RYEVSSYTDQFSRNY
S991	SSYTDQFSRNYDHRL
Y994	TDQFSRNYDHRLRFE
T1006	RFEDRIPTYEDQWSY
Y1007	FEDRIPTYEDQWSYY
K1017	QWSYYDDKQPYQPRP
Y1020	YYDDKQPYQPRPFEN
P1030	RPFENQHPRDLDSRQ
Y1047	EEASERGYFQRFEEP
S1058	FEEPAPLSYDSRTRY
Y1059	EEPAPLSYDSRTRYE
S1061	PAPLSYDSRTRYEQL
Y1065	SYDSRTRYEQLPRTS
T1073	EQLPRTSTLRHEEQP
Y1084	EEQPAPAYEVHNRYR
V1086	QPAPAYEVHNRYRPE
Y1097	YRPEAQPYSSTGPKS
S1098	RPEAQPYSSTGPKSS
S1105	SSTGPKSSEPKQYFD
K1108	GPKSSEPKQYFDQYP
Y1110	KSSEPKQYFDQYPRS
Y1114	PKQYFDQYPRSYEQV
P1115	KQYFDQYPRSYEQVP
S1117	YFDQYPRSYEQVPPP
Y1118	FDQYPRSYEQVPPPG
T1170	QPPPPTLTEEEEDPA
K1193	RVKMFENKRSASLEN
T1241	QFSEHDKTLYRLPEP
Y1243	SEHDKTLYRLPEPQK
Y1265	DIVRSNHYDPEEDEE
Y1273	DPEEDEEYYRKQLSY
Y1274	PEEDEEYYRKQLSYF
K1276	EDEEYYRKQLSYFDR
Y1280	YYRKQLSYFDRRSFE
S1285	LSYFDRRSFESKPSA
S1291	RSFESKPSAHLPAGH
S1308	EPAKPVHSQSQPNFS
S1310	AKPVHSQSQPNFSSY
S1315	SQSQPNFSSYSSKGK
S1331	ETDAVDRSFSEKRYD
K1335	VDRSFSEKRYDPAQA
Y1337	RSFSEKRYDPAQATP
T1343	RYDPAQATPPPPPLP
S1351	PPPPPLPSQYSQPAP
Y1353	PPPLPSQYSQPAPPL
A1357	PSQYSQPAPPLSSSS
S1361	SQPAPPLSSSSLHIH
S1362	QPAPPLSSSSLHIHS
S1364	APPLSSSSLHIHSKG
S1369	SSSLHIHSKGAQGEG
Y1441	QKTITPVYNRFTPKP
Y1449	NRFTPKPYTSSARPF
S1451	FTPKPYTSSARPFER
S1462	PFERKFESPKFNHNL
S1487	LSSKTPTSPKTLMKA
K1518	SVHTDKPKYQMNNIS
Y1519	VHTDKPKYQMNNIST
S1534	MPKAVPVSPSAVEED
S1536	KAVPVSPSAVEEDED
S1572	SSIETGVSIIIPQGA
K1626	PHGLKFLKPVELRLP

	rat
S113-p	HPDPDPVsDNEDDSy
S119	VsDNEDDSyDEDVHD
Y120-p	sDNEDDSyDEDVHDP
S129	EDVHDPRSGRGALAN
G132	HDPRSGRGALANRRG
G139	GALANRRGEKSWARD
S148	KSWARDRSASRDRsL
S150	WARDRSASRDRsLsP
S154-p	RSASRDRsLsPRSDR
S156-p	ASRDRsLsPRSDRRs
S163-p	sPRSDRRsVAsSQPA
S166-p	SDRRsVAsSQPAKPT
S167	DRRsVAsSQPAKPTK
K171	VAsSQPAKPTKVTLV
T173	sSQPAKPTKVTLVKS
K182	VTLVKSRKNEEYGLR
S200-p	HIFVKEIsQDSLAAR
S229	GTVTENMSLTDAKTL
S263	LLNVPDLSDSIHSAN
S265	NVPDLSDSIHSANAS
S268	DLSDSIHSANASERD
S272	SIHSANASERDDISE
S278	ASERDDISEIQSLAS
S282	DDISEIQSLASDHSV
S285	SEIQSLASDHSVRSH
S288	QSLASDHSVRSHDRP
S299	HDRPPRRSQSRSPDQ
S301	RPPRRSQSRSPDQRS
S303	PRRSQSRSPDQRSEP
S308	SRSPDQRSEPSDHST
S311	PDQRSEPSDHSTQSP
S314	RSEPSDHSTQSPQQP
T315	SEPSDHSTQSPQQPS
S317	PSDHSTQSPQQPSNG
S322	TQSPQQPSNGSLRSR
S325	PQQPSNGSLRSREEE
S328	PSNGSLRSREEERMS
S335	SREEERMSKPGAVST
K336	REEERMSKPGAVSTP
S341	MSKPGAVSTPVKHVD
T342	SKPGAVSTPVKHVDD
T351	VKHVDDHTPKAVEEV
K362	VEEVTVEKHEKQTPT
T367	VEKHEKQTPTLPEPK
Y377	LPEPKPVYAQVGQPD
S420	VKFRKGDSVGLRLAG
T464	RVNNVDFTNIIREEA
Y508	SDVGDSFYIRTHFEY
T536	EVFRVVDTLYNGKLG
Y538	FRVVDTLYNGKLGSW
K541	VDTLYNGKLGSWLAI
S573	NRAEQLASVQYTLPK
Y576	EQLASVQYTLPKTAG
T577	QLASVQYTLPKTAGG
K580	SVQYTLPKTAGGDRA
S605-p	SKRNLRKsREDLSAQ
S610	RKsREDLSAQPVQTK
Y621	VQTKFPAYERVVLRE
T636	AGFLRPVTIFGPIAD
Y657	AREEPDIYQIAKSEP
K683	IIRLHTIKQIIDQDK
K690	KQIIDQDKHALLDVT
Y706	NAVDRLNYAQWYPIV
K721	VFLNPDSKQGVKTMR
K725	PDSKQGVKTMRMRLC
T726	DSKQGVKTMRMRLCP
T760	NHHLFTTTINLNSMN
T797	EGKADGATSDDLDLH
S798	GKADGATSDDLDLHD
S809	DLHDDRLSYLSAPGS
Y810	LHDDRLSYLSAPGSE
S812	DDRLSYLSAPGSEYS
S816	SYLSAPGSEYSMYST
Y818	LSAPGSEYSMYSTDS
S819	SAPGSEYSMYSTDSR
Y821	PGSEYSMYSTDSRHT
S825	YSMYSTDSRHTSDYE
S829	STDSRHTSDYEDTDT
Y831	DSRHTSDYEDTDTEG
T834	HTSDYEDTDTEGGAY
T836	SDYEDTDTEGGAYTD
T842	DTEGGAYTDQELDET
T849	TDQELDETLNDEVGT
T856	TLNDEVGTPPESAIT
S865	PESAITRSSEPVRED
S873	SEPVREDSSGMHHEN
S874	EPVREDSSGMHHENQ
T882	GMHHENQTYPPYSPQ
Y883	MHHENQTYPPYSPQA
S887	NQTYPPYSPQAQPQA
S900-p	QAIHRIDsPGLKTAS
S907	sPGLKTASQQKAEAS
S914	SQQKAEASSPVPYLS
S915	QQKAEASSPVPYLSP
Y919	EASSPVPYLSPETNP
S921	SSPVPYLSPETNPAS
P952	EEPTPAPPTSHVSQA
S954	PTPAPPTSHVSQADC
H955	TPAPPTSHVSQADCL
V956	PAPPTSHVSQADCLG
C961	SHVSQADCLGAPSPE
A964	SQADCLGAPSPEAPH
S966	ADCLGAPSPEAPHTM
P967	DCLGAPSPEAPHTML
Y991	HVDPAKVYRKEPYPE
K993	DPAKVYRKEPYPEEM
G1013	ILKQPALGHPGQRLD
Y1027	DKEPNPAYDPQLPYV
S1039	PYVEKQASRDLEQPP
P1046	SRDLEQPPYRYESSS
Y1047	RDLEQPPYRYESSSY
Y1049	LEQPPYRYESSSYTD
S1052	PPYRYESSSYTDQFS
S1053	PYRYESSSYTDQFSR
Y1054	YRYESSSYTDQFSRN
T1055	RYESSSYTDQFSRNY
S1059	SSYTDQFSRNYDHRL
Y1062	TDQFSRNYDHRLRFE
T1074	RFEDRVPTYEDQWSY
Y1075	FEDRVPTYEDQWSYY
K1085	QWSYYDDKQPYPTRP
Y1088	YYDDKQPYPTRPFDT
P1098	RPFDTQHPRDLDSRQ
Y1115	EEASERGYFQRFEEP
P1126	FEEPAPLPYDSRPRY
Y1127	EEPAPLPYDSRPRYE
S1129	PAPLPYDSRPRYEQL
Y1133	PYDSRPRYEQLPRTS
T1141	EQLPRTSTLRHEEQP
Y1152-p	EEQPTSGyEVHNRYR
V1154	QPTSGyEVHNRYRPE
Y1165-p	YRPEAQPyAPAGPKS
A1166	RPEAQPyAPAGPKSS
S1173	APAGPKSSEPKQYFD
K1176	GPKSSEPKQYFDQYP
Y1178	KSSEPKQYFDQYPRS
Y1182	PKQYFDQYPRSYEQV
P1183	KQYFDQYPRSYEQVP
S1185	YFDQYPRSYEQVPPP
Y1186	FDQYPRSYEQVPPPG
T1238	QPPPPALTEEEEDPA
K1261	RVKMFENKRSASLEN
T1309	QFSEHDKTLYRLPEP
Y1311	SEHDKTLYRLPEPQK
Y1333	DIVRSNHYDPEEDEE
Y1341	DPEEDEEYYRKQLSY
Y1342	PEEDEEYYRKQLSYF
K1344	EDEEYYRKQLSYFDR
Y1348	YYRKQLSYFDRRSFE
S1353	LSYFDRRSFESKPPA
P1359	RSFESKPPAHIPAGH
S1376	EPAKPVHSQSQPNFS
S1378	AKPVHSQSQPNFSSY
S1383	SQSQPNFSSYSSKGK
S1399	ETDAMDRSFSEKRYD
K1403	MDRSFSEKRYDPTQA
Y1405	RSFSEKRYDPTQAMP
M1411	RYDPTQAMPPPPPLP
S1419	PPPPPLPSQYSQPVP
Y1421	PPPLPSQYSQPVPPL
V1425	PSQYSQPVPPLSNSS
S1429	SQPVPPLSNSSLHIH
N1430	QPVPPLSNSSLHIHS
S1432	VPPLSNSSLHIHSKA
S1437	NSSLHIHSKAAQSEG
Y1509	QKTITPAYNRFTPKP
Y1517	NRFTPKPYTSSARPF
S1519	FTPKPYTSSARPFER
S1530	PFERKFESPKFNHNL
S1555	LSSKPPPSPKTLMKA
K1586	SVHTDKPKYQINNIS
Y1587	VHTDKPKYQINNIST
S1602-p	MPKAVPVsPsAVEED
S1604-p	KAVPVsPsAVEEDED
S1640	SSIETGVSIIIPQGA
K1694	PHGLKFLKPVELRLP

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