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Protein Page:
RB1CC1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RB1CC1 a putative transcription factor that functions as a key regulator of Rb expression. Required for autophagosome formation. Contains a nuclear localization signal, a leucine zipper motif and a coiled-coil structure. Thought to play a biological role in controlling cell growth and progression of various cancers. Probably involved in the tumorigenesis of breast cancer. It is frequently mutated in breast cancer and shows characteristics of a classical tumor suppressor gene. Plays a crucial role in muscular differentiation and required for myogenic differentiation. Part of a complex consisting of ATG13, ULK1 and RB1CC1. This complex associates with ATG101. Under starvation conditions, is localized to phagophores. Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. Expression was difficult to detect in immature proliferating chondroblasts or myogenic cells in embryos, but became obvious and prominent concomitantly with the maturation of osteocytes, chondrocytes, and skeletal muscle cells. Expression in these musculoskeletal cells increased with RB1 expression, which is linked to the terminal differentiation of many tissues and cells. The introduction of the wild-type protein decreased the formation of macroscopic colonies in a cell growth assay. Note: This description may include information from UniProtKB.
Protein type: Autophagy; DNA binding protein; Transcription factor
Cellular Component: nuclear membrane; pre-autophagosomal structure membrane; cytoplasm; cytosol
Molecular Function: protein binding; protein kinase binding
Biological Process: transcription, DNA-dependent; positive regulation of cell size; regulation of transcription, DNA-dependent; heart development; JNK cascade; regulation of autophagy; positive regulation of protein amino acid phosphorylation; cell cycle; liver development; negative regulation of apoptosis; autophagic vacuole formation
Reference #:  Q8TDY2 (UniProtKB)
Alt. Names/Synonyms: 200 kDa FAK family kinase-interacting protein; CC1; FIP200; KIAA0203; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1; RB1CC1; RBCC1; RBICC
Gene Symbols: RB1CC1
Molecular weight: 183,091 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RB1CC1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S105-p MEIKVEEsLMMPAVF
0 1 T114 MMPAVFHTVASRTQL
0 1 S117 AVFHTVASRTQLALE
0 3 K201 TAVSVMAKIPLLECL
0 53 S222-p ECLGRLDsLPEHEDs
0 1 S229-p sLPEHEDsEKAEMKR
0 8 S237-p EKAEMKRstELVLsP
0 7 T238-p KAEMKRstELVLsPD
0 12 S243-p RstELVLsPDMPRTT
0 2 S253-p MPRTTNEsLLtsFPK
0 1 T256-p TTNEsLLtsFPKsVE
0 13 S257-p TNEsLLtsFPKsVEH
0 7 S261-p LLtsFPKsVEHVsPD
0 1 S266-p PKsVEHVsPDTADAE
0 1 K387 GRLVNEQKELAQGFL
0 1 S537-p AEKSKREsFGKLFRK
0 3 S624-p NLVKAAQsLDEMsQT
0 1 S629-p AQsLDEMsQTITDLL
0 5 S644-p SEQKASVsQTsPQsA
0 11 S647-p KASVsQTsPQsAssP
0 5 S650-p VsQTsPQsAssPRME
0 1 S652-p QTsPQsAssPRMEST
0 11 S653-p TsPQsAssPRMESTA
0 1 T666 TAGITTTTSPRTPPP
0 1 S667 AGITTTTSPRTPPPL
0 1 K883-a GKLDGLIkETEENEN
0 1 K891-a ETEENENkIKKLKGE
0 2 K930 VICLQNEKDQKLLEM
0 1 S986-p ELQSLEQsHLKELED
0 1 S1091 QQKETLKSLLEQETE
0 1 S1222-p DRQKLVSsQEQDREQ
0 1 K1263-a VEKELLEkVKHLENQ
0 1 S1286 STRGDSSSLVAELQE
0 3 K1343 LTREKMRKENIINDL
0 3 K1353 IINDLSDKLKSTMQQ
0 2 S1370-p RDKDLIEsLSEDRAR
0 3 S1482-p RLNQRLMsQsMSSVS
0 2 S1484-p NQRLMsQsMSSVSSR
  mouse

 
S105-p MEIKVEEsLMMPAVF
T114-p MMPAVFHtVAsRTQL
S117-p AVFHtVAsRTQLAVE
K201-a TAVSVMAkIPLLECL
S222-p ECLGRPDsLNEHEGS
S229 sLNEHEGSEKAEMKR
S237-p EKAEMKRstELVLsP
T238-p KAEMKRstELVLsPD
S243-p RstELVLsPDMPRTT
S253-p MPRTTNTsLVtsFHK
T256-p TTNTsLVtsFHKsME
S257-p TNTsLVtsFHKsMEH
S261-p LVtsFHKsMEHVAPD
A266 HKsMEHVAPDPTGTE
K386-u SRLVNEQkELAQGFL
S536 AEKSKRESFGKLFRK
S623-p NLVKAAQsLDEMsQT
S628-p AQsLDEMsQTITDLL
S643-p NEQKVSTsQAsPQsA
S646-p KVSTsQAsPQsAAsP
S649-p TsQAsPQsAAsPRIE
A651 QAsPQsAAsPRIEST
S652-p AsPQsAAsPRIESTT
T665-p TTGITTTtSPKTPPP
S666 TGITTTtSPKTPPPL
K882 CKLDALVKDSEENVN
K890 DSEENVNKILKLKEN
K929-a IVCVQQEkDQKLLEM
N982 EFQCLEQNHLKELED
S1087-p QQKEMLKsLLEQETE
N1218 DKERLVKNHEQDKEH
K1259 VEKELLEKVKHLENQ
S1282-p SAREDSSsLVAELQE
K1339-a LTREKMRkENIINDL
K1349-a IINDLSDkLKSTMQQ
S1366-p RDKDLIEsLSEDRAR
S1476 RLNQRLMSQsLSSVS
S1478-p NQRLMSQsLSSVSSR
  rat

 
S105 MEIKVEESLMMPAVF
T114 MMPAVFHTVASRTQL
S117 AVFHTVASRTQLAVE
K201 TAVSVMAKIPLLECL
S222 ECLGRPDSLNEHEGS
S229 SLNEHEGSEKADMKR
S237-p EKADMKRsTELVLSP
T238 KADMKRsTELVLSPD
S243 RsTELVLSPDMPRTT
S253 MPRTTNTSLLTSFHK
T256 TTNTSLLTSFHKSVE
S257 TNTSLLTSFHKSVEH
S261 LLTSFHKSVEHVAPD
A266 HKSVEHVAPDVTDAE
K386 SRLVNEQKELAQGFL
S536 AEKSKRESFGKLFRK
S623 NLVKAAQSLDEMSQT
S628 AQSLDEMSQTITDLL
S643 NEQKVSTSQASPQSA
S646 KVSTSQASPQSAASP
S649 TSQASPQSAASPRIE
A651 QASPQSAASPRIEST
S652 ASPQSAASPRIESTT
T665 TTGITTTTsPKAPPP
S666-p TGITTTTsPKAPPPL
K882 CKLNTLEKDSEENVN
K890 DSEENVNKILKLKED
K929 IVCMQHEKDQKLLEM
N982 EFQCLEQNHLKELED
S1087 QQKETLKSLLEQETE
- under review  
K1259 VEKELLEKVKHLENQ
S1282 SAREDSSSLVAELQE
K1339 LTREKMRKENIINDL
K1349 IINDLSDKLKSTMQQ
S1366 RDKDLIESLSEDRAR
S1476 RLNQRLMSQSLSSVS
S1478 NQRLMSQSLSSVSSR
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