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RB1CC1 (human)

Overview RB1CC1 a putative transcription factor that functions as a key regulator of Rb expression. Required for autophagosome formation. Contains a nuclear localization signal, a leucine zipper motif and a coiled-coil structure. Thought to play a biological role in controlling cell growth and progression of various cancers. Probably involved in the tumorigenesis of breast cancer. It is frequently mutated in breast cancer and shows characteristics of a classical tumor suppressor gene. Plays a crucial role in muscular differentiation and required for myogenic differentiation. Part of a complex consisting of ATG13, ULK1 and RB1CC1. This complex associates with ATG101. Under starvation conditions, is localized to phagophores. Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. Expression was difficult to detect in immature proliferating chondroblasts or myogenic cells in embryos, but became obvious and prominent concomitantly with the maturation of osteocytes, chondrocytes, and skeletal muscle cells. Expression in these musculoskeletal cells increased with RB1 expression, which is linked to the terminal differentiation of many tissues and cells. The introduction of the wild-type protein decreased the formation of macroscopic colonies in a cell growth assay. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein; Autophagy Cellular Component: pre-autophagosomal structure membrane; cytosol; nucleus Molecular Function: protein binding; protein kinase binding Biological Process: positive regulation of cell size; regulation of transcription, DNA-dependent; transcription, DNA-dependent; heart development; JNK cascade; regulation of autophagy; positive regulation of protein amino acid phosphorylation; liver development; cell cycle; negative regulation of apoptosis; autophagic vacuole formation Reference #:  Q8TDY2 (UniProtKB) Alt. Names/Synonyms: 200 kDa FAK family kinase-interacting protein; CC1; FIP200; KIAA0203; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1; RB1CC1; RBCC1; RBICC Gene Symbols: RB1CC1 Molecular weight: 183,091 Da Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RB1CC1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S105-p	MEIKVEEsLMMPAVF
0	1		T114	MMPAVFHTVASRTQL
0	1		S117	AVFHTVASRTQLALE
0	1		S134-p	EVAKKLCsFCEGLVH
0	3		K201	TAVSVMAKIPLLECL
0	52		S222-p	ECLGRLDsLPEHEDS
0	6		S237-p	EKAEMKRstELVLsP
0	7		T238-p	KAEMKRstELVLsPD
0	10		S243-p	RstELVLsPDMPRTT
0	1		E252	DMPRTTNESLLtsFP
0	1		S253	MPRTTNESLLtsFPK
0	1		T256-p	TTNESLLtsFPKsVE
0	11		S257-p	TNESLLtsFPKsVEH
0	7		S261-p	LLtsFPKsVEHVSPD
0	1		A270	EHVSPDTADAESGKE
0	1		K387	GRLVNEQKELAQGFL
0	1		S490-p	VKIVEALsTVPQMYC
0	1		K522	EWAGALVKDGKRLYE
0	1		S537-p	AEKSKREsFGKLFRK
0	3		S624-p	NLVKAAQsLDEMsQT
0	1		S629-p	AQsLDEMsQTITDLL
0	5		S644-p	SEQKASVsQTsPQsA
0	10		S647-p	KASVsQTsPQsASsP
0	4		S650-p	VsQTsPQsASsPRME
0	11		S653-p	TsPQsASsPRMESTA
0	1		T664-p	ESTAGITtTTSPRTP
0	1		T666	TAGITtTTSPRTPPP
0	1		K883-a	GKLDGLIkETEENEN
0	1		K891-a	ETEENENkIKKLKGE
0	1		C901	KLKGELVCLEEVLQN
0	2		K930	VICLQNEKDQKLLEM
0	1		K952	NCEIKELKQSREIVL
0	1		K963	EIVLEDLKKLHVEND
0	1		S1091	QQKETLKSLLEQETE
0	1		Y1205-p	ITQQEEKyEAIIQNL
0	1		K1263-a	VEKELLEkVKHLENQ
0	1		S1286	STRGDSSSLVAELQE
0	3		K1343-a	LTREKMRkENIINDL
0	3		K1353-a	IINDLSDkLKSTMQQ
0	1		S1370-p	RDKDLIEsLSEDRAR
0	1		K1456	IHMLSEEKQRIMLLE
0	3		S1482-p	RLNQRLMsQsMSSVS
0	1		S1484-p	NQRLMsQsMSSVSSR

	mouse
S105-p	MEIKVEEsLMMPAVF
T114-p	MMPAVFHtVAsRTQL
S117-p	AVFHtVAsRTQLAVE
S134	DVAKKLCSFCEGLVH
K201-a	TAVSVMAkIPLLECL
S222-p	ECLGRPDsLNEHEGS
S237-p	EKAEMKRstELVLsP
T238-p	KAEMKRstELVLsPD
S243-p	RstELVLsPDMPRTT
T252-p	DMPRTTNtsLVtsFH
S253-p	MPRTTNtsLVtsFHK
T256-p	TTNtsLVtsFHKsME
S257-p	TNtsLVtsFHKsMEH
S261-p	LVtsFHKsMEHVAPD
T270-p	EHVAPDPtGTERGKE
K386-u	SRLVNEQkELAQGFL
S489	VRIVEALSTVPQMYC
K521-a	EWAGALVkDGKQLYE
S536	AEKSKRESFGKLFRK
S623-p	NLVKAAQsLDEMsQT
S628-p	AQsLDEMsQTITDLL
S643-p	NEQKVSTsQAsPQsA
S646-p	KVSTsQAsPQsAAsP
S649-p	TsQAsPQsAAsPRIE
S652-p	AsPQsAAsPRIESTT
T663	ESTTGITTTtSPKTP
T665-p	TTGITTTtSPKTPPP
K882	CKLDALVKDSEENVN
K890	DSEENVNKILKLKEN
S900-p	KLKENLVsLEEALQN
K929-a	IVCVQQEkDQKLLEM
K951-a	HCEIKELkQSREMAL
K962-a	EMALEDLkKLHDEKI
S1087-p	QQKEMLKsLLEQETE
Y1201	ITQQEEKYEALIQNL
K1259	VEKELLEKVKHLENQ
S1282-p	SAREDSSsLVAELQE
K1339-a	LTREKMRkENIINDL
K1349-a	IINDLSDkLKSTMQQ
S1366-p	RDKDLIEsLSEDRAR
K1450-a	ENMLSEEkQRIMLLE
S1476	RLNQRLMSQsLSSVS
S1478-p	NQRLMSQsLSSVSSR

	rat
S105	MEIKVEESLMMPAVF
T114	MMPAVFHTVASRTQL
S117	AVFHTVASRTQLAVE
S134	EVAKKLCSFCEGLVH
K201	TAVSVMAKIPLLECL
S222	ECLGRPDSLNEHEGS
S237-p	EKADMKRsTELVLSP
T238	KADMKRsTELVLSPD
S243	RsTELVLSPDMPRTT
T252	DMPRTTNTSLLTSFH
S253	MPRTTNTSLLTSFHK
T256	TTNTSLLTSFHKSVE
S257	TNTSLLTSFHKSVEH
S261	LLTSFHKSVEHVAPD
T270	EHVAPDVTDAEQGKE
K386	SRLVNEQKELAQGFL
S489	VRIVEALSTVPQMYC
K521	EWAGALVKDGKQLYE
S536	AEKSKRESFGKLFRK
S623	NLVKAAQSLDEMSQT
S628	AQSLDEMSQTITDLL
S643	NEQKVSTSQASPQSA
S646	KVSTSQASPQSAASP
S649	TSQASPQSAASPRIE
S652	ASPQSAASPRIESTT
T663	ESTTGITTTTSPKAP
T665	TTGITTTTSPKAPPP
-	under review
K890	DSEENVNKILKLKED
S900	KLKEDLVSLEEALQN
K929	IVCMQHEKDQKLLEM
K951	NSEIKELKQSREMVL
K962	EMVLEDLKKLHDEKI
S1087	QQKETLKSLLEQETE
Y1201	ITQQEEKYKALIQNL
K1259	VEKELLEKVKHLENQ
S1282	SAREDSSSLVAELQE
K1339	LTREKMRKENIINDL
K1349	IINDLSDKLKSTMQQ
S1366	RDKDLIESLSEDRAR
K1450	ENMLSEEKQRIMLLE
S1476	RLNQRLMSQSLSSVS
S1478	NQRLMSQSLSSVSSR

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