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Protein Page:
PZR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PZR an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Cellular Component: integral to plasma membrane
Molecular Function: protein binding; structural molecule activity
Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  O95297 (UniProtKB)
Alt. Names/Synonyms: FLJ21047; immunoglobulin family transmembrane protein; MPZL1; MPZL1b; myelin protein zero-like 1; Myelin protein zero-like protein 1; protein zero related; Protein zero-related; PZR; PZR1b; PZRa; PZRb
Gene Symbols: MPZL1
Molecular weight: 29,082 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PZR

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y241‑p, Y263‑p
molecular association, regulation: Y241‑p, Y263‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S16-p AVIAAPDsRRWLWsV
0 1 S22-p DsRRWLWsVLAAALG
0 1 T32-p AAALGLLtAGVSALE
0 1 K115-ub SWAGDLDkKDASINI
0 94 Y200-p RKNSKRDyTGCstsE
0 1 S204-p KRDyTGCstsEsLsP
0 2 T205-p RDyTGCstsEsLsPV
0 3 S206-p DyTGCstsEsLsPVk
0 4 S208-p TGCstsEsLsPVkQA
0 14 S210-p CstsEsLsPVkQAPR
0 38 K213-ub sEsLsPVkQAPRKsP
0 9 S219-p VkQAPRKsPsDtEGL
0 14 S221-p QAPRKsPsDtEGLVK
0 1 T223-p PRKsPsDtEGLVKsL
0 1 S229-p DtEGLVKsLPsGsHQ
0 10 S232-p GLVKsLPsGsHQGPV
0 13 S234-p VKsLPsGsHQGPVIy
1 450 Y241-p sHQGPVIyAQLDHsG
0 6 S247-p IyAQLDHsGGHHsDK
0 6 S252-p DHsGGHHsDKINksE
0 2 K257-ub HHsDKINksEsVVyA
0 3 S258-p HsDKINksEsVVyAD
0 40 S260-p DKINksEsVVyADIR
1 1097 Y263-p NksEsVVyADIRKN_
0 3 - gap
0 14 - gap
0 2 - under review  
8131 : Phospho-PZR (Tyr241) (D6F9) Rabbit mAb
5543 : Phospho-PZR (Tyr263) Antibody
8088 : Phospho-PZR (Tyr263) (D6A5) Rabbit mAb
  PZR iso3  
S16 AVIAAPDSRRWLWSV
S22 DSRRWLWSVLAAALG
T32 AAALGLLTAGVSALE
K115 SWAGDLDKKDASINI
Y200-p RKNSKRDyTGAQsyM
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S205-p RDyTGAQsyMHs___
Y206-p DyTGAQsyMHs____
S209-p GAQsyMHs_______
  mouse

► Hide Isoforms
 
R16 ALIAAPARRRWLWSV
S22 ARRRWLWSVLAAMLG
T32 AAMLGLLTARISALE
K115 TWAGDLDKKDASINI
Y200 RKHSKRDYTGCSTSE
S204 KRDYTGCSTSERLsP
T205 RDYTGCSTSERLsPV
S206 DYTGCSTSERLsPVK
R208 TGCSTSERLsPVKQA
S210-p CSTSERLsPVKQAPR
K213 SERLsPVKQAPRKCP
C219 VKQAPRKCPSDTEGL
S221 QAPRKCPSDTEGLVK
T223 PRKCPSDTEGLVKSP
S229 DTEGLVKSPPsAGsH
S232-p GLVKSPPsAGsHQGP
S235-p KSPPsAGsHQGPVIy
Y242-p sHQGPVIyAQLDHSG
S248 IyAQLDHSGGHHSGK
S253 DHSGGHHSGKINKSE
K258 HHSGKINKSEsVVyA
S259 HSGKINKSEsVVyAD
S261-p GKINKSEsVVyADIR
Y264-p NKSEsVVyADIRKD_
- gap
- gap
- under review  
8131 : Phospho-PZR (Tyr241) (D6F9) Rabbit mAb
5543 : Phospho-PZR (Tyr263) Antibody
8088 : Phospho-PZR (Tyr263) (D6A5) Rabbit mAb
  PZR iso3  
R16 ALIAAPARRRWLWSV
S22 ARRRWLWSVLAAMLG
T32 AAMLGLLTARISALE
K115 TWAGDLDKKDASINI
Y200 RKHSKRDYTGAQsFT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S205-p RDYTGAQsFTHS___
F206 DYTGAQsFTHS____
S209 GAQsFTHS_______
  rat

 
R16 TLIAAPARRRWLWSA
S22 ARRRWLWSALAAMLG
T32 AAMLGLLTARISALE
K115 TWAGDLDKKDASINI
Y200 RKHSKRDYTGCSTSE
S204 KRDYTGCSTSERLSP
T205 RDYTGCSTSERLSPV
S206 DYTGCSTSERLSPVK
R208 TGCSTSERLSPVKQA
S210 CSTSERLSPVKQAPR
K213 SERLSPVKQAPRKCP
C219 VKQAPRKCPSDTEGL
S221 QAPRKCPSDTEGLVK
T223 PRKCPSDTEGLVKSP
S229 DTEGLVKSPPSAGSH
S232 GLVKSPPSAGSHQGP
S235 KSPPSAGSHQGPVIy
Y242-p SHQGPVIyAQLDHSG
S248 IyAQLDHSGGHHSGK
S253 DHSGGHHSGKINKSE
K258 HHSGKINKSESVVyA
S259 HSGKINKSESVVyAD
S261 GKINKSESVVyADIR
Y264-p NKSESVVyADIRKD_
- gap
- gap
- under review  
8131 : Phospho-PZR (Tyr241) (D6F9) Rabbit mAb
5543 : Phospho-PZR (Tyr263) Antibody
8088 : Phospho-PZR (Tyr263) (D6A5) Rabbit mAb
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