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ZO2 (human)

Overview ZO2 a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. Note: This description may include information from UniProtKB.. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: nucleoplasm; tight junction; adherens junction; cytoplasm; plasma membrane; cell junction; cytosol Molecular Function: guanylate kinase activity; protein binding Biological Process: apoptosis; cell structure disassembly during apoptosis Reference #:  Q9UDY2 (UniProtKB) Alt. Names/Synonyms: Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; Tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO 2; Tight junction protein ZO-2; TJP2; X104; ZO2; Zona occludens protein 2; Zonula occludens protein 2 Gene Symbols: TJP2 Molecular weight: 133,958 Da Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ZO2 2OSG - A/B=306-385 (human) 3E17 - A/B=306-384 (human) 2CSJ - A=1-106 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2OSG 3E17  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S16-p	FPPRRELsGWLRAPG
0	1		T91-p	RVVMVNGtPMEDVLH
0	34		S130-p	QVAALQAsPPLDQDD
0	3		D134	LQAsPPLDQDDRAFE
0	1		S150-p	MDEFDGRsFRsGYsE
0	2		S153-p	FDGRsFRsGYsERSR
0	1		S156-p	RsFRsGYsERSRLNs
0	28		S163-p	sERSRLNsHGGRsRs
0	8		S168-p	LNsHGGRsRsWEDsP
0	31		S170-p	sHGGRsRsWEDsPER
0	29		S174-p	RsRsWEDsPERGRPH
0	1		S186-p	RPHERARsRERDLsR
0	5		S192-p	RsRERDLsRDRsRGR
0	4		S196-p	RDLsRDRsRGRsLER
0	3		S200-p	RDRsRGRsLERGLDQ
0	3		T212-p	LDQDHARtRDRsRGR
0	21		S216-p	HARtRDRsRGRsLER
0	21		S220-p	RDRsRGRsLERGLDH
0	1		S232-p	LDHDFGPsRDRDRDR
0	5		D236	FGPsRDRDRDRsRGR
0	12		S240-p	RDRDRDRsRGRsIDQ
0	167		S244-p	RDRsRGRsIDQDyER
0	2		I245	DRsRGRsIDQDyERA
0	179		Y249-p	GRsIDQDyERAyHRA
0	1		A252	IDQDyERAyHRAyDP
0	24		Y253-p	DQDyERAyHRAyDPD
0	14		Y257-p	ERAyHRAyDPDyERA
0	297		Y261-p	HRAyDPDyERAysPE
0	48		Y265-p	DPDyERAysPEyRRG
0	135		S266-p	PDyERAysPEyRRGA
0	1		E268	yERAysPEyRRGARH
0	44		Y269-p	ERAysPEyRRGARHD
0	1		S279-p	GARHDARsRGPRsRs
0	1		S284-p	ARsRGPRsRsREHPH
0	1		S286-p	sRGPRsRsREHPHsR
0	6		S292-p	RsREHPHsRsPsPEP
0	6		S294-p	REHPHsRsPsPEPRG
0	7		S296-p	HPHsRsPsPEPRGRP
0	1		R314	GVLLMKSRANEEyGL
0	1		Y319-p	KSRANEEyGLRLGsQ
0	5		S325-p	EyGLRLGsQIFVKEM
0	1		T333-p	QIFVKEMtRtGLAtK
0	1		T335-p	FVKEMtRtGLAtKDG
0	2		T339-p	MtRtGLAtKDGNLHE
0	1		K340	tRtGLAtKDGNLHEG
1	0		S385	QLVVLRDSQQTLINI
0	1		T388	VLRDSQQTLINIPsL
0	1		S394-p	QTLINIPsLNDsDsE
0	11		S398-p	NIPsLNDsDsEIEDI
0	12		S400-p	PsLNDsDsEIEDISE
0	1		S413	SEIESNRSFsPEERR
0	11		S415-p	IESNRSFsPEERRHQ
0	20		Y423-p	PEERRHQysDyDyHs
0	42		S424-p	EERRHQysDyDyHss
0	261		Y426-p	RRHQysDyDyHsssE
0	108		Y428-p	HQysDyDyHsssEKL
0	12		S430-p	ysDyDyHsssEKLKE
0	14		S431-p	sDyDyHsssEKLKER
0	5		S432-p	DyDyHsssEKLKERP
0	1		K434	DyHsssEKLKERPss
0	2		S440-p	EKLKERPssREDTPS
0	2		S441-p	KLKERPssREDTPSR
0	3		T455-p	RLSRMGAtPtPFKst
0	2		T457-p	SRMGAtPtPFKstGD
0	1		K460	GAtPtPFKstGDIAG
0	12		S461-p	AtPtPFKstGDIAGT
0	6		T462-p	tPtPFKstGDIAGTV
0	1		K475-u	TVVPETNkEPRyQED
0	1		Y479-p	ETNkEPRyQEDPPAP
0	1		P483	EPRyQEDPPAPQPKA
0	3		S499-p	PRTFLRPsPEDEAIy
0	190		Y506-p	sPEDEAIyGPNtKMV
0	3		T510-p	EAIyGPNtKMVRFKK
0	6		Y574-p	VREDAVLyLLEIPKG
0	1		T585-p	IPKGEMVtILAQsRA
0	3		S590-p	MVtILAQsRADVYRD
0	1		Y638-p	FRVVDTLyDGKLGNW
0	1		K641	VDTLyDGKLGNWLAV
0	1		K696	RGQRSGVKKNLRKsR
0	7		S702-p	VKKNLRKsREDLtAV
0	1		T707-p	RKsREDLtAVVsVsT
0	1		S711-p	EDLtAVVsVsTKFPA
0	1		S713-p	LtAVVsVsTKFPAYE
0	1		T760-p	DWFQTAKtEPKDAGs
0	1		S767-p	tEPKDAGsEKstGVV
0	1		K769	PKDAGsEKstGVVRL
0	1		K769	PKDAGsEKstGVVRL
0	1		S770-p	KDAGsEKstGVVRLN
0	1		T771-p	DAGsEKstGVVRLNt
0	1		T778-p	tGVVRLNtVRQIIEQ
0	2		T831-p	MRQRLNPtsNKSsRK
0	1		S832-p	RQRLNPtsNKSsRKL
0	1		S836-p	NPtsNKSsRKLFDQA
0	1		S886-p	QGEAVWVsEGKMEGM
0	1		S902	DDPEDRMSyLTAMGA
0	1		Y903-p	DPEDRMSyLTAMGAD
0	1		T905	EDRMSyLTAMGADyL
0	48		Y911-p	LTAMGADyLsCDsRL
0	17		S913-p	AMGADyLsCDsRLIs
0	1		S916-p	ADyLsCDsRLIsDFE
0	33		S920-p	sCDsRLIsDFEDtDG
0	26		T925-p	LIsDFEDtDGEGGAy
0	9		Y932-p	tDGEGGAytDNELDE
0	20		T933-p	DGEGGAytDNELDEP
0	4		S961-p	EPVQHEEsIRKPsPE
0	3		P965	HEEsIRKPsPEPRAQ
0	64		S966-p	EEsIRKPsPEPRAQM
0	114		S978-p	AQMRRAAssDQLRDN
0	15		S979-p	QMRRAAssDQLRDNs
0	171		S986-p	sDQLRDNsPPPAFKP
0	25		S1006-p	KTQNKEEsyDFSKsy
0	173		Y1007-p	TQNKEEsyDFSKsyE
0	3		F1009	NKEEsyDFSKsyEyk
0	1		S1010	KEEsyDFSKsyEykS
0	2		S1012-p	EsyDFSKsyEykSNP
0	15		Y1013-p	syDFSKsyEykSNPS
0	1		Y1015-p	DFSKsyEykSNPSAV
0	2		K1016-u	FSKsyEykSNPSAVA
0	2		T1027-p	SAVAGNEtPGASTKG
0	1		S1048-p	AKPTFGRsILKPstP
0	3		S1053-p	GRsILKPstPIPPQE
0	5		T1054-p	RsILKPstPIPPQEG
0	7		S1067-p	EGEEVGEssEEQDNA
0	7		S1068-p	GEEVGEssEEQDNAP
0	946		Y1118-p	AQKHPDIyAVPIKtH
0	1		T1124-p	IyAVPIKtHKPDPGt
0	3		T1131-p	tHKPDPGtPQHtSSR
0	1		T1135-p	DPGtPQHtSSRPPEP
0	3		S1147-p	PEPQKAPsRPyQDTR
0	1		Y1150-p	QKAPsRPyQDTRGsy
0	7		S1156-p	PyQDTRGsyGsDAEE
0	3		Y1157-p	yQDTRGsyGsDAEEE
0	79		S1159-p	DTRGsyGsDAEEEEy
0	23		Y1166-p	sDAEEEEyRQQLSEH
0	59		Y1178-p	SEHSKRGyyGQSARY
0	35		Y1179-p	EHSKRGyyGQSARYR

	ZO2 iso6
S16	FPPRRELSGWLRAPG
T91	RVVMVNGTPMEDVLH
S130	QVAALQASPPLDQDD
D134	LQASPPLDQDDRAFE
S150	MDEFDGRSFRSGYSE
S153	FDGRSFRSGYSERSR
S156	RSFRSGYSERSRLNS
S163	SERSRLNSHGGRSRS
S168	LNSHGGRSRSWEDSP
S170	SHGGRSRSWEDSPER
S174	RSRSWEDSPERGRPH
S186	RPHERARSRERDLSR
S192	RSRERDLSRDRSRGR
S196	RDLSRDRSRGRSLER
S200	RDRSRGRSLERGLDQ
T212	LDQDHARTRDRSRGR
S216	HARTRDRSRGRSLER
S220	RDRSRGRSLERGLDH
S232	LDHDFGPSRDRDRDR
D236	FGPSRDRDRDRSRGR
S240	RDRDRDRSRGRSIDQ
S244	RDRSRGRSIDQDYER
I245	DRSRGRSIDQDYERA
Y249	GRSIDQDYERAYHRA
A252	IDQDYERAYHRAYDP
Y253	DQDYERAYHRAYDPD
Y257	ERAYHRAYDPDyERA
Y261-p	HRAYDPDyERAySPE
Y265-p	DPDyERAySPEYRRG
S266	PDyERAySPEYRRGA
E268	yERAySPEYRRGARH
Y269	ERAySPEYRRGARHD
S279	GARHDARSRGPRSRS
S284	ARSRGPRSRSREHPH
S286	SRGPRSRSREHPHSR
S292	RSREHPHSRSPSPEP
S294	REHPHSRSPSPEPRG
S296	HPHSRSPSPEPRGRP
R314	GVLLMKSRANEEYGL
Y319	KSRANEEYGLRLGSQ
S325	EYGLRLGSQIFVKEM
T333	QIFVKEMTRTGLATK
T335	FVKEMTRTGLATKDG
T339	MTRTGLATKDGNLHE
K340	TRTGLATKDGNLHEG
S385	QLVVLRDSQQTLINI
T388	VLRDSQQTLINIPSL
S394	QTLINIPSLNDSDSE
S398	NIPSLNDSDSEIEDI
S400	PSLNDSDSEIEDISE
S413	SEIESNRSFSPEERR
S415	IESNRSFSPEERRHQ
Y423	PEERRHQYSDyDyHS
S424	EERRHQYSDyDyHSS
Y426-p	RRHQYSDyDyHSSSE
Y428-p	HQYSDyDyHSSSEKL
S430	YSDyDyHSSSEKLKE
S431	SDyDyHSSSEKLKER
S432	DyDyHSSSEKLKERP
K434	DyHSSSEKLKERPSS
S440	EKLKERPSSREDTPS
S441	KLKERPSSREDTPSR
T455	RLSRMGATPTPFKST
T457	SRMGATPTPFKSTGD
K460	GATPTPFKSTGDIAG
S461	ATPTPFKSTGDIAGT
T462	TPTPFKSTGDIAGTV
K475	TVVPETNKEPRYQED
Y479	ETNKEPRYQEDPPAP
P483	EPRYQEDPPAPQPKA
S499	PRTFLRPSPEDEAIy
Y506-p	SPEDEAIyGPNTKMV
T510	EAIyGPNTKMVRFKK
Y574	VREDAVLYLLEIPKG
T585	IPKGEMVTILAQSRA
S590	MVTILAQSRADVYRD
Y638	FRVVDTLYDGKLGNW
K641	VDTLYDGKLGNWLAV
K696	RGQRSGVKKNLRKSR
S702	VKKNLRKSREDLTAV
T707	RKSREDLTAVVSVST
S711	EDLTAVVSVSTKFPA
S713	LTAVVSVSTKFPAYE
T760	DWFQTAKTEPKDAGS
S767	TEPKDAGSEKSTGVV
K769	PKDAGSEKSTGVVRL
K769	PKDAGSEKSTGVVRL
S770	KDAGSEKSTGVVRLN
T771	DAGSEKSTGVVRLNT
T778	TGVVRLNTVRQIIEQ
T831	MRQRLNPTSNKSSRK
S832	RQRLNPTSNKSSRKL
S836	NPTSNKSSRKLFDQA
S886	QGEAVWVSEGKMEGM
S902	DDPEDRMSYLTAMGA
Y903	DPEDRMSYLTAMGAD
T905	EDRMSYLTAMGADYL
Y911	LTAMGADYLSCDSRL
S913	AMGADYLSCDSRLIS
S916	ADYLSCDSRLISDFE
S920	SCDSRLISDFEDTDG
T925	LISDFEDTDGEGGAY
Y932	TDGEGGAYTDNELDE
T933	DGEGGAYTDNELDEP
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y971-p	AQKHPDIyAVPIKTH
T977	IyAVPIKTHKPDPGT
T984	THKPDPGTPQHTSSR
T988	DPGTPQHTSSRPPEP
S1000	PEPQKAPSRPYQDTR
Y1003	QKAPSRPYQDTRGSY
S1009	PYQDTRGSYGSDAEE
Y1010	YQDTRGSYGSDAEEE
S1012	DTRGSYGSDAEEEEY
Y1019	SDAEEEEYRQQLSEH
Y1031	SEHSKRGYYGQSARY
Y1032	EHSKRGYYGQSARYR

	mouse
-	gap
T68	RVVMVNGTPMEDVLH
S107-p	QVAPLQGsPPLsHDD
S111-p	LQGsPPLsHDDRGFE
S127-p	IEEFDGRsFRsGYSE
S130-p	FDGRsFRsGYSERSR
S133	RsFRsGYSERSRHSs
S140-p	SERSRHSsHDMLsHs
S145-p	HSsHDMLsHsWEGNR
S147-p	sHDMLsHsWEGNRER
N151	LsHsWEGNRERGRPH
S163	RPHQRTQSRERERSR
-	gap
S169	QSRERERSRGRSLER
S173	RERSRGRSLERGLDQ
S186-p	DQEDYGRsRERsRGR
S190-p	YGRsRERsRGRsLER
S194-p	RERsRGRsLERGLDR
S205-p	GLDRDFVsRDHsRGR
S209-p	DFVsRDHsRGRsIDR
S213-p	RDHsRGRsIDRDyDR
D217	RGRsIDRDyDRDYER
Y218-p	GRsIDRDyDRDYERs
Y222	DRDyDRDYERsYHEA
S225-p	yDRDYERsYHEAyEP
Y226	DRDYERsYHEAyEPD
Y230-p	ERsYHEAyEPDyGGG
Y234-p	HEAyEPDyGGGysPs
Y238-p	EPDyGGGysPsyDRR
S239-p	PDyGGGysPsyDRRA
S241-p	yGGGysPsyDRRAHP
Y242-p	GGGysPsyDRRAHPE
Y252	RAHPETRYERSRSRE
S255	PETRYERSRSREHLR
S257	TRYERSRSREHLRsR
S263-p	RSREHLRsRsPsPES
S265-p	REHLRsRsPsPESRS
S267-p	HLRsRsPsPESRSRH
K294-u	GVLLTKSkANEEYGL
Y299	KSkANEEYGLRLGsQ
S305-p	EYGLRLGsQIFIKEM
T313	QIFIKEMTRTGLATk
T315	FIKEMTRTGLATkDG
T319	MTRTGLATkDGNLHE
K320-u	TRTGLATkDGNLHEG
S365	QLVVLRDSKQtLINI
T368-p	VLRDSKQtLINIPAL
A374	QtLINIPALNDsDsE
S378-p	NIPALNDsDsEVEDI
S380-p	PALNDsDsEVEDISE
S393-p	SEIESNRsFsPEERR
S395-p	IESNRsFsPEERRQQ
Y403-p	PEERRQQysDQDyHs
S404-p	EERRQQysDQDyHss
Q406	RRQQysDQDyHsstE
Y408-p	QQysDQDyHsstEkL
S410-p	ysDQDyHsstEkLKE
S411-p	sDQDyHsstEkLKER
T412-p	DQDyHsstEkLKERP
K414-u	DyHsstEkLKERPSS
S420	EkLKERPSSREETSG
S421	kLKERPSSREETSGR
T435-p	RLSRMGAtPtPFkst
T437-p	SRMGAtPtPFkstGD
K440-u	GAtPtPFkstGDITA
S441-p	AtPtPFkstGDITAA
T442-p	tPtPFkstGDITAAG
R455	AGVTEASREPRYQEE
Y459	EASREPRYQEEGPVP
G463	EPRYQEEGPVPQPRT
S479-p	PRVFLRPsPEDEAIy
Y486-p	sPEDEAIyGPNTKMV
T490	EAIyGPNTKMVRFKK
Y554-p	VREDAVLyLLEIPKG
T565	IPKGETVTILAQsRA
S570-p	TVTILAQsRADVYRD
Y618	FRVVDTLYDGkLGHW
K621-u	VDTLYDGkLGHWLAV
K678-u	QRSSGGVkKNLRKsR
S684-p	VkKNLRKsREDLAAA
A689	RKsREDLAAAVSVST
S693	EDLAAAVSVSTKFPA
S695	LAAAVSVSTKFPAYE
T742	DLFQTAKTEPKDAGS
S749	TEPKDAGSEkSSGVV
K751-a	PKDAGSEkSSGVVRL
K751-u	PKDAGSEkSSGVVRL
S752	KDAGSEkSSGVVRLN
S753	DAGSEkSSGVVRLNT
T760	SGVVRLNTVRQIIEQ
T813	IRQRLSPTSNKSSRK
S814	RQRLSPTSNKSSRKL
S818	SPTSNKSSRKLFDQA
S868	QNEAVWVSEGKMEGM
S884-p	DDAEDRMsYLtAMGA
Y885	DAEDRMsYLtAMGAD
T887-p	EDRMsYLtAMGADYL
Y893	LtAMGADYLsCDSRL
S895-p	AMGADYLsCDSRLIs
S898	ADYLsCDSRLIsDFE
S902-p	sCDSRLIsDFEDtDG
T907-p	LIsDFEDtDGEGGAy
Y914-p	tDGEGGAytDNELEE
T915-p	DGEGGAytDNELEEP
N943	EPVQHEENIRKssPE
S947-p	HEENIRKssPEPRAQ
S948-p	EENIRKssPEPRAQM
S960-p	AQMRRAAsRDQLRDA
R961	QMRRAAsRDQLRDAs
S968-p	RDQLRDAsPPPAFKP
S988-p	RSQNREDsFDyskSN
F989	SQNREDsFDyskSNL
Y991-p	NREDsFDyskSNLPA
S992-p	REDsFDyskSNLPAT
-	gap
-	gap
-	gap
K993-u	EDsFDyskSNLPATA
I1004	PATAGSEIPGGSTKG
P1025	AKPAFGRPILKPSTP
S1030	GRPILKPSTPVPMPE
T1031	RPILKPSTPVPMPES
S1044	ESEEVGESTEEQEDA
T1045	SEEVGESTEEQEDAP
Y1095-p	AQKHPDIyAVPIKAP
A1101	IyAVPIKAPKPDAGL
L1108	APKPDAGLPPHMSSR
M1112	DAGLPPHMSSRPPEP
S1124	PEPQKAPSRLYQDTR
Y1127	QKAPSRLYQDTRGsy
S1133-p	LYQDTRGsyGsDPEE
Y1134-p	YQDTRGsyGsDPEEE
S1136-p	DTRGsyGsDPEEEEY
Y1143	sDPEEEEYRQQLAAH
Y1155-p	AAHSKRGyySQPSRY
Y1156-p	AHSKRGyySQPSRYR

	rat
-	gap
T68	RVVMVNGTPMEDVLH
S107-p	QVAPLQGsPPLSHDD
S111	LQGsPPLSHDDRGFE
S127	MDEFDGRSFRSGYSE
S130	FDGRSFRSGYSERSR
S133	RSFRSGYSERSRHSS
S140	SERSRHSSHDMLSHS
S145	HSSHDMLSHSWEDSR
S147	SHDMLSHSWEDSRER
S151	LSHSWEDSRERGRPH
S163	RPHQRAQSRERERSR
-	gap
S169	QSRERERSRGRSLER
S173	RERSRGRSLERGLDH
S186	DHEDYGRSHERSRGR
S190	YGRSHERSRGRSLER
S194	HERSRGRSLERGLDR
S205	GLDRDFVSRDYSRGR
S209	DFVSRDYSRGRSIDR
S213	RDYSRGRSIDRDYDR
D217	RGRSIDRDYDRDYER
Y218	GRSIDRDYDRDYERS
Y222	DRDYDRDYERSYHQA
S225	YDRDYERSYHQAYEP
Y226	DRDYERSYHQAYEPD
Y230	ERSYHQAYEPDYEGR
Y234	HQAYEPDYEGRYsPS
Y238	EPDYEGRYsPSYDRR
S239-p	PDYEGRYsPSYDRRA
S241	YEGRYsPSYDRRAHP
Y242	EGRYsPSYDRRAHPE
Y252	RAHPETRYERSRSRE
S255	PETRYERSRSREHLR
S257	TRYERSRSREHLRSR
S263	RSREHLRSRSPTPES
S265	REHLRSRSPTPESRS
T267	HLRSRSPTPESRSRQ
K294	GVLLTKSKANEEYGL
Y299	KSKANEEYGLRLGSQ
S305	EYGLRLGSQIFIKEM
T313	QIFIKEMTRTGLATK
T315	FIKEMTRTGLATKDG
T319	MTRTGLATKDGNLHE
K320	TRTGLATKDGNLHEG
S365	QLVVLRDSKQTLINI
T368	VLRDSKQTLINIPSL
S374	QTLINIPSLNDsDsE
S378-p	NIPSLNDsDsEVEDI
S380-p	PSLNDsDsEVEDISE
S393	SEIESNRSFSPEERR
S395	IESNRSFSPEERRQQ
Y403	PEERRQQYsDQEYHS
S404-p	EERRQQYsDQEYHSS
Q406	RRQQYsDQEYHSSTE
Y408	QQYsDQEYHSSTEKL
S410	YsDQEYHSSTEKLKE
S411	sDQEYHSSTEKLKER
T412	DQEYHSSTEKLKERP
K414	EYHSSTEKLKERPSS
S420	EKLKERPSSREETSG
S421	KLKERPSSREETSGR
T435	RMSRMGATPTPFKST
T437	SRMGATPTPFKSTGD
K440	GATPTPFKSTGDITA
S441	ATPTPFKSTGDITAA
T442	TPTPFKSTGDITAAG
K455	AGVTEANKEPRSQEE
S459	EANKEPRSQEEsPVP
S463-p	EPRSQEEsPVPQPRT
S479	SRVFLRPSPEDEAIY
Y486	SPEDEAIYGPNTKMV
T490	EAIYGPNTKMVKFKK
Y554-p	VREDAVLyLLEIPKG
T565	IPKGETVTILAQSRA
S570	TVTILAQSRADVYRD
Y618	FRVVDTLYDGKLGHW
K621	VDTLYDGKLGHWLAV
K676	RGQRSGVKKNIRKSR
S682	VKKNIRKSREDLAAA
A687	RKSREDLAAAVSVST
S691	EDLAAAVSVSTKFPA
S693	LAAAVSVSTKFPAYE
T740	DLFQTAKTEPKDAGS
S747	TEPKDAGSEKSSGVV
K749	PKDAGSEKSSGVVRL
K749	PKDAGSEKSSGVVRL
S750	KDAGSEKSSGVVRLN
S751	DAGSEKSSGVVRLNT
T758	SGVVRLNTVRQIIEQ
T811	IRQRLNPTSNKSSRK
S812	RQRLNPTSNKSSRKL
S816	NPTSNKSSRKLFDQA
S866	QNEAVWVSEGKMEGM
S882	DDAEDRMSYLTAMGA
Y883	DAEDRMSYLTAMGAD
T885	EDRMSYLTAMGADYL
Y891	LTAMGADYLSCDSRL
S893	AMGADYLSCDSRLIS
S896	ADYLSCDSRLISDFE
S900	SCDSRLISDFEDTDG
T905	LISDFEDTDGEGGAY
Y912	TDGEGGAYTDNELDE
T913	DGEGGAYTDNELDEP
S941	EPVQHEESIRKPSPE
P945	HEESIRKPSPEPRAQ
S946	EESIRKPSPEPRAQM
S958	AQMRRAASRDQLRDG
R959	QMRRAASRDQLRDGs
S966-p	RDQLRDGsPPPAFKP
S986	RNQNREDSFNYSKSN
F987	NQNREDSFNYSKSNL
Y989	NREDSFNYSKSNLSA
S990	REDSFNYSKSNLSAM
-	gap
-	gap
-	gap
K991	EDSFNYSKSNLSAMA
I1002	SAMAGSEIPGGSTKG
S1023	VKPAFGRSILKPSTP
S1028	GRSILKPSTPVPMPE
T1029	RSILKPSTPVPMPES
S1042	ESEEVGESTEEQEEA
T1043	SEEVGESTEEQEEAP
Y1093-p	AQKHPDIyAVPIKAP
A1099	IyAVPIKAPKPDAGL
L1106	APKPDAGLPQHMRPP
M1110	DAGLPQHMRPPEPQK
S1120	PEPQKAPSRLYQDTR
Y1123	QKAPSRLYQDTRGsY
S1129-p	LYQDTRGsYGsDPEE
Y1130	YQDTRGsYGsDPEEE
S1132-p	DTRGsYGsDPEEEEE
Y1140	DPEEEEEYRQQLAAH
Y1152	AAHSKRGYYSQPSRY
Y1153	AHSKRGYYSQPSRYR

	dog
-	gap
T68	RVVMVNGTPMEDVLH
S107	QLAPPQGSLPVDEDD
D111	PQGSLPVDEDDRAFE
S127	MDEFDGRSARSGYSE
S130	FDGRSARSGYSERSR
S133	RSARSGYSERSRRSS
S140	SERSRRSSHGGRSRS
S145	RSSHGGRSRSWEDSP
S147	SHGGRSRSWEDSPER
S151	RSRSWEDSPERGRPH
S163	RPHERAWSQERERSR
-	gap
S169	WSQERERSRGRSLER
S173	RERSRGRSLERGLDH
P187	HDDDYRRPRERSRGR
S191	YRRPRERSRGRSLER
S195	RERSRGRSLERGLDH
G207	LDHDDDYGRPGERSH
-	gap
S213	YGRPGERSHGMSTDR
S217	GERSHGMSTDRGYDR
T218	ERSHGMSTDRGYDRG
Y222	GMSTDRGYDRGYDRG
G225	TDRGYDRGYDRGYDR
Y226	DRGYDRGYDRGYDRG
Y230	DRGYDRGYDRGYDRT
Y234	DRGYDRGYDRTYSPE
Y238	DRGYDRTYSPEAEYG
S239	RGYDRTYSPEAEYGR
E243	RTYSPEAEYGRRTQP
Y244	TYSPEAEYGRRTQPD
H254	RTQPDARHAGSRSRS
S259	ARHAGSRSRSREHLR
S261	HAGSRSRSREHLRSR
S267	RSREHLRSRSPSPEL
S269	REHLRSRSPSPELRG
S271	HLRSRSPSPELRGRP
K298	GVLLMKSKANEEYGL
Y303	KSKANEEYGLRLGSQ
S309	EYGLRLGSQIFIKQM
T317	QIFIKQMTRTALATK
T319	FIKQMTRTALATKDG
T323	MTRTALATKDGNLHE
K324	TRTALATKDGNLHEG
S369-p	QLVVLRDsKQTLINI
T372	VLRDsKQTLINIPSL
S378	QTLINIPSLNDSDSE
S382	NIPSLNDSDSEIEDI
S384	PSLNDSDSEIEDISE
S397	SEIESNRSFSPEERR
S399	IESNRSFSPEERRQQ
Y407	PEERRQQYSDYDYHS
S408	EERRQQYSDYDYHSS
Y410	RRQQYSDYDYHSSNE
Y412	QQYSDYDYHSSNEKL
S414	YSDYDYHSSNEKLKE
S415	SDYDYHSSNEKLKER
N416	DYDYHSSNEKLKERP
K418	DYHSSNEKLKERPNS
N424	EKLKERPNSREDMQN
S425	KLKERPNSREDMQNR
T439	RWSRMGATPTPFKSM
T441	SRMGATPTPFKSMGD
K444	GATPTPFKSMGDIAS
S445	ATPTPFKSMGDIASV
M446	TPTPFKSMGDIASVV
K459	VVGTENSKEPRYQEE
Y463	ENSKEPRYQEEPPAP
P467	EPRYQEEPPAPQPKA
S483	PRTFLRPSPEDEAIY
Y490	SPEDEAIYGPNTKMV
T494	EAIYGPNTKMVRFKK
Y558	VREDAVLYLLEIPKG
T569	IPKGEMVTILAQSRA
S574	MVTILAQSRADVYRD
Y622	FRVVDTLYDGKLGHW
K625	VDTLYDGKLGHWLAV
K680	RGQRSGMKKNLRKSR
S686	MKKNLRKSREDLTAA
T691	RKSREDLTAAVSVST
S695	EDLTAAVSVSTKFPA
S697	LTAAVSVSTKFPAYE
T744	DLFQTAKTEPKDAGS
S751	TEPKDAGSEKSSGVV
K753	PKDAGSEKSSGVVRL
K753	PKDAGSEKSSGVVRL
S754	KDAGSEKSSGVVRLN
S755	DAGSEKSSGVVRLNT
T762	SGVVRLNTVRQIIEQ
T815	MRQRLNPTSNKSSRK
S816	RQRLNPTSNKSSRKL
S820	NPTSNKSSRKLYDQA
S870	QGEAVWVSEGKMEGM
S886	DDPEDRMSYLTAMGA
Y887	DPEDRMSYLTAMGAD
T889	EDRMSYLTAMGADYL
Y895	LTAMGADYLSCDSRL
S897	AMGADYLSCDSRLIS
S900	ADYLSCDSRLISDFE
S904	SCDSRLISDFEDTDG
T909	LISDFEDTDGEGGAY
Y916	TDGEGGAYTDNELDE
T917	DGEGGAYTDNELDEP
S945	EPVQHEESIRKPSPE
P949	HEESIRKPSPEPRAQ
S950	EESIRKPSPEPRAQM
S962	AQMRRAASRDQLRDS
R963	QMRRAASRDQLRDSS
S970	RDQLRDSSPPPAFKP
S990	KTQNREESFDISRSH
F991	TQNREESFDISRSHD
I993	NREESFDISRSHDYK
S994	REESFDISRSHDYKS
S996	ESFDISRSHDYKSNP
H997	SFDISRSHDYKSNPS
Y999	DISRSHDYKSNPSAV
K1000	ISRSHDYKSNPSAVA
V1011	SAVAGNEVSGASTRS
S1032	AKPSFGRSILKPSTP
S1037	GRSILKPSTPVPSPE
T1038	RSILKPSTPVPSPES
G1051	ESEEVGEGSEEQEGA
S1052	SEEVGEGSEEQEGAP
Y1102	AQKHPDIYAVPIKTH
T1108	IYAVPIKTHKPDPGL
L1115	THKPDPGLSQHTSSR
T1119	DPGLSQHTSSRPPEP
S1131	PEPQKGPSRLYQDPR
Y1134	QKGPSRLYQDPRGSY
S1140	LYQDPRGSYGSDAEE
Y1141	YQDPRGSYGSDAEEE
S1143	DPRGSYGSDAEEEEY
Y1150	SDAEEEEYRQQLSEH
Y1162	SEHSKRGYYSQPSRY
Y1163	EHSKRGYYSQPSRYR

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