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Protein Page:
ZO2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZO2 a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. Note: This description may include information from UniProtKB.. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; tight junction; adherens junction; cytoplasm; plasma membrane; cytosol; cell junction
Molecular Function: protein C-terminus binding; guanylate kinase activity; protein binding
Biological Process: response to organic substance; apoptosis; cell structure disassembly during apoptosis; nucleotide phosphorylation
Reference #:  Q9UDY2 (UniProtKB)
Alt. Names/Synonyms: Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; Tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO 2; Tight junction protein ZO-2; TJP2; X104; ZO2; Zona occludens protein 2; Zonula occludens protein 2
Gene Symbols: TJP2
Molecular weight: 133,958 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ZO2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S16-p FPPRRELsGWLRAPG
0 1 T91-p RVVMVNGtPMEDVLH
0 44 S130-p QVAALQAsPPLDQDD
0 5 D134 LQAsPPLDQDDRAFE
0 3 S150-p MDEFDGRsFRsGYsE
0 2 S153-p FDGRsFRsGYsERSR
0 1 S156-p RsFRsGYsERSRLNs
0 29 S163-p sERSRLNsHGGRsRs
0 8 S168-p LNsHGGRsRsWEDsP
0 38 S170-p sHGGRsRsWEDsPER
0 35 S174-p RsRsWEDsPERGRPH
0 1 S186-p RPHERARsRERDLsR
0 5 S192-p RsRERDLsRDRsRGR
0 4 S196-p RDLsRDRsRGRsLER
0 4 S200-p RDRsRGRsLERGLDQ
0 3 T212-p LDQDHARtRDRsRGR
0 21 S216-p HARtRDRsRGRsLER
0 21 S220-p RDRsRGRsLERGLDH
0 2 S232-p LDHDFGPsRDRDRDR
0 5 D236 FGPsRDRDRDRsRGR
0 14 S240-p RDRDRDRsRGRsIDQ
0 181 S244-p RDRsRGRsIDQDyER
0 2 I245 DRsRGRsIDQDyERA
0 191 Y249-p GRsIDQDyERAyHRA
0 1 A252 IDQDyERAyHRAyDP
0 24 Y253-p DQDyERAyHRAyDPD
0 14 Y257-p ERAyHRAyDPDyERA
0 304 Y261-p HRAyDPDyERAysPE
0 45 Y265-p DPDyERAysPEyRRG
0 142 S266-p PDyERAysPEyRRGA
0 1 E268 yERAysPEyRRGARH
0 45 Y269-p ERAysPEyRRGARHD
0 1 S279-p GARHDARsRGPRsRs
1 0 P282 HDARsRGPRsRsREH
1 0 P282 HDARsRGPRsRsREH
0 1 S284-p ARsRGPRsRsREHPH
0 1 S286-p sRGPRsRsREHPHsR
0 8 S292-p RsREHPHsRsPsPEP
0 8 S294-p REHPHsRsPsPEPRG
0 9 S296-p HPHsRsPsPEPRGRP
0 1 P299 sRsPsPEPRGRPGPI
0 1 R314 GVLLMKSRANEEyGL
0 1 Y319-p KSRANEEyGLRLGsQ
0 11 S325-p EyGLRLGsQIFVKEM
0 1 T333-p QIFVKEMtRtGLAtK
0 1 T335-p FVKEMtRtGLAtKDG
0 2 T339-p MtRtGLAtKDGNLHE
0 1 K340 tRtGLAtKDGNLHEG
1 1 S385-p QLVVLRDsQQTLINI
0 1 T388 VLRDsQQTLINIPsL
0 2 S394-p QTLINIPsLNDsDsE
0 15 S398-p NIPsLNDsDsEIEDI
0 16 S400-p PsLNDsDsEIEDIsE
0 1 S406-p DsEIEDIsEIESNRs
0 2 S413-p sEIESNRsFsPEERR
0 18 S415-p IESNRsFsPEERRHQ
0 20 Y423-p PEERRHQysDyDyHs
0 47 S424-p EERRHQysDyDyHss
0 263 Y426-p RRHQysDyDyHsssE
0 107 Y428-p HQysDyDyHsssEKL
0 15 S430-p ysDyDyHsssEKLKE
0 19 S431-p sDyDyHsssEKLKER
0 6 S432-p DyDyHsssEKLKERP
0 1 K434 DyHsssEKLKERPss
0 3 S440-p EKLKERPssREDtPS
0 3 S441-p KLKERPssREDtPSR
0 1 T445-p RPssREDtPSRLSRM
0 5 T455-p RLSRMGAtPtPFKst
0 2 T457-p SRMGAtPtPFKstGD
0 1 K460 GAtPtPFKstGDIAG
0 15 S461-p AtPtPFKstGDIAGT
0 7 T462-p tPtPFKstGDIAGTV
0 1 A466 FKstGDIAGTVVPET
0 1 K475-ub TVVPETNkEPRyQED
0 2 Y479-p ETNkEPRyQEDPPAP
0 2 P483 EPRyQEDPPAPQPKA
0 4 S499-p PRTFLRPsPEDEAIy
0 215 Y506-p sPEDEAIyGPNtKMV
0 5 T510-p EAIyGPNtKMVRFKK
0 6 Y574-p VREDAVLyLLEIPKG
0 1 T585-p IPKGEMVtILAQsRA
0 3 S590-p MVtILAQsRADVYRD
0 1 Y638-p FRVVDTLyDGKLGNW
0 1 K641 VDTLyDGKLGNWLAV
0 1 K696 RGQRSGVKKNLRKsR
0 8 S702-p VKKNLRKsREDLtAV
0 1 T707-p RKsREDLtAVVsVsT
0 1 S711-p EDLtAVVsVsTKFPA
0 1 S713-p LtAVVsVsTKFPAYE
0 1 T760-p DWFQTAKtEPKDAGs
0 1 S767-p tEPKDAGsEKstGVV
0 1 K769 PKDAGsEKstGVVRL
0 1 K769 PKDAGsEKstGVVRL
0 1 S770-p KDAGsEKstGVVRLN
0 1 T771-p DAGsEKstGVVRLNt
0 1 T778-p tGVVRLNtVRQIIEQ
0 2 T831-p MRQRLNPtsNKSsRK
0 1 S832-p RQRLNPtsNKSsRKL
0 1 S836-p NPtsNKSsRKLFDQA
0 1 S886-p QGEAVWVsEGKMEGM
0 2 S902-p DDPEDRMsyLtAMGA
0 1 Y903-p DPEDRMsyLtAMGAD
0 2 T905-p EDRMsyLtAMGADyL
0 54 Y911-p LtAMGADyLsCDsRL
0 23 S913-p AMGADyLsCDsRLIs
0 3 S916-p ADyLsCDsRLIsDFE
0 31 S920-p sCDsRLIsDFEDtDG
0 23 T925-p LIsDFEDtDGEGGAy
0 9 Y932-p tDGEGGAytDNELDE
0 20 T933-p DGEGGAytDNELDEP
0 5 S961-p EPVQHEEsIRKPsPE
0 3 P965 HEEsIRKPsPEPRAQ
0 79 S966-p EEsIRKPsPEPRAQM
0 135 S978-p AQMRRAAssDQLRDN
0 20 S979-p QMRRAAssDQLRDNs
0 203 S986-p sDQLRDNsPPPAFKP
0 25 S1006-p KTQNKEEsyDFSKsy
0 174 Y1007-p TQNKEEsyDFSKsyE
0 3 F1009 NKEEsyDFSKsyEyk
0 1 S1010 KEEsyDFSKsyEykS
0 3 S1012-p EsyDFSKsyEykSNP
0 15 Y1013-p syDFSKsyEykSNPS
0 1 Y1015-p DFSKsyEykSNPSAV
0 2 K1016-ub FSKsyEykSNPSAVA
0 4 T1027-p SAVAGNEtPGASTKG
0 1 S1031 GNEtPGASTKGYPPP
0 1 S1048-p AKPTFGRsILKPstP
0 3 S1053-p GRsILKPstPIPPQE
0 4 T1054-p RsILKPstPIPPQEG
0 1 G1061 tPIPPQEGEEVGEss
0 11 S1067-p EGEEVGEssEEQDNA
0 10 S1068-p GEEVGEssEEQDNAP
0 927 Y1118-p AQKHPDIyAVPIKtH
0 1 T1124-p IyAVPIKtHKPDPGt
0 3 T1131-p tHKPDPGtPQHtSSR
0 1 T1135-p DPGtPQHtSSRPPEP
0 3 S1147-p PEPQKAPsRPyQDTR
0 1 Y1150-p QKAPsRPyQDTRGsy
0 9 S1156-p PyQDTRGsyGsDAEE
0 4 Y1157-p yQDTRGsyGsDAEEE
0 89 S1159-p DTRGsyGsDAEEEEy
0 24 Y1166-p sDAEEEEyRQQLSEH
0 64 Y1178-p SEHSKRGyyGQSARY
0 38 Y1179-p EHSKRGyyGQSARYR
  ZO2 iso2  
S16 FPPRRELSGWLRAPG
T91 RVVMVNGTPMEDVLH
S130 QVAALQASPPLDQDD
D134 LQASPPLDQDDRAFE
S150 MDEFDGRSFRSGYSE
S153 FDGRSFRSGYSERSR
S156 RSFRSGYSERSRLNS
S163 SERSRLNSHGGRSRS
S168 LNSHGGRSRSWEDSP
S170 SHGGRSRSWEDSPER
S174 RSRSWEDSPERGRPH
S186 RPHERARSRERDLSR
S192 RSRERDLSRDRSRGR
S196 RDLSRDRSRGRSLER
S200 RDRSRGRSLERGLDQ
T212 LDQDHARTRDRSRGR
S216 HARTRDRSRGRSLER
S220 RDRSRGRSLERGLDH
S232 LDHDFGPSRDRDRDR
D236 FGPSRDRDRDRSRGR
S240 RDRDRDRSRGRSIDQ
S244 RDRSRGRSIDQDYER
I245 DRSRGRSIDQDYERA
Y249 GRSIDQDYERAYHRA
A252 IDQDYERAYHRAYDP
Y253 DQDYERAYHRAYDPD
Y257 ERAYHRAYDPDyERA
Y261-p HRAYDPDyERAySPE
Y265-p DPDyERAySPEYRRG
S266 PDyERAySPEYRRGA
E268 yERAySPEYRRGARH
Y269 ERAySPEYRRGARHD
S279 GARHDARSRGPRSRS
P282 HDARSRGPRSRSREH
P282 HDARSRGPRSRSREH
S284 ARSRGPRSRSREHPH
S286 SRGPRSRSREHPHSR
S292 RSREHPHSRSPSPEP
S294 REHPHSRSPSPEPRG
S296 HPHSRSPSPEPRGRP
P299 SRSPSPEPRGRPGPI
R314 GVLLMKSRANEEYGL
Y319 KSRANEEYGLRLGSQ
S325 EYGLRLGSQIFVKEM
T333 QIFVKEMTRTGLATK
T335 FVKEMTRTGLATKDG
T339 MTRTGLATKDGNLHE
K340 TRTGLATKDGNLHEG
S385 QLVVLRDSQQTLINI
T388 VLRDSQQTLINIPSL
S394 QTLINIPSLNDSDSE
S398 NIPSLNDSDSEIEDI
S400 PSLNDSDSEIEDISE
S406 DSEIEDISEIESNRS
S413 SEIESNRSFSPEERR
S415 IESNRSFSPEERRHQ
Y423 PEERRHQYSDyDyHS
S424 EERRHQYSDyDyHSS
Y426-p RRHQYSDyDyHSSSE
Y428-p HQYSDyDyHSSSEKL
S430 YSDyDyHSSSEKLKE
S431 SDyDyHSSSEKLKER
S432 DyDyHSSSEKLKERP
K434 DyHSSSEKLKERPSS
S440 EKLKERPSSREDTPS
S441 KLKERPSSREDTPSR
T445 RPSSREDTPSRLSRM
T455 RLSRMGATPTPFKST
T457 SRMGATPTPFKSTGD
K460 GATPTPFKSTGDIAG
S461 ATPTPFKSTGDIAGT
T462 TPTPFKSTGDIAGTV
A466 FKSTGDIAGTVVPET
K475 TVVPETNKEPRYQED
Y479 ETNKEPRYQEDPPAP
P483 EPRYQEDPPAPQPKA
S499 PRTFLRPSPEDEAIy
Y506-p SPEDEAIyGPNTKMV
T510 EAIyGPNTKMVRFKK
Y574 VREDAVLYLLEIPKG
T585 IPKGEMVTILAQSRA
S590 MVTILAQSRADVYRD
Y638 FRVVDTLYDGKLGNW
K641 VDTLYDGKLGNWLAV
K696 RGQRSGVKKNLRKSR
S702 VKKNLRKSREDLTAV
T707 RKSREDLTAVVSVST
S711 EDLTAVVSVSTKFPA
S713 LTAVVSVSTKFPAYE
T760 DWFQTAKTEPKDAGS
S767 TEPKDAGSEKSTGVV
K769 PKDAGSEKSTGVVRL
K769 PKDAGSEKSTGVVRL
S770 KDAGSEKSTGVVRLN
T771 DAGSEKSTGVVRLNT
T778 TGVVRLNTVRQIIEQ
T831 MRQRLNPTSNKSSRK
S832 RQRLNPTSNKSSRKL
S836 NPTSNKSSRKLFDQA
S886 QGEAVWVSEGKMEGM
S902 DDPEDRMSYLTAMGA
Y903 DPEDRMSYLTAMGAD
T905 EDRMSYLTAMGADYL
Y911 LTAMGADYLSCDSRL
S913 AMGADYLSCDSRLIS
S916 ADYLSCDSRLISDFE
S920 SCDSRLISDFEDTDG
T925 LISDFEDTDGEGGAY
Y932 TDGEGGAYTDNELDE
T933 DGEGGAYTDNELDEP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y971-p AQKHPDIyAVPIKTH
T977 IyAVPIKTHKPDPGT
T984 THKPDPGTPQHTSSR
T988 DPGTPQHTSSRPPEP
S1000 PEPQKAPSRPYQDTR
Y1003 QKAPSRPYQDTRGSY
S1009 PYQDTRGSYGSDAEE
Y1010 YQDTRGSYGSDAEEE
S1012 DTRGSYGSDAEEEEY
Y1019 SDAEEEEYRQQLSEH
Y1031 SEHSKRGYYGQSARY
Y1032 EHSKRGYYGQSARYR
  mouse

 
- gap
T68 RVVMVNGTPMEDVLH
S107-p QVAPLQGsPPLsHDD
S111-p LQGsPPLsHDDRGFE
S127-p IEEFDGRsFRsGYSE
S130-p FDGRsFRsGYSERSR
S133 RsFRsGYSERSRHSs
S140-p SERSRHSsHDMLsHs
S145-p HSsHDMLsHsWEGNR
S147-p sHDMLsHsWEGNRER
N151 LsHsWEGNRERGRPH
S163 RPHQRTQSRERERSR
- gap
S169 QSRERERSRGRSLER
S173 RERSRGRSLERGLDQ
S186-p DQEDYGRsRERsRGR
S190-p YGRsRERsRGRsLER
S194-p RERsRGRsLERGLDR
S205-p GLDRDFVsRDHsRGR
S209-p DFVsRDHsRGRsIDR
S213-p RDHsRGRsIDRDyDR
D217 RGRsIDRDyDRDYER
Y218-p GRsIDRDyDRDYERs
Y222 DRDyDRDYERsYHEA
S225-p yDRDYERsYHEAyEP
Y226 DRDYERsYHEAyEPD
Y230-p ERsYHEAyEPDyGGG
Y234-p HEAyEPDyGGGysPs
Y238-p EPDyGGGysPsyDRR
S239-p PDyGGGysPsyDRRA
S241-p yGGGysPsyDRRAHP
Y242-p GGGysPsyDRRAHPE
Y252 RAHPETRYERSRSRE
- gap
- gap
S255 PETRYERSRSREHLR
S257 TRYERSRSREHLRsR
S263-p RSREHLRsRsPsPES
S265-p REHLRsRsPsPESRS
S267-p HLRsRsPsPESRSRH
S270 sRsPsPESRSRHEHK
K294-ub GVLLTKSkANEEYGL
Y299 KSkANEEYGLRLGsQ
S305-p EYGLRLGsQIFIKEM
T313 QIFIKEMTRTGLATk
T315 FIKEMTRTGLATkDG
T319 MTRTGLATkDGNLHE
K320-ub TRTGLATkDGNLHEG
S365 QLVVLRDSKQtLINI
T368-p VLRDSKQtLINIPAL
A374 QtLINIPALNDsDsE
S378-p NIPALNDsDsEVEDI
S380-p PALNDsDsEVEDISE
S386 DsEVEDISEIESNRs
S393-p SEIESNRsFsPEERR
S395-p IESNRsFsPEERRQQ
Y403-p PEERRQQysDQDyHs
S404-p EERRQQysDQDyHss
Q406 RRQQysDQDyHsstE
Y408-p QQysDQDyHsstEkL
S410-p ysDQDyHsstEkLKE
S411-p sDQDyHsstEkLKER
T412-p DQDyHsstEkLKERP
K414-ub DyHsstEkLKERPss
S420-p EkLKERPssREETSG
S421-p kLKERPssREETSGR
T425 RPssREETSGRLSRM
T435-p RLSRMGAtPtPFkst
T437-p SRMGAtPtPFkstGD
K440-ub GAtPtPFkstGDItA
S441-p AtPtPFkstGDItAA
T442-p tPtPFkstGDItAAG
T446-p FkstGDItAAGVTEA
R455 AGVTEASREPRYQEE
Y459 EASREPRYQEEGPVP
G463 EPRYQEEGPVPQPRT
S479-p PRVFLRPsPEDEAIy
Y486-p sPEDEAIyGPNTKMV
T490 EAIyGPNTKMVRFKK
Y554-p VREDAVLyLLEIPKG
T565 IPKGETVTILAQsRA
S570-p TVTILAQsRADVYRD
Y618 FRVVDTLYDGkLGHW
K621-ub VDTLYDGkLGHWLAV
K678-ub QRSSGGVkKNLRKsR
S684-p VkKNLRKsREDLAAA
A689 RKsREDLAAAVSVST
S693 EDLAAAVSVSTKFPA
S695 LAAAVSVSTKFPAYE
T742 DLFQTAKTEPKDAGS
S749 TEPKDAGSEkSSGVV
K751-ac PKDAGSEkSSGVVRL
K751-ub PKDAGSEkSSGVVRL
S752 KDAGSEkSSGVVRLN
S753 DAGSEkSSGVVRLNT
T760 SGVVRLNTVRQIIEQ
T813 IRQRLSPTSNKSSRK
S814 RQRLSPTSNKSSRKL
S818 SPTSNKSSRKLFDQA
S868 QNEAVWVSEGKMEGM
S884-p DDAEDRMsYLtAMGA
Y885 DAEDRMsYLtAMGAD
T887-p EDRMsYLtAMGADYL
Y893 LtAMGADYLsCDsRL
S895-p AMGADYLsCDsRLIs
S898-p ADYLsCDsRLIsDFE
S902-p sCDsRLIsDFEDtDG
T907-p LIsDFEDtDGEGGAy
Y914-p tDGEGGAytDNELEE
T915-p DGEGGAytDNELEEP
N943 EPVQHEENIRKssPE
S947-p HEENIRKssPEPRAQ
S948-p EENIRKssPEPRAQM
S960-p AQMRRAAsRDQLRDA
R961 QMRRAAsRDQLRDAs
S968-p RDQLRDAsPPPAFKP
S988-p RSQNREDsFDyskSN
F989 SQNREDsFDyskSNL
Y991-p NREDsFDyskSNLPA
S992-p REDsFDyskSNLPAT
- gap
- gap
- gap
K993-ub EDsFDyskSNLPATA
I1004 PATAGSEIPGGsTKG
S1008-p GSEIPGGsTKGYPPP
P1025 AKPAFGRPILKPSTP
S1030 GRPILKPSTPVPMPE
T1031 RPILKPSTPVPMPES
S1038 TPVPMPESEEVGEST
S1044 ESEEVGESTEEQEDA
T1045 SEEVGESTEEQEDAP
Y1095-p AQKHPDIyAVPIKAP
A1101 IyAVPIKAPKPDAGL
L1108 APKPDAGLPPHMSSR
M1112 DAGLPPHMSSRPPEP
S1124 PEPQKAPSRLYQDTR
Y1127 QKAPSRLYQDTRGsy
S1133-p LYQDTRGsyGsDPEE
Y1134-p YQDTRGsyGsDPEEE
S1136-p DTRGsyGsDPEEEEY
Y1143 sDPEEEEYRQQLAAH
Y1155-p AAHSKRGyySQPSRY
Y1156-p AHSKRGyySQPSRYR
  rat

 
- gap
T68 RVVMVNGTPMEDVLH
S107-p QVAPLQGsPPLsHDD
S111-p LQGsPPLsHDDRGFE
S127 MDEFDGRSFRSGYSE
S130 FDGRSFRSGYSERSR
S133 RSFRSGYSERSRHSS
S140 SERSRHSSHDMLSHS
S145 HSSHDMLSHSWEDSR
S147 SHDMLSHSWEDSRER
S151 LSHSWEDSRERGRPH
S163 RPHQRAQSRERERSR
- gap
S169 QSRERERSRGRSLER
S173 RERSRGRSLERGLDH
S186 DHEDYGRSHERSRGR
S190 YGRSHERSRGRSLER
S194 HERSRGRSLERGLDR
S205 GLDRDFVSRDYSRGR
S209 DFVSRDYSRGRsIDR
S213-p RDYSRGRsIDRDYDR
D217 RGRsIDRDYDRDYER
Y218 GRsIDRDYDRDYERS
Y222 DRDYDRDYERSYHQA
S225 YDRDYERSYHQAYEP
Y226 DRDYERSYHQAYEPD
Y230 ERSYHQAYEPDYEGR
Y234 HQAYEPDYEGRYsPS
Y238 EPDYEGRYsPSyDRR
S239-p PDYEGRYsPSyDRRA
S241 YEGRYsPSyDRRAHP
Y242-p EGRYsPSyDRRAHPE
Y252 RAHPETRYERSRSRE
- gap
- gap
S255 PETRYERSRSREHLR
S257 TRYERSRSREHLRsR
S263-p RSREHLRsRsPtPEs
S265-p REHLRsRsPtPEsRS
T267-p HLRsRsPtPEsRSRQ
S270-p sRsPtPEsRSRQEHK
K294 GVLLTKSKANEEYGL
Y299 KSKANEEYGLRLGSQ
S305 EYGLRLGSQIFIKEM
T313 QIFIKEMTRTGLATK
T315 FIKEMTRTGLATKDG
T319 MTRTGLATKDGNLHE
K320 TRTGLATKDGNLHEG
S365 QLVVLRDSKQTLINI
T368 VLRDSKQTLINIPSL
S374 QTLINIPSLNDsDsE
S378-p NIPSLNDsDsEVEDI
S380-p PSLNDsDsEVEDISE
S386 DsEVEDISEIESNRS
S393 SEIESNRSFsPEERR
S395-p IESNRSFsPEERRQQ
Y403 PEERRQQYsDQEYHS
S404-p EERRQQYsDQEYHSs
Q406 RRQQYsDQEYHSsTE
Y408 QQYsDQEYHSsTEKL
S410 YsDQEYHSsTEKLKE
S411-p sDQEYHSsTEKLKER
T412 DQEYHSsTEKLKERP
K414 EYHSsTEKLKERPsS
S420-p EKLKERPsSREETSG
S421 KLKERPsSREETSGR
T425 RPsSREETSGRMSRM
T435 RMSRMGATPTPFKST
T437 SRMGATPTPFKSTGD
K440 GATPTPFKSTGDITA
S441 ATPTPFKSTGDITAA
T442 TPTPFKSTGDITAAG
T446 FKSTGDITAAGVTEA
K455 AGVTEANKEPRsQEE
S459-p EANKEPRsQEEsPVP
S463-p EPRsQEEsPVPQPRT
S479 SRVFLRPSPEDEAIY
Y486 SPEDEAIYGPNTKMV
T490 EAIYGPNTKMVKFKK
Y554-p VREDAVLyLLEIPKG
T565 IPKGETVTILAQSRA
S570 TVTILAQSRADVYRD
Y618 FRVVDTLYDGKLGHW
K621 VDTLYDGKLGHWLAV
K676 RGQRSGVKKNIRKSR
S682 VKKNIRKSREDLAAA
A687 RKSREDLAAAVSVST
S691 EDLAAAVSVSTKFPA
S693 LAAAVSVSTKFPAYE
T740 DLFQTAKTEPKDAGS
S747 TEPKDAGSEKSSGVV
K749 PKDAGSEKSSGVVRL
K749 PKDAGSEKSSGVVRL
S750 KDAGSEKSSGVVRLN
S751 DAGSEKSSGVVRLNT
T758 SGVVRLNTVRQIIEQ
T811 IRQRLNPTSNKSSRK
S812 RQRLNPTSNKSSRKL
S816 NPTSNKSSRKLFDQA
S866 QNEAVWVSEGKMEGM
S882 DDAEDRMSYLTAMGA
Y883 DAEDRMSYLTAMGAD
T885 EDRMSYLTAMGADYL
Y891 LTAMGADYLsCDSRL
S893-p AMGADYLsCDSRLIs
S896 ADYLsCDSRLIsDFE
S900-p sCDSRLIsDFEDTDG
T905 LIsDFEDTDGEGGAY
Y912 TDGEGGAYtDNELDE
T913-p DGEGGAYtDNELDEP
S941 EPVQHEESIRKPsPE
P945 HEESIRKPsPEPRAQ
S946-p EESIRKPsPEPRAQM
S958 AQMRRAASRDQLRDG
R959 QMRRAASRDQLRDGs
S966-p RDQLRDGsPPPAFKP
S986 RNQNREDSFNYSKSN
F987 NQNREDSFNYSKSNL
Y989 NREDSFNYSKSNLSA
S990 REDSFNYSKSNLSAM
- gap
- gap
- gap
K991 EDSFNYSKSNLSAMA
I1002 SAMAGSEIPGGSTKG
S1006 GSEIPGGSTKGCPPP
S1023 VKPAFGRSILKPSTP
S1028 GRSILKPSTPVPMPE
T1029 RSILKPSTPVPMPEs
S1036-p TPVPMPEsEEVGEst
S1042-p EsEEVGEstEEQEEA
T1043-p sEEVGEstEEQEEAP
Y1093-p AQKHPDIyAVPIKAP
A1099 IyAVPIKAPKPDAGL
L1106 APKPDAGLPQHMRPP
M1110 DAGLPQHMRPPEPQK
S1120 PEPQKAPSRLYQDTR
Y1123 QKAPSRLYQDTRGsY
S1129-p LYQDTRGsYGsDPEE
Y1130 YQDTRGsYGsDPEEE
S1132-p DTRGsYGsDPEEEEE
Y1140 DPEEEEEYRQQLAAH
Y1152 AAHSKRGYYSQPSRY
Y1153 AHSKRGYYSQPSRYR
  dog

 
- gap
T68 RVVMVNGTPMEDVLH
S107 QLAPPQGSLPVDEDD
D111 PQGSLPVDEDDRAFE
S127 MDEFDGRSARSGYSE
S130 FDGRSARSGYSERSR
S133 RSARSGYSERSRRSS
S140 SERSRRSSHGGRSRS
S145 RSSHGGRSRSWEDSP
S147 SHGGRSRSWEDSPER
S151 RSRSWEDSPERGRPH
S163 RPHERAWSQERERSR
- gap
S169 WSQERERSRGRSLER
S173 RERSRGRSLERGLDH
P187 HDDDYRRPRERSRGR
S191 YRRPRERSRGRSLER
S195 RERSRGRSLERGLDH
G207 LDHDDDYGRPGERSH
- gap
S213 YGRPGERSHGMSTDR
S217 GERSHGMSTDRGYDR
T218 ERSHGMSTDRGYDRG
Y222 GMSTDRGYDRGYDRG
G225 TDRGYDRGYDRGYDR
Y226 DRGYDRGYDRGYDRG
Y230 DRGYDRGYDRGYDRT
Y234 DRGYDRGYDRTYSPE
Y238 DRGYDRTYSPEAEYG
S239 RGYDRTYSPEAEYGR
E243 RTYSPEAEYGRRTQP
Y244 TYSPEAEYGRRTQPD
H254 RTQPDARHAGsRSRS
S257-p PDARHAGsRSRSREH
S257-gl PDARHAGsRSRSREH
S259 ARHAGsRSRSREHLR
S261 HAGsRSRSREHLRSR
S267 RSREHLRSRSPSPEL
S269 REHLRSRSPSPELRG
S271 HLRSRSPSPELRGRP
L274 SRSPSPELRGRPDHA
K298 GVLLMKSKANEEYGL
Y303 KSKANEEYGLRLGSQ
S309 EYGLRLGSQIFIKQM
T317 QIFIKQMTRTALATK
T319 FIKQMTRTALATKDG
T323 MTRTALATKDGNLHE
K324 TRTALATKDGNLHEG
S369-p QLVVLRDsKQTLINI
T372 VLRDsKQTLINIPSL
S378 QTLINIPSLNDSDSE
S382 NIPSLNDSDSEIEDI
S384 PSLNDSDSEIEDISE
S390 DSEIEDISEIESNRS
S397 SEIESNRSFSPEERR
S399 IESNRSFSPEERRQQ
Y407 PEERRQQYSDYDYHS
S408 EERRQQYSDYDYHSS
Y410 RRQQYSDYDYHSSNE
Y412 QQYSDYDYHSSNEKL
S414 YSDYDYHSSNEKLKE
S415 SDYDYHSSNEKLKER
N416 DYDYHSSNEKLKERP
K418 DYHSSNEKLKERPNS
N424 EKLKERPNSREDMQN
S425 KLKERPNSREDMQNR
M429 RPNSREDMQNRWSRM
T439 RWSRMGATPTPFKSM
T441 SRMGATPTPFKSMGD
K444 GATPTPFKSMGDIAS
S445 ATPTPFKSMGDIASV
M446 TPTPFKSMGDIASVV
A450 FKSMGDIASVVGTEN
K459 VVGTENSKEPRYQEE
Y463 ENSKEPRYQEEPPAP
P467 EPRYQEEPPAPQPKA
S483 PRTFLRPSPEDEAIY
Y490 SPEDEAIYGPNTKMV
T494 EAIYGPNTKMVRFKK
Y558 VREDAVLYLLEIPKG
T569 IPKGEMVTILAQSRA
S574 MVTILAQSRADVYRD
Y622 FRVVDTLYDGKLGHW
K625 VDTLYDGKLGHWLAV
K680 RGQRSGMKKNLRKSR
S686 MKKNLRKSREDLTAA
T691 RKSREDLTAAVSVST
S695 EDLTAAVSVSTKFPA
S697 LTAAVSVSTKFPAYE
T744 DLFQTAKTEPKDAGS
S751 TEPKDAGSEKSSGVV
K753 PKDAGSEKSSGVVRL
K753 PKDAGSEKSSGVVRL
S754 KDAGSEKSSGVVRLN
S755 DAGSEKSSGVVRLNT
T762 SGVVRLNTVRQIIEQ
T815 MRQRLNPTSNKSSRK
S816 RQRLNPTSNKSSRKL
S820 NPTSNKSSRKLYDQA
S870 QGEAVWVSEGKMEGM
S886 DDPEDRMSYLTAMGA
Y887 DPEDRMSYLTAMGAD
T889 EDRMSYLTAMGADYL
Y895 LTAMGADYLSCDSRL
S897 AMGADYLSCDSRLIS
S900 ADYLSCDSRLISDFE
S904 SCDSRLISDFEDTDG
T909 LISDFEDTDGEGGAY
Y916 TDGEGGAYTDNELDE
T917 DGEGGAYTDNELDEP
S945 EPVQHEESIRKPSPE
P949 HEESIRKPSPEPRAQ
S950 EESIRKPSPEPRAQM
S962 AQMRRAASRDQLRDS
R963 QMRRAASRDQLRDSS
S970 RDQLRDSSPPPAFKP
S990 KTQNREESFDISRSH
F991 TQNREESFDISRSHD
I993 NREESFDISRSHDYK
S994 REESFDISRSHDYKS
S996 ESFDISRSHDYKSNP
H997 SFDISRSHDYKSNPS
Y999 DISRSHDYKSNPSAV
K1000 ISRSHDYKSNPSAVA
V1011 SAVAGNEVSGASTRS
S1015 GNEVSGASTRSCPPP
S1032 AKPSFGRSILKPSTP
S1037 GRSILKPSTPVPSPE
T1038 RSILKPSTPVPSPES
S1045 TPVPSPESEEVGEGS
G1051 ESEEVGEGSEEQEGA
S1052 SEEVGEGSEEQEGAP
Y1102 AQKHPDIYAVPIKTH
T1108 IYAVPIKTHKPDPGL
L1115 THKPDPGLSQHTSSR
T1119 DPGLSQHTSSRPPEP
S1131 PEPQKGPSRLYQDPR
Y1134 QKGPSRLYQDPRGSY
S1140 LYQDPRGSYGSDAEE
Y1141 YQDPRGSYGSDAEEE
S1143 DPRGSYGSDAEEEEY
Y1150 SDAEEEEYRQQLSEH
Y1162 SEHSKRGYYSQPSRY
Y1163 EHSKRGYYSQPSRYR
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