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plakophilin 3 (human)

Overview plakophilin 3 a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells and dendritic reticular cells of lymphatic follicles. Note: This description may include information from UniProtKB. Protein type: Cell adhesion Cellular Component: desmosome; intercellular junction; nucleus Biological Process: cell adhesion Reference #:  Q9Y446 (UniProtKB) Alt. Names/Synonyms: PKP3; plakophilin 3; Plakophilin-3 Gene Symbols: PKP3 Molecular weight: 87,082 Da Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states

Select Structure to View Below plakophilin 3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S19	QPEAGVCSLALPSDL
0	1		A66	QQPRHNGAAEPEPEA
0	1		T75	EPEPEAETARGTSRG
0	609		Y84-p	RGTSRGQyHtLQAGF
0	116		T86-p	TSRGQyHtLQAGFSS
0	2		S95-p	QAGFSSRsQGLSGDK
0	34		Y114-p	RPIAKPAysPAsWSS
0	16		S115-p	PIAKPAysPAsWSSR
0	1		S118-p	KPAysPAsWSSRsAV
0	5		S123-p	PAsWSSRsAVDLSCS
0	8		S134-p	LSCSRRLsSAHNGGS
0	4		Y148-p	SAFGAAGyGGAQPtP
0	1		T154-p	GyGGAQPtPPMPTRP
0	6		S163-p	PMPTRPVsFHERGGV
0	1		S172-p	HERGGVGsRADyDtL
0	598		Y176-p	GVGsRADyDtLsLRs
0	4		T178-p	GsRADyDtLsLRsLR
0	65		S180-p	RADyDtLsLRsLRLG
0	8		S183-p	yDtLsLRsLRLGPGG
0	163		Y195-p	PGGLDDRysLVsEQL
0	24		S196-p	GGLDDRysLVsEQLE
0	2		S199-p	DDRysLVsEQLEPAA
0	3		T207-p	EQLEPAAtstyRAFA
0	2		S208-p	QLEPAAtstyRAFAy
0	13		T209-p	LEPAAtstyRAFAyE
0	145		Y210-p	EPAAtstyRAFAyER
0	13		Y215-p	styRAFAyERQAsSS
0	1		S220-p	FAyERQAsSSSSRAG
0	14		S238-p	WPEATEVsPsRTIRA
0	1		S240-p	EATEVsPsRTIRAPA
0	11		R261-m1	FQSSHRSrGVGGAVP
0	1		A266	RSrGVGGAVPGAVLE
0	9		S280-p	EPVARAPsVRSLSLS
0	1		S283	ARAPsVRSLSLSLAD
0	2		S285	APsVRSLSLSLADSG
0	4		S302-p	PDVHGFNsyGsHRtL
0	13		Y303-p	DVHGFNsyGsHRtLQ
0	1		S305-p	HGFNsyGsHRtLQRL
0	3		T308-p	NsyGsHRtLQRLssG
0	89		S313-p	HRtLQRLssGFDDID
0	92		S314-p	RtLQRLssGFDDIDL
0	2		S331-p	AVKYLMAsDPNLQVL
0	3		Y342-p	LQVLGAAyIQHKCYS
0	251		Y390-p	GAMRNLIyDNADNKL
0	2		Y539-p	RNLSYRLyDEMPPSA
0	3		K752-a	LRKLIFIkKKRDSPD

	mouse ► Hide Isoforms
S19	QPETGVCSLALPSDL
S66-p	QQSRHNGsAELDGSA
S75-p	ELDGSAEsARGMPRG
Y84	RGMPRGQYHTMQTGF
T86	MPRGQYHTMQTGFSS
S95	QTGFSSRSQGMSGDK
Y114	RPIAKPAYSPASWSS
S115	PIAKPAYSPASWSSR
S118	KPAYSPASWSSRsAV
S123-p	PASWSSRsAVDLTCS
S134	LTCSRRLSSAHNGGS
Y148	SAFGAVGYGGTQPTP
T154	GYGGTQPTPPMPTRP
S163	PMPTRPVSFHERGGA
S172	HERGGAASRADyDtL
Y176-p	GAASRADyDtLsLRs
T178-p	ASRADyDtLsLRsLR
S180-p	RADyDtLsLRsLRLG
S183-p	yDtLsLRsLRLGPGG
Y195	PGGLDDRYsVVsEQL
S196-p	GGLDDRYsVVsEQLE
S199-p	DDRYsVVsEQLEPAA
A207	EQLEPAAASTYRAYA
S208	QLEPAAASTYRAYAY
T209	LEPAAASTYRAYAYE
Y210	EPAAASTYRAYAYER
Y215	STYRAYAYERQASSG
S220	YAYERQASSGSSRAG
P238	WPEATEGPPSRTIRA
S240	EATEGPPSRTIRAPA
R261-m1	FQSSHRSrGGTGsVS
S266-p	RSrGGTGsVSGAGLE
S280	EPVARAPSVRsLsLS
S283-p	ARAPSVRsLsLSLAD
S285-p	APSVRsLsLSLADSG
S302	PDVRGLDSYTGHRtL
Y303	DVRGLDSYTGHRtLQ
G305	RGLDSYTGHRtLQRL
T308-p	DSYTGHRtLQRLssG
S313-p	HRtLQRLssGFDDID
S314-p	RtLQRLssGFDDIDL
S331-p	AVKYLMAsDPNLQVL
Y342	LQVLGAAYIQHRCYS
Y390-p	GAMRNLIyDNVDNKL
Y539	RNLSYRLYDEMPPSA
K752	LRKLVFIKKKRDSPD

	plakophilin 3 iso2
S44-p	KPETGVCsLALPSDL
S91	QQSRHNGSAELDGSA
-	under review
Y109	RGMPRGQYHTMQTGF
T111	MPRGQYHTMQTGFSS
S120	QTGFSSRSQGMSGDK
Y139	RPIAKPAYSPASWSS
S140	PIAKPAYSPASWSSR
S143	KPAYSPASWSSRSAV
S148	PASWSSRSAVDLTCS
S159	LTCSRRLSSAHNGGS
Y173	SAFGAVGYGGTQPTP
T179	GYGGTQPTPPMPTRP
S188	PMPTRPVSFHERGGA
S197	HERGGAASRADYDTL
Y201	GAASRADYDTLSLRS
T203	ASRADYDTLSLRSLR
S205	RADYDTLSLRSLRLG
S208	YDTLSLRSLRLGPGG
Y220	PGGLDDRYSVVSEQL
S221	GGLDDRYSVVSEQLE
S224	DDRYSVVSEQLEPAA
A232	EQLEPAAASTYRAYA
S233	QLEPAAASTYRAYAY
T234	LEPAAASTYRAYAYE
Y235	EPAAASTYRAYAYER
Y240	STYRAYAYERQASSG
S245	YAYERQASSGSSRAG
P263	WPEATEGPPSRTIRA
S265	EATEGPPSRTIRAPA
R286	FQSSHRSRGGTGSVS
S291	RSRGGTGSVSGAGLE
S305	EPVARAPSVRSLSLS
S308	ARAPSVRSLSLSLAD
S310	APSVRSLSLSLADSG
S327	PDVRGLDSYTGHRTL
Y328	DVRGLDSYTGHRTLQ
G330	RGLDSYTGHRTLQRL
T333	DSYTGHRTLQRLSSG
S338	HRTLQRLSSGFDDID
S339	RTLQRLSSGFDDIDL
S356	AVKYLMASDPNLQVL
Y367	LQVLGAAYIQHRCYS
Y415	GAMRNLIYDNVDNKL
Y564	RNLSYRLYDEMPPSA
K777	LRKLVFIKKKRDSPD

	rat
S44	KPEAGVCSLALPSDL
S91	QQSRHNGSTELDGSA
-	under review
Y109	RGLPRGQYHTMQSGF
T111	LPRGQYHTMQSGFSS
S120	QSGFSSRSQGMSGDK
Y139	RPIAKPAYNPASWSS
N140	PIAKPAYNPASWSSR
S143	KPAYNPASWSSRSAV
S148	PASWSSRSAVDLTCS
S159-p	LTCSRRLsSAHNGGS
Y173	SAFGAVGYGGAQPTP
T179	GYGGAQPTPPMPTRP
S188-p	PMPTRPVsFHERGGA
S197	HERGGAASRADyDTL
Y201-p	GAASRADyDTLsLRS
T203	ASRADyDTLsLRSLR
S205-p	RADyDTLsLRSLRLG
S208	yDTLsLRSLRLGPGG
Y220	PGGLDDRYSVVSEQL
S221	GGLDDRYSVVSEQLE
S224	DDRYSVVSEQLEPAA
A232	EQLEPAAASTYRAYA
S233	QLEPAAASTYRAYAY
T234	LEPAAASTYRAYAYE
Y235	EPAAASTYRAYAYER
Y240	STYRAYAYERQASSS
S245	YAYERQASSSSSRAG
P263	WPEATEGPPSRTIRA
S265	EATEGPPSRTIRAPA
R286-m1	FQSSHRSrGGTGSVS
S291	RSrGGTGSVSGAGLE
S305	EPVARAPSVRSLSLS
S308	ARAPSVRSLSLSLGD
S310	APSVRSLSLSLGDSG
S327	PDVRGLDSyTGHRTL
Y328-p	DVRGLDSyTGHRTLQ
G330	RGLDSyTGHRTLQRL
T333	DSyTGHRTLQRLssG
S338-p	HRTLQRLssGFDDID
S339-p	RTLQRLssGFDDIDL
S356	AVKYLMASDPNLQVL
Y367	LQVLGAAYIQHRCYS
Y415-p	GAMRNLIyDNVDNKL
Y564	RNLSYRLYDEMPPSA
K777	LRKLVFIKKKRDSPD

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