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Protein Page:
UBR5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
UBR5 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulates target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2. Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Ubiquitin ligase
Cellular Component: cytoplasm; nucleus
Molecular Function: ubiquitin binding; protein binding; zinc ion binding; RNA binding; ubiquitin-protein ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; progesterone receptor signaling pathway; protein polyubiquitination; positive regulation of protein import into nucleus, translocation; protein ubiquitination during ubiquitin-dependent protein catabolic process; DNA repair; response to DNA damage stimulus
Reference #:  O95071 (UniProtKB)
Alt. Names/Synonyms: DD5; E3 identified by differential display; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; EDD; EDD1; FLJ11310; hHYD; HYD; Hyperplastic discs protein homolog; KIAA0896; MGC57263; progestin induced protein; Progestin-induced protein; ubiquitin protein ligase E3 component n-recognin 5; ubiquitin-protein ligase; UBR5
Gene Symbols: UBR5
Molecular weight: 309,352 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UBR5
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S36-p LNKyNLNsHPPLNVL
0 1 Y32-p VSEKLNKyNLNsHPP
0 3 K49-u VLEQATIkQCVVGPN
0 2 K91-u PDNNDGSkLNSNSGA
0 8 S110-p RPGRTSDsPWFLSGS
0 3 T119-p WFLSGSEtLGRLAGN
0 1 S130-p LAGNTLGsRWSsGVG
0 2 S134-p TLGsRWSsGVGGsGG
0 3 S139-p WSsGVGGsGGGSSGR
0 1 S154-p SSAGARDsRRQTRVI
1 1 S174-p RGSGLLGsQPQPVIP
1 2 S191-p VIPEELIsQAQVVLQ
0 14 K200-u AQVVLQGkSRsVIIR
0 1 S203-p VLQGkSRsVIIRELQ
0 1 T212-p IIRELQRtNLDVNLA
0 4 S287-p YPSFRRSsLsRLGss
0 4 S289-p SFRRSsLsRLGssRV
0 1 S293-p SsLsRLGssRVLLLP
0 2 S294-p sLsRLGssRVLLLPL
0 10 S327-p RRWLDGAsFDNERGS
0 3 K337-u NERGSTSkEGEPNLD
0 2 K346-u GEPNLDKkNTPVQsP
0 1 S352-p KkNTPVQsPVSLGED
0 1 K442-u TVATENNkVATWVDE
0 1 K457-u TLSSVASkLEHTAQT
0 1 K504 VPFSQRKKMLEKARA
0 1 K508 QRKKMLEKARAKNKK
0 2 S578-p SCRFQLRsPESLKNM
0 1 S598-p TTEAKPEsKQEPVKt
0 2 T605-p sKQEPVKtEMGPPPs
0 5 S612-p tEMGPPPsPAsTCSD
0 1 S615-p GPPPsPAsTCSDASS
0 1 S625-p SDASSIAsSASMPYK
0 4 T637-p PYKRRRStPAPKEEE
0 3 K672-u VPVGKVLkVDGAYVA
0 2 K720-u IDELQVVkTGGTPKV
0 1 K761-u KGVHAVLkTGNWVRY
0 1 S808-p IFTAGQEsPIILRDG
0 1 T875 IMAVEKQTLMQHILR
0 1 S928-p NILHACVsVCFPTSN
0 1 S971-p NAISVVSsNGPGNRA
0 2 R977 SsNGPGNRAGSSSSR
0 2 R984 RAGSSSSRsLRLREM
0 8 S985-p AGSSSSRsLRLREMM
0 12 S995-p LREMMRRsLRAAGLG
0 2 S1018-p SDHQDPVsPPIAPPS
0 1 K1109 LRELLSAKDARGMtP
0 29 K1109-u LRELLSAkDARGMtP
0 1 T1115-p AkDARGMtPFMSAVS
0 1 T1135-p AAITILEtAQKIAKA
0 1 S1227-p DCKLKRTsPTAYCDC
0 1 T1282 LLLFLVQTVARQTVE
0 1 K1305-u IREDRNRkTAsPEDS
0 3 S1308-p DRNRkTAsPEDSDMP
0 1 K1340-u LQDWNALkSMIMFGs
0 2 S1347-p kSMIMFGsQENkDPL
0 2 K1351-u MFGsQENkDPLsASS
0 1 S1355-p QENkDPLsASSRIGH
0 1 S1375-p QVYLNQQsGTIRLDC
0 1 S1481-p ELCNVAEsLIVPVRM
1 1 S1532-p SDQSSSSsQSQSSYI
0 41 S1549-p NPQQRRIsQsQPVRG
0 2 S1551-p QQRRIsQsQPVRGRD
0 1 S1610-p DEHDEDGsDMELDLL
1 1 S1679-p SDSDSSSsQSDDIEQ
0 1 S1728-p TQHQRAAsTAPsSTS
0 1 S1732-p RAAsTAPsSTStPAA
0 2 T1736-p TAPsSTStPAAssAG
0 1 S1740-p STStPAAssAGLIyI
0 2 S1741-p TStPAAssAGLIyID
0 123 Y1746-p AssAGLIyIDPSNLR
0 1 T1760-p RRSGTIStSAAAAAA
0 1 S1772 AAAALEASNASSYLT
0 1 S1780-p NASSYLTsASSLARA
0 1 T1885 SARRERMTAREEASL
0 1 T1902-p LEGRRRAtLLSARQG
0 1 T1965-p IKAMNQQttLDtPQL
0 1 T1966-p KAMNQQttLDtPQLE
0 6 T1969-p NQQttLDtPQLERKR
0 2 S1990-p LGIDNEDsEHENDDD
0 4 S2011-p LNDKDDDsLPAETGQ
0 1 S2026-p NHPFFRRsDsMtFLG
0 3 S2028-p PFFRRsDsMtFLGCI
0 2 T2030-p FRRsDsMtFLGCIPP
0 2 S2071-p EDLFGRPsQGLysSS
0 1 Y2075-p GRPsQGLysSSASSG
0 1 S2076-p RPsQGLysSSASSGK
0 1 K2136-u PEETESSkPGPSAHD
0 1 T2213-p AEPGSILtELGGFEV
0 1 K2221-u ELGGFEVkESKFRRE
0 4 S2241-p NQQSRDLsLEVDRDR
0 2 K2282-u HRVKVTFkDEPGEGs
0 1 S2289-p kDEPGEGsGVARSFY
0 1 S2325-p ANKGTHTsLMQRLRN
0 3 S2369-p RDFRRQLsIDTRPFR
0 1 S2460-p GRENGADsILDLGLV
0 1 S2470-p DLGLVDSsEkVQQEN
0 1 K2472-u GLVDSsEkVQQENRK
0 13 S2483-p ENRKRHGssRsVVDM
0 7 S2484-p NRKRHGssRsVVDMD
0 15 S2486-p KRHGssRsVVDMDLD
0 1 K2510-u PLFYQPGkRGFYTPR
1 1 S2586-p LRQLILAsQSSDADA
0 1 T2724 IVEKMSMTERQDLVY
  mouse

 
S36 LNKYNLNSHPPLNVL
Y32 VSEKLNKYNLNSHPP
K49 VLEQATIKQCVVGPN
K91 PDNNDGSKLNSSSGT
S110-p RPGRTSDsPWFLSGS
T119 WFLSGSETLGRLAGN
S130 LAGNTLGSRWSSGVG
S134 TLGSRWSSGVGGSGG
S139 WSSGVGGSGGGSSGR
S154 SSAGARDSRRQTRVI
S174 RGSGLLGSQPQPVIP
S191 VIPEELISQAQVVLQ
K200-u AQVVLQGkSRSVIIR
S203 VLQGkSRSVIIRELQ
T212 IIRELQRTNLDVNLA
S287 YPSFRRSSLsRLGSS
S289-p SFRRSSLsRLGSSRE
S293 SSLsRLGSSRERDSE
S294 SLsRLGSSRERDSEL
S321-p RRWLDGAsFDNERGS
K331 NERGSTSKEGESNPD
K340-u GESNPDKkNTPVQSP
S346 KkNTPVQSPVSLGED
K436 TVATENNKVATWVDE
K451 TLSSVASKLEHTAQT
K498-m1 VPFSQRKkMLEkARA
K502-m1 QRKkMLEkARAKNKK
S572 SCRFQLRSPESLKSM
S592 TLETKPESKQEPVKT
T599 SKQEPVKTEMGPPPS
S606 TEMGPPPSPASTCSD
S609 GPPPSPASTCSDASS
S619 SDASSIASSASMPYK
T631 PYKRRRSTPAPREEE
K666 VPVGKVLKVDGAYVA
K714 IDELQVVKTGGTPKV
K755 KGVHAVLKTGSWVRY
S802 IFTAGQESPIVLRDG
T869-p IMAVEKQtLMQHILR
S922 NILHACVSVCFPTSN
S965 NAISVVSSNGPGNrA
R971-m1 SSNGPGNrAGSSNSr
R978-m1 rAGSSNSrSLRLREM
S979 AGSSNSrSLRLREMM
S989 LREMMRRSLRAAGLG
S1012-p SDHQDPVsPPIAPPS
K1103-a LRELLSAkDARGMTP
K1103-u LRELLSAkDARGMTP
T1109 AkDARGMTPFMSAVS
T1129 AAITILETAQKIAKA
S1221 DCKLKRTSPTAYCDC
T1276-p LLLFLVQtVARQTVE
K1299 IREDRNRKTASPEDS
S1302 DRNRKTASPEDSDMP
R1334 LQDWNALRSMIMFGS
S1341 RSMIMFGSQENkDPL
K1345-u MFGSQENkDPLSASS
S1349 QENkDPLSASSRIGH
S1369 QVYLNQQSGTIRLDC
S1475 ELCNVAESLIVPVRM
S1526 SDQASSSSQSQSSYI
S1543-p NPQQRRIsQSQPVRG
S1545 QQRRIsQSQPVRGRD
S1604 DEHDEDGSDMELDLL
S1673 SDSDSSSSQSDDIEQ
S1722 PQHQRAASTAPSSTS
S1726 RAASTAPSSTSTPAA
T1730 TAPSSTSTPAAssAG
S1734-p STSTPAAssAGLIyI
S1735-p TSTPAAssAGLIyID
Y1740-p AssAGLIyIDPSNLR
T1754 RRSGTISTSAAAAAA
S1766-p AAAALEAsNASSYLT
S1774 NASSYLTSASSLARA
T1879-p SARRERMtAREEASL
T1896 LEGRRRATLLSARQG
T1959 IKAMNQQTTLDTPQL
T1960 KAMNQQTTLDTPQLE
T1963 NQQTTLDTPQLERKR
S1984-p LGIDNEDsEHENDDD
S2005-p LNDKDDDsLPAETGQ
S2020 NHPFFRRSDSMtFLG
S2022 PFFRRSDSMtFLGCI
T2024-p FRRSDSMtFLGCIPP
S2065 EDLFGRPSQGLYSSS
Y2069 GRPSQGLYSSSAGSG
S2070 RPSQGLYSSSAGSGK
K2130 AEEADSSKPGPSAPD
T2207 AEPGSILTELGGFEV
K2215 ELGGFEVKESKFRRE
S2235-p NQQSRDLsLEVDRDR
K2276 HRVKVTFKDEPGEGS
S2283 KDEPGEGSGVARSFY
S2319 ANKGTHTSLMQRLRN
S2363-p RDFRRQLsIDTRPFR
S2454 GRENGADSILDLGLL
S2464 DLGLLDSSEKVQENR
K2466 GLLDSSEKVQENRKR
S2476-p ENRKRHGssRsVVDM
S2477-p NRKRHGssRsVVDMD
S2479-p KRHGssRsVVDMDLE
K2503 PLFYQPGKRGFYTPR
S2579 LRQLILASQSSDADA
T2717-p IVEKMSMtERQDLVY
  rat

 
S26 LNKYNLNSHPPLNVL
Y22 VSEKLNKYNLNSHPP
K39 VLEQATIKQCVVGPN
K81 PDNNDGSKLNSSSGT
S100 RPGRTSDSPWFLSGS
T109 WFLSGSETLGRLAGN
S120 LAGNTLGSRWSSGVG
S124 TLGSRWSSGVGGSGG
S129 WSSGVGGSGGGSSGR
S144 SSAGARDSRRQTRVI
S164 RGSGLLGSQPQPVIP
S181 VIPEELISQAQVVLQ
K190 AQVVLQGKSRSVIIR
S193 VLQGKSRSVIIRELQ
T202 IIRELQRTNLDVNLA
S277 YPSFRRSSLSRLGSS
S279 SFRRSSLSRLGSSRE
S283 SSLSRLGSSRERDSE
S284 SLSRLGSSRERDSEL
S311 RRWLDGASFDNERGS
K321 NERGSTSKEGEPNPD
K330 GEPNPDKKNTPVQSP
S336 KKNTPVQSPVSLGED
K426 TVATENNKVATWVDE
K441 TLSSVASKLEHTAQT
K488 VPFSQRKKMLEKARA
K492 QRKKMLEKARAKNKK
S562 SCRFQLRSPESLKSM
S582 TIETKPESKQEPVKT
T589 SKQEPVKTEMGPPPS
S596 TEMGPPPSPASTCSD
S599 GPPPSPASTCSDASS
S609 SDASSIASSASMPYK
T621 PYKRRRSTPAPKEEE
K656 VPVGKVLKVDGAYVA
K704 IDELQVVKTGGTPKV
K745 KGVHAVLKTGNWVRY
S792 IFTAGQESPIILRDG
T859 IMAVEKQTLMQHILR
S912 NILHACVSVCFPTSN
S955 NAISVVSSNGPGNrA
R961-m1 SSNGPGNrAGSSSSR
R968 rAGSSSSRSLRLREM
S969 AGSSSSRSLRLREMM
S979 LREMMRRSLRAAGLG
S1002 SDHQDPVSPPIAPPS
K1093 LRELLSAKDARGMTP
K1093 LRELLSAKDARGMTP
T1099 AKDARGMTPFMSAVS
T1119 AAITILETAQKIAKA
S1211 DCKLKRTSPTAYCDC
T1266 LLLFLVQTVARQTVE
K1289 IREDRNRKTASPDDS
S1292 DRNRKTASPDDSDMP
R1324 LQDWNALRSMIMFGS
S1331 RSMIMFGSQENKDPL
K1335 MFGSQENKDPLSASS
S1339 QENKDPLSASSRIGH
S1359 QVYLNQQSGTIRLDC
S1465 ELCNVAESLIVPVRM
S1516 SDQSSSSSQSQSSYI
S1533 NPQQRRISQSQPVRG
S1535 QQRRISQSQPVRGRE
S1594 DEHDEDGSDMELDLL
S1663 SDSDSSSSQSDDIEQ
S1712 TQHQRAASTAPSSTS
S1716 RAASTAPSSTSTPAA
T1720 TAPSSTSTPAASSAG
S1724 STSTPAASSAGLIYI
S1725 TSTPAASSAGLIYID
Y1730 ASSAGLIYIDPSNLR
T1744 RRSGTISTSAAAAAA
S1756 AAAALEASNASSYLT
S1764 NASSYLTSASSLARA
T1869 SARRERMTAREEASL
T1886 LEGRRRATLLSARQG
T1949 IKAMNQQTTLDTPQL
T1950 KAMNQQTTLDTPQLE
T1953 NQQTTLDTPQLERKR
S1974 LGIDNEDSEHENDDD
S1995 LNDKDDESLPAETGQ
S2010 NHPFFRRSDSMTFLG
S2012 PFFRRSDSMTFLGCI
T2014 FRRSDSMTFLGCIPP
S2055 EDLFGRPSQGLYSSS
Y2059 GRPSQGLYSSSAGSG
S2060 RPSQGLYSSSAGSGK
K2120 AEEADSSKPGPSAHD
T2197 AEPGSILTELGGFEV
K2205 ELGGFEVKESKFRRE
S2225 NQQSRDLSLEVDRDR
K2266 HRVKVTFKDEPGEGS
S2273 KDEPGEGSGVARSFY
S2309 ANKGTHTSLMQRLRN
S2353 RDFRRQLSIDTRPFR
S2444 GRENGADSILDLGLL
S2454 DLGLLDSSEKVQENR
K2456 GLLDSSEKVQENRKR
S2466 ENRKRHGSSRSVVDM
S2467 NRKRHGSSRSVVDMD
S2469 KRHGSSRSVVDMDLD
K2493 PLFYQPGKRGFYTPR
S2569 LRQLILASQSSDADA
T2707 IVERMSMTERQDLVY
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