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Protein Page:
UBR5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UBR5 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulates target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2. Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Nuclear receptor co-regulator; Ubiquitin ligase; Ubiquitin conjugating system
Cellular Component: membrane; cytoplasm; nucleolus; nucleus
Molecular Function: ubiquitin binding; protein binding; zinc ion binding; RNA binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein polyubiquitination; progesterone receptor signaling pathway; positive regulation of protein import into nucleus, translocation; protein ubiquitination during ubiquitin-dependent protein catabolic process; DNA repair; response to DNA damage stimulus
Reference #:  O95071 (UniProtKB)
Alt. Names/Synonyms: DD5; E3 identified by differential display; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; EDD; EDD1; FLJ11310; hHYD; HYD; Hyperplastic discs protein homolog; KIAA0896; MGC57263; progestin induced protein; Progestin-induced protein; ubiquitin protein ligase E3 component n-recognin 5; ubiquitin-protein ligase; UBR5
Gene Symbols: UBR5
Molecular weight: 309,352 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UBR5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y32-p VSEKLNKyNLNsHPP
0 1 S36-p LNKyNLNsHPPLNVL
0 3 K49-ub VLEQATIkQCVVGPN
0 1 S73-p RVCRIGFsVQPDRLE
0 1 S90-p KPDNNDGskLNSNSG
0 2 K91-ub PDNNDGskLNSNSGA
0 1 S108-p TSRPGRTsDsPWFLS
0 10 S110-p RPGRTsDsPWFLSGS
0 3 T119-p WFLSGSEtLGRLAGN
0 1 S130-p LAGNTLGsRWssGVG
0 1 S133-p NTLGsRWssGVGGsG
0 2 S134-p TLGsRWssGVGGsGG
0 4 S139-p WssGVGGsGGGsSGR
0 1 S143-p VGGsGGGsSGRSSAG
0 1 S154-p SSAGARDsRRQTRVI
1 1 S174-p RGSGLLGsQPQPVIP
1 2 S191-p VIPEELIsQAQVVLQ
0 14 K200-ub AQVVLQGkSRsVIIR
0 2 S203-p VLQGkSRsVIIRELQ
0 1 T212-p IIRELQRtNLDVNLA
0 4 S287-p YPSFRRSsLsRLGss
0 4 S289-p SFRRSsLsRLGssRV
0 1 S293-p SsLsRLGssRVLLLP
0 2 S294-p sLsRLGssRVLLLPL
0 2 S313-p ELLREREsVLRLRER
0 13 S327-p RRWLDGAsFDNERGS
0 3 K337-ub NERGSTSkEGEPNLD
0 2 K346-ub GEPNLDKkNTPVQsP
0 1 S352-p KkNTPVQsPVSLGED
0 1 K442-ub TVATENNkVATWVDE
0 1 K457-ub TLSSVASkLEHTAQT
0 1 K504 VPFSQRKKMLEKARA
0 1 K508 QRKKMLEKARAKNKK
0 4 S578-p SCRFQLRsPESLKNM
0 1 S598-p TTEAKPEsKQEPVKt
0 2 T605-p sKQEPVKtEMGPPPs
0 6 S612-p tEMGPPPsPAsTCSD
0 1 S615-p GPPPsPAsTCSDASS
0 1 S625-p SDASSIAsSASMPYK
0 1 S636 MPYKRRRStPAPKEE
0 5 T637-p PYKRRRStPAPKEEE
0 1 K663-ac VVFVEDVkNVPVGKV
0 3 K672-ub VPVGKVLkVDGAYVA
0 2 K720-ub IDELQVVkTGGTPKV
0 1 K761-ub KGVHAVLkTGNWVRY
0 2 S808-p IFTAGQEsPIILRDG
0 1 T875 IMAVEKQTLMQHILR
0 1 S928-p NILHACVsVCFPTSN
0 1 S967-p EAIANAIsVVSsNGP
0 1 S971-p NAIsVVSsNGPGNRA
0 2 R977 SsNGPGNRAGSSSSR
0 2 R984 RAGSSSSRsLRLREM
0 8 S985-p AGSSSSRsLRLREMM
0 12 S995-p LREMMRRsLRAAGLG
0 2 S1018-p SDHQDPVsPPIAPPS
0 1 K1109 LRELLSAKDARGMtP
0 29 K1109-ub LRELLSAkDARGMtP
0 1 T1115-p AkDARGMtPFMSAVS
0 1 T1135-p AAITILEtAQKIAKA
0 1 S1227-p DCKLKRTsPTAYCDC
0 1 T1282 LLLFLVQTVARQTVE
0 1 K1305-ub IREDRNRktAsPEDs
0 1 T1306-p REDRNRktAsPEDsD
0 5 S1308-p DRNRktAsPEDsDMP
0 1 S1312-p ktAsPEDsDMPDHDL
0 1 K1340-ub LQDWNALkSMIMFGs
0 2 S1347-p kSMIMFGsQENkDPL
0 2 K1351-ub MFGsQENkDPLsASS
0 1 S1355-p QENkDPLsASSRIGH
0 1 S1375-p QVYLNQQsGTIRLDC
0 1 S1481-p ELCNVAEsLIVPVRM
1 1 S1532-p SDQSSSSsQSQSSYI
0 50 S1549-p NPQQRRIsQsQPVRG
0 3 S1551-p QQRRIsQsQPVRGRD
0 1 S1610-p DEHDEDGsDMELDLL
1 1 S1679-p SDSDSSSsQSDDIEQ
0 2 S1728-p TQHQRAAstAPsSTS
0 1 T1729-p QHQRAAstAPsSTSt
0 1 S1732-p RAAstAPsSTStPAA
0 2 T1736-p tAPsSTStPAAssAG
0 2 S1740-p STStPAAssAGLIyI
0 2 S1741-p TStPAAssAGLIyID
0 115 Y1746-p AssAGLIyIDPSNLR
0 1 T1760-p RRSGTIStSAAAAAA
0 1 S1772 AAAALEASNASSYLT
0 1 S1780-p NASSYLTsAsSLARA
0 1 S1782-p SSYLTsAsSLARAYS
0 1 S1875-p PNHPLHAsQNsARRE
0 1 S1878-p PLHAsQNsARRERMT
0 1 T1885 sARRERMTAREEASL
0 1 T1902-p LEGRRRAtLLsARQG
0 1 S1905-p RRRAtLLsARQGMMS
0 1 T1965-p IKAMNQQttLDtPQL
0 1 T1966-p KAMNQQttLDtPQLE
0 8 T1969-p NQQttLDtPQLERKR
0 4 S1990-p LGIDNEDsEHENDDD
0 1 T1998-p EHENDDDtNQSATLN
0 6 S2011-p LNDKDDDsLPAETGQ
0 2 S2026-p NHPFFRRsDsMtFLG
0 4 S2028-p PFFRRsDsMtFLGCI
0 2 T2030-p FRRsDsMtFLGCIPP
0 5 S2071-p EDLFGRPsQGLysSS
0 1 Y2075-p GRPsQGLysSSASSG
0 1 S2076-p RPsQGLysSSASSGK
0 1 S2103-p EVLPTKMsYAANLKN
0 1 K2136-ub PEETESSkPGPSAHD
0 1 T2213-p AEPGSILtELGGFEV
0 1 K2221-ub ELGGFEVkESKFRRE
0 7 S2241-p NQQSRDLsLEVDRDR
0 1 T2270-p FGRRCATtPMAVHRV
0 2 K2282-ub HRVKVTFkDEPGEGs
0 1 S2289-p kDEPGEGsGVARSFY
0 1 S2325-p ANKGTHTsLMQRLRN
0 4 S2369-p RDFRRQLsIDTRPFR
0 1 S2434-p QLLLLLAsEDsLRAR
0 1 S2437-p LLLAsEDsLRARVDE
0 2 S2460-p GRENGADsILDLGLV
0 2 S2469-p LDLGLVDssEkVQQE
0 1 S2470-p DLGLVDssEkVQQEN
0 1 K2472-ub GLVDssEkVQQENRK
0 14 S2483-p ENRKRHGssRsVVDM
0 9 S2484-p NRKRHGssRsVVDMD
0 19 S2486-p KRHGssRsVVDMDLD
0 1 K2510-ub PLFYQPGkRGFYTPR
1 1 S2586-p LRQLILAsQSSDADA
0 1 T2724 IVEKMSMTERQDLVY
0 1 Y2731 TERQDLVYFWTSSPS
0 1 T2734 QDLVYFWTSSPSLPA
0 1 T2767 QHLPTANTCISRLYV
0 1 S2770 PTANTCISRLYVPLY
0 1 Y2773 NTCISRLYVPLYSsK
0 1 Y2777 SRLYVPLYSsKQILK
0 1 S2778 RLYVPLYSsKQILKQ
0 2 S2779-p LYVPLYSsKQILKQK
  mouse

 
Y32 VSEKLNKYNLNSHPP
S36 LNKYNLNSHPPLNVL
K49 VLEQATIKQCVVGPN
S73 RICRIGFSVQPDRLE
S90 KPDNNDGSKLNSSSG
K91 PDNNDGSKLNSSSGT
S108 TSRPGRTSDsPWFLS
S110-p RPGRTSDsPWFLSGS
T119 WFLSGSETLGRLAGN
S130 LAGNTLGSRWSSGVG
S133 NTLGSRWSSGVGGSG
S134 TLGSRWSSGVGGSGG
S139 WSSGVGGSGGGSSGR
S143 VGGSGGGSSGRSSAG
S154 SSAGARDSRRQTRVI
S174 RGSGLLGSQPQPVIP
S191 VIPEELISQAQVVLQ
K200-ub AQVVLQGkSRSVIIR
S203 VLQGkSRSVIIRELQ
T212 IIRELQRTNLDVNLA
S287 YPSFRRSSLsRLGSS
S289-p SFRRSSLsRLGSSRE
S293 SSLsRLGSSRERDSE
S294 SLsRLGSSRERDSEL
S307 ELLRERESVLRLRER
S321-p RRWLDGAsFDNERGS
K331 NERGSTSKEGESNPD
K340-ub GESNPDKkNTPVQSP
S346 KkNTPVQSPVSLGED
K436 TVATENNKVATWVDE
K451 TLSSVASKLEHTAQT
K498-m1 VPFSQRKkMLEkARA
K502-m1 QRKkMLEkARAKNKK
S572 SCRFQLRSPESLKSM
S592 TLETKPESKQEPVKT
T599 SKQEPVKTEMGPPPS
S606 TEMGPPPSPASTCSD
S609 GPPPSPASTCSDASS
S619 SDASSIASSASMPYK
S630-p MPYKRRRsTPAPREE
T631 PYKRRRsTPAPREEE
K657 VVFVEDVKNVPVGKV
K666 VPVGKVLKVDGAYVA
K714 IDELQVVKTGGTPKV
K755 KGVHAVLKTGSWVRY
S802 IFTAGQESPIVLRDG
T869-p IMAVEKQtLMQHILR
S922 NILHACVSVCFPTSN
S961 EAIANAISVVSSNGP
S965 NAISVVSSNGPGNrA
R971-m1 SSNGPGNrAGSSNSr
R978-m1 rAGSSNSrSLRLREM
S979 AGSSNSrSLRLREMM
S989 LREMMRRSLRAAGLG
S1012-p SDHQDPVsPPIAPPS
K1103-ac LRELLSAkDARGMTP
K1103-ub LRELLSAkDARGMTP
T1109 AkDARGMTPFMSAVS
T1129 AAITILETAQKIAKA
S1221 DCKLKRTSPTAYCDC
T1276-p LLLFLVQtVARQTVE
K1299 IREDRNRKTASPEDS
T1300 REDRNRKTASPEDSD
S1302 DRNRKTASPEDSDMP
S1306 KTASPEDSDMPDHDL
R1334 LQDWNALRSMIMFGS
S1341 RSMIMFGSQENkDPL
K1345-ub MFGSQENkDPLSASS
S1349 QENkDPLSASSRIGH
S1369 QVYLNQQSGTIRLDC
S1475 ELCNVAESLIVPVRM
S1526 SDQASSSSQSQSSYI
S1543-p NPQQRRIsQSQPVRG
S1545 QQRRIsQSQPVRGRD
S1604 DEHDEDGSDMELDLL
S1673 SDSDSSSSQSDDIEQ
S1722 PQHQRAASTAPSSTS
T1723 QHQRAASTAPSSTST
S1726 RAASTAPSSTSTPAA
T1730 TAPSSTSTPAAssAG
S1734-p STSTPAAssAGLIyI
S1735-p TSTPAAssAGLIyID
Y1740-p AssAGLIyIDPSNLR
T1754 RRSGTISTSAAAAAA
S1766-p AAAALEAsNASSYLT
S1774 NASSYLTSASSLARA
S1776 SSYLTSASSLARAYS
S1869 PNHPLHASQNSARRE
S1872 PLHASQNSARRERMt
T1879-p SARRERMtAREEASL
T1896 LEGRRRATLLSARQG
S1899 RRRATLLSARQGMMS
T1959 IKAMNQQTTLDTPQL
T1960 KAMNQQTTLDTPQLE
T1963 NQQTTLDTPQLERKR
S1984-p LGIDNEDsEHENDDD
T1992 EHENDDDTSQSATLN
S2005-p LNDKDDDsLPAETGQ
S2020 NHPFFRRSDSMtFLG
S2022 PFFRRSDSMtFLGCI
T2024-p FRRSDSMtFLGCIPP
S2065 EDLFGRPSQGLYSSS
Y2069 GRPSQGLYSSSAGSG
S2070 RPSQGLYSSSAGSGK
S2097 EVLPTKMSYAANLKN
K2130 AEEADSSKPGPSAPD
T2207 AEPGSILTELGGFEV
K2215 ELGGFEVKESKFRRE
S2235-p NQQSRDLsLEVDRDR
T2264 FGRRCATTPMAVHRV
K2276 HRVKVTFKDEPGEGS
S2283 KDEPGEGSGVARSFY
S2319 ANKGTHTSLMQRLRN
S2363-p RDFRRQLsIDTRPFR
S2428 QLLLLLASEDSLRAR
S2431 LLLASEDSLRARVDE
S2454 GRENGADSILDLGLL
S2463 LDLGLLDSSEKVQEN
S2464 DLGLLDSSEKVQENR
K2466 GLLDSSEKVQENRKR
S2476-p ENRKRHGssRsVVDM
S2477-p NRKRHGssRsVVDMD
S2479-p KRHGssRsVVDMDLE
K2503 PLFYQPGKRGFYTPR
S2579 LRQLILASQSSDADA
T2717-p IVEKMSMtERQDLVy
Y2724-p tERQDLVyFWtSSPS
T2727-p QDLVyFWtSSPSLPA
T2760-p QHLPTANtCIsRLyV
S2763-p PTANtCIsRLyVPLy
Y2766-p NtCIsRLyVPLyssK
Y2770-p sRLyVPLyssKQILK
S2771-p RLyVPLyssKQILKQ
S2772-p LyVPLyssKQILKQK
  rat

 
Y22 VSEKLNKYNLNSHPP
S26 LNKYNLNSHPPLNVL
K39 VLEQATIKQCVVGPN
S63 RICRIGFSVQPDRLE
S80 KPDNNDGSKLNSSSG
K81 PDNNDGSKLNSSSGT
S98 TSRPGRTSDSPWFLS
S100 RPGRTSDSPWFLSGS
T109 WFLSGSETLGRLAGN
S120 LAGNTLGSRWSSGVG
S123 NTLGSRWSSGVGGSG
S124 TLGSRWSSGVGGSGG
S129 WSSGVGGSGGGSSGR
S133 VGGSGGGSSGRSSAG
S144 SSAGARDSRRQTRVI
S164 RGSGLLGSQPQPVIP
S181 VIPEELISQAQVVLQ
K190 AQVVLQGKSRSVIIR
S193 VLQGKSRSVIIRELQ
T202 IIRELQRTNLDVNLA
S277 YPSFRRSSLSRLGSS
S279 SFRRSSLSRLGSSRE
S283 SSLSRLGSSRERDSE
S284 SLSRLGSSRERDSEL
S297 ELLRERESVLRLRER
S311 RRWLDGASFDNERGS
K321 NERGSTSKEGEPNPD
K330 GEPNPDKKNTPVQSP
S336 KKNTPVQSPVSLGED
K426 TVATENNKVATWVDE
K441 TLSSVASKLEHTAQT
K488 VPFSQRKKMLEKARA
K492 QRKKMLEKARAKNKK
S562 SCRFQLRSPESLKSM
S582 TIETKPESKQEPVKT
T589 SKQEPVKTEMGPPPS
S596 TEMGPPPSPASTCSD
S599 GPPPSPASTCSDASS
S609 SDASSIASSASMPYK
S620 MPYKRRRSTPAPKEE
T621 PYKRRRSTPAPKEEE
K647 VVFVEDVKNVPVGKV
K656 VPVGKVLKVDGAYVA
K704 IDELQVVKTGGTPKV
K745 KGVHAVLKTGNWVRY
S792 IFTAGQESPIILRDG
T859 IMAVEKQTLMQHILR
S912 NILHACVSVCFPTSN
S951 EAIANAISVVSSNGP
S955 NAISVVSSNGPGNrA
R961-m1 SSNGPGNrAGSSSSR
R968 rAGSSSSRSLRLREM
S969 AGSSSSRSLRLREMM
S979 LREMMRRSLRAAGLG
S1002 SDHQDPVSPPIAPPS
K1093 LRELLSAKDARGMTP
K1093 LRELLSAKDARGMTP
T1099 AKDARGMTPFMSAVS
T1119 AAITILETAQKIAKA
S1211 DCKLKRTSPTAYCDC
T1266 LLLFLVQTVARQTVE
K1289 IREDRNRKTASPDDS
T1290 REDRNRKTASPDDSD
S1292 DRNRKTASPDDSDMP
S1296 KTASPDDSDMPDHDL
R1324 LQDWNALRSMIMFGS
S1331 RSMIMFGSQENKDPL
K1335 MFGSQENKDPLSASS
S1339 QENKDPLSASSRIGH
S1359 QVYLNQQSGTIRLDC
S1465 ELCNVAESLIVPVRM
S1516 SDQSSSSSQSQSSYI
S1533-p NPQQRRIsQSQPVRG
S1535 QQRRIsQSQPVRGRE
S1594 DEHDEDGSDMELDLL
S1663 SDSDSSSSQSDDIEQ
S1712 TQHQRAASTAPSSTS
T1713 QHQRAASTAPSSTST
S1716 RAASTAPSSTSTPAA
T1720 TAPSSTSTPAASSAG
S1724 STSTPAASSAGLIYI
S1725 TSTPAASSAGLIYID
Y1730 ASSAGLIYIDPSNLR
T1744 RRSGTISTSAAAAAA
S1756 AAAALEASNASSYLT
S1764 NASSYLTSASSLARA
S1766 SSYLTSASSLARAYS
S1859 PNHPLHASQNSARRE
S1862 PLHASQNSARRERMT
T1869 SARRERMTAREEASL
T1886 LEGRRRATLLSARQG
S1889 RRRATLLSARQGMMS
T1949 IKAMNQQTTLDTPQL
T1950 KAMNQQTTLDTPQLE
T1953 NQQTTLDTPQLERKR
S1974 LGIDNEDSEHENDDD
T1982 EHENDDDTSQSATLN
S1995 LNDKDDESLPAETGQ
S2010 NHPFFRRSDSMTFLG
S2012 PFFRRSDSMTFLGCI
T2014 FRRSDSMTFLGCIPP
S2055 EDLFGRPSQGLYSSS
Y2059 GRPSQGLYSSSAGSG
S2060 RPSQGLYSSSAGSGK
S2087 EVLPTKMSYAANLKN
K2120 AEEADSSKPGPSAHD
T2197 AEPGSILTELGGFEV
K2205 ELGGFEVKESKFRRE
S2225 NQQSRDLSLEVDRDR
T2254 FGRRCATTPMAVHRV
K2266 HRVKVTFKDEPGEGS
S2273 KDEPGEGSGVARSFY
S2309 ANKGTHTSLMQRLRN
S2353 RDFRRQLSIDTRPFR
S2418 QLLLLLASEDSLRAR
S2421 LLLASEDSLRARVEE
S2444 GRENGADSILDLGLL
S2453 LDLGLLDSSEKVQEN
S2454 DLGLLDSSEKVQENR
K2456 GLLDSSEKVQENRKR
S2466 ENRKRHGSSRSVVDM
S2467 NRKRHGSSRSVVDMD
S2469 KRHGSSRSVVDMDLD
K2493 PLFYQPGKRGFYTPR
S2569 LRQLILASQSSDADA
T2707 IVERMSMTERQDLVY
Y2714 TERQDLVYFWTSSPS
T2717 QDLVYFWTSSPSLPA
T2750 QHLPTANTCISRLYV
S2753 PTANTCISRLYVPLY
Y2756 NTCISRLYVPLYSSK
Y2760 SRLYVPLYSSKQILK
S2761 RLYVPLYSSKQILKQ
S2762 LYVPLYSSKQILKQK
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