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Protein Page:
HEFL (human)

Overview
HEFL Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. Belongs to the CAS family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: cytoskeleton; focal adhesion; membrane; cytoplasm
Molecular Function: two-component sensor activity
Biological Process: two-component signal transduction system (phosphorelay); cell adhesion
Reference #:  Q9NQ75 (UniProtKB)
Alt. Names/Synonyms: C20orf32; Cas scaffolding protein family member 4; CAS4; CASS4; HEF-like protein; HEF1-EFS-p130Cas-like protein; HEFL; HEPL
Gene Symbols: CASS4
Molecular weight: 87,144 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Select Structure to View Below

HEFL

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y350‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T4-p ____MKGtGIMDCAP
0 8 Y98-p PASSEETyQVPTLPR
0 8 T108-p PTLPRPPtPGPVyEQ
0 21 Y113-p PPtPGPVyEQMRsWA
0 1 S118-p PVyEQMRsWAEGPQP
0 1 T127-p AEGPQPPtAQVyEFP
0 71 Y131-p QPPtAQVyEFPDPPT
0 3 S149-p IICEKTLsFPKQAIL
0 8 T157-p FPKQAILtLPRPVRA
0 1 S171-p ASLPTLPsQVyDVPt
0 42 Y174-p PTLPsQVyDVPtQHR
0 1 T178-p sQVyDVPtQHRGPVV
0 273 Y195-p EPEKQQLyDIPAsPK
0 108 S200-p QLyDIPAsPKKAGLH
0 1 S211 AGLHPPDSQASGQGV
0 1 S214 HPPDSQASGQGVPLI
0 203 Y231-p TTLRRGGystLPNPQ
0 3 S232-p TLRRGGystLPNPQK
0 1 T233-p LRRGGystLPNPQKS
0 214 Y244-p PQKSEWIyDtPVsPG
0 4 T246-p KSEWIyDtPVsPGKA
0 21 S249-p WIyDtPVsPGKASVR
0 1 S274-p SRPHALPsSSSTFyN
0 104 Y280-p PsSSSTFyNPPSGRS
0 1 S289-p PPSGRSRsLTPQLNN
0 24 S305-p VPMQKKLsLPEIPsy
0 7 S311-p LsLPEIPsyGFLVPR
0 89 Y312-p sLPEIPsyGFLVPRG
0 9 S328-p FPLDEDVsyKVPSSF
0 114 Y329-p PLDEDVsyKVPSSFL
0 2 T345-p PRVEQQNtKPNIyDI
0 343 Y350-p QNtKPNIyDIPKATS
0 1 S376-p AKEVSENsAGHNSSW
0 3 T388-p SSWFSRRtTsPSPEP
0 2 S390-p WFSRRtTsPSPEPDR
0 1 S401-p EPDRLSGsSSDSRAS
0 1 S414-p ASIVSSCsTTStDDs
0 1 T418-p SSCsTTStDDsSSSS
0 1 S421-p sTTStDDsSSSSSEE
0 1 S434-p EESAKELsLDLDVAK
0 2 S463-p AGLMLFVsRKWRFRD
0 1 N554 LVTDSVQNSPDDLER
0 1 S555 VTDSVQNSPDDLERF
0 1 T597-p RNCEKEEtVQLTPNA
0 1 S673 PERKPRLSEHCRLyF
0 1 C676 KPRLSEHCRLyFGAL
0 21 Y679-p LSEHCRLyFGALFKA
  HEFL iso3  
T4 ____MKGTGIMDCAP
Y98 PASSEETYQVPTLPR
T108 PTLPRPPTPGPVYEQ
Y113 PPTPGPVYEQMRSWA
S118 PVYEQMRSWAEGPQP
T127 AEGPQPPTAQVYEFP
Y131 QPPTAQVYEFPDPPT
S149 IICEKTLSFPKQAIL
T157 FPKQAILTLPRPVRA
S171 ASLPTLPSQVYDVPT
Y174 PTLPSQVYDVPTQHR
T178 SQVYDVPTQHRGPVV
Y195 EPEKQQLYDIPASPK
S200 QLYDIPASPKKAGLH
S211-p AGLHPPDsQAsNPGP
S214-p HPPDsQAsNPGPLIP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S236 PERKPRLSEHCRLYF
C239 KPRLSEHCRLYFGAL
Y242 LSEHCRLYFGALFKA
  mouse

 
T4 ____MRGTSIREGAP
Y98 LTSSGAPYQVQDLIS
P108 QDLISPPPQGPVyEP
Y113-p PPPQGPVyEPMRSWV
S118 PVyEPMRSWVEGPSP
T127 VEGPSPATAQVYELP
Y131 SPATAQVYELPESPS
S149 IICEKTLSFPKQALS
V157 FPKQALSVLPRPTRA
S171 ASLPTLPSQVyDVPV
Y174-p PTLPSQVyDVPVQRQ
V178 SQVyDVPVQRQGFST
Y195-p RLEKQQFyDIPTSSQ
S200 QFyDIPTSSQKALLH
S211 ALLHSSTSQGRDVTL
- gap
Y230 AFRQGGGYNPLSSPQ
N231 FRQGGGYNPLSSPQK
P232 RQGGGYNPLSSPQKS
H243 PQKSERIHDTPVLLE
T245 KSERIHDTPVLLEKA
L248 RIHDTPVLLEKADVR
S274 GSRAIPGSSAVHTGA
T279 PGSSAVHTGAVALSP
A283 AVHTGAVALSPQLGN
S297-p NTVQRKNsLPEEPTy
T303 NsLPEEPTyAFPTSR
Y304-p sLPEEPTyAFPTSRD
S320 LPSDAGGSYKVPSRF
Y321 PSDAGGSYKVPSRFL
T337 PRVEQQNTMPNIyDT
Y342-p QNTMPNIyDTPKAMQ
S379 GREAPENSPWISGQT
T386 SPWISGQTSFLSPDS
F388 WISGQTSFLSPDSDR
A399 DSDRLSVASSDSRAS
S412 ASVVSSCSSISMDSS
M416 SSCSSISMDSSSGSS
S419 SSISMDSSSGSSSED
W432 EDSVKELWMDVDFAK
S461 AGLLLFVSRTWRFKD
N552 LVTDKVQNSLDDLER
S553 VTDKVQNSLDDLERF
- gap
S690-p TERKIHLsKHsRLYF
S693-p KIHLsKHsRLYFGAL
Y696 LsKHsRLYFGALFKA
  rat

 
T4 ____MRGTGIREGAT
C98 LTGSEAPCQVFNSFS
T108 FNSFSPPTPGPVYEP
Y113 PPTPGPVYEPMKSWV
S118 PVYEPMKSWVEGPSP
T127 VEGPSPATAQVYELP
Y131 SPATAQVYELPDSPS
N149 IICEKTLNFPKQALF
V157 FPKQALFVLPRPTRA
S171 ASLPTLPSQVYDVPV
Y174 PTLPSQVYDVPVQRQ
V178 SQVYDVPVQRQVSST
Y195 RPEKQQFYDIPTSSQ
S200 QFYDIPTSSQKAVFH
S211 AVFHISTSQGPGVTL
- gap
Y230 AFRQGGGYNPLSSPQ
N231 FRQGGGYNPLSSPQK
P232 RQGGGYNPLSSPQKS
H243 PQKSDWIHDTPVSLG
T245 KSDWIHDTPVSLGKA
S248 WIHDTPVSLGKADVR
S274 CSNTIPGSSVVRIGA
I279 PGSSVVRIGAVTLSP
T283 VVRIGAVTLSPQLGN
S297 NAVQKKSSPPEETSY
S303 SSPPEETSYAFLTPR
Y304 SPPEETSYAFLTPRG
S321 LPSDAGSSYKVPSRF
Y322 PSDAGSSYKVPSRFL
T338 PRVERQNTKPNIYDT
Y343 QNTKPNIYDTPKAMQ
S380 GREAPENSPWVSRQT
T387 SPWVSRQTNFLSPDS
F389 WVSRQTNFLSPDSDR
A400 DSDRLSVASSDSRAS
S413 ASVVSSCSSLSTDSS
T417 SSCSSLSTDSSPGSS
S420 SSLSTDSSPGSSSED
W433 EDSVKELWMDLDFAK
S462 AGLLLFVSRTWRFKD
S553-p LVVDKAQssVDDLER
S554-p VVDKAQssVDDLERF
- gap
S692 VERKIRLSEHSRLYF
S695 KIRLSEHSRLYFGAL
Y698 LSEHSRLYFGALFKA
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