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Protein Page:
HEFL (human)

Overview
HEFL Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. Belongs to the CAS family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: focal adhesion; cytoskeleton; membrane; cytoplasm
Molecular Function: two-component sensor activity
Biological Process: cell adhesion
Reference #:  Q9NQ75 (UniProtKB)
Alt. Names/Synonyms: C20orf32; Cas scaffolding protein family member 4; CAS4; CASS4; HEF-like protein; HEF1-EFS-p130Cas-like protein; HEFL; HEPL
Gene Symbols: CASS4
Molecular weight: 87,144 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Select Structure to View Below

HEFL

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y350‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 Y98-p PASSEETyQVPTLPR
0 5 T108-p PTLPRPPtPGPVyEQ
0 17 Y113-p PPtPGPVyEQMRSWA
0 71 Y131-p QPPTAQVyEFPDPPT
0 3 S149-p IICEKTLsFPKQAIL
0 6 T157-p FPKQAILtLPRPVRA
0 43 Y174-p PTLPSQVyDVPTQHR
0 273 Y195-p EPEKQQLyDIPAsPK
0 105 S200-p QLyDIPAsPKKAGLH
0 203 Y231-p TTLRRGGystLPNPQ
0 3 S232-p TLRRGGystLPNPQK
0 1 T233-p LRRGGystLPNPQKS
0 217 Y244-p PQKSEWIyDtPVsPG
0 3 T246-p KSEWIyDtPVsPGKA
0 20 S249-p WIyDtPVsPGKASVR
0 102 Y280-p PSSSSTFyNPPSGRS
0 1 S289-p PPSGRSRsLTPQLNN
0 16 S305-p VPMQKKLsLPEIPsy
0 6 S311-p LsLPEIPsyGFLVPR
0 87 Y312-p sLPEIPsyGFLVPRG
0 8 S328-p FPLDEDVsyKVPSSF
0 119 Y329-p PLDEDVsyKVPSSFL
0 2 T345-p PRVEQQNtKPNIyDI
0 346 Y350-p QNtKPNIyDIPKATS
0 1 S376-p AKEVSENsAGHNSSW
0 3 T388-p SSWFSRRtTsPSPEP
0 2 S390-p WFSRRtTsPSPEPDR
0 2 S463-p AGLMLFVsRKWRFRD
0 1 N554 LVTDSVQNSPDDLER
0 1 S555 VTDSVQNSPDDLERF
0 1 S673 PERKPRLSEHCRLyF
0 1 C676 KPRLSEHCRLyFGAL
0 20 Y679-p LSEHCRLyFGALFKA
  mouse

 
Y98 LTSSGAPYQVQDLIS
P108 QDLISPPPQGPVyEP
Y113-p PPPQGPVyEPMRSWV
Y131 SPATAQVYELPESPS
S149 IICEKTLSFPKQALS
V157 FPKQALSVLPRPTRA
Y174-p PTLPSQVyDVPVQRQ
Y195-p RLEKQQFyDIPTSSQ
S200 QFyDIPTSSQKALLH
Y230 AFRQGGGYNPLSSPQ
N231 FRQGGGYNPLSSPQK
P232 RQGGGYNPLSSPQKS
H243 PQKSERIHDTPVLLE
T245 KSERIHDTPVLLEKA
L248 RIHDTPVLLEKADVR
T279 PGSSAVHTGAVALSP
- under review  
S297-p NTVQRKNsLPEEPTy
T303 NsLPEEPTyAFPTSR
Y304-p sLPEEPTyAFPTSRD
S320 LPSDAGGSYKVPSRF
Y321 PSDAGGSYKVPSRFL
T337 PRVEQQNTMPNIyDT
Y342-p QNTMPNIyDTPKAMQ
S379 GREAPENSPWISGQT
T386 SPWISGQTSFLSPDS
F388 WISGQTSFLSPDSDR
S461 AGLLLFVSRTWRFKD
N552 LVTDKVQNSLDDLER
S553 VTDKVQNSLDDLERF
S690-p TERKIHLsKHsRLYF
S693-p KIHLsKHsRLYFGAL
Y696 LsKHsRLYFGALFKA
  rat

 
C98 LTGSEAPCQVFNSFS
T108 FNSFSPPTPGPVYEP
Y113 PPTPGPVYEPMKSWV
Y131 SPATAQVYELPDSPS
N149 IICEKTLNFPKQALF
V157 FPKQALFVLPRPTRA
Y174 PTLPSQVYDVPVQRQ
Y195 RPEKQQFYDIPTSSQ
S200 QFYDIPTSSQKAVFH
Y230 AFRQGGGYNPLSSPQ
N231 FRQGGGYNPLSSPQK
- under review  
H243 PQKSDWIHDTPVSLG
T245 KSDWIHDTPVSLGKA
S248 WIHDTPVSLGKADVR
I279 PGSSVVRIGAVTLSP
- under review  
S297 NAVQKKSSPPEETSY
S303 SSPPEETSYAFLTPR
Y304 SPPEETSYAFLTPRG
S321 LPSDAGSSYKVPSRF
Y322 PSDAGSSYKVPSRFL
T338 PRVERQNTKPNIYDT
Y343 QNTKPNIYDTPKAMQ
- under review  
T387 SPWVSRQTNFLSPDS
F389 WVSRQTNFLSPDSDR
S462 AGLLLFVSRTWRFKD
S553-p LVVDKAQssVDDLER
S554-p VVDKAQssVDDLERF
S692 VERKIRLSEHSRLYF
S695 KIRLSEHSRLYFGAL
Y698 LSEHSRLYFGALFKA
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