an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: filamentous actin; ruffle; endocytic vesicle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; actin cytoskeleton
Molecular Function: protein C-terminus binding; protein binding; structural constituent of cytoskeleton; cadherin binding; protein complex binding; beta-catenin binding; vascular endothelial growth factor receptor binding; SH3 domain binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; mitosis; cell-cell adhesion; vesicle organization and biogenesis; protein complex assembly; signal transduction; regulation of receptor-mediated endocytosis; substrate-bound cell migration, cell extension
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.