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Protein Page:
CD2AP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD2AP an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3). Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: ruffle; filamentous actin; perinuclear region of cytoplasm; endocytic vesicle; cytoplasm; plasma membrane; actin cytoskeleton
Molecular Function: protein C-terminus binding; protein binding; structural constituent of cytoskeleton; cadherin binding; protein complex binding; beta-catenin binding; SH3 domain binding; vascular endothelial growth factor receptor binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; mitosis; cell-cell adhesion; vesicle organization and biogenesis; protein complex assembly; signal transduction; regulation of receptor-mediated endocytosis; substrate-bound cell migration, cell extension
Reference #:  Q9Y5K6 (UniProtKB)
Alt. Names/Synonyms: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; CD2AP; CMS; DKFZp586H0519
Gene Symbols: CD2AP
Molecular weight: 71,451 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD2AP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K55-ac MFPDNFVkEIKRETE
0 1 S67-p ETEFKDDsLPIKRER
0 1 K71 KDDsLPIKRERHGNV
0 9 S80-p ERHGNVAsLVQRIst
0 6 S86-p AsLVQRIstyGLPAG
0 3 T87-p sLVQRIstyGLPAGG
0 244 Y88-p LVQRIstyGLPAGGI
0 1 K102 IQPHPQTKNIKKKTK
0 1 S180-p THEAQDDsETVLAGP
0 2 S189-p TVLAGPTsPIPsLGN
0 3 S193-p GPTsPIPsLGNVSET
0 1 K221 IGFGDIFKEGsVKLR
0 15 S224-p GDIFKEGsVKLRtRt
0 16 T229-p EGsVKLRtRtsssEt
0 106 T231-p sVKLRtRtsssEtEE
0 91 S232-p VKLRtRtsssEtEEK
1 356 S233-p KLRtRtsssEtEEKK
0 40 S234-p LRtRtsssEtEEKKP
0 6 T236-p tRtsssEtEEKKPEK
0 4 S256-p SLGPKTQsVEITKTD
0 4 K359-ac PELIAAEkkyFsLKP
0 1 K360-ac ELIAAEkkyFsLKPE
0 67 Y361-p LIAAEkkyFsLKPEE
0 26 S363-p AAEkkyFsLKPEEKD
0 3 S380-p STLEQKPsKPAAPQV
0 2 T393-p QVPPKKPtPPtKASN
0 1 T396-p PKKPtPPtKASNLLR
0 13 S404 KASNLLRSSGTVyPK
0 3 Y409-p LRSSGTVyPKRPEKP
0 2 K425-ac PPPPPIAkINGEVSS
0 1 K457 EQLPLRPKsVDFDsL
0 39 S458-p QLPLRPKsVDFDsLt
0 4 S463-p PKsVDFDsLtVRTSK
0 3 T465-p sVDFDsLtVRTSKET
0 32 S510-p GRFNGGHsPtHsPEK
0 2 T512-p FNGGHsPtHsPEKIL
0 23 S514-p GGHsPtHsPEKILKL
0 1 S527 KLPKEEDSANLKPSE
0 3 T539-p PSELKKDtCysPKPs
0 142 Y541-p ELKKDtCysPKPsVy
0 33 S542-p LKKDtCysPKPsVyL
0 15 S546-p tCysPKPsVyLstPs
0 323 Y548-p ysPKPsVyLstPssA
0 3 S550-p PKPsVyLstPssAsK
0 22 T551-p KPsVyLstPssAsKA
0 4 S553-p sVyLstPssAsKANT
0 13 S554-p VyLstPssAsKANTT
0 2 S556-p LstPssAsKANTTAF
0 15 T565-p ANTTAFLtPLEIKAK
0 1 K570 FLtPLEIKAKVETDD
0 7 S582-p TDDVKKNsLDELRAQ
0 1 K631 NLEMEIEKLKKAVLS
  mouse

 
K55 MFPDNFVKEIKRETE
N67 ETEPKDDNLPIkRER
K71-ub KDDNLPIkRERQGNV
S80 ERQGNVASLVQRIST
S86 ASLVQRISTyGLPAG
T87 SLVQRISTyGLPAGG
Y88-p LVQRISTyGLPAGGI
K102-ub IQPHPQTkAIKKKTK
S180 THNAQEESEVPLTGP
S189-p VPLTGPTsPLPsPGN
S193-p GPTsPLPsPGNGSEP
K221-ub IGFGDIFkEGsVKLR
S224-p GDIFkEGsVKLRtRt
T229-p EGsVKLRtRtsssET
T231-p sVKLRtRtsssETEE
S232-p VKLRtRtsssETEEK
S233-p KLRtRtsssETEEKK
S234-p LRtRtsssETEEKKT
T236 tRtsssETEEKKTEK
N256 PLGSRTQNVEVTKPD
K359 PDLSAAEKKAFPLKA
K360 DLSAAEKKAFPLKAE
A361 LSAAEKKAFPLKAEE
P363 AAEKKAFPLKAEEKD
S380-p SLLEQKPsKPAAPQV
T393 QVPPKKPTAPTKASN
T396 PKKPTAPTKASNLLR
S404-p KASNLLRsPGAVYPK
Y409 LRsPGAVYPKRPEKP
K425 PPPPPAAKINGEVSI
K457-ub EQLPVRPksVDLDAF
S458-p QLPVRPksVDLDAFV
A463 PksVDLDAFVARNSK
V465 sVDLDAFVARNSKET
S510-p GRFNGGHsPtQsPEK
T512-p FNGGHsPtQsPEKTL
S514-p GGHsPtQsPEKTLKL
S527-p KLPKEDDsGNLKPLE
A539 PLEFKKDASySSKSS
Y541-p EFKKDASySSKSSLs
S542 FKKDASySSKSSLst
S546 ASySSKSSLstPssA
- gap
S548-p ySSKSSLstPssASK
T549-p SSKSSLstPssASKV
S551-p KSSLstPssASKVNT
S552-p SSLstPssASKVNTA
S554 LstPssASKVNTAAF
T563-p VNTAAFLtPLELkAK
K568-ub FLtPLELkAKAEADD
S580-p ADDGKRNsVDELRAQ
K629-ub NLEVEIAkLKKAVLL
  rat

 
K55-ac MFPDNFVkEIKRETE
N67 ETEPKDDNLPIKRER
K71 KDDNLPIKRERPGNV
S80 ERPGNVASLVQRIST
S86 ASLVQRISTYGLPAG
T87 SLVQRISTYGLPAGG
Y88 LVQRISTYGLPAGGI
K102 IQPHPQTKAMKKKTK
S180 MHDAQEESEVSLTGP
S189 VSLTGPTSPMPSPGN
S193 GPTSPMPSPGNGSEP
K221 VGFGDIFKEGsVKLR
S224-p GDIFKEGsVKLRTRT
T229 EGsVKLRTRTSSSET
T231 sVKLRTRTSSSETEE
S232 VKLRTRTSSSETEEK
S233 KLRTRTSSSETEEKK
S234 LRTRTSSSETEEKKS
T236 TRTSSSETEEKKSEK
N256 SLGSRTQNVEVTKPD
K359 PDPLAGEKKTFPLKA
K360 DPLAGEKKTFPLKAE
T361 PLAGEKKTFPLKAED
P363 AGEKKTFPLKAEDRD
S380 SLLEQKPSKPAAPQV
T393 QVPPKKPTPPTKANN
T396 PKKPTPPTKANNLLR
S404 KANNLLRSPGTMYPK
Y409 LRSPGTMYPKRPEKP
K425 PPPPPTAKINGEVST
K457 EQLPVRPKsVDLDAL
S458-p QLPVRPKsVDLDALV
A463 PKsVDLDALVARNSK
V465 sVDLDALVARNSKET
S510-p GRFNGGHsPTQsPEK
T512 FNGGHsPTQsPEKTL
S514-p GGHsPTQsPEKTLKL
S527 KLPKDDDSGNIKPSE
A539 PSEFKKDAGYSSKPS
Y541 EFKKDAGYSSKPSLS
S542 FKKDAGYSSKPSLSA
S546 AGYSSKPSLSAPSSA
- gap
S548 YSSKPSLSAPSSASK
A549 SSKPSLSAPSSASKV
S551 KPSLSAPSSASKVNT
S552 PSLSAPSSASKVNTA
S554 LSAPSSASKVNTAAF
S563 VNTAAFLSPLELKAK
K568 FLSPLELKAKVEADD
S580-p ADDGKKSsLDELRAQ
K629 NLEVEIAKLKKAVLL
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