Home

CD2AP (human)

Overview CD2AP an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3). Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: ruffle; filamentous actin; cytoplasm; nucleolus; plasma membrane; actin cytoskeleton Molecular Function: protein binding; structural constituent of cytoskeleton; SH3 domain binding Biological Process: mitosis; cell division; protein complex assembly; signal transduction; substrate-bound cell migration, cell extension Reference #:  Q9Y5K6 (UniProtKB) Alt. Names/Synonyms: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; CD2AP; CMS; DKFZp586H0519 Gene Symbols: CD2AP Molecular weight: 71,451 Da Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CD2AP 2FEI - A=111-166 (human) 2J6F - A=1-62 (human) 2J6K - A/B/C/D/E/F/G/H/I/J/K/L=1-62 (human) 2J6O - A=1-62 (human) 2J7I - A/B=1-62 (human) 3AA6 - C=485-507 (human) 3LK4 - 6/F/O/3/X/9/0/C/I/R/L/U=475-503 (human) 3U23 - A=109-168 (human) 2JTE - A=270-329 (mouse) 2KRM - A=2-58 (mouse) 2KRN - A=111-166 (mouse) 2KRO - A=270-329 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23  |  Phospho3D  |  DISEASE 604241 607832  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K55-a	MFPDNFVkEIKRETE
0	1		K71	KDDSLPIKRERHGNV
0	7		S80-p	ERHGNVAsLVQRIst
0	4		S86-p	AsLVQRIstyGLPAG
0	3		T87-p	sLVQRIstyGLPAGG
0	256		Y88-p	LVQRIstyGLPAGGI
0	1		K102	IQPHPQTKNIKKKTK
0	1		S189	TVLAGPTSPIPSLGN
0	2		S193	GPTSPIPSLGNVSET
0	1		K221	IGFGDIFKEGsVKLR
0	10		S224-p	GDIFKEGsVKLRtRt
0	16		T229-p	EGsVKLRtRtsssEt
0	106		T231-p	sVKLRtRtsssEtEE
0	91		S232-p	VKLRtRtsssEtEEK
0	350		S233-p	KLRtRtsssEtEEKK
0	39		S234-p	LRtRtsssEtEEKKP
0	6		T236-p	tRtsssEtEEKKPEK
0	1		S256-p	SLGPKTQsVEITKTD
0	4		K359-a	PELIAAEkkyFsLKP
0	1		K360-a	ELIAAEkkyFsLKPE
0	33		Y361-p	LIAAEkkyFsLKPEE
0	11		S363-p	AAEkkyFsLKPEEKD
0	1		S380	STLEQKPSKPAAPQV
0	1		T393-p	QVPPKKPtPPTKASN
0	12		S404	KASNLLRSSGTVyPK
0	3		Y409-p	LRSSGTVyPKRPEKP
0	2		K425-a	PPPPPIAkINGEVSS
0	1		K457	EQLPLRPKsVDFDsL
0	28		S458-p	QLPLRPKsVDFDsLt
0	2		S463-p	PKsVDFDsLtVRTSK
0	3		T465-p	sVDFDsLtVRTSKET
0	25		S510-p	GRFNGGHsPtHsPEK
0	2		T512-p	FNGGHsPtHsPEKIL
0	17		S514-p	GGHsPtHsPEKILKL
0	1		S527	KLPKEEDSANLKPSE
0	2		T539-p	PSELKKDtCysPKPs
0	147		Y541-p	ELKKDtCysPKPsVy
0	30		S542-p	LKKDtCysPKPsVyL
0	12		S546-p	tCysPKPsVyLstPs
0	320		Y548-p	ysPKPsVyLstPssA
0	2		S550-p	PKPsVyLstPssAsK
0	19		T551-p	KPsVyLstPssAsKA
0	3		S553-p	sVyLstPssAsKANT
0	10		S554-p	VyLstPssAsKANTT
0	2		S556-p	LstPssAsKANTTAF
0	12		T565-p	ANTTAFLtPLEIKAK
0	1		K570	FLtPLEIKAKVETDD
0	5		S582-p	TDDVKKNsLDELRAQ
0	1		K631	NLEMEIEKLKKAVLS

	mouse
K55	MFPDNFVKEIKRETE
K71-u	KDDNLPIkRERQGNV
S80	ERQGNVASLVQRIST
S86	ASLVQRISTyGLPAG
T87	SLVQRISTyGLPAGG
Y88-p	LVQRISTyGLPAGGI
K102-u	IQPHPQTkAIKKKTK
S189-p	VPLTGPTsPLPsPGN
S193-p	GPTsPLPsPGNGSEP
K221-u	IGFGDIFkEGsVKLR
S224-p	GDIFkEGsVKLRtRt
T229-p	EGsVKLRtRtsssET
T231-p	sVKLRtRtsssETEE
S232-p	VKLRtRtsssETEEK
S233-p	KLRtRtsssETEEKK
S234-p	LRtRtsssETEEKKT
T236	tRtsssETEEKKTEK
N256	PLGSRTQNVEVTKPD
K359	PDLSAAEKKAFPLKA
K360	DLSAAEKKAFPLKAE
A361	LSAAEKKAFPLKAEE
P363	AAEKKAFPLKAEEKD
S380-p	SLLEQKPsKPAAPQV
T393	QVPPKKPTAPTKASN
S404-p	KASNLLRsPGAVYPK
Y409	LRsPGAVYPKRPEKP
K425	PPPPPAAKINGEVSI
K457-u	EQLPVRPksVDLDAF
S458-p	QLPVRPksVDLDAFV
A463	PksVDLDAFVARNSK
V465	sVDLDAFVARNSKET
S510-p	GRFNGGHsPtQsPEK
T512-p	FNGGHsPtQsPEKTL
S514-p	GGHsPtQsPEKTLKL
S527-p	KLPKEDDsGNLKPLE
A539	PLEFKKDASySSKSS
Y541-p	EFKKDASySSKSSLS
S542	FKKDASySSKSSLST
S546	ASySSKSSLSTPSSA
-	gap
S548	ySSKSSLSTPSSASK
T549	SSKSSLSTPSSASKV
S551	KSSLSTPSSASKVNT
S552	SSLSTPSSASKVNTA
S554	LSTPSSASKVNTAAF
T563-p	VNTAAFLtPLELkAK
K568-u	FLtPLELkAKAEADD
S580-p	ADDGKRNsVDELRAQ
K629-u	NLEVEIAkLKKAVLL

	rat
K55	MFPDNFVKEIKRETE
K71	KDDNLPIKRERPGNV
S80	ERPGNVASLVQRIST
S86	ASLVQRISTYGLPAG
T87	SLVQRISTYGLPAGG
Y88	LVQRISTYGLPAGGI
K102	IQPHPQTKAMKKKTK
S189	VSLSGPTSPMPSPGN
S193	GPTSPMPSPGNGSEP
K221	VGFGDIFKEGsVKLR
S224-p	GDIFKEGsVKLRTRT
T229	EGsVKLRTRTSSSET
T231	sVKLRTRTSSSETEE
S232	VKLRTRTSSSETEEK
S233	KLRTRTSSSETEEKK
S234	LRTRTSSSETEEKKS
T236	TRTSSSETEEKKSEK
N256	SLGSRTQNVEVTKPD
K359	PDPLAGEKKTFPLKA
K360	DPLAGEKKTFPLKAE
T361	PLAGEKKTFPLKAED
P363	AGEKKTFPLKAEDRD
S380	SLLEQKPSKPAAPQV
T393	QVPPKKPTPPTKANN
S404	KANNLLRSPGTMYPK
Y409	LRSPGTMYPKRPEKP
K425	PPPPPTAKINGEVST
K457	DQLPVRPKsVDLDAL
S458-p	QLPVRPKsVDLDALV
A463	PKsVDLDALVARNSK
V465	sVDLDALVARNSKET
S510-p	GRFNGGHsPTQsPEK
T512	FNGGHsPTQsPEKTL
S514-p	GGHsPTQsPEKTLKL
S527	KLPKDDDSGNIKPSE
A539	PSEFKKDAGYSSKPS
Y541	EFKKDAGYSSKPSLS
S542	FKKDAGYSSKPSLSA
S546	AGYSSKPSLSAPSSA
-	gap
S548	YSSKPSLSAPSSASK
A549	SSKPSLSAPSSASKV
S551	KPSLSAPSSASKVNT
S552	PSLSAPSSASKVNTA
S554	LSAPSSASKVNTAAF
S563	VNTAAFLSPLELKAK
K568	FLSPLELKAKVEADD
S580	ADDGKKSSLDELRAQ
K629	NLEVEIAKLKKAVLL

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.