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Protein Page:
ANXA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ANXA2 a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; protein complex; lysosomal membrane; late endosome membrane; early endosome; lipid particle; cell cortex; lipid raft; extracellular matrix; ruffle; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; basement membrane; midbody; nucleus; endosome; sarcolemma; vesicle
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; calcium-dependent protein binding; Rab GTPase binding
Biological Process: fibrinolysis; positive regulation of fibroblast proliferation; collagen fibril organization; negative regulation of catalytic activity; protein heterotetramerization; positive regulation of vesicle fusion; positive regulation of protein amino acid phosphorylation; angiogenesis; positive regulation of binding; lipid raft formation; body fluid secretion; membrane budding
Reference #:  P07355 (UniProtKB)
Alt. Names/Synonyms: Annexin A2; Annexin II; Annexin-2; ANX2; ANX2L4; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2; LPC2D; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Gene Symbols: ANXA2
Molecular weight: 38,604 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANXA2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S26‑p
intracellular localization: S12‑p, T19‑p, Y24‑p, S26‑p
molecular association, regulation: S12‑p, Y24‑p, S26‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T3-p _____MStVHEILCk
0 1 K10-ac tVHEILCkLsLEGDH
7 13 S12-p HEILCkLsLEGDHst
1 10 S18-p LsLEGDHstPPsAyG
1 36 T19-p sLEGDHstPPsAyGs
2 166 S22-p GDHstPPsAyGsVkA
10 2610 Y24-p HstPPsAyGsVkAyt
8 113 S26-p tPPsAyGsVkAytNF
0 1 K28 PsAyGsVKAytNFDA
0 2 K28-ub PsAyGsVkAytNFDA
2 890 Y30-p AyGsVkAytNFDAER
0 4 T31-p yGsVkAytNFDAERD
0 1 T44-p RDALNIEtAIkTkGV
0 1 K47-ac LNIEtAIkTkGVDEV
0 2 K47-ub LNIEtAIkTkGVDEV
0 4 K49-ac IEtAIkTkGVDEVtI
0 18 K49-ub IEtAIkTkGVDEVtI
0 1 T55-p TkGVDEVtIVNILtN
0 1 T61-p VtIVNILtNRSNAQR
0 9 Y75-p RQDIAFAyQRRTKKE
0 2 S85-p RTKKELAsALkSALs
0 1 K88-ub KELAsALkSALsGHL
0 1 S89 ELAsALkSALsGHLE
0 1 S92-p sALkSALsGHLETVI
0 3 K104-ac TVILGLLktPAQyDA
0 26 K104-ub TVILGLLktPAQyDA
0 2 T105-p VILGLLktPAQyDAs
0 25 Y109-p LLktPAQyDAsELkA
0 3 S112-p tPAQyDAsELkASMk
0 4 K115-ac QyDAsELkASMkGLG
0 7 K115-ub QyDAsELkASMkGLG
0 1 K115-sc QyDAsELkASMkGLG
0 1 K119 sELkASMKGLGtDED
0 15 K119-ub sELkASMkGLGtDED
0 1 K119-sc sELkASMkGLGtDED
0 2 T123-p ASMkGLGtDEDsLIE
0 9 S127-p GLGtDEDsLIEIICs
0 2 S134-p sLIEIICsRtNQELQ
0 1 T136-p IEIICsRtNQELQEI
0 2 Y147-p LQEINRVykEMYkTD
0 2 K148-ac QEINRVykEMYkTDL
0 13 K148-ub QEINRVykEMYkTDL
0 1 K148-sc QEINRVykEMYkTDL
0 2 K152-ac RVykEMYkTDLEkDI
0 2 K152-ub RVykEMYkTDLEkDI
0 1 K152-sc RVykEMYkTDLEkDI
0 12 K157-ac MYkTDLEkDIIsDTs
0 2 K157-ub MYkTDLEkDIIsDTs
0 1 K157-sc MYkTDLEkDIIsDTs
0 1 S161-p DLEkDIIsDTsGDFR
0 3 S164-p kDIIsDTsGDFRkLM
0 1 K169-ac DTsGDFRkLMVALAk
0 1 K169-ub DTsGDFRkLMVALAk
0 2 K176-ac kLMVALAkGRRAEDG
0 1 K176-sc kLMVALAkGRRAEDG
0 8 S184-p GRRAEDGsVIDyELI
0 138 Y188-p EDGsVIDyELIDQDA
0 185 Y199-p DQDARDLyDAGVkRK
0 1 K204-ac DLyDAGVkRKGTDVP
0 8 K204-ub DLyDAGVkRKGTDVP
0 1 K204-sc DLyDAGVkRKGTDVP
0 2 K212-ac RKGTDVPkWIsIMTE
0 1 K212-ub RKGTDVPkWIsIMTE
0 2 S215-p TDVPkWIsIMTERSV
0 22 K227-ac RSVPHLQkVFDRyKs
0 1 K227-ub RSVPHLQkVFDRyKs
0 1 K227-sc RSVPHLQkVFDRyKs
0 1 Y232-p LQkVFDRyKsySPyD
0 2 S234-p kVFDRyKsySPyDML
0 5 Y235-p VFDRyKsySPyDMLE
0 1 S236 FDRyKsySPyDMLEs
1 931 Y238-p RyKsySPyDMLEsIR
0 5 S243-p SPyDMLEsIRKEVkG
0 5 K249-ub EsIRKEVkGDLENAF
0 20 K266-ub LVQCIQNkPLYFADR
0 83 Y275-p LYFADRLyDSMkGKG
0 21 K279-ac DRLyDSMkGKGTRDK
0 1 K279-sc DRLyDSMkGKGTRDK
0 1 K286 kGKGTRDKVLIRIMV
0 1 S296-p IRIMVSRsEVDMLkI
0 3 K302-ac RsEVDMLkIRSEFkR
0 2 K302-ub RsEVDMLkIRSEFkR
0 1 K308-ac LkIRSEFkRKYGksL
0 1 Y311 RSEFkRKYGksLyyy
0 4 K313-ac EFkRKYGksLyyyIQ
0 6 K313-ub EFkRKYGksLyyyIQ
0 1 K313-sc EFkRKYGksLyyyIQ
0 5 S314-p FkRKYGksLyyyIQQ
0 537 Y316-p RKYGksLyyyIQQDt
0 316 Y317-p KYGksLyyyIQQDtk
0 551 Y318-p YGksLyyyIQQDtkG
0 2 T323-p yyyIQQDtkGDYQkA
0 3 K324-ac yyIQQDtkGDYQkAL
0 10 K324-ub yyIQQDtkGDYQkAL
0 2 K329-ub DtkGDYQkALLyLCG
0 17 Y333-p DYQkALLyLCGGDD_
  ANXA2 iso2  
T21 KASFKMSTVHEILCK
K28 TVHEILCKLSLEGDH
S30 HEILCKLSLEGDHST
S36 LSLEGDHSTPPSAYG
T37 SLEGDHSTPPSAYGS
S40 GDHSTPPSAYGSVKA
Y42 HSTPPSAYGSVKAYT
S44 TPPSAYGSVKAYTNF
K46 PSAYGSVKAYTNFDA
K46 PSAYGSVKAYTNFDA
Y48 AYGSVKAYTNFDAER
T49 YGSVKAYTNFDAERD
T62 RDALNIETAIKTKGV
K65 LNIETAIKTKGVDEV
K65 LNIETAIKTKGVDEV
K67 IETAIKTKGVDEVTI
K67 IETAIKTKGVDEVTI
T73 TKGVDEVTIVNILTN
T79 VTIVNILTNRSNAQR
Y93 RQDIAFAYQRRTKKE
S103 RTKKELASALKSALS
K106 KELASALKSALSGHL
S107 ELASALKSALSGHLE
S110 SALKSALSGHLETVI
K122 TVILGLLKTPAQYDA
K122 TVILGLLKTPAQYDA
T123 VILGLLKTPAQYDAS
Y127 LLKTPAQYDASELKA
S130 TPAQYDASELKASMK
K133 QYDASELKASMKGLG
K133 QYDASELKASMKGLG
K133 QYDASELKASMKGLG
K137 SELKASMKGLGTDED
K137 SELKASMKGLGTDED
K137 SELKASMKGLGTDED
T141 ASMKGLGTDEDSLIE
S145 GLGTDEDSLIEIICS
S152 SLIEIICSRTNQELQ
T154 IEIICSRTNQELQEI
Y165 LQEINRVYKEMYKTD
K166 QEINRVYKEMYKTDL
K166 QEINRVYKEMYKTDL
K166 QEINRVYKEMYKTDL
K170 RVYKEMYKTDLEKDI
K170 RVYKEMYKTDLEKDI
K170 RVYKEMYKTDLEKDI
K175 MYKTDLEKDIISDTS
K175 MYKTDLEKDIISDTS
K175 MYKTDLEKDIISDTS
S179 DLEKDIISDTSGDFR
S182 KDIISDTSGDFRkLM
K187-ac DTSGDFRkLMVALAK
K187 DTSGDFRKLMVALAK
K194 kLMVALAKGRRAEDG
K194 kLMVALAKGRRAEDG
S202 GRRAEDGSVIDYELI
Y206 EDGSVIDYELIDQDA
Y217 DQDARDLYDAGVkRK
K222-ac DLYDAGVkRKGTDVP
K222 DLYDAGVKRKGTDVP
K222 DLYDAGVKRKGTDVP
K230-ac RKGTDVPkWISIMTE
K230 RKGTDVPKWISIMTE
S233 TDVPkWISIMTERSV
K245 RSVPHLQKVFDRYKS
K245 RSVPHLQKVFDRYKS
K245 RSVPHLQKVFDRYKS
Y250 LQKVFDRYKSYSPYD
S252 KVFDRYKSYSPYDML
Y253 VFDRYKSYSPYDMLE
S254 FDRYKSYSPYDMLES
Y256 RYKSYSPYDMLESIR
S261 SPYDMLESIRKEVKG
K267 ESIRKEVKGDLENAF
K284 LVQCIQNKPLYFADR
Y293 LYFADRLYDSMKGKG
K297 DRLYDSMKGKGTRDK
K297 DRLYDSMKGKGTRDK
K304 KGKGTRDKVLIRIMV
S314 IRIMVSRSEVDMLKI
K320 RSEVDMLKIRSEFkR
K320 RSEVDMLKIRSEFkR
K326-ac LKIRSEFkRKYGKSL
Y329 RSEFkRKYGKSLYYY
K331 EFkRKYGKSLYYYIQ
K331 EFkRKYGKSLYYYIQ
K331 EFkRKYGKSLYYYIQ
S332 FkRKYGKSLYYYIQQ
Y334 RKYGKSLYYYIQQDT
Y335 KYGKSLYYYIQQDTK
Y336 YGKSLYYYIQQDTKG
T341 YYYIQQDTKGDYQKA
K342 YYIQQDTKGDYQKAL
K342 YYIQQDTKGDYQKAL
K347 DTKGDYQKALLYLCG
Y351 DYQKALLYLCGGDD_
  mouse

 
T3 _____MSTVHEILCK
K10 TVHEILCKLsLEGDH
S12-p HEILCKLsLEGDHst
S18-p LsLEGDHstPPsAyG
T19-p sLEGDHstPPsAyGs
S22-p GDHstPPsAyGsVKP
Y24-p HstPPsAyGsVKPyt
S26-p tPPsAyGsVKPytNF
K28 PsAyGsVKPytNFDA
K28 PsAyGsVKPytNFDA
Y30-p AyGsVKPytNFDAER
T31-p yGsVKPytNFDAERD
T44 RDALNIETAVKTkGV
K47 LNIETAVKTkGVDEV
K47 LNIETAVKTkGVDEV
K49 IETAVKTKGVDEVTI
K49-ub IETAVKTkGVDEVTI
T55 TkGVDEVTIVNILTN
T61 VTIVNILTNRSNVQR
Y75 RQDIAFAYQRRTKKE
S85 RTKKELPSALKSALS
K88 KELPSALKSALSGHL
S89 ELPSALKSALSGHLE
S92 SALKSALSGHLETVI
K104 TVILGLLKTPAQYDA
K104 TVILGLLKTPAQYDA
T105 VILGLLKTPAQYDAS
Y109 LLKTPAQYDASELkA
S112 TPAQYDASELkASMK
K115-ac QYDASELkASMKGLG
K115-ub QYDASELkASMKGLG
K115 QYDASELKASMKGLG
K119 SELkASMKGLGTDED
K119 SELkASMKGLGTDED
K119 SELkASMKGLGTDED
T123 ASMKGLGTDEDsLIE
S127-p GLGTDEDsLIEIICS
S134 sLIEIICSRTNQELQ
T136 IEIICSRTNQELQEI
Y147 LQEINRVYkEMYKTD
K148 QEINRVYKEMYKTDL
K148-ub QEINRVYkEMYKTDL
K148 QEINRVYKEMYKTDL
K152 RVYkEMYKTDLEkDI
K152 RVYkEMYKTDLEkDI
K152 RVYkEMYKTDLEkDI
K157-ac MYKTDLEkDIISDTS
K157 MYKTDLEKDIISDTS
K157 MYKTDLEKDIISDTS
S161 DLEkDIISDTSGDFR
S164 kDIISDTSGDFRkLM
K169-ac DTSGDFRkLMVALAK
K169 DTSGDFRKLMVALAK
K176 kLMVALAKGRRAEDG
K176 kLMVALAKGRRAEDG
S184-p GRRAEDGsVIDyELI
Y188-p EDGsVIDyELIDQDA
Y199-p DQDARELyDAGVkRK
K204-ac ELyDAGVkRKGTDVP
K204 ELyDAGVKRKGTDVP
K204 ELyDAGVKRKGTDVP
K212 RKGTDVPKWIsIMTE
K212 RKGTDVPKWIsIMTE
S215-p TDVPKWIsIMTERSV
K227-ac RSVCHLQkVFERYKS
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
Y232 LQkVFERYKSYsPyD
S234 kVFERYKSYsPyDML
Y235 VFERYKSYsPyDMLE
S236-p FERYKSYsPyDMLES
Y238-p RYKSYsPyDMLESIK
S243 sPyDMLESIKKEVKG
K249 ESIKKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275-p LYFADRLyDSMkGKG
K279-ac DRLyDSMkGKGTRDK
K279 DRLyDSMKGKGTRDK
K286 kGKGTRDKVLIRIMV
S296 IRIMVSRSEVDMLkI
K302 RSEVDMLKIRSEFKR
K302-ub RSEVDMLkIRSEFKR
K308 LkIRSEFKRKyGKSL
Y311-p RSEFKRKyGKSLyyy
K313 EFKRKyGKSLyyyIQ
K313 EFKRKyGKSLyyyIQ
K313 EFKRKyGKSLyyyIQ
S314 FKRKyGKSLyyyIQQ
Y316-p RKyGKSLyyyIQQDT
Y317-p KyGKSLyyyIQQDTk
Y318-p yGKSLyyyIQQDTkG
T323 yyyIQQDTkGDYQKA
K324 yyIQQDTKGDYQKAL
K324-ub yyIQQDTkGDYQKAL
K329 DTkGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
  rat

 
T3 _____MSTVHEILCK
K10 TVHEILCKLsLEGDH
S12-p HEILCKLsLEGDHST
S18 LsLEGDHSTPPsAyG
T19 sLEGDHSTPPsAyGS
S22-p GDHSTPPsAyGSVkP
Y24-p HSTPPsAyGSVkPYT
S26 TPPsAyGSVkPYTNF
K28-ac PsAyGSVkPYTNFDA
K28 PsAyGSVKPYTNFDA
Y30 AyGSVkPYTNFDAER
T31 yGSVkPYTNFDAERD
T44 RDALNIETAIKTkGV
K47 LNIETAIKTkGVDEV
K47 LNIETAIKTkGVDEV
K49-ac IETAIKTkGVDEVTI
K49 IETAIKTKGVDEVTI
T55 TkGVDEVTIVNILTN
T61 VTIVNILTNRSNAQR
Y75 RQDIAFAYQRRTKKE
S85 RTKKELPSAMKsALS
K88 KELPSAMKsALSGHL
S89-p ELPSAMKsALSGHLE
S92 SAMKsALSGHLETVM
K104-ac TVMLGLLkTPAQYDA
K104 TVMLGLLKTPAQYDA
T105 VMLGLLkTPAQYDAS
Y109 LLkTPAQYDASELkA
S112 TPAQYDASELkASMk
K115-ac QYDASELkASMkGLG
K115 QYDASELKASMkGLG
K115 QYDASELKASMkGLG
K119-ac SELkASMkGLGTDED
K119 SELkASMKGLGTDED
K119 SELkASMKGLGTDED
T123 ASMkGLGTDEDSLIE
S127 GLGTDEDSLIEIICS
S134 SLIEIICSRTNQELQ
T136 IEIICSRTNQELQEI
Y147 LQEINRVYkEMYkTD
K148-ac QEINRVYkEMYkTDL
K148 QEINRVYKEMYkTDL
K148 QEINRVYKEMYkTDL
K152-ac RVYkEMYkTDLEkDI
K152 RVYkEMYKTDLEkDI
K152 RVYkEMYKTDLEkDI
K157-ac MYkTDLEkDIISDTS
K157 MYkTDLEKDIISDTS
K157 MYkTDLEKDIISDTS
S161 DLEkDIISDTSGEFR
S164 kDIISDTSGEFRKLL
K169 DTSGEFRKLLVALAK
K169 DTSGEFRKLLVALAK
K176 KLLVALAKGKRAEDG
K176 KLLVALAKGKRAEDG
S184-p GKRAEDGsVIDyELI
Y188-p EDGsVIDyELIDQDA
Y199 DQDARELYDAGVKRK
K204 ELYDAGVKRKGTDVP
K204 ELYDAGVKRKGTDVP
K204 ELYDAGVKRKGTDVP
K212-ac RKGTDVPkWISIMTE
K212 RKGTDVPKWISIMTE
S215 TDVPkWISIMTERSV
K227-ac RSVCHLQkVFERYKS
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
Y232 LQkVFERYKSYSPyD
S234 kVFERYKSYSPyDML
Y235 VFERYKSYSPyDMLE
S236 FERYKSYSPyDMLES
Y238-p RYKSYSPyDMLESIR
S243 SPyDMLESIRKEVKG
K249 ESIRKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275 LYFADRLYDSMkGKG
K279-ac DRLYDSMkGKGTRDk
K279 DRLYDSMKGKGTRDk
K286-ac kGKGTRDkVLIRIMV
S296 IRIMVSRSEVDMLkI
K302-ac RSEVDMLkIRSEFkR
K302 RSEVDMLKIRSEFkR
K308-ac LkIRSEFkRKYGkSL
Y311 RSEFkRKYGkSLYYF
K313-ac EFkRKYGkSLYYFIQ
K313 EFkRKYGKSLYYFIQ
K313 EFkRKYGKSLYYFIQ
S314 FkRKYGkSLYYFIQQ
Y316 RKYGkSLYYFIQQDT
Y317 KYGkSLYYFIQQDTk
F318 YGkSLYYFIQQDTkG
T323 YYFIQQDTkGDYQKA
K324-ac YFIQQDTkGDYQKAL
K324 YFIQQDTKGDYQKAL
K329 DTkGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
  dog

 
T3 _____MSTVHEILCK
K10 TVHEILCKLSLEGDH
S12 HEILCKLSLEGDHST
S18 LSLEGDHSTPPSAyG
T19 SLEGDHSTPPSAyGS
S22 GDHSTPPSAyGSVKA
Y24-p HSTPPSAyGSVKAYT
S26 TPPSAyGSVKAYTNF
K28 PSAyGSVKAYTNFDA
K28 PSAyGSVKAYTNFDA
Y30 AyGSVKAYTNFDAER
T31 yGSVKAYTNFDAERD
T44 RDALNIETAIKTKGV
K47 LNIETAIKTKGVDEV
K47 LNIETAIKTKGVDEV
K49 IETAIKTKGVDEVTI
K49 IETAIKTKGVDEVTI
T55 TKGVDEVTIVNILTN
T61 VTIVNILTNRSNEQR
Y75 RQDIAFAYQRRTKKE
S85 RTKKELASALKSALS
K88 KELASALKSALSGHL
S89 ELASALKSALSGHLE
S92 SALKSALSGHLETVI
K104 TVILGLLKTPAQYDA
K104 TVILGLLKTPAQYDA
T105 VILGLLKTPAQYDAS
Y109 LLKTPAQYDASELKA
S112 TPAQYDASELKASMK
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K119 SELKASMKGLGTDED
K119 SELKASMKGLGTDED
K119 SELKASMKGLGTDED
T123 ASMKGLGTDEDSLIE
S127 GLGTDEDSLIEIICS
S134 SLIEIICSRTNQELQ
T136 IEIICSRTNQELQEI
Y147 LQEINRVYKEMYKTD
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K157 MYKTDLEKDIISDTS
K157 MYKTDLEKDIISDTS
K157 MYKTDLEKDIISDTS
S161 DLEKDIISDTSGDFR
S164 KDIISDTSGDFRKLM
K169 DTSGDFRKLMVALAK
K169 DTSGDFRKLMVALAK
K176 KLMVALAKGRRAEDG
K176 KLMVALAKGRRAEDG
S184 GRRAEDGSVIDYELI
Y188 EDGSVIDYELIDQDA
Y199 DQDARDLYDAGVKRK
K204 DLYDAGVKRKGTDVP
K204 DLYDAGVKRKGTDVP
K204 DLYDAGVKRKGTDVP
K212 RKGTDVPKWISIMTE
K212 RKGTDVPKWISIMTE
S215 TDVPKWISIMTERSV
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
Y232 LQKVFERYKSYSPYD
S234 KVFERYKSYSPYDML
Y235 VFERYKSYSPYDMLE
S236 FERYKSYSPYDMLES
Y238 RYKSYSPYDMLESIK
S243 SPYDMLESIKKEVKG
K249 ESIKKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275 LYFADRLYDSMKGKG
K279 DRLYDSMKGKGTRDK
K279 DRLYDSMKGKGTRDK
K286 KGKGTRDKVLIRIMV
S296 IRIMVSRSEVDMLKI
K302 RSEVDMLKIRSEFKR
K302 RSEVDMLKIRSEFKR
K308 LKIRSEFKRKYGKSL
Y311 RSEFKRKYGKSLYYY
K313 EFKRKYGKSLYYYIQ
K313 EFKRKYGKSLYYYIQ
K313 EFKRKYGKSLYYYIQ
S314 FKRKYGKSLYYYIQQ
Y316 RKYGKSLYYYIQQDT
Y317 KYGKSLYYYIQQDTK
Y318 YGKSLYYYIQQDTKG
T323 YYYIQQDTKGDYQKA
K324 YYIQQDTKGDYQKAL
K324 YYIQQDTKGDYQKAL
K329 DTKGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
  cow

 
T3 _____MSTVHEILCK
K10 TVHEILCKLSLEGDH
S12 HEILCKLSLEGDHST
S18 LSLEGDHSTPPSAYG
T19 SLEGDHSTPPSAYGs
S22 GDHSTPPSAYGsVKA
Y24 HSTPPSAYGsVKAYT
S26-p TPPSAYGsVKAYTNF
K28 PSAYGsVKAYTNFDA
K28 PSAYGsVKAYTNFDA
Y30 AYGsVKAYTNFDAER
T31 YGsVKAYTNFDAERD
T44 RDALNIETAIKTKGV
K47 LNIETAIKTKGVDEV
K47 LNIETAIKTKGVDEV
K49 IETAIKTKGVDEVTI
K49 IETAIKTKGVDEVTI
T55 TKGVDEVTIVNILTN
T61 VTIVNILTNRSNEQR
Y75 RQDIAFAYQRRTKKE
S85 RTKKELASALKSALS
K88 KELASALKSALSGHL
S89 ELASALKSALSGHLE
S92 SALKSALSGHLETVI
K104 TVILGLLKTPAQYDA
K104 TVILGLLKTPAQYDA
T105 VILGLLKTPAQYDAS
Y109 LLKTPAQYDASELKA
S112 TPAQYDASELKASMK
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K119 SELKASMKGLGTDED
K119 SELKASMKGLGTDED
K119 SELKASMKGLGTDED
T123 ASMKGLGTDEDSLIE
S127 GLGTDEDSLIEIICS
S134 SLIEIICSRTNQELQ
T136 IEIICSRTNQELQEI
Y147 LQEINRVYKEMYKTD
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K157 MYKTDLEKDIVSDTS
K157 MYKTDLEKDIVSDTS
K157 MYKTDLEKDIVSDTS
S161 DLEKDIVSDTSGDFR
S164 KDIVSDTSGDFRKLM
K169 DTSGDFRKLMVALAK
K169 DTSGDFRKLMVALAK
K176 KLMVALAKGRRAEDG
K176 KLMVALAKGRRAEDG
S184 GRRAEDGSVIDYELI
Y188 EDGSVIDYELIDQDA
Y199 DQDARDLYDAGVKRK
K204 DLYDAGVKRKGTDVP
K204 DLYDAGVKRKGTDVP
K204 DLYDAGVKRKGTDVP
K212 RKGTDVPKWISIMTE
K212 RKGTDVPKWISIMTE
S215 TDVPKWISIMTERSV
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
Y232 LQKVFERYKSYSPYD
S234 KVFERYKSYSPYDML
Y235 VFERYKSYSPYDMLE
S236 FERYKSYSPYDMLES
Y238 RYKSYSPYDMLESIK
S243 SPYDMLESIKKEVKG
K249 ESIKKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275 LYFADRLYDSMKGKG
K279 DRLYDSMKGKGTRDK
K279 DRLYDSMKGKGTRDK
K286 KGKGTRDKVLIRIMV
S296 IRIMVSRSEVDMLKI
K302 RSEVDMLKIRSEFKK
K302 RSEVDMLKIRSEFKK
K308 LKIRSEFKKKYGKSL
Y311 RSEFKKKYGKSLYYY
K313 EFKKKYGKSLYYYIQ
K313 EFKKKYGKSLYYYIQ
K313 EFKKKYGKSLYYYIQ
S314 FKKKYGKSLYYYIQQ
Y316 KKYGKSLYYYIQQDT
Y317 KYGKSLYYYIQQDTK
Y318 YGKSLYYYIQQDTKG
T323 YYYIQQDTKGDYQKA
K324 YYIQQDTKGDYQKAL
K324 YYIQQDTKGDYQKAL
K329 DTKGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
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