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Protein Page:
ANXA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ANXA2 a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Lipid binding protein; Calcium-binding protein
Cellular Component: extrinsic to plasma membrane; extracellular space; protein complex; cell surface; early endosome; lipid particle; cell cortex; lipid raft; extracellular matrix; ruffle; perinuclear region of cytoplasm; melanosome; basement membrane; midbody; nucleus; sarcolemma
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; Rab GTPase binding
Biological Process: fibrinolysis; positive regulation of fibroblast proliferation; collagen fibril organization; negative regulation of catalytic activity; positive regulation of vesicle fusion; protein heterotetramerization; positive regulation of protein amino acid phosphorylation; angiogenesis; positive regulation of binding; body fluid secretion; lipid raft formation; membrane budding
Reference #:  P07355 (UniProtKB)
Alt. Names/Synonyms: Annexin A2; Annexin II; Annexin-2; ANX2; ANX2L4; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2; LPC2D; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Gene Symbols: ANXA2
Molecular weight: 38,604 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANXA2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S26‑p
intracellular localization: S12‑p, T19‑p, Y24‑p, S26‑p
molecular association, regulation: S12‑p, Y24‑p, S26‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MStVHEILCK
6 8 S12-p HEILCKLsLEGDHst
1 8 S18-p LsLEGDHstPPsAyG
1 32 T19-p sLEGDHstPPsAyGs
1 162 S22-p GDHstPPsAyGsVkA
8 2628 Y24-p HstPPsAyGsVkAyt
7 118 S26-p tPPsAyGsVkAytNF
0 2 K28-u PsAyGsVkAytNFDA
1 899 Y30-p AyGsVkAytNFDAER
0 4 T31-p yGsVkAytNFDAERD
0 2 K47-u LNIETAIkTkGVDEV
0 2 K49-a IETAIkTkGVDEVTI
0 18 K49-u IETAIkTkGVDEVTI
0 9 Y75-p RQDIAFAyQRRTKKE
0 1 S85-p RTKKELAsALKSALS
0 1 S89 ELAsALKSALSGHLE
0 1 K104-a TVILGLLkTPAQyDA
0 27 K104-u TVILGLLkTPAQyDA
0 24 Y109-p LLkTPAQyDAsELkA
0 1 S112-p TPAQyDAsELkASMk
0 2 K115-a QyDAsELkASMkGLG
0 7 K115-u QyDAsELkASMkGLG
0 15 K119-u sELkASMkGLGtDED
0 1 T123-p ASMkGLGtDEDsLIE
0 7 S127-p GLGtDEDsLIEIICs
0 1 S134-p sLIEIICsRTNQELQ
0 2 Y147-p LQEINRVykEMYkTD
0 1 K148-a QEINRVykEMYkTDL
0 13 K148-u QEINRVykEMYkTDL
0 1 K152-a RVykEMYkTDLEkDI
0 2 K152-u RVykEMYkTDLEkDI
0 10 K157-a MYkTDLEkDIISDTs
0 2 K157-u MYkTDLEkDIISDTs
0 1 S164-p kDIISDTsGDFRKLM
0 1 K169 DTsGDFRKLMVALAk
0 2 K176-a KLMVALAkGRRAEDG
0 5 S184-p GRRAEDGsVIDyELI
0 122 Y188-p EDGsVIDyELIDQDA
0 186 Y199-p DQDARDLyDAGVkRK
0 8 K204-u DLyDAGVkRKGTDVP
0 1 K212-u RKGTDVPkWIsIMTE
0 1 S215-p TDVPkWIsIMTERSV
0 20 K227-a RSVPHLQkVFDRYKS
0 1 K227-u RSVPHLQkVFDRYKS
0 6 Y235-p VFDRYKSySPyDMLE
0 925 Y238-p RYKSySPyDMLEsIR
0 4 S243-p SPyDMLEsIRKEVkG
0 5 K249-u EsIRKEVkGDLENAF
0 21 K266-u LVQCIQNkPLYFADR
0 86 Y275-p LYFADRLyDSMkGKG
0 20 K279-a DRLyDSMkGKGTRDK
0 1 K302-a RSEVDMLkIRSEFKR
0 2 K302-u RSEVDMLkIRSEFKR
0 1 Y311 RSEFKRKYGksLyyy
0 2 K313-a EFKRKYGksLyyyIQ
0 6 K313-u EFKRKYGksLyyyIQ
0 3 S314-p FKRKYGksLyyyIQQ
0 543 Y316-p RKYGksLyyyIQQDT
0 322 Y317-p KYGksLyyyIQQDTk
0 566 Y318-p YGksLyyyIQQDTkG
0 10 K324-u yyIQQDTkGDYQkAL
0 2 K329-u DTkGDYQkALLyLCG
0 17 Y333-p DYQkALLyLCGGDD_
  mouse

 
T3 _____MSTVHEILCK
S12-p HEILCKLsLEGDHst
S18-p LsLEGDHstPPsAyG
T19-p sLEGDHstPPsAyGs
S22-p GDHstPPsAyGsVKP
Y24-p HstPPsAyGsVKPyt
S26-p tPPsAyGsVKPytNF
K28 PsAyGsVKPytNFDA
Y30-p AyGsVKPytNFDAER
T31-p yGsVKPytNFDAERD
K47 LNIETAVKTkGVDEV
K49 IETAVKTKGVDEVTI
K49-u IETAVKTkGVDEVTI
Y75 RQDIAFAYQRRTKKE
S85 RTKKELPSALKSALS
S89 ELPSALKSALSGHLE
K104 TVILGLLKTPAQYDA
K104 TVILGLLKTPAQYDA
Y109 LLKTPAQYDASELkA
S112 TPAQYDASELkASMK
K115-a QYDASELkASMKGLG
K115-u QYDASELkASMKGLG
K119 SELkASMKGLGTDED
T123 ASMKGLGTDEDsLIE
S127-p GLGTDEDsLIEIICS
S134 sLIEIICSRTNQELQ
Y147 LQEINRVYkEMYKTD
K148 QEINRVYKEMYKTDL
K148-u QEINRVYkEMYKTDL
K152 RVYkEMYKTDLEKDI
K152 RVYkEMYKTDLEKDI
K157 MYKTDLEKDIISDTS
K157 MYKTDLEKDIISDTS
S164 KDIISDTSGDFRkLM
K169-a DTSGDFRkLMVALAK
K176 kLMVALAKGRRAEDG
S184-p GRRAEDGsVIDyELI
Y188-p EDGsVIDyELIDQDA
Y199-p DQDARELyDAGVKRK
K204 ELyDAGVKRKGTDVP
K212 RKGTDVPKWIsIMTE
S215-p TDVPKWIsIMTERSV
K227-a RSVCHLQkVFERYKS
K227 RSVCHLQKVFERYKS
Y235 VFERYKSYSPyDMLE
Y238-p RYKSYSPyDMLESIK
S243 SPyDMLESIKKEVKG
K249 ESIKKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275-p LYFADRLyDSMkGKG
K279-a DRLyDSMkGKGTRDK
K302 RSEVDMLKIRSEFKR
K302-u RSEVDMLkIRSEFKR
Y311-p RSEFKRKyGKSLyyy
K313 EFKRKyGKSLyyyIQ
K313 EFKRKyGKSLyyyIQ
S314 FKRKyGKSLyyyIQQ
Y316-p RKyGKSLyyyIQQDT
Y317-p KyGKSLyyyIQQDTk
Y318-p yGKSLyyyIQQDTkG
K324-u yyIQQDTkGDYQKAL
K329 DTkGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
  rat

 
T3 _____MSTVHEILCK
S12 HEILCKLSLEGDHST
S18 LSLEGDHSTPPSAyG
T19 SLEGDHSTPPSAyGS
S22 GDHSTPPSAyGSVKP
Y24-p HSTPPSAyGSVKPYT
S26 TPPSAyGSVKPYTNF
K28 PSAyGSVKPYTNFDA
Y30 AyGSVKPYTNFDAER
T31 yGSVKPYTNFDAERD
K47 LNIETAIKTKGVDEV
K49 IETAIKTKGVDEVTI
K49 IETAIKTKGVDEVTI
Y75 RQDIAFAYQRRTKKE
S85 RTKKELPSAMKsALS
S89-p ELPSAMKsALSGHLE
K104 TVMLGLLKTPAQYDA
K104 TVMLGLLKTPAQYDA
Y109 LLKTPAQYDASELKA
S112 TPAQYDASELKASMK
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K119 SELKASMKGLGTDED
T123 ASMKGLGTDEDSLIE
S127 GLGTDEDSLIEIICS
S134 SLIEIICSRTNQELQ
Y147 LQEINRVYKEMYKTD
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K157 MYKTDLEKDIISDTS
K157 MYKTDLEKDIISDTS
S164 KDIISDTSGEFRKLL
K169 DTSGEFRKLLVALAK
K176 KLLVALAKGKRAEDG
S184-p GKRAEDGsVIDyELI
Y188-p EDGsVIDyELIDQDA
Y199 DQDARELYDAGVKRK
K204 ELYDAGVKRKGTDVP
K212 RKGTDVPKWISIMTE
S215 TDVPKWISIMTERSV
K227-a RSVCHLQkVFERYKS
K227 RSVCHLQKVFERYKS
Y235 VFERYKSYSPyDMLE
Y238-p RYKSYSPyDMLESIR
S243 SPyDMLESIRKEVKG
K249 ESIRKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275 LYFADRLYDSMKGKG
K279 DRLYDSMKGKGTRDK
K302 RSEVDMLKIRSEFKR
K302 RSEVDMLKIRSEFKR
Y311 RSEFKRKYGKSLYYF
K313 EFKRKYGKSLYYFIQ
K313 EFKRKYGKSLYYFIQ
S314 FKRKYGKSLYYFIQQ
Y316 RKYGKSLYYFIQQDT
Y317 KYGKSLYYFIQQDTK
F318 YGKSLYYFIQQDTKG
K324 YFIQQDTKGDYQKAL
K329 DTKGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
  dog

 
T3 _____MSTVHEILCK
S12 HEILCKLSLEGDHST
S18 LSLEGDHSTPPSAyG
T19 SLEGDHSTPPSAyGS
S22 GDHSTPPSAyGSVKA
Y24-p HSTPPSAyGSVKAYT
S26 TPPSAyGSVKAYTNF
K28 PSAyGSVKAYTNFDA
Y30 AyGSVKAYTNFDAER
T31 yGSVKAYTNFDAERD
K47 LNIETAIKTKGVDEV
K49 IETAIKTKGVDEVTI
K49 IETAIKTKGVDEVTI
Y75 RQDIAFAYQRRTKKE
S85 RTKKELASALKSALS
S89 ELASALKSALSGHLE
K104 TVILGLLKTPAQYDA
K104 TVILGLLKTPAQYDA
Y109 LLKTPAQYDASELKA
S112 TPAQYDASELKASMK
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K119 SELKASMKGLGTDED
T123 ASMKGLGTDEDSLIE
S127 GLGTDEDSLIEIICS
S134 SLIEIICSRTNQELQ
Y147 LQEINRVYKEMYKTD
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K157 MYKTDLEKDIISDTS
K157 MYKTDLEKDIISDTS
S164 KDIISDTSGDFRKLM
K169 DTSGDFRKLMVALAK
K176 KLMVALAKGRRAEDG
S184 GRRAEDGSVIDYELI
Y188 EDGSVIDYELIDQDA
Y199 DQDARDLYDAGVKRK
K204 DLYDAGVKRKGTDVP
K212 RKGTDVPKWISIMTE
S215 TDVPKWISIMTERSV
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
Y235 VFERYKSYSPYDMLE
Y238 RYKSYSPYDMLESIK
S243 SPYDMLESIKKEVKG
K249 ESIKKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275 LYFADRLYDSMKGKG
K279 DRLYDSMKGKGTRDK
K302 RSEVDMLKIRSEFKR
K302 RSEVDMLKIRSEFKR
Y311 RSEFKRKYGKSLYYY
K313 EFKRKYGKSLYYYIQ
K313 EFKRKYGKSLYYYIQ
S314 FKRKYGKSLYYYIQQ
Y316 RKYGKSLYYYIQQDT
Y317 KYGKSLYYYIQQDTK
Y318 YGKSLYYYIQQDTKG
K324 YYIQQDTKGDYQKAL
K329 DTKGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
  cow

 
T3 _____MSTVHEILCK
S12 HEILCKLSLEGDHST
S18 LSLEGDHSTPPSAYG
T19 SLEGDHSTPPSAYGs
S22 GDHSTPPSAYGsVKA
Y24 HSTPPSAYGsVKAYT
S26-p TPPSAYGsVKAYTNF
K28 PSAYGsVKAYTNFDA
Y30 AYGsVKAYTNFDAER
T31 YGsVKAYTNFDAERD
K47 LNIETAIKTKGVDEV
K49 IETAIKTKGVDEVTI
K49 IETAIKTKGVDEVTI
Y75 RQDIAFAYQRRTKKE
S85 RTKKELASALKSALS
S89 ELASALKSALSGHLE
K104 TVILGLLKTPAQYDA
K104 TVILGLLKTPAQYDA
Y109 LLKTPAQYDASELKA
S112 TPAQYDASELKASMK
K115 QYDASELKASMKGLG
K115 QYDASELKASMKGLG
K119 SELKASMKGLGTDED
T123 ASMKGLGTDEDSLIE
S127 GLGTDEDSLIEIICS
S134 SLIEIICSRTNQELQ
Y147 LQEINRVYKEMYKTD
K148 QEINRVYKEMYKTDL
K148 QEINRVYKEMYKTDL
K152 RVYKEMYKTDLEKDI
K152 RVYKEMYKTDLEKDI
K157 MYKTDLEKDIVSDTS
K157 MYKTDLEKDIVSDTS
S164 KDIVSDTSGDFRKLM
K169 DTSGDFRKLMVALAK
K176 KLMVALAKGRRAEDG
S184 GRRAEDGSVIDYELI
Y188 EDGSVIDYELIDQDA
Y199 DQDARDLYDAGVKRK
K204 DLYDAGVKRKGTDVP
K212 RKGTDVPKWISIMTE
S215 TDVPKWISIMTERSV
K227 RSVCHLQKVFERYKS
K227 RSVCHLQKVFERYKS
Y235 VFERYKSYSPYDMLE
Y238 RYKSYSPYDMLESIK
S243 SPYDMLESIKKEVKG
K249 ESIKKEVKGDLENAF
K266 LVQCIQNKPLYFADR
Y275 LYFADRLYDSMKGKG
K279 DRLYDSMKGKGTRDK
K302 RSEVDMLKIRSEFKK
K302 RSEVDMLKIRSEFKK
Y311 RSEFKKKYGKSLYYY
K313 EFKKKYGKSLYYYIQ
K313 EFKKKYGKSLYYYIQ
S314 FKKKYGKSLYYYIQQ
Y316 KKYGKSLYYYIQQDT
Y317 KYGKSLYYYIQQDTK
Y318 YGKSLYYYIQQDTKG
K324 YYIQQDTKGDYQKAL
K329 DTKGDYQKALLYLCG
Y333 DYQKALLYLCGGDD_
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