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Protein Page:
P2Y2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
P2Y2 a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: purinergic nucleotide receptor activity, G-protein coupled; receptor activity
Biological Process: cellular ion homeostasis; regulation of vasodilation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
Reference #:  P41231 (UniProtKB)
Alt. Names/Synonyms: HP2U; MGC20088; MGC40010; P2RU1; P2RY2; P2U; P2U nucleotide receptor; P2U purinoceptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; purinergic receptor P2Y, G-protein coupled, 2; purinergic receptor P2Y2; purinoceptor P2Y2
Gene Symbols: P2RY2
Molecular weight: 42,273 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
Select Structure to View Below

P2Y2

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S243‑p, T344‑p, S356‑p
receptor desensitization, altered: S243‑p, T344‑p, S356‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K227-u LMARRLLkPAYGTSG
1 0 S243-p LPRAKRKsVRTIAVV
0 1 T266 LPFHVTRTLYYSFRS
0 1 S270 VTRTLYYSFRSLDLS
0 1 S273 TLYYSFRSLDLSCHT
0 1 S277 SFRSLDLSCHTLNAI
0 7 T324-p ARDAKPPtGPsPAtP
0 5 S327-p AKPPtGPsPAtPARR
0 3 A329 PPtGPsPAtPARRRL
0 7 T330-p PtGPsPAtPARRRLG
1 0 T344-p GLRRSDRtDMQRIED
1 0 S356-p IEDVLGSsEDSRRTE
  mouse

 
K227 LMARRLLKPAYGTTG
S243 LPRAKRKSVRTIALV
T266 LPFHVTRTLYYSFRS
S270 VTRTLYYSFRSLDLS
S273 TLYYSFRSLDLSCHT
S277 SFRSLDLSCHTLNAI
T324-p ARDAKPPtEPtPsPQ
T327-p AKPPtEPtPsPQARR
S329-p PPtEPtPsPQARRKL
P330 PtEPtPsPQARRKLG
- gap
S353 RKDLSVSSDDSRRTE
  rat

 
K227 LMARRLLKPAYGTTG
S242 LPRAKRKSVRTIALV
T265-p LPFHVTRtLYYsFRs
S269-p VTRtLYYsFRsLDLs
S272-p tLYYsFRsLDLsCHT
S276-p sFRsLDLsCHTLNAI
T323 ARDAKPATEPTPSPQ
T326 AKPATEPTPSPQARR
S328 PATEPTPSPQARRKL
P329 ATEPTPSPQARRKLG
T343 GLHRPNRTDTVRKDL
S354 RKDLSISSDDSRRTE
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