a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Receptor, misc.
Biological Process: elevation of cytosolic calcium ion concentration; wound healing; cellular ion homeostasis; in utero embryonic development; regulation of vasodilation; positive regulation of prostaglandin secretion; negative regulation of ossification; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); sensory perception of pain; positive regulation of smooth muscle cell migration; positive regulation of chemokine production; aging
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.