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NEDD8 (human)

Overview NEDD8 a member of the ubiquitin family of proteins. Approximately 60% identical to ubiquitin protein.. Activated by an E1-like complex, consisting of App-b1 and Uba3 and then linked to the E2-like enzyme, Ubc12. The major target protein modified by nedd8 is cullin-4a. Down-regulated during the development of brain. Note: This description may include information from UniProtKB. Protein type: Ubiquitin-like modifier Cellular Component: nucleus Molecular Function: ubiquitin protein ligase binding Biological Process: regulation of transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; protein neddylation; protein localization; anatomical structure morphogenesis; protein modification process; proteolysis; response to organic cyclic substance Reference #:  Q15843 (UniProtKB) Alt. Names/Synonyms: FLJ43224; MGC104393; MGC125896; MGC125897; NEDD-8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein Nedd8 Gene Symbols: NEDD8 Molecular weight: 9,072 Da Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NEDD8 1NDD - A/B/C/D=1-76 (human) 1R4M - I/J/K/L=1-76 (human) 1R4N - I/J/K/L=1-76 (human) 1XT9 - B=1-76 (human) 2BKR - B=1-76 (human) 2KO3 - A=1-76 (human) 2NVU - I/J=1-76 (human) 3DBH - J/K/I/L=1-76 (human) 3DBL - J/K/I/L=1-76 (human) 3DBR - J/K/I/L=1-76 (human) 3DQV - A/B=1-76 (human) 3GZN - J/I=1-76 (human) 4F8C - D/B=1-81 (human) 4FBJ - B=1-81 (human) 4HCP - B=1-76 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	10		K4-u	____MLIkVktLtGk
0	25		K6-u	__MLIkVktLtGkEI
0	2		T7-p	_MLIkVktLtGkEIE
0	2		T9-p	LIkVktLtGkEIEID
0	149		K11-u	kVktLtGkEIEIDIE
0	1		K11-n	kVktLtGkEIEIDIE
0	1		T20-p	IEIDIEPtDkVERIk
0	71		K22-u	IDIEPtDkVERIkER
0	1		K22-n	IDIEPtDkVERIkER
0	5		K27-u	tDkVERIkERVEEkE
0	21		K33-u	IkERVEEkEGIPPQQ
0	4		Y45-p	PQQQRLIySGkQMND
0	4		K48-a	QRLIySGkQMNDEkT
0	164		K48-u	QRLIySGkQMNDEkT
0	1		K48-n	QRLIySGkQMNDEkT
0	129		K54-u	GkQMNDEkTAADykI
0	1		T55	kQMNDEkTAADykIL
0	18		Y59-p	DEkTAADykILGGsV
1	81		K60-u	EkTAADykILGGsVL
0	1		K60-n	EkTAADykILGGsVL
0	2		S65-p	DykILGGsVLHLVLA

	mouse
K4-u	____MLIkVkTLTGk
K6-u	__MLIkVkTLTGkEI
T7	_MLIkVkTLTGkEIE
T9	LIkVkTLTGkEIEID
K11-u	kVkTLTGkEIEIDIE
K11	kVkTLTGKEIEIDIE
T20	IEIDIEPTDkVERIK
K22-u	IDIEPTDkVERIKER
K22	IDIEPTDKVERIKER
K27	TDkVERIKERVEEkE
K33-u	IKERVEEkEGIPPQQ
Y45	PQQQRLIYSGkQMND
K48	QRLIYSGKQMNDEkt
K48-u	QRLIYSGkQMNDEkt
K48	QRLIYSGKQMNDEkt
K54-u	GkQMNDEktAADYkI
T55-p	kQMNDEktAADYkIL
Y59	DEktAADYkILGGsV
K60-u	EktAADYkILGGsVL
K60	EktAADYKILGGsVL
S65-p	DYkILGGsVLHLVLA

	rat
K4	____MLIKVKTLTGk
K6	__MLIKVKTLTGkEI
T7	_MLIKVKTLTGkEIE
T9	LIKVKTLTGkEIEID
K11-u	KVKTLTGkEIEIDIE
K11	KVKTLTGKEIEIDIE
T20	IEIDIEPTDKVERIk
K22	IDIEPTDKVERIkER
K22	IDIEPTDKVERIkER
K27-u	TDKVERIkERVEEKE
K33	IkERVEEKEGIPPQQ
Y45	PQQQRLIYSGkQMND
K48	QRLIYSGKQMNDEkT
K48-u	QRLIYSGkQMNDEkT
K48	QRLIYSGKQMNDEkT
K54-u	GkQMNDEkTAADYKI
T55	kQMNDEkTAADYKIL
Y59	DEkTAADYKILGGSV
K60	EkTAADYKILGGSVL
K60	EkTAADYKILGGSVL
S65	DYKILGGSVLHLVLA

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