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Protein Page:
SLAP-130 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLAP-130 an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: nucleus; cytosol; actin cytoskeleton
Molecular Function: protein binding; protein complex binding; receptor binding
Biological Process: immune response; NLS-bearing substrate import into nucleus; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation
Reference #:  O15117 (UniProtKB)
Alt. Names/Synonyms: ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB; FYB-120/130; FYN binding protein (FYB-120/130); FYN-binding protein; FYN-binding protein (FYB-120/130); FYN-T-binding protein; p120/p130; PRO0823; SLAP-130; SLAP130; SLP-76-associated phosphoprotein
Gene Symbols: FYB
Molecular weight: 85,387 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLAP-130

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y559‑p, Y595‑p, Y651‑p, Y755‑p, Y771‑p, Y780‑p
cell motility, altered: Y559‑p, Y571‑p, Y595‑p, Y651‑p, Y755‑p, Y771‑p
molecular association, regulation: Y595‑p, Y651‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K3-ac _____MAkyNTGGNP
0 2 Y4-p ____MAkyNTGGNPT
0 1 N27 PFRVTGPNSSSGIQA
0 8 S28 FRVTGPNSSSGIQAR
0 1 S30 VTGPNSSSGIQARKN
0 8 S46-p FNNQGNAsPPAGPSN
0 2 T86 KPPFLKPTGAGQRFG
0 1 G89 FLKPTGAGQRFGTPA
0 6 G114 VGFLKPVGPKPINLP
0 1 N119 PVGPKPINLPKEDSK
0 1 K149-ac VNQDHDLkPLGPKSG
0 3 T158-p LGPKSGPtPPtSENE
0 1 T161-p KSGPtPPtSENEQKQ
0 1 P203 PAFGQKPPLSTENSH
0 2 S205 FGQKPPLSTENSHED
0 2 T206 GQKPPLSTENSHEDE
0 1 S222-p PMKNVSSsKGsPAPL
0 9 S225-p NVSSsKGsPAPLGVR
0 4 S233-p PAPLGVRsKSGPLKP
0 1 S245-p LKPAREDsENKDHAG
0 1 K265-ac PFPGVVLkPAASRGG
0 1 S269 VVLkPAASRGGPGLS
0 1 K287-ub EEKKEDRkIDAAkNT
0 1 K292-ub DRkIDAAkNTFQSkI
0 1 K298-ub AkNTFQSkINQEELA
0 1 S306-p INQEELAsGtPPARF
0 13 T308-p QEELAsGtPPARFPK
0 2 S329-p VGGPWGQsQEKEkGD
0 1 K334-ac GQsQEKEkGDKNSAT
0 1 T374-p DLTKFHKtSSGNSTS
0 1 S379 HKtSSGNSTSKGQts
0 3 T385-p NSTSKGQtsySTTSL
0 3 S386-p STSKGQtsySTTSLP
0 7 Y387-p TSKGQtsySTTSLPP
0 1 K425-ac SLPPRNIkPPFDLKs
0 4 S432-p kPPFDLKsPVNEDNQ
0 3 S445 NQDGVTHSdGAGNLD
0 2 D446-ca QDGVTHSdGAGNLDE
0 1 A448 GVTHSdGAGNLDEEQ
0 84 S457-p NLDEEQDsEGEtyED
0 9 T461-p EQDsEGEtyEDIEAS
0 54 Y462-p QDsEGEtyEDIEASK
0 1 K496-ub EQKEKEKkEQEIKKk
0 1 K503-ub kEQEIKKkFKLtGPI
0 1 T507-p IKKkFKLtGPIQVIH
0 1 K523 AKACCDVKGGKNELS
0 4 S558-p LGRTARGsyGyIKTT
2 8 Y559-p GRTARGsyGyIKTTA
0 2 Y561-p TARGsyGyIKTTAVE
1 788 Y571-p TTAVEIDyDsLKLKK
0 157 S573-p AVEIDyDsLKLKKDS
0 2 S580 sLKLKKDSLGAPSRP
4 61 Y595-p IEDDQEVyDDVAEQD
1 10 Y625-p PPPDDDIydGIEEED
0 1 D626-ca PPDDDIydGIEEEDA
0 1 - gap
0 1 - gap
0 1 - gap
4 15 Y651-p LDMGDEVyDDVDTSD
0 12 Y701-p DFRKKFKyDGEIRVL
0 1 Y709-p DGEIRVLyStKVTTS
0 1 T711-p EIRVLyStKVTTSIT
1 174 Y755-p CRNEEGKyGyVLRSy
1 211 Y757-p NEEGKyGyVLRSyLA
0 4 Y762-p yGyVLRSyLADNDGE
3 69 Y771-p ADNDGEIyDDIAdGC
0 1 D776-ca EIyDDIAdGCIyDND
1 17 Y780-p DIAdGCIyDND____
  SLAP-130 iso2  
K3 _____MAKYNTGGNP
Y4 ____MAKYNTGGNPT
N27 PFRVTGPNSSSGIQA
S28 FRVTGPNSSSGIQAR
S30 VTGPNSSSGIQARKN
S46 FNNQGNASPPAGPSN
T86 KPPFLKPTGAGQRFG
G89 FLKPTGAGQRFGTPA
G114 VGFLKPVGPKPINLP
N119 PVGPKPINLPKEDSK
K149 VNQDHDLKPLGPKSG
T158 LGPKSGPTPPTSENE
T161 KSGPTPPTSENEQKQ
P203 PAFGQKPPLSTENSH
S205 FGQKPPLSTENSHED
T206 GQKPPLSTENSHEDE
S222 PMKNVSSSKGSPAPL
S225 NVSSSKGSPAPLGVR
S233 PAPLGVRSKSGPLKP
S245 LKPAREDSENKDHAG
K265 PFPGVVLKPAASRGG
S269 VVLKPAASRGGPGLS
K287 EEKKEDRKIDAAKNT
K292 DRKIDAAKNTFQSKI
K298 AKNTFQSKINQEELA
S306 INQEELASGTPPARF
T308 QEELASGTPPARFPK
S329 VGGPWGQSQEKEKGD
K334 GQSQEKEKGDKNSAT
T374 DLTKFHKTSSGNSTS
S379 HKTSSGNSTSKGQTS
T385 NSTSKGQTSYSTTSL
S386 STSKGQTSYSTTSLP
Y387 TSKGQTSYSTTSLPP
K425 SLPPRNIKPPFDLKS
S432 KPPFDLKSPVNEDNQ
S445 NQDGVTHSDGAGNLD
D446 QDGVTHSDGAGNLDE
A448 GVTHSDGAGNLDEEQ
S457 NLDEEQDSEGETYED
T461 EQDSEGETYEDIEAS
Y462 QDSEGETYEDIEASK
K496 EQKEKEKKEQEIKKK
K503 KEQEIKKKFKLTGPI
T507 IKKKFKLTGPIQVIH
K523 AKACCDVKGGKNELS
S558 LGRTARGSYGYIKTT
Y559 GRTARGSYGYIKTTA
Y561 TARGSYGYIKTTAVE
Y571 TTAVEIDYDSLKLKK
S573 AVEIDYDSLKLKKDS
S580 SLKLKKDSLGAPSRP
Y595 IEDDQEVYDDVAEQD
Y625 PPPDDDIYDGIEEED
D626 PPDDDIYDGIEEEDA
T647-p QVQEKSNtWSWGILK
K657 WGILKMLKGKDDRKK
S673 IREKPKVSDSDNNEG
Y697 LDMGDEVYDDVDTSD
Y747 DFRKKFKYDGEIRVL
Y755 DGEIRVLYSTKVTTS
T757 EIRVLYSTKVTTSIT
Y801 CRNEEGKYGYVLRSY
Y803 NEEGKYGYVLRSYLA
Y808 YGYVLRSYLADNDGE
Y817 ADNDGEIYDDIADGC
D822 EIYDDIADGCIYDND
Y826 DIADGCIYDND____
  mouse

 
K3 _____MAKFNTGSNP
F4 ____MAKFNTGSNPT
S27-p PFKVAGQssPsGIQS
S28-p FKVAGQssPsGIQSR
S30-p VAGQssPsGIQSRKN
S46-p FDNQGNAsPPAGPSS
T86-p KPPFLKPtGGsPRFG
S89-p FLKPtGGsPRFGTQP
S114-p VGFLKPVsPKPTsLT
S119-p PVsPKPTsLTKEDSK
K147 LNQESDLKTPGPKPG
A156 PGPKPGPAPPVPENE
V159 KPGPAPPVPENELKP
S201-p HTFGQKPsLstEDSQ
S203-p FGQKPsLstEDSQEE
T204-p GQKPsLstEDSQEEN
Q219 TSKNVPVQKGsPVQL
S222-p NVPVQKGsPVQLGAK
S230 PVQLGAKSKGAPFKP
P242 FKPPKEDPEDKDHGA
K260 PFPGVVLKPAAsRGS
S264-p VVLKPAAsRGSPGLS
K282 EEKKEDRKTDLAKNI
K287 DRKTDLAKNIFLNKL
K293 AKNIFLNKLNQEEPA
- gap
- gap
S318 AGTPWGQSQEKEGDK
- gap
A362 DLTRFRKADSANsAT
S367-p RKADSANsATKSQtP
T373-p NsATKSQtPySTTSL
P374 sATKSQtPySTTSLP
Y375-p ATKSQtPySTTSLPP
K413 SLPPRNIKPPLDLKH
H420 KPPLDLKHPINDENQ
S433-p NQDGVMHsDGtGNLE
D434 QDGVMHsDGtGNLEE
T436-p GVMHsDGtGNLEEEQ
S445-p NLEEEQEsEGETyED
T449 EQEsEGETyEDIDSS
Y450-p QEsEGETyEDIDSSK
K484 EQKEREKKEQELKKK
K491 KEQELKKKFKLTGPI
T495 LKKKFKLTGPIQVIH
K511-ac AKACCDVkGGKNELS
S546-p LGRTARGsyGYIKTT
Y547-p GRTARGsyGYIKTTA
Y549 TARGsyGYIKTTAVE
Y559-p TTAVEIDyDsLKRKK
S561-p AVEIDyDsLKRKKNs
S568-p sLKRKKNsLNAVPPR
Y584 VEDDQDVYDDVAEQD
Y615 PPTDDEIYDGIEEED
D616 PTDDEIYDGIEEEDD
A637 QVDEKTNAWSWGILK
K647-ac WGILKMLkGKDDRKK
S663-p IREKPKVsESDNNEG
Y687-p LDVGEEVyDDVDASD
Y737 DLRKKFKYDGEIRVL
Y745 DGEIRVLYSTKVASS
T747 EIRVLYSTKVASSLT
Y791-p CRNEEGKyGyVLRSY
Y793-p NEEGKyGyVLRSYLV
Y798 yGyVLRSYLVDNDGE
Y807-p VDNDGEIyDDIADGC
D812 EIyDDIADGCIYDND
Y816 DIADGCIYDND____
  rat

 
K3-ac _____MAkFNTGSNP
F4 ____MAkFNTGSNPT
N27 PFKVAGQNsPSGIQS
S28-p FKVAGQNsPSGIQSK
S30 VAGQNsPSGIQSKKN
S46-p FDNQGNAsPPAGPSN
T86 KPPFLKPTGVSPRFG
S89 FLKPTGVSPRFGTQP
S114 VGFLKPVSPKPTSLT
S119 PVSPKPTSLTKEDSK
K147 LNQESDLKTLGPKPG
T156-p LGPKPGStPPVPEND
V159 KPGStPPVPENDLKP
S201 HTYGQKPSLsTEDAQ
S203-p YGQKPSLsTEDAQEE
T204 GQKPSLsTEDAQEEE
Q220 IPKNTPVQKGsPVQL
S223-p NTPVQKGsPVQLGAK
S231 PVQLGAKSRGSPFKP
P243 FKPAKEDPEDKDHGT
K261 PFAGVVLKPAASRGS
S265 VVLKPAASRGSPGLS
K283 EEKKEERKTDIPKNI
K288 ERKTDIPKNIFLNKL
K294 PKNIFLNKLNQEEPA
- gap
- gap
S319-p AGTPWGQsQEKEGDK
- gap
A363 DLTRFRKADSANSSN
S368 RKADSANSSNKSQTP
T374 NSSNKSQTPYSTTSL
P375 SSNKSQTPYSTTSLP
Y376 SNKSQTPYSTTSLPP
K414-ac SLPPRNIkPPLDLKH
H421 kPPLDLKHPINEENQ
S434 NQDGVMHSDGTGNLE
D435 QDGVMHSDGTGNLEE
T437 GVMHSDGTGNLEEEQ
S446-p NLEEEQEsDGEMYED
M450 EQEsDGEMYEDIESS
Y451 QEsDGEMYEDIESSK
K485 EQKEREKKEQELRKK
K492 KEQELRKKFKLTGPI
T496 LRKKFKLTGPIQVIH
K512 AKACCDVKGGKNELS
S547-p LGRTARGsYGYIKTT
Y548 GRTARGsYGYIKTTA
Y550 TARGsYGYIKTTAVK
Y560-p TTAVKIDyDsLKRKK
S562-p AVKIDyDsLKRKKNT
T569 sLKRKKNTINAVPPR
Y585 VEEDQDVYDDVAEQD
Y616 PPADDDIYDGIEEED
D617 PADDDIYDGIEEEDA
A638 QVDEKTNAWSWGILK
K648 WGILKMLKGKDERKK
S664 IREKPKVSESDSNEG
Y688 LDVGEEVYDDVDASD
Y738 DLRKKFKYDGEIRVL
Y746 DGEIRVLYSTKVASS
T748 EIRVLYSTKVASSLT
Y792 CRNEEGKYGYVLRSY
Y794 NEEGKYGYVLRSYLV
Y799 YGYVLRSYLVDNDGE
Y808 VDNDGEIYDDIADGC
D813 EIYDDIADGCIYDND
Y817 DIADGCIYDND____
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