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Protein Page:
p47phox (human)

Overview
p47phox the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Oxidoreductase
Cellular Component: Golgi apparatus; extrinsic to membrane; cell soma; rough endoplasmic reticulum; dendrite; cytosol; NADPH oxidase complex
Molecular Function: protein binding; electron carrier activity; superoxide-generating NADPH oxidase activity; phosphatidylinositol-3,4-bisphosphate binding; SH3 domain binding; phosphoinositide binding
Biological Process: respiratory burst; respiratory burst during defense response; interaction with host; apoptosis; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; leukotriene metabolic process; cell proliferation; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of smooth muscle contraction; cellular defense response; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; response to yeast; protein targeting to membrane; inflammatory response; superoxide release; hydrogen peroxide biosynthetic process
Reference #:  P14598 (UniProtKB)
Alt. Names/Synonyms: 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; FLJ79451; NADPH oxidase organizer 2; NCF-1; NCF-47K; NCF1; NCF1A; Neutrophil cytosol factor 1; neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; NOXO2; p47-phox; p47phox; SH3 and PX domain-containing protein 1A; SH3PXD1A
Gene Symbols: NCF1
Molecular weight: 44,652 Da
Basal Isoelectric point: 9.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p47phox

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S303‑p, S304‑p, S345‑p, S359‑p, S370‑p
enzymatic activity, induced: S303‑p, S304‑p, S328‑p, S359‑p, S370‑p
intracellular localization: S304‑p, S359‑p, S370‑p, S379‑p
molecular association, regulation: S303‑p, S304‑p, S315‑p, S320‑p, S328‑p, S359‑p, S370‑p, S379‑p
phosphorylation: S359‑p, S370‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y41-p DLSEKVVyRRFTEIy
0 13 Y48-p yRRFTEIyEFHKTLK
0 1 T133-p KLPTDNQtKKPEtYL
1 0 T138-p NQtKKPEtYLMPKDG
1 0 T153-p KSTATDItGPIILQT
1 0 S208-p KRGWIPAsFLEPLDS
1 0 Y279-p TGYFPSMyLQKsGQD
1 0 S283-p PSMyLQKsGQDVsQA
0 1 S288-p QKsGQDVsQAQRQIK
5 0 S303-p RGAPPRRssIRNAHs
8 0 S304-p GAPPRRssIRNAHsI
1 0 S310-p ssIRNAHsIHQRsRK
6 0 S315-p AHsIHQRsRKRLsQD
7 14 S320-p QRsRKRLsQDAYRRN
9 0 S328-p QDAYRRNsVRFLQQR
9 4 S345-p QARPGPQsPGsPLEE
8 4 S348-p PGPQsPGsPLEEERQ
0 1 T356-p PLEEERQtQRsKPQP
9 0 S359-p EERQtQRsKPQPAVP
9 0 S370-p PAVPPRPsADLILNR
8 0 S379-p DLILNRCsESTKRKL
  mouse

 
Y41 DLSEKVVYRKFTEIY
Y48 YRKFTEIYEFHKMLK
A133 KLPTDSQAKKPETYL
T138 SQAKKPETYLVPKDG
T153 KNNVADITGPIILQT
S208 KRGWVPASYLEPLDS
Y279 TGYFPSMYLQKAGEE
A283 PSMYLQKAGEEITQA
T288 QKAGEEITQAQRQIR
S304 RGAPPRRSTIRNAQS
T305 GAPPRRSTIRNAQSI
S311 STIRNAQSIHQRSRK
S316 AQSIHQRSRKRLsQD
S321-p QRSRKRLsQDTYRRN
S329 QDTYRRNSVRFLQQR
S346 PGRPGPLSTDGTKDN
G349 PGPLSTDGTKDNPST
T356 GTKDNPSTPRVKPQP
V359 DNPSTPRVKPQPAVP
S370 PAVPPRPSSDLILHR
T379 DLILHRCTESTKRKL
  rat

 
Y41 DLSEKVVYRKFTEIY
Y48 YRKFTEIYEFHKMLK
V133 KLPNDSQVKKPETYL
T138 SQVKKPETYLTAKDG
M153 KNNVADIMGPIILQT
S208 KRGWVPASYLEPLDS
Y279 TGYFPSMYLQKAGEE
A283 PSMYLQKAGEEITQA
T288 QKAGEEITQAQRQIR
S304 RGAPPRRSTIRNAQS
T305 GAPPRRSTIRNAQSI
S311 STIRNAQSIHQRSRK
S316 AQSIHQRSRKRLSQD
S321 QRSRKRLSQDTYRRN
S329 QDTYRRNSVRFLQQR
S346 PARPGPQSPDSKDNP
S349 PGPQSPDSKDNPSTP
T355 DSKDNPSTPRAKPQP
A358 DNPSTPRAKPQPAVP
S369 PAVPPRPSSDLILHR
T378 DLILHRCTESTKRKL
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